Comparative study of instantaneous frequency based methods for leak detection in pipeline networks

Methods of pressure transient analysis can be seen as a promising, accurate and low-cost tool for leak and feature detection in pipelines. Various systems have been developed by several groups of researchers in recent years. Such techniques have been successfully demonstrated under laboratory conditions but are not yet established for use with real field test data. The current paper presents a comparative study of instantaneous frequency analysis techniques based on pressure transients recorded within a live distribution network. The instantaneous frequency of the signals are analysed using the Hilbert transform (HT), the Normalised Hilbert transform (NHT), Direct Quadrature (DQ), Teager Energy Operator (TEO) and Cepstrum. This work demonstrates the effectiveness of the instantaneous frequency analysis in detecting a leaks and other features within the network. NHT and DQ allowed for the identification of the approximate location of leaks. The performance TEO is moderate, with Cepstrum being the worst performing method. © 2011 Elsevier Ltd. All rights reserved

Faculty bridging individual and organizational resilience: results of a qualitative analysis

Background: Medical student burnout and anxiety has received growing attention in the past decade. The culture of competition and assessment has resulted in increasing stress levels amongst medical students, causing a decline in their academic performance and overall mental health. The objective of this qualitative analysis was to characterize recommendations from educational experts to aid students’ academic progress. Methods: At an international meeting in 2019, worksheets were completed by medical educators during a panel discussion. Participants responded to four scenarios representing common challenges medical students face in school (eg. Postponing Step 1, failing clerkships, etc.). For each case, participants addressed what students, faculty and medical schools could do to mitigate the challenge. Inductive thematic analysis was conducted by two authors followed by deductive categorization using an individual-organizational resilience model. Results: Across the four cases, common suggestions made for students, faculty and medical schools were aligned to a resilience model representing the complex interplay between individuals and organizations and the impact on student wellbeing. Discussion: Using suggestions from medical educators from across the US, we were able to identify recommendations for students, faculty, and medical schools to help students succeed in medical school. By applying a model of resilience, faculty serve as a critical bridge to connect students to the medical school administration. Our findings also support a pass/fail curriculum to ease the competition and burden students place on themselves

Contact-dependent killing by cytotoxic T lymphocytes is insufficient for EL4 tumor regression in vivo

Immunotherapies are an emerging strategy for treatment of solid tumors. Improved understanding of the mechanisms employed by cytotoxic T lymphocytes (CTLs) to control tumors will aid in the development of immunotherapies. CTLs can directly kill tumor cells in a contact-dependent manner or may exert indirect effects on tumor cells via secretion of cytokines. Here we aim to quantify the importance of these mechanisms in murine thymoma EL4/EG7 cells. We developed an agent-based model (ABM) and an ordinary differential equation (ODE) model of tumor regression after adoptive transfer of a population of CTLs. Models were parameterized based on in vivo measurements of CTL infiltration and killing rates applied to EL4/EG7 tumors and OTI T cells. We quantified whether infiltrating CTLs are capable of controlling tumors through only direct, contact-dependent killing. Both models agreed that the low measured killing rate of CTLs in vivo was insufficient to cause tumor regression. In our ABM we also simulated CTL production of the cytokine interferon gamma (IFNγ) in order to explore how an antiproliferative effect of IFNγ might aid CTLs in tumor control. In this model IFNγ substantially reduced tumor growth compared to direct killing alone. Collectively these data demonstrate that contact-dependent killing is insufficient for EL4 regression in vivo and highlight the potential importance of cytokine-induced antiproliferative effects in T cell-mediated tumor control.Toxicolog

Experimental configuration of direct drive cylindrical implosions on the Omega Laser

Details about the cylindrical implosions using direct-drive irradiation on the OMEGA Laser facility are provided. The experimental configuration, including orientation, construction, and mounting of the targets is described. An attempt to characterize the modulation transfer function of the primary x-ray framing camera diagnostic results in insufficient exposure contrast but relative agreement with other determinations. The x-ray intensity of the titanium backlighter driven by the 2.5-nsec linear ramp of the laser beams is described, and the relative intensity on film is compared to similar Nova experiments. The parallax effects of different length marker layers of high-opacity dichloropolystyrene is measured, resulting in the conclusion that the marker layer length should be matched to the laser drive illumination profile

Heterogeneous, delayed-onset killing by multiple-hitting T cells: Stochastic simulations to assess methods for analysis of imaging data

Although quantitative insights into the killing behaviour of Cytotoxic T Lymphocytes (CTLs) are necessary for the rational design of immune-based therapies, CTL killing function remains insufficiently characterised. One established model of CTL killing treats CTL cytotoxicity as a Poisson process, based on the assumption that CTLs serially kill antigen-presenting target cells via delivery of lethal hits, each lethal hit corresponding to a single injection of cytotoxic proteins into the target cell cytoplasm. Contradicting this model, a recent in vitro study of individual CTLs killing targets over a 12-hour period found significantly greater heterogeneity in CTL killing performance than predicted by Poisson-based killing. The observed killing process was dynamic and varied between CTLs, with the best performing CTLs exhibiting a marked increase in killing during the final hours of the experiments, along with a "burst killing" kinetic. Despite a search for potential differences between CTLs, no mechanistic explanation for the heterogeneous killing kinetics was found. Here we have used stochastic simulations to assess whether target cells might require multiple hits from CTLs before undergoing apoptosis, in order to verify whether multiple-hitting could explain the late onset, burst killing dynamics observed in vitro. We found that multiple-hitting from CTLs was entirely consistent with the observed killing kinetics. Moreover, the number of available targets and the spatiotemporal kinetics of CTL:target interactions influenced the realised CTL killing rate. We subsequently used realistic, spatial simulations to assess methods for estimating the hitting rate and the number of hits required for target death, to be applied to microscopy data of individual CTLs killing targets. We found that measuring the cumulative duration of individual contacts that targets have with CTLs would substantially improve accuracy when estimating the killing kinetics of CTLs.Toxicolog

Closed Contour Fractal Dimension Estimation by the Fourier Transform

This work proposes a novel technique for the numerical calculus of the fractal dimension of fractal objects which can be represented as a closed contour. The proposed method maps the fractal contour onto a complex signal and calculates its fractal dimension using the Fourier transform. The Fourier power spectrum is obtained and an exponential relation is verified between the power and the frequency. From the parameter (exponent) of the relation, it is obtained the fractal dimension. The method is compared to other classical fractal dimension estimation methods in the literature, e. g., Bouligand-Minkowski, box-couting and classical Fourier. The comparison is achieved by the calculus of the fractal dimension of fractal contours whose dimensions are well-known analytically. The results showed the high precision and robustness of the proposed technique

Nonextensive thermal sources of cosmic rays?

The energy spectrum of cosmic rays (CR) exhibits power-like behavior with a very characteristic "knee" structure. We consider a possibility that such a spectrum could be generated by some specific nonstatistical temperature fluctuations in the source of CR with the "knee" structure reflecting an abrupt change of the pattern of such fluctuations. This would result in a generalized nonextensive statistical model for the production of CR. The possible physical mechanisms leading to these effects are discussed together with the resulting chemical composition of the CR, which follows the experimentally observed abundance of nuclei.Comment: 16 pages, 3 figures, rewritten and updated version, to be published in Centr. Eur. J. Phy

Lesions of Endodontic Origin and Risk of Coronary Heart Disease

A paucity of epidemiologic research exists regarding systemic health consequences of endodontic disease. This study evaluated whether incident radiographically evident lesions of endodontic origin were related to development of coronary heart disease (CHD) among 708 male participants in the VA Dental Longitudinal Study. At baseline and every three years for up to 32 years, participants (who were not VA patients) received complete medical and dental examinations, including full-mouth radiographs. Cox regression models estimated the relationship between incident lesions of endodontic origin and time to CHD diagnosis. Among those ≤ 40 years old, incident lesions of endodontic origin were significantly associated with time to CHD diagnosis (p 40 years old, no statistically significant association was observed. These findings are consistent with research that suggests relationships between chronic periodontal inflammation and the development of CHD, especially among younger men