Accurate automatic tuning circuit for bipolar integrated filters

An accurate automatic tuning circuit for tuning the cutoff frequency and Q-factor of high-frequency bipolar filters is presented. The circuit is based on a voltage controlled quadrature oscillator (VCO). The frequency and the RMS (root mean square) amplitude of the oscillator output signal are locked to the frequency and the RMS amplitude of a reference signal, respectively. Special attention is paid to the actual Q-factor in the oscillator. Experimental results for a breadboard circuit operating from 136 to 317 kHz are presente

Magnetization reversal mechanism in La0.67Sr0.33MnO3 thin films on NdGaO3 substrates

The field angle dependence of the coercive field of La0.67Sr0.33MnO3 thin films grown epitaxially on NdGaO3 substrates with different crystallographic orientations was determined. All films show uniaxial anisotropy. The angle dependence of the coercivity is best described by a two-phase model, explaining the strong increase in the coercive field for increasing field angles, away from the easy axis direction, as well as the sharp decrease for angles close to the hard direction. This implies that magnetization reversal starts with the depinning of domain walls, analogous to the Kondorsky model. With increasing field the reversal in the domains is not abrupt, but is determined by the gradual displacement of the domain walls. These results are of significance for understanding and possibly engineering of the switching behavior of magnetic tunnel junctions

Anisotropic stress relief mechanism in epitaxial La0.67Sr0.33MnO3 films

We report an anisotropic misfit stress relief mechanism in thin La0.67Sr0.33MnO3 (LSMO) films coherently grown on NdGaO3(110) substrates. These results are uniquely related to the orthorhombicity of the LSMO. The x-ray diffraction measurements and quantitative simulations demonstrate that biaxial mismatch stress is relieved differently along in-plane directions perpendicular to each other: in the [1math0] direction stress is accommodated by decrease of the γ angle of the orthorhombic LSMO unit cell, while in the [001] direction stress is partially relieved by periodic lattice modulations

Accurate automatic tuning circuit for bipolar integrated filters

An accurate automatic tuning circuit for tuning the cutoff frequency and Q-factor of high-frequency bipolar filters is presented. The circuit is based on a voltage controlled quadrature oscillator (VCO). The frequency and the RMS (root mean square) amplitude of the oscillator output signal are locked to the frequency and the RMS amplitude of a reference signal, respectively. Special attention is paid to the actual Q-factor in the oscillator. Experimental results for a breadboard circuit operating from 136 to 317 kHz are presente

Rotation of the magnetic easy axis in La0.67Sr0.33MnO3 thin film on NdGaO3(112)

The in-plane magnetic anisotropy is studied for pseudocubic {011}pc oriented La0.67Sr0.33MnO3 (LSMO) thin film grown on orthorhombic NdGaO3(NGO)(112)o (the subindices “pc” and “o” indicate the pseudocubic and orthorhombic lattice structure, respectively). The direction of the in-plane remanent magnetization of LSMO thin films with different thicknesses is determined. With increasing film thickness the easy axes rotate and the anisotropy changes from uniaxial to biaxial. This is associated with the increasing symmetry of the LSMO with increasing thickness, starting with a monoclinic LSMO structure at the nonrectangular NGO(112)o surface unit cell of the substrate, developing into an orthorhombic structure at the top part of the thickest films

Optimized fabrication of high-quality La0.67Sr0.33MnO3 thin films considering all essential characteristics

In this paper, an overview of the fabrication and properties of high-quality La0.67Sr0.33MnO3 (LSMO) thin films is given. A high-quality LSMO film combines a smooth surface morphology with a large magnetization and a small residual resistivity, while avoiding precipitates and surface segregation. In the literature, typically only a few of these issues are adressed. We therefore present a thorough characterization of our films, which were grown by pulsed laser deposition. The films were characterized with reflection high energy electron diffraction, atomic force microscopy, x-ray diffraction, magnetization and transport measurements, x-ray photoelectron spectroscopy and scanning transmission electron microscopy. The films have a saturation magnetization of 4.0 µB/Mn, a Curie temperature of 350 K and a residual resistivity of 60 µΩ cm. These results indicate that high-quality films, combining both large magnetization and small residual resistivity, were realized. A comparison between different samples presented in the literature shows that focussing on a single property is insufficient for the optimization of the deposition process. For high-quality films, all properties have to be adressed. For LSMO devices, the thin-film quality is crucial for the device performance. Therefore, this research is important for the application of LSMO in devices

Processo como um serviço na computação em nuvem para o desenvolvimento de aplicações na saúde

This project aims to investigate the deployment of business processes in cloud environments, using the Process-as-a-Service model. This model allows a business process to be entirely or partially executed in a cloud computing environment. Due to security requirements, for example, in healthcare applications, certain data or activities of a business process should be kept within the premises of the user, while other data or activities can be allocated in a computing cloud, requiring a decomposition of this process

Fusion transcripts and their genomic breakpoints in polyadenylated and ribosomal RNA-minus RNA sequencing data

BACKGROUND: Fusion genes are typically identified by RNA sequencing (RNA-seq) without elucidating the causal genomic breakpoints. However, non–poly(A)-enriched RNA-seq contains large proportions of intronic reads that also span genomic breakpoints. RESULTS: We have developed an algorithm, Dr. Disco, that searches for fusion transcripts by taking an entire reference genome into account as search space. This includes exons but also introns, intergenic regions, and sequences that do not meet splice junction motifs. Using 1,275 RNA-seq samples, we investigated to what extent genomic breakpoints can be extracted from RNA-seq data and their implications regarding poly(A)-enriched and ribosomal RNA–minus RNA-seq data. Comparison with whole-genome sequencing data revealed that most genomic breakpoints are not, or minimally, transcribed while, in contrast, the genomic breakpoints of all 32 TMPRSS2-ERG–positive tumours were present at RNA level. We also revealed tumours in which the ERG breakpoint was located before ERG, which co-existed with additional deletions and messenger RNA that incorporated intergenic cryptic exons. In breast cancer we identified rearrangement hot spots near CCND1 and in glioma near CDK4 and MDM2 and could directly associate this with increased expression. Furthermore, in all datasets we find fusions to intergenic regions, often spanning multiple cryptic exons that potentially encode neo-antigens. Thus, fusion transcripts other than classical gene-to-gene fusions are prominently present and can be identified using RNA-seq. CONCLUSION: By using the full potential of non–poly(A)-enriched RNA-seq data, sophisticated analysis can reliably identify expressed genomic breakpoints and their transcriptional effects