71,700 research outputs found

    VISHNU hybrid model for viscous QCD matter at RHIC and LHC energies

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    In this proceeding, we briefly describe the viscous hydrodynamics + hadron cascade hybrid model VISHNU for relativistic heavy ion collisions and report the current status on extracting the QGP viscosity from elliptic flow data.Comment: 4 pages, 1 figure, the proceedings of 7th International Workshop on Critical Point and Onset of Deconfinement, Wuhan, China, Nov. 7-11, 201

    DNA mismatch binding and antiproliferative activity of rhodium metalloinsertors

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    Deficiencies in mismatch repair (MMR) are associated with carcinogenesis. Rhodium metalloinsertors bind to DNA base mismatches with high specificity and inhibit cellular proliferation preferentially in MMR-deficient cells versus MMR-proficient cells. A family of chrysenequinone diimine complexes of rhodium with varying ancillary ligands that serve as DNA metalloinsertors has been synthesized, and both DNA mismatch binding affinities and antiproliferative activities against the human colorectal carcinoma cell lines HCT116N and HCT116O, an isogenic model system for MMR deficiency, have been determined. DNA photocleavage experiments reveal that all complexes bind to the mismatch sites with high specificities; DNA binding affinities to oligonucleotides containing single base CA and CC mismatches, obtained through photocleavage titration or competition, vary from 10^4 to 10^8 M^−1 for the series of complexes. Significantly, binding affinities are found to be inversely related to ancillary ligand size and directly related to differential inhibition of the HCT116 cell lines. The observed trend in binding affinity is consistent with the metalloinsertion mode where the complex binds from the minor groove with ejection of mismatched base pairs. The correlation between binding affinity and targeting of the MMR-deficient cell line suggests that rhodium metalloinsertors exert their selective biological effects on MMR-deficient cells through mismatch binding in vivo

    Enhanced toluene removal using granular activated carbon and a yeast strain candida tropicalis in bubble-column bioreactors

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    The yeast strain Candida tropicalis was used for the biodegradation of gaseous toluene. Toluene was effectively treated by a liquid culture of C. tropicalis in abubble-column bioreactor, and the tolueneremoval efficiency increased with decreasing gas flow rate. However, toluene mass transfer from the gas-to-liquid phase was a major limitation for the uptake of toluene by C. tropicalis. The tolueneremoval efficiency was enhanced when granularactivatedcarbon (GAC) was added as a fluidized material. The GAC fluidized bioreactor demonstrated tolueneremoval efficiencies ranging from 50 to 82% when the inlet toluene loading was varied between 13.1 and 26.9 g/m3/h. The yield value of C. tropicalis ranged from 0.11 to 0.21 g-biomass/g-toluene, which was substantially lower than yield values for bacteria reported in the literature. The maximum elimination capacity determined in the GAC fluidized bioreactor was 172 g/m3/h at atoluene loading of 291 g/m3/h. Transient loading experiments revealed that approximately 50% of the toluene introduced was initially adsorbed onto the GAC during an increased loading period, and then slowly desorbed and became available to the yeast culture. Hence, the fluidized GAC mediated in improving the gas-to-liquid mass transfer of toluene, resulting in a high tolueneremoval capacity. Consequently, the GAC bubble-column bioreactor using the culture of C. tropicalis can be successfully applied for the removal of gaseous toluene

    A Quantum Computer Architecture using Nonlocal Interactions

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    Several authors have described the basic requirements essential to build a scalable quantum computer. Because many physical implementation schemes for quantum computing rely on nearest neighbor interactions, there is a hidden quantum communication overhead to connect distant nodes of the computer. In this paper we propose a physical solution to this problem which, together with the key building blocks, provides a pathway to a scalable quantum architecture using nonlocal interactions. Our solution involves the concept of a quantum bus that acts as a refreshable entanglement resource to connect distant memory nodes providing an architectural concept for quantum computers analogous to the von Neumann architecture for classical computers.Comment: 4 pages, 2 figures, Slight modifications to satisfy referee, 2 new references, modified acknowledgement. This draft to appear in PRA Rapid Communication

    Drastic Reduction of Shot Noise in Semiconductor Superlattices

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    We have found experimentally that the shot noise of the tunneling current II through an undoped semiconductor superlattice is reduced with respect to the Poissonian noise value 2eI2eI, and that the noise approaches 1/3 of that value in superlattices whose quantum wells are strongly coupled. On the other hand, when the coupling is weak or when a strong electric field is applied to the superlattice the noise becomes Poissonian. Although our results are qualitatively consistent with existing theories for one-dimensional mulitple barriers, the theories cannot account for the dependence of the noise on superlattice parameters that we have observed.Comment: 4 Pages, 3Figure

    Systematic study of nuclear matrix elements in neutrinoless double-beta decay with a beyond mean-field covariant density functional theory

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    We report a systematic study of nuclear matrix elements (NMEs) in neutrinoless double-beta decays with a state-of-the-art beyond mean-field covariant density functional theory. The dynamic effects of particle-number and angular-momentum conservations as well as quadrupole shape fluctuations are taken into account with projections and generator coordinate method for both initial and final nuclei. The full relativistic transition operator is adopted to calculate the NMEs. The present systematic studies show that in most of the cases there is a much better agreement with the previous non-relativistic calculation based on the Gogny force than in the case of the nucleus 150^{150}Nd found in Song et al. [Phys. Rev. C 90, 054309 (2014)]. In particular, we find that the total NMEs can be well approximated by the pure axial-vector coupling term with a considerable reduction of the computational effort.Comment: 9 pages with 7 figures and 3 table
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