Sex differences in variability across timescales in BALB/c mice.

BackgroundFemales are markedly underinvestigated in the biological and behavioral sciences due to the presumption that cyclic hormonal changes across the ovulatory cycle introduce excess variability to measures of interest in comparison to males. However, recent analyses indicate that male and female mice and rats exhibit comparable variability across numerous physiological and behavioral measures, even when the stage of the estrous cycle is not considered. Hormonal changes across the ovulatory cycle likely contribute cyclic, intra-individual variability in females, but the source(s) of male variability has, to our knowledge, not been investigated. It is unclear whether male variability, like that of females, is temporally structured and, therefore, quantifiable and predictable. Finally, whether males and females exhibit variability on similar time scales has not been explored.MethodsThese questions were addressed by collecting chronic, high temporal resolution locomotor activity (LA) and core body temperature (CBT) data from male and female BALB/c mice.ResultsContrary to expectation, males are more variable than females over the course of the day (diel variability) and exhibit higher intra-individual daily range than females in both LA and CBT. Between mice of a given sex, variability is comparable for LA but the inter-individual daily range in CBT is greater for males. To identify potential rhythmic processes contributing to these sex differences, we employed wavelet transformations across a range of periodicities (1-39 h).ConclusionsAlthough variability in circadian power is comparable between the sexes for both LA and CBT, infradian variability is greater in females and ultradian variability is greater in males. Thus, exclusion of female mice from studies because of estrous cycle variability may increase variance in investigations where only male measures are collected over a span of several hours and limit generalization of findings from males to females

Teaching Object-Oriented Programming Concepts Using Visual Basic .NET

This paper presents an object-oriented approach to Visual Basic .NET instruction to be delivered in a traditional academic semester for information system curricula. The paper first discusses some of the inherent problems with Visual Basic .NET instruction and then proposes an object-oriented approach. This approach includes a systematic set of programming projects to take students on a journey that traces the principles of the object-oriented, the event-driven, and the procedural paradigms into a coherent framework. The Unified Modeling Language Class Diagram notation is used to model an object-oriented system that is developed and enhanced throughout the duration of the course. Practical recommendations and programming exercises are provided and evaluated in the discussion. This course is intended to be at minimum a second programming course for information system students to satisfy IS 2002 guidelines

Hodge numbers for the cohomology of Calabi-Yau type local systems

We use Higgs cohomology to determine the Hodge numbers of the first intersection cohomology group of a local system V arising from the third direct image of a family of Calabi-Yau 3-folds over a smooth, quasi-projective curve. We give applications to Rhode's families of Calabi-Yau 3-folds without MUM.Comment: Some signs corrected. This article draws heavily from arXiv:0911.027

Vacuum energy for the supersymmetric twisted D-brane in constant electromagnetic field

We calculate vacuum energy for twisted SUSY D-brane on toroidal background with constant magnetic or constant electric field. Its behaviour for toroidal D-brane (p=2) in constant electric field shows the presence of stable minimum for twisted versions of the theory. That indicates such a background maybe reasonable groundstate.Comment: LaTeX, 10 page

Leo V: A Companion of a Companion of the Milky Way Galaxy

We report the discovery of a new Milky Way dwarf spheroidal galaxy in the constellation of Leo identified in data from the Sloan Digital Sky Survey. Leo V lies at a distance of about 180 kpc, and is separated by about 3 degrees from another recent discovery, Leo IV. We present follow-up imaging from the Isaac Newton Telescope and spectroscopy from the Hectochelle fiber spectrograph at the Multiple Mirror Telescope. Leo V's heliocentric velocity is 173.4 km/s, which is offset by about 40 km/s from that of Leo IV. A simple interpretation of the kinematic data is that both objects may lie on the same stream, though the implied orbit is only modestly eccentric (e = 0.2)Comment: Submitted to ApJ (Letters

The Via Lactea INCITE Simulation: Galactic Dark Matter Substructure at High Resolution

It is a clear unique prediction of the cold dark matter paradigm of cosmological structure formation that galaxies form hierarchically and are embedded in massive, extended dark halos teeming with self-bound substructure or "subhalos". The amount and spatial distribution of subhalos around their host provide unique information and clues on the galaxy assembly process and the nature of the dark matter. Here we present results from the Via Lactea INCITE simulation, a one billion particle, one million cpu-hour simulation of the formation and evolution of a Galactic dark matter halo and its substructure population.Comment: 10 pages, Proceedings of the SciDAC 2008 conference, (Seattle, July 13-17, 2008

Investigation of the New Local Group Galaxy VV 124

We present the results of our stellar photometry and spectroscopy for the new Local Group galaxy VV 124 (UGC 4879) obtained with the 6-m BTA telescope. The presence of a few bright supergiants in the galaxy indicates that the current star formation process is weak. The apparent distribution of stars with different ages in VV 124 does not differ from the analogous distributions of stars in irregular galaxies, but the ratio of the numbers of young and old stars indicates that VV 124 belongs to the rare Irr/Sph type of galaxies. The old stars (red giants) form the most extended structure, a thick disk with an exponential decrease in the star number density to the edge. Definitely, the young population unresolvable in images makes a great contribution to the background emission from the central galactic regions. The presence of young stars is also confirmed by the [O III] emission line visible in the spectra that belongs to extensive diffuse galactic regions. The mean radial velocity of several components (two bright supergiants, the unresolvable stellar population, and the diffuse gas) is v_h = -70+/-15 km/s and the velocity with which VV 124 falls into the Local Group is v_LG = -12+/-15 km/s. We confirm the distance to the galaxy D = 1.1+/-0.1 Mpc and the metallicity of red giants ([Fe/H] = -1.37) found by Kopylov et al. (2008).VV 124 is located on the periphery of the Local Group approximately at the same distance from M 31 and our Galaxy and is isolated from other galaxies. The galaxy LeoA nearest to it is 0.5 Mpc away.Comment: 10 pages, 8 figures. Accepted for publication in Astronomy Letters (2010, Vol. 36, No. 5, pp. 309-318

Alcohol Schema Acquisition in Preschoolers: Differences Between Children of Alcoholics and Children of Nonalcoholics

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65209/1/j.1530-0277.1995.tb00982.x.pd

The discovery of two extremely low luminosity Milky Way globular clusters

We report the discovery of two extremely low luminosity globular clusters in the Milky Way Halo. These objects were detected in the Sloan Digital Sky Survey Data Release 5 and confirmed with deeper imaging at the Calar Alto Observatory. The clusters, Koposov 1 and Koposov 2, are located at $\sim 40-50$ kpc and appear to have old stellar populations and luminosities of only $M_V \sim -1$ mag. Their observed sizes of $\sim 3$ pc are well within the expected tidal limit of $\sim$10 pc at that distance. Together with Palomar 1, AM 4 and Whiting 1, these new clusters are the lowest luminosity globulars orbiting the Milky Way, with Koposov 2 the most extreme. Koposov 1 appears to lie close to distant branch of the Sagittarius stream. The half-mass relaxation times of Koposov 1 and 2 are only $\sim 70$ and $\sim 55$ Myr respectively (2 orders of magnitude shorter than the age of the stellar populations), so it would seem that they have undergone drastic mass segregation. Since they do not appear to be very concentrated, their evaporation timescales may be as low as $\sim 0.1 t_{\rm Hubble}$. These discoveries show that the structural parameter space of globular clusters in the Milky Way halo is not yet fully explored. They also add, through their short remaining survival times, significant direct evidence for a once much larger population of globular clusters.Comment: accepted for publication in ApJ, minor revision

HD 5388 b is a 69 M_Jup companion instead of a planet

We examined six exoplanet host stars with non-standard Hipparcos astrometric solution, which may be indicative of unrecognised orbital motion. Using Hipparcos intermediate astrometric data, we detected the astrometric orbit of HD 5388 at a significance level of 99.4 % (2.7 sigma). HD 5388 is a metal-deficient star and hosts a planet candidate with a minimum mass of 1.96 M_J discovered in 2010. We determined its orbit inclination to be i = 178.3 +0.4/-0.7 deg and the corresponding mass of its companion HD 5388 b to be M_2 = 69 +/- 20 M_J. The orbit is seen almost face-on and the companion mass lies at the upper end of the brown-dwarf mass range. A mass lower than 13 M_J was excluded at the 3-sigma level. The astrometric motions of the five other stars had been investigated by other authors revealing two planetary companions, one stellar companion, and two statistically insignificant orbits. We conclude that HD 5388 b is not a planet but most likely a brown-dwarf companion. In addition, we find that the inclinations of the stellar rotation axis and the companion's orbital axis differ significantly.Comment: 5 pages, 4 figures, Accepted for publication in Astronomy and Astrophysics Letter