Cosmic ray spectral hardening due to dispersion in the source injection spectra

Recent cosmic ray (CR) experiments discovered that the CR spectra experience a remarkable hardening for rigidity above several hundred GV. We propose that this is caused by the superposition of the CR energy spectra of many sources that have a dispersion in the injection spectral indices. Adopting similar parameters as those of supernova remnants derived from the Fermi $\gamma$-ray observations, we can reproduce the observational CR spectra of different species well. This may be interpreted as evidence to support the supernova remnant origin of CRs below the knee. We further propose that the same mechanism may explain the "ankle" of the ultra high energy CR spectrum.Comment: 5 pages, 3 figures and 1 table. Updated with the diffusion propagation model, accepted by Phys. Rev.

Far-infrared optical properties of the pyrochlore spin ice compound Dy2Ti2O4

Near normal incident far-infrared reflectivity spectra of [111] dysprosium titanate (Dy2Ti2O4) single crystal have been measured at different temperatures. Seven phonon modes (eight at low temperature) are identified at frequency below 1000 cm-1. Optical conductivity spectra are obtained by fitting all the reflectivity spectra with the factorized form of the dielectric function. Both the Born effective charges and the static optical primitivity are found to increase with decreasing temperature. Moreover, phonon linewidth narrowering and phonon modes shift with decreasing temperature are also observed, which may result from enhanced charge localization. The redshift of several low frequency modes is attributed to the spin-phonon coupling. All observed optical properties can be explained within the framework of nearest neighbor ferromagnetic(FM) spin ice model

DNA damage by the cobalt (II) and zinc (II) complexes of tetraazamacrocyclic in Tetrahymena thermophila

Using the single cell gel electrophoresis method, the tetraazamacrocycle Zn(II) complex (Zn(II)-L) and the tetraazamacrocycle Co(II) complex (Co(II)-L) were investigated focusing on their DNA damage to Tetrahymena thermophila. When the cells were treated with the 0.05, 0.25 and 0.50 mg/ml Zn(II)-L, the tail length increased significantly, with 10.83, 11.56 and 11.87 m, respectively. With the dose of 0.5mg/ml Zn(II)-L treatment, 45.5% cells distributed in grade 3. After treatment with the 0.05, 0.25 and 0.50 mg/ml Co(II)-L, the tail length of the cells also increased significantly, with the length of 15.64, 17.75 and19.21 m, respectively. When treated with 0.5 mg/ml Co(II)-L, 98.1% cells showed tail and 75.6% cells distributed in grade 3. The results indicated that Co(II)-L induced a relatively high level of DNA damagein comparison with the level of damage induced by Zn(II)-L

Ages and Masses of 0.64 million Red Giant Branch stars from the LAMOST Galactic Spectroscopic Survey

We present a catalog of stellar age and mass estimates for a sample of 640\,986 red giant branch (RGB) stars of the Galactic disk from the LAMOST Galactic Spectroscopic Survey (DR4). The RGB stars are distinguished from the red clump stars utilizing period spacing derived from the spectra with a machine learning method based on kernel principal component analysis (KPCA). Cross-validation suggests our method is capable of distinguishing RC from RGB stars with only 2 per cent contamination rate for stars with signal-to-noise ratio (SNR) higher than 50. The age and mass of these RGB stars are determined from their LAMOST spectra with KPCA method by taking the LAMOST - $Kepler$ giant stars having asteroseismic parameters and the LAMOST-TGAS sub-giant stars based on isochrones as training sets. Examinations suggest that the age and mass estimates of our RGB sample stars with SNR $>$ 30 have a median error of 30 per cent and 10 per cent, respectively. Stellar ages are found to exhibit positive vertical and negative radial gradients across the disk, and the age structure of the disk is strongly flared across the whole disk of $6<R<13$\,kpc. The data set demonstrates good correlations among stellar age, [Fe/H] and [$\alpha$/Fe]. There are two separate sequences in the [Fe/H] -- [$\alpha$/Fe] plane: a high--$\alpha$ sequence with stars older than $\sim$\,8\,Gyr and a low--$\alpha$ sequence composed of stars with ages covering the whole range of possible ages of stars. We also examine relations between age and kinematic parameters derived from the Gaia DR2 parallax and proper motions. Both the median value and dispersion of the orbital eccentricity are found to increase with age. The vertical angular momentum is found to fairly smoothly decrease with age from 2 to 12\,Gyr, with a rate of about $-$50\,kpc\,km\,s$^{-1}$\,Gyr$^{-1}$. A full table of the catalog is public available online.Comment: 16 pages, 22 figures,accepted by MNRA

Prognostic Importance of Circulating Tumor Cells in Nonsmall Cell Lung Cancer: A Prospective Study

Purpose: To investigate the prognostic value of circulating tumor cells (CTCs) and to predict the treatment response in a non-small cell lung cancer (NSCLC).Methodology: A single-center prospective study involving 93 patients with NSCLC was conducted. Blood samples were analyzed for CTC count before and after chemotherapy. Clinical relevance of CTCs with patient`s characteristics and treatment response were determined.Results: Higher levels of CTCs were associated with severe stage of NSCLC (p = 0.003), tumor histology (p = 0.014) and metastases (p = 0.013). Significant difference in CTC count was observed in favorable (CTCs &lt; 5) and unfavorable (CTCs ≥ 5) groups. Progression-free survival (PFS) was 5.8 months (range: 5.32 to 6.43) and 2.2 months (range: 1.85 to 3.01) in the favorable and unfavorable groups, respectively (HR: 3.88, 95% CI, p &lt; 0.001). Similarly, overall survival (OS) was 7.3 months (95% CI, 6.51 to 7.92) and 3.9 months (95% CI, 1.99 to 5.13), respectively (HR: 4.8, 95% CI, p &lt; 0.001). Multivariate  regression analysis revealed CTCs as strong predictors of OS and PFS. Significant reduction (p &lt; 0.001) in CTC count was also observed after one cycle of chemotherapy.Conclusion: Patients with low CTC count live longer and remain progression-free for a longer period of time than those with high CTC count. High CTCs can be detected in severe forms of lung cancer and can be used as a valid prognostic marker. However, this assertion requires validation in larger prospective clinical cohorts.Keywords: Circulating tumor cells, Non-small cell lung cancer, Circulating tumor cell, Prognosi

Non-intrusive stochastic analysis with parameterized imprecise probability models: I. Performance estimation

© 2019 Elsevier Ltd Uncertainty propagation through the simulation models is critical for computational mechanics engineering to provide robust and reliable design in the presence of polymorphic uncertainty. This set of companion papers present a general framework, termed as non-intrusive imprecise stochastic simulation, for uncertainty propagation under the background of imprecise probability. This framework is composed of a set of methods developed for meeting different goals. In this paper, the performance estimation is concerned. The local extended Monte Carlo simulation (EMCS) is firstly reviewed, and then the global EMCS is devised to improve the global performance. Secondly, the cut-HDMR (High-Dimensional Model Representation) is introduced for decomposing the probabilistic response functions, and the local EMCS method is used for estimating the cut-HDMR component functions. Thirdly, the RS (Random Sampling)-HDMR is introduced to decompose the probabilistic response functions, and the global EMCS is applied for estimating the RS-HDMR component functions. The statistical errors of all estimators are derived, and the truncation errors are estimated by two global sensitivity indices, which can also be used for identifying the influential HDMR components. In the companion paper, the reliability and rare event analysis are treated. The effectiveness of the proposed methods are demonstrated by numerical and engineering examples

Non-intrusive stochastic analysis with parameterized imprecise probability models: II. Reliability and rare events analysis

© 2019 Elsevier Ltd Structural reliability analysis for rare failure events in the presence of hybrid uncertainties is a challenging task drawing increasing attentions in both academic and engineering fields. Based on the new imprecise stochastic simulation framework developed in the companion paper, this work aims at developing efficient methods to estimate the failure probability functions subjected to rare failure events with the hybrid uncertainties being characterized by imprecise probability models. The imprecise stochastic simulation methods are firstly improved by the active learning procedure so as to reduce the computational costs. For the more challenging rare failure events, two extended subset simulation based sampling methods are proposed to provide better performances in both local and global parameter spaces. The computational costs of both methods are the same with the classical subset simulation method. These two methods are also combined with the active learning procedure so as to further substantially reduce the computational costs. The estimation errors of all the methods are analyzed based on sensitivity indices and statistical properties of the developed estimators. All these new developments enrich the imprecise stochastic simulation framework. The feasibility and efficiency of the proposed methods are demonstrated with numerical and engineering test examples

On higher analogues of Courant algebroids

In this paper, we study the algebraic properties of the higher analogues of Courant algebroid structures on the direct sum bundle $TM\oplus\wedge^nT^*M$ for an $m$-dimensional manifold. As an application, we revisit Nambu-Poisson structures and multisymplectic structures. We prove that the graph of an $(n+1)$-vector field $\pi$ is closed under the higher-order Dorfman bracket iff $\pi$ is a Nambu-Poisson structure. Consequently, there is an induced Leibniz algebroid structure on $\wedge^nT^*M$. The graph of an $(n+1)$-form $\omega$ is closed under the higher-order Dorfman bracket iff $\omega$ is a premultisymplectic structure of order $n$, i.e. \dM\omega=0. Furthermore, there is a Lie algebroid structure on the admissible bundle $A\subset\wedge^{n}T^*M$. In particular, for a 2-plectic structure, it induces the Lie 2-algebra structure given in \cite{baez:classicalstring}.Comment: 13 page