Postcard: Advertisement for Luyties Homeopathic Pharmacy Company

This black and white printed postcard features an advertisement for homeopathic pharmaceutical items. There is printed text on the left and an emblem of a globe. The back side has printed text and a handwritten name and address.https://scholars.fhsu.edu/tj_postcards/1132/thumbnail.jp

Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury

Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine-glycine-aspartic acid (RGD)-binding integrins are important mediators of the pro-fibrotic response by activating latent TGF-β at sites of injury and by providing myofibroblasts information about the composition and stiffness of the extracellular matrix. Therefore, blockade of RGD-binding integrins may have therapeutic potential for CKD. To test this idea, we used small-molecule peptidomimetics that potently inhibit a subset of RGD-binding integrins in a murine model of kidney fibrosis. Acute kidney injury leading to fibrosis was induced by administration of aristolochic acid. Continuous subcutaneous administration of CWHM-12, an RGD integrin antagonist, for 28 days improved kidney function as measured by serum creatinine. CWHM-12 significantly reduced Collagen 1 (Col1a1) mRNA expression and scar collagen deposition in the kidney. Protein and gene expression markers of activated myofibroblasts, a major source of extracellular matrix deposition in kidney fibrosis, were diminished by treatment. RNA sequencing revealed that inhibition of RGD integrins influenced multiple pathways that determine the outcome of the response to injury and of repair processes. A second RGD integrin antagonist, CWHM-680, administered once daily by oral gavage was also effective in ameliorating fibrosis. We conclude that targeting RGD integrins with such small-molecule antagonists is a promising therapeutic approach in fibrotic kidney disease

Bostonia: The Boston University Alumni Magazine. Volume 29

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Effects of Sex and Hormonal Implant on Beef Carcass Characteristics and Palatability

A comparison of crossbred bulls, steers and heifers indicated that bulls have heavier carcasses, larger rib eyes and a more desirable yield grade. The USDA quality grade of the bulls was one-third of a grade lower than for the steers and heifers. The sensory and palatability characteristics showed no significant differences among axes. Implanted bulls as compared to non-implanted bulls showed more desirable taste panel scores for tenderness, juiciness and overall panel desirability

Extremal discs and the holomorphic extension from convex hypersurfaces

Let D be a convex domain with smooth boundary in complex space and let f be a continuous function on the boundary of D. Suppose that f holomorphically extends to the extremal discs tangent to a convex subdomain of D. We prove that f holomorphically extends to D. The result partially answers a conjecture by Globevnik and Stout of 1991

Spatial-Distance Cues Influence Economic Decision-Making in a Social Context

Social distance (i.e., the degree of closeness to another person) affects the way humans perceive and respond to fairness during financial negotiations. Feeling close to someone enhances the acceptance of monetary offers. Here, we explored whether this effect also extends to the spatial domain. Specifically, using an iterated version of the Ultimatum Game in a within-subject design, we investigated whether different visual spatial distance-cues result in different rates of acceptance of otherwise identical monetary offers. Study 1 found that participants accepted significantly more offers when they were cued with spatial closeness than when they were cued with spatial distance. Study 2 replicated this effect using identical procedures but different spatial- distance cues in an independent sample. Importantly, our results could not be explained by feelings of social closeness. Our results demonstrate that mere perceptions of spatial closeness produce analogous–but independent–effects to those of social closeness

Critical temperature of a fully anisotropic three-dimensional Ising model

The critical temperature of a three-dimensional Ising model on a simple cubic lattice with different coupling strengths along all three spatial directions is calculated via the transfer matrix method and a finite size scaling for L x L oo clusters (L=2 and 3). The results obtained are compared with available calculations. An exact analytical solution is found for the 2 x 2 oo Ising chain with fully anisotropic interactions (arbitrary J_x, J_y and J_z).Comment: 17 pages in tex using preprint.sty for IOP journals, no figure

Accretion-Induced Lithium Line Enhancements in Classical T Tauri Stars: RW Aur

It is widely accepted that much of the stochastic variability of T Tauri stars is due to accretion by a circumstellar disk. The emission line spectrum as well as the excess continuum emission are common probes of this process. In this communication, we present additional probes of the circumstellar environment in the form of resonance lines of low ionization potential elements. Using a set of 14 high resolution echelle observations of the classical T Tauri star (CTTS), RW Aur, taken between 1986 and 1996, we carefully measure the continuum veiling at each epoch by comparing more than 500 absorption lines with those of an appropriate template. This allows us to accurately subtract out the continuum emission and to recover the underlying photospheric spectrum. In doing so, we find that selected photospheric lines are enhanced by the accretion process, namely the resonance lines of LiI and KI. A resonance line of TiI and a low excitation potential line of CaI also show weak enhancements. Simple slab models and computed line bisectors lead us to propose that these line enhancements are markers of cool gas at the beginning of the accretion flow which provides an additional source of line opacity. These results suggest that published values of surface lithium abundances of classical T Tauri stars are likely to be overestimated. This would account for the various reports of surface lithium abundances in excess of meteoritic values among the extreme CTTS. Computing LTE lithium abundances of RW Aur in a low and then high accretion state yields abundances which vary by one order of magnitude. The low accretion state lithium abundance is consistent with theoretical predictions for a star of this age and mass while the high accretion state spectrum yields a super-meteoritic lithium abundance.Comment: 28 pages, 8 figures, accepted by Ap