115 research outputs found
Ice-lens formation and geometrical supercooling in soils and other colloidal materials
We present a new, physically-intuitive model of ice-lens formation and growth
during the freezing of soils and other dense, particulate suspensions.
Motivated by experimental evidence, we consider the growth of an ice-filled
crack in a freezing soil. At low temperatures, ice in the crack exerts large
pressures on the crack walls that will eventually cause the crack to split
open. We show that the crack will then propagate across the soil to form a new
lens. The process is controlled by two factors: the cohesion of the soil, and
the geometrical supercooling of the water in the soil; a new concept introduced
to measure the energy available to form a new ice lens. When the supercooling
exceeds a critical amount (proportional to the cohesive strength of the soil) a
new ice lens forms. This condition for ice-lens formation and growth does not
appeal to any ad hoc, empirical assumptions, and explains how periodic ice
lenses can form with or without the presence of a frozen fringe. The proposed
mechanism is in good agreement with experiments, in particular explaining
ice-lens pattern formation, and surges in heave rate associated with the growth
of new lenses. Importantly for systems with no frozen fringe, ice-lens
formation and frost heave can be predicted given only the unfrozen properties
of the soil. We use our theory to estimate ice-lens growth temperatures
obtaining quantitative agreement with the limited experimental data that is
currently available. Finally we suggest experiments that might be performed in
order to verify this theory in more detail. The theory is generalizable to
complex natural-soil scenarios, and should therefore be useful in the
prediction of macroscopic frost heave rates.Comment: Submitted to PR
Calibration and Control of a Redundant Robotic Workcell for Milling Tasks
This article deals with the tuning of a complex robotic workcell of eight joints devoted to milling tasks. It consists of a KUKA (TM) manipulator mounted on a linear track and synchronised with a rotary table. Prior to any machining, the additional joints require an in situ calibration in an industrial environment. For this purpose, a novel planar calibration method is developed to estimate the external joint configuration parameters by means of a laser displacement sensor and avoiding direct contact with the pattern. Moreover, a redundancy resolution scheme on the joint rate level is integrated within a computer aided manufacturing system for the complete control of the workcell during the path tracking of a milling task. Finally, the whole system is tested in the prototyping of an orographic model.Andres De La Esperanza, FJ.; Gracia Calandin, LI.; Tornero Montserrat, J. (2011). Calibration and Control of a Redundant Robotic Workcell for Milling Tasks. International Journal of Computer Integrated Manufacturing. 24(6):561-573. doi:10.1080/0951192X.2011.566284S56157324
Rock Glaciers as Water Stores in the Bolivian Andes: An Assessment of Their Hydrological Importance
Avalanche Defence Strategies and Monitoring of Two Sites in Mountain Permafrost Terrain, Pontresina, Eastern Swiss Alps
Biomedical informatics and translational medicine
Biomedical informatics involves a core set of methodologies that can provide a foundation for crossing the "translational barriers" associated with translational medicine. To this end, the fundamental aspects of biomedical informatics (e.g., bioinformatics, imaging informatics, clinical informatics, and public health informatics) may be essential in helping improve the ability to bring basic research findings to the bedside, evaluate the efficacy of interventions across communities, and enable the assessment of the eventual impact of translational medicine innovations on health policies. Here, a brief description is provided for a selection of key biomedical informatics topics (Decision Support, Natural Language Processing, Standards, Information Retrieval, and Electronic Health Records) and their relevance to translational medicine. Based on contributions and advancements in each of these topic areas, the article proposes that biomedical informatics practitioners ("biomedical informaticians") can be essential members of translational medicine teams
Active-site-directed specific competitive inhibitors of phospholipase A2: novel transition-state analogs.
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