Admission Diagnosis of Cerebral Malaria in Adults in an Endemic Area of Tanzania:Implications and Clinical Description

Cerebralmalariais commonly diagnosed in adults in endemic areas in Africa, both in hospitals and in the community. This presents a paradox inconsistent with the epidemiological understanding that the development of immunity during childhood confers protection against severe disease in adult life. To establish the contribution of Plasmodium falciparum infection in adults admitted with neurological dysfunction in an endemic area, to assess the implications of an admission clinical diagnosis of ‘cerebral malaria’ on the treatment and clinical outcome, and to describe the clinical features of patients with malaria parasitaemia. Prospective observational study. We studied adult patients admitted with neurological dysfunction to Muhimbili National Hospital, Dar-es-Salaam, Tanzania from October 2000 to July 2001. A full blood count was done and serum creatinine, blood glucose and P. falciparum parasite load were measured. Of 199 patients (median age 34.5 years), 38% were diagnosed as ‘cerebral malaria’ on admission, but only 7.5% had detectable parasitaemia, giving a positive predictive value of 13.3%. Only 1% fulfilled the WHO criteria for cerebral malaria. The prevalence of parasitaemia (7.5%) was less than that observed in a group of asymptomatic controls (9.3%), but distribution of parasite densities was higher in the patients. Mortality was higher in patients with no parasitaemia (22.3%) than in those with parasitaemia (13%). Cerebral malaria was grossly overdiagnosed, resulting in unnecessary treatment and insufficient investigation of other possible diagnoses, which could lead to higher mortality. Extension of this misperception to the assessment of cause of death in community surveys may lead to an overestimation of the impact of malaria in adults.\u

Analyses of the solid earth and ocean tidal perturbations on the orbits of the GEOS-1 and GEOS-2 satellites

The luni-solar tidal perturbations in the inclination of the GEOS-I and GEOS-II satellite orbits were analyzed for the solid Earth and ocean tide conditions. Precision reduced camera and TRANET Doppler observations spanning periods of over 600 days for each satellite were used to derive mean orbital elements. Perturbations due to the earth's gravity field, solar radiation pressure, and atmospheric drag were modelled, and the resulting inclination residuals were analyzed for tidal effects. The amplitudes of the observed total tidal effects were about 1.2 arc seconds (36 meters) in the inclination of GEOS-I and 4.5 arc seconds (135 meters) for GEOS-II. The solid earth tides were then modelled using earth tide measurements, earth rotation observations, and seismic data. The resulting inclination residuals were analyzed for ocean tide parameters. The derived parameters consist of one second degree coefficient and an accompanying phase angle in a spherical harmonic expansion of the ocean tidal potential for each tidal constituent. The results are presented

A comparison and evaluation of satellite derived positions of tracking stations

A comparison is presented of sets of satellite tracking station coordinate values published in the past few years by a number of investigators, i.e. Goddard Space Flight Center, Smithsonian Astrophysical Observatory, Ohio State University, The Naval Weapons Laboratory, Air Force Cambridge Research Laboratories, and Wallops Island. The comparisons have been made in terms of latitude, longitude and height. The results of the various solutions have been compared directly and also with external standards such as local survey data and gravimetrically derived geoid heights. After taking into account systematic rotations, latitude and longitude agreement on a global basis is generally 15 meters or better, on the North American Datum agreement is generally better than 10 meters. Allowing for scale differences (of the order of 2 ppm) radial agreement is generally of the order of 10 meters

Alignment and Aperture Scan at the Fermilab Booster

The Fermilab booster has an intensity upgrade plan called the Proton Improvement plan (PIP). The flux throughput goal is 2E17 protons/hour, which is almost double the current operation at 1.1E17 protons/hour. The beam loss in the machine is going to be the source of issues. The booster accelerates beam from 400 MeV to 8 GeV and extracts to the Main Injector. Several percent of the beam is lost within 3 msec after the injection. The aperture at injection energy was measured and compared with the survey data. The magnets are going to be realigned in March 2012 in order to increase the aperture. The beam studies, analysis of the scan and alignment data, and the result of the magnet moves will be discussed in this paper.Comment: 3 pp. 3rd International Particle Accelerator Conference (IPAC 2012) 20-25 May 2012, New Orleans, Louisian

On Lorentz Invariance, Spin-Charge Separation And SU(2) Yang-Mills Theory

Previously it has been shown that in spin-charge separated SU(2) Yang-Mills theory Lorentz invariance can become broken by a one-cocycle that appears in the Lorentz boosts. Here we study in detail the structure of this one-cocycle. In particular we show that its non-triviality relates to the presence of a (Dirac) magnetic monopole bundle. We also explicitely present the finite version of the cocycle.Comment: 4 page

Academic self-concept, gender and single-sex schooling

This paper assesses gender differences in academic self-concept for a cohort of children born in 1958 (the National Child Development Study). We address the question of whether attending single-sex or co-educational schools affected students’ perceptions of their own academic abilities (academic self-concept). Academic selfconcept was found to be highly gendered, even controlling for prior test scores. Boys had higher self-concepts in maths and science, and girls in English. Single-sex schooling reduced the gender gap in self-concept, while selective schooling was linked to lower academic self-concept overall

Testing a model of antecedents and consequences of defensive pessimism and self-handicapping in school physical education

There has been very limited research on the use of self-worth protection strategies in the achievement context of school physical education (PE). Thus, this study aimed to examine some antecedents and consequences of defensive pessimism and self-handicapping. The sample comprised 534 (females n = 275; males n = 259) British pupils recruited from two schools who responded to established questionnaires. Results of structural equation modelling analysis indicated that self-handicapping and defensive pessimism were positively predicted by fear of failure and negatively predicted by competence valuation. In addition, defensive pessimism was negatively predicted by physical self-concept. In turn, defensive pessimism negatively predicted enjoyment in PE and intentions to participate in future optional PE programs. Self-handicapping did not predict enjoyment or intentions. Results from multi-sample structural equation modelling showed the specified model to be largely invariant across males and females. The findings indicate that although both strategies aim to protect one’s self-worth, some of their antecedents and consequences in PE may differ

Acute lung injury in paediatric intensive care: course and outcome

Introduction: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) carry a high morbidity and mortality (10-90%). ALI is characterised by non-cardiogenic pulmonary oedema and refractory hypoxaemia of multifactorial aetiology [1]. There is limited data about outcome particularly in children. Methods This retrospective cohort study of 85 randomly selected patients with respiratory failure recruited from a prospectively collected database represents 7.1% of 1187 admissions. They include those treated with High Frequency Oscillation Ventilation (HFOV). The patients were admitted between 1 November 1998 and 31 October 2000. Results: Of the 85, 49 developed acute lung injury and 47 had ARDS. There were 26 males and 23 females with a median age and weight of 7.7 months (range 1 day-12.8 years) and 8 kg (range 0.8-40 kg). There were 7 deaths giving a crude mortality of 14.3%, all of which fulfilled the Consensus I [1] criteria for ARDS. Pulmonary occlusion pressures were not routinely measured. The A-a gradient and PaO2/FiO2 ratio (median + [95% CI]) were 37.46 [31.82-43.1] kPa and 19.12 [15.26-22.98] kPa respectively. The non-survivors had a significantly lower PaO2/FiO2 ratio (13 [6.07-19.93] kPa) compared to survivors (23.85 [19.57-28.13] kPa) (P = 0.03) and had a higher A-a gradient (51.05 [35.68-66.42] kPa) compared to survivors (36.07 [30.2-41.94]) kPa though not significant (P = 0.06). Twenty-nine patients (59.2%) were oscillated (Sensormedics 3100A) including all 7 non-survivors. There was no difference in ventilation requirements for CMV prior to oscillation. Seventeen of the 49 (34.7%) were treated with Nitric Oxide including 5 out of 7 non-survivors (71.4%). The median (95% CI) number of failed organs was 3 (1.96-4.04) for non-survivors compared to 1 (0.62-1.62) for survivors (P = 0.03). There were 27 patients with isolated respiratory failure all of whom survived. Six (85.7%) of the non-survivors also required cardiovascular support.Conclusion: A crude mortality of 14.3% compares favourably to published data. The A-a gradient and PaO2/FiO2 ratio may be of help in morbidity scoring in paediatric ARDS. Use of Nitric Oxide and HFOV is associated with increased mortality, which probably relates to the severity of disease. Multiple organ failure particularly respiratory and cardiac disease is associated with increased mortality. ARDS with isolated respiratory failure carries a good prognosis in children

ULTRACAM photometry of the eclipsing cataclysmic variable OU Vir

We present high-speed, three-colour photometry of the faint eclipsing cataclysmic variable OU Vir. For the first time in OU Vir, separate eclipses of the white dwarf and bright spot have been observed. We use timings of these eclipses to derive a purely photometric model of the system, obtaining a mass ratio of q = 0.175 +/- 0.025, an inclination of i = 79.2 +/- 0.7 degrees and a disc radius of Rd/a = 0.2315 +/- 0.0150. We separate the white dwarf eclipse from the lightcurve and, by fitting a blackbody spectrum to its flux in each passband, obtain a white dwarf temperature of T = 21700 +/- 1200 K and a distance of D = 650 +/- 210 pc. Assuming that the primary obeys the Nauenberg (1972) mass-radius relation for white dwarfs and allowing for temperature effects, we also find a primary mass Mw/Msun = 0.90 +/- 0.19, primary radius Rw/Rsun = 0.0097 +/- 0.0031 and orbital separation a/Rsun = 0.75 +/- 0.05.Comment: 8 pages LaTeX, 6 figures. Accepted by MNRAS; erratum added at end. Mon.Not.Roy.Astron.Soc. 347 (2004) 1173, erratum in pres

A Proposal to Detect Dark Matter Using Axionic Topological Antiferromagnets

Antiferromagnetically doped topological insulators (A-TI) are among the candidates to host dynamical axion fields and axion-polaritons; weakly interacting quasiparticles that are analogous to the dark axion, a long sought after candidate dark matter particle. Here we demonstrate that using the axion quasiparticle antiferromagnetic resonance in A-TI's in conjunction with low-noise methods of detecting THz photons presents a viable route to detect axion dark matter with mass 0.7 to 3.5 meV, a range currently inaccessible to other dark matter detection experiments and proposals. The benefits of this method at high frequency are the tunability of the resonance with applied magnetic field, and the use of A-TI samples with volumes much larger than 1 mm$^3$.Comment: 6 pages, 4 figures. v2 accepted for publication in Physical Review Letters. Many points clarified, some parameter estimates revise