27 research outputs found
Importance of grain boundary Josephson junctions in the electron-doped infinite-layer cuprate superconductor SrLaCuO
Grain boundary bicrystal Josephson junctions of the electron-doped
infinite-layer superconductor SrLaCuO () were grown
by pulsed laser deposition. BaTiO-buffered 24\,^\circ [001]-tilt
symmetric SrTiO bicrystals were used as substrates. We examined both Cooper
pair (CP) and quasiparticle (QP) tunneling by electric transport measurements
at temperatures down to 4.2\,K. CP tunneling revealed an extraordinary high
critical current density for electron-doped cuprates of A/cm
at 4.2\,K. Thermally activated phase slippage was observed as dissipative
mechanism close to the transition temperature. Out-of-plane magnetic fields
revealed a remarkably regular Fraunhofer-like pattern as well as Fiske
and flux flow resonances, both yielding a Swihart velocity of
m/s. Furthermore, we examined the superconducting gap by means
of QP tunneling spectroscopy. The gap was found to be V-shaped with an
extrapolated zero temperature energy gap meV. No zero
bias conductance peak was observed.Comment: 6 pages, 3 figure
Properties of the electron-doped infinite-layer superconductor SrLaCuO epitaxially grown by pulsed laser deposition
Thin films of the electron-doped infinite-layer cuprate superconductor
SrLaCuO (SLCO) with doping were grown by means
of pulsed laser deposition. (001)-oriented KTaO and SrTiO single
crystals were used as substrates. In case of SrTiO, a BaTiO thin film
was deposited prior to SLCO, acting as buffer layer providing tensile strain to
the SLCO film. To induce superconductivity, the as-grown films were annealed
under reducing conditions, which will be described in detail. The films were
characterized by reflection high-energy electron diffraction, atomic force
microscopy, x-ray diffraction, Rutherford backscattering spectroscopy, and
electric transport measurements at temperatures down to K. We
discuss in detail the influence of different process parameters on the final
film properties.Comment: 16 pages, 14 figure
Vortex phase diagram in BSCCO with damage tracks created by 30 MeV fullerene irradiation
Using 30 MeV C60 fullerene irradiation, we have produced latent tracks of
diameter 20 nm and length 200 nm, near the surface of single crystalline BSCCO.
A preliminary transmission electron microscopy study shows evidence for a very
high density of deposited energy, and the ejection of material from the track
core in very thin specimens. The latent tracks reveal themselves to be
exceptionally strong pinning centers for vortices in the superconducting mixed
state. Both the critical current density and magnetic irreversibility line are
significantly enhanced. The irradiated crystals present salient features of the
(B,T) phase diagram of vortex matter both of pristine crystals, such as the
first order vortex phase transition, and the exponential Bose-glass line
characteristic of heavy ion-irradiated crystals. We show that the latter is
manifestly independent of the pinning potential.Comment: 10 pages, 13 figure
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The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung cancer was assessed. A3B expression in EGFR mutant (EGFRmut) non-small-cell lung cancer (NSCLC) mouse models constrained tumorigenesis, while A3B expression in tumors treated with EGFR-targeted cancer therapy was associated with treatment resistance. Analyses of human NSCLC models treated with EGFR-targeted therapy showed upregulation of A3B and revealed therapy-induced activation of nuclear factor kappa B (NF-κB) as an inducer of A3B expression. Significantly reduced viability was observed with A3B deficiency, and A3B was required for the enrichment of APOBEC mutation signatures, in targeted therapy-treated human NSCLC preclinical models. Upregulation of A3B was confirmed in patients with NSCLC treated with EGFR-targeted therapy. This study uncovers the multifaceted roles of A3B in NSCLC and identifies A3B as a potential target for more durable responses to targeted cancer therapy.</p
The genetic mating system of a sea spider with male-biased sexual size dimorphism: evidence for paternity skew despite random mating success
Male-biased size dimorphism is usually expected to evolve in taxa with intense male–male competition for mates, and it is hence associated with high variances in male mating success. Most species of pycnogonid sea spiders exhibit female-biased size dimorphism, and are notable among arthropods for having exclusive male parental care of embryos. Relatively little, however, is known about their natural history, breeding ecology, and mating systems. Here we first show that Ammothella biunguiculata, a small intertidal sea spider, exhibits male-biased size dimorphism. Moreover, we combine genetic parentage analysis with quantitative measures of sexual selection to show that male body size does not appear to be under directional selection. Simulations of random mating revealed that mate acquisition in this species is largely driven by chance factors, although actual paternity success is likely non-randomly distributed. Finally, the opportunity for sexual selection (Is), an indirect metric for the potential strength of sexual selection, in A. biunguiculata males was less than half of that estimated in a sea spider with female-biased size dimorphism, suggesting the direction of size dimorphism may not be a reliable predictor of the intensity of sexual selection in this group. We highlight the suitability of pycnogonids as model systems for addressing questions relating parental investment and sexual selection, as well as the current lack of basic information on their natural history and breeding ecology
Serotonin-immunoreactivity in the ventral nerve cord of Pycnogonida – support for individually identifiable neurons as ancestral feature of the arthropod nervous system
Implementation of an interprofessional counseling program on complementary and integrative health care (CIH) at Comprehensive Cancer Centers: study protocol and baseline data
Effekte eines interprofessionellen evidenzbasierten Beratungsprogramms zu Komplementärmedizin und -pflege bei Patienten:innen mit Krebs: Ergebnisse des primären Outcomes der kontrollierten Implementierungsstudie "CCC-Integrativ"
High expression of vinculin predicts poor prognosis and distant metastasis and associates with influencing tumor-associated NK cell infiltration and epithelial-mesenchymal transition in gastric cancer.
In the process of epithelial-mesenchymal transition (EMT), epithelial cancer cells transdifferentiate into mesenchymal-like cells with high motility and aggressiveness, resulting in the spread of tumor cells. Immune cells and inflammation in the tumor microenvironment are the driving factors of EMT, but few studies have explored the core targets of the interaction between EMT and tumor immune cells. We analyzed thousands of cases of gastric cancer and gastric tissue specimens of TCGA, CPTAC, GTEx and analyzing QPCR and IHC data of 56 gastric cancer patients in SYSU Gastric Cancer Research Center. It was known that EMT has an important connection with the infiltration of NK cells, and that the expression of vinculin may be the target of the phenomenon. The increased expression of vinculin is closely related to the aggressiveness and distant metastasis of cancer, which affects the survival prognosis of the patient. Moreover, through in vitro experiments under 3D conditions, we found that vinculin, cell invasion and metastasis are clearly linked. VCL can affect EMT and tumor immunity by regulating EPCAM gene expression. The role and mechanism of action of vinculin have been controversial, but this molecule may downregulate EpCAM (epithelial cellular adhesion molecule) and its own role in gastric cancer through DNA methylation, causing NK cells to enrich into tumor cells and kill tumor cells. At the same time, it promotes the occurrence of EMT, which in turn causes tumor metastasis and thus poorer prognosis