1,399 research outputs found
Polarization Gradient Study of Interstellar Medium Turbulence Using The Canadian Galactic Plane Survey
We have investigated the magneto-ionic turbulence in the interstellar medium
through spatial gradients of the complex radio polarization vector in the
Canadian Galactic Plane Survey (CGPS). The CGPS data cover 1300 square-degrees,
over the range ,
with an extension to
in the range , and arcminute
resolution at 1420 MHz. Previous studies found a correlation between the
skewness and kurtosis of the polarization gradient and the Mach number of the
turbulence, or assumed this correlation to deduce the Mach number of an
observed turbulent region. We present polarization gradient images of the
entire CGPS dataset, and analyze the dependence of these images on angular
resolution. The polarization gradients are filamentary, and the length of these
filaments is largest towards the Galactic anti-center, and smallest towards the
inner Galaxy. This may imply that small-scale turbulence is stronger in the
inner Galaxy, or that we observe more distant features at low Galactic
longitudes. For every resolution studied, the skewness of the polarization
gradient is influenced by the edges of bright polarization gradient regions,
which are not related to the turbulence revealed by the polarization gradients.
We also find that the skewness of the polarization gradient is sensitive to the
size of the box used to calculate the skewness, but insensitive to Galactic
longitude, implying that the skewness only probes the number and magnitude of
the inhomogeneities within the box. We conclude that the skewness and kurtosis
of the polarization gradient are not ideal statistics for probing natural
magneto-ionic turbulence.Comment: 21 pages, 15 figures, accepted by Ap
Advanced Diagnostics for the Study of Linearly Polarized Emission. II: Application to Diffuse Interstellar Radio Synchrotron Emission
Diagnostics of polarized emission provide us with valuable information on the
Galactic magnetic field and the state of turbulence in the interstellar medium,
which cannot be obtained from synchrotron intensity alone. In Paper I (Herron
et al. 2017b), we derived polarization diagnostics that are rotationally and
translationally invariant in the - plane, similar to the polarization
gradient. In this paper, we apply these diagnostics to simulations of ideal
magnetohydrodynamic turbulence that have a range of sonic and Alfv\'enic Mach
numbers. We generate synthetic images of Stokes and for these
simulations, for the cases where the turbulence is illuminated from behind by
uniform polarized emission, and where the polarized emission originates from
within the turbulent volume. From these simulated images we calculate the
polarization diagnostics derived in Paper I, for different lines of sight
relative to the mean magnetic field, and for a range of frequencies. For all of
our simulations, we find that the polarization gradient is very similar to the
generalized polarization gradient, and that both trace spatial variations in
the magnetoionic medium for the case where emission originates within the
turbulent volume, provided that the medium is not supersonic. We propose a
method for distinguishing the cases of emission coming from behind or within a
turbulent, Faraday rotating medium, and a method to partly map the rotation
measure of the observed region. We also speculate on statistics of these
diagnostics that may allow us to constrain the physical properties of an
observed turbulent region.Comment: 34 pages, 25 figures, accepted for publication in Ap
First Temperature Observations with the USU Very Large Rayleigh Lidar: An Examination of Mesopause Temperatures
As the impetus for extended observational measurements throughout the middle atmosphere has increased1 , the limits of previous instrumentation need to be pushed. The Rayleigh lidar group at the Atmospheric Lidar Observatory (ALO) at Utah State University has pushed such limits on existing Rayleigh scatter lidar technology and, through major upgrades to the previous lidar system, has been able to gather temperature measurements in the upper mesosphere and lower thermosphere from approximately 70P109 km. A data campaign with the new system was conducted around the annual temperature minimum, centered on late June 2012, in this region. The temperatures from this campaign show a considerable night to night variation as well as evidence of wave activity on several nights
Scaffold attachment factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis
<p>Abstract</p> <p>Background</p> <p>Scaffold Attachment Factor B1 (SAFB1) is a multifunctional protein which has been implicated in breast cancer previously. We recently generated SAFB1 knockout mice (SAFB1<sup>-/-</sup>), but pleiotropic phenotypes including high lethality, dwarfism associated with low IGF-I levels, and infertility and subfertility in male and female mice, respectively, do not allow for straightforward tumorigenesis studies in these mice. Therefore, we asked whether SAFB1 heterozygosity would influence tumor development and progression in MMTV-Wnt-1 oncomice or DMBA induced tumorigenicity, in a manner consistent with haploinsufficiency of the remaining allele.</p> <p>Methods</p> <p>We crossed female SAFB1<sup>+/- </sup>(C57B6/129) mice with male MMTV-Wnt-1 (C57B6/SJL) mice to obtain SAFB1<sup>+/+</sup>/Wnt-1, SAFB1<sup>+/-</sup>/Wnt-1, and SAFB1<sup>+/- </sup>mice. For the chemical induced tumorigenesis study we treated 8 weeks old SAFB1<sup>+/- </sup>and SAFB<sup>+/+ </sup>BALB/c mice with 1 mg DMBA once per week for 6 weeks. Animals were monitored for tumor incidence and tumor growth. Tumors were characterized by performing H&E, and by staining for markers of proliferation and apoptosis.</p> <p>Results</p> <p>We did not detect significant differences in tumor incidence and growth between SAFB1<sup>+/+</sup>/Wnt-1 and SAFB1<sup>+/-</sup>/Wnt-1 mice, and between DMBA-treated SAFB1<sup>+/+ </sup>and SAFB1<sup>+/-</sup>mice. Histological evaluation of tumors showed that SAFB1 heterozygosity did not lead to changes in proliferation or apoptosis. There were, however, significant differences in the distribution of tumor histologies with an increase in papillary and cribriform tumors, and a decrease in squamous tumors in the SAFB1<sup>+/-</sup>/Wnt-1 compared to the SAFB1<sup>+/+</sup>/Wnt-1 tumors. Of note, DMBA treatment resulted in shortened survival of SAFB1<sup>+/- </sup>mice compared to their wildtype littermates, however this trend did not reach statistical significance.</p> <p>Conclusion</p> <p>Our data show that SAFB1 heterozygosity does not influence Wnt-1 or DMBA-induced mammary tumorigenesis.</p
Comparative mitochondrial genomics of snakes: extraordinary substitution rate dynamics and functionality of the duplicate control region
<p>Abstract</p> <p>Background</p> <p>The mitochondrial genomes of snakes are characterized by an overall evolutionary rate that appears to be one of the most accelerated among vertebrates. They also possess other unusual features, including short tRNAs and other genes, and a duplicated control region that has been stably maintained since it originated more than 70 million years ago. Here, we provide a detailed analysis of evolutionary dynamics in snake mitochondrial genomes to better understand the basis of these extreme characteristics, and to explore the relationship between mitochondrial genome molecular evolution, genome architecture, and molecular function. We sequenced complete mitochondrial genomes from Slowinski's corn snake (<it>Pantherophis slowinskii</it>) and two cottonmouths (<it>Agkistrodon piscivorus</it>) to complement previously existing mitochondrial genomes, and to provide an improved comparative view of how genome architecture affects molecular evolution at contrasting levels of divergence.</p> <p>Results</p> <p>We present a Bayesian genetic approach that suggests that the duplicated control region can function as an additional origin of heavy strand replication. The two control regions also appear to have different intra-specific versus inter-specific evolutionary dynamics that may be associated with complex modes of concerted evolution. We find that different genomic regions have experienced substantial accelerated evolution along early branches in snakes, with different genes having experienced dramatic accelerations along specific branches. Some of these accelerations appear to coincide with, or subsequent to, the shortening of various mitochondrial genes and the duplication of the control region and flanking tRNAs.</p> <p>Conclusion</p> <p>Fluctuations in the strength and pattern of selection during snake evolution have had widely varying gene-specific effects on substitution rates, and these rate accelerations may have been functionally related to unusual changes in genomic architecture. The among-lineage and among-gene variation in rate dynamics observed in snakes is the most extreme thus far observed in animal genomes, and provides an important study system for further evaluating the biochemical and physiological basis of evolutionary pressures in vertebrate mitochondria.</p
Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity
Growing evidence suggests water-soluble, non-fibrillar forms of amyloid-β protein (Aβ) have important roles in Alzheimer's disease with toxicities mimicked by synthetic Aβ1-42. However, no defined toxic structures acting via specific receptors have been identified and roles of proposed receptors, such as prion protein (PrP), remain controversial. Here we quantify binding to PrP of Aβ1-42 after different durations of aggregation. We show PrP-binding and PrP-dependent inhibition of long-term potentiation (LTP) correlate with the presence of protofibrils. Globular oligomers bind less avidly to PrP and do not inhibit LTP, whereas fibrils inhibit LTP in a PrP-independent manner. That only certain transient Aβ assemblies cause PrP-dependent toxicity explains conflicting reports regarding the involvement of PrP in Aβ-induced impairments. We show that these protofibrils contain a defined nanotubular structure with a previously unidentified triple helical conformation. Blocking the formation of Aβ nanotubes or their interaction with PrP might have a role in treatment of Alzheimer's disease
EPS architecture analysis for future highpower missions
The space tug can represent a valid solution to provide transportation capabilities for future space missions. In particular, the tug can be effectively adopted for different applications such as electric orbit raising for commercial satellites and cargo transfer to resupply space infrastructures. The adoption of high-power electric propulsion is a fundamental enabler for these mission scenarios, owing to its advantages in terms of long lifetime, high performance and operational flexibility. However, further investigation should be performed in order to optimize the design of the space tug considering different architecture alternatives. We defined two sets of thruster operative points for a more representative comparison of EPS architecture cases. In particular, we analyzed three aspects: the adoption of a cluster of thrusters vs the monolithic approach; the implementation of a direct drive power supply vs the traditional power processing unit; the selection of krypton propellant vs xenon. The design of the space tug is performed with MAGNETO tool, a software developed in a collaboration between SITAEL and Politecnico di Torino in the framework of an ESA GSTP project. The results are compared by means of the analytical hierarchy process to identify the optimal design solution for the spacecraft design
Synthesis of CdS and CdSe nanocrystallites using a novel single-molecule precursors approach
The synthesis of CdS and CdSe nanocrystallites using the thermolysis of several dithioor
diselenocarbamato complexes of cadmium in trioctylphosphine oxide (TOPO) is reported.
The nanodispersed materials obtained show quantum size effects in their optical spectra
and exhibit near band-edge luminescence. The influence of experimental parameters on
the properties of the nanocrystallites is discussed. HRTEM images of these materials show
well-defined, crystalline nanosized particles. Standard size fractionation procedures can
be performed in order to narrow the size dispersion of the samples. The TOPO-capped CdS
and CdSe nanocrystallites and simple organic bridging ligands, such as 2,2¢-bipyrimidine,
are used as the starting materials for the preparation of novel nanocomposites. The optical
properties shown by these new nanocomposites are compared with those of the starting
nanodispersed materials
Survey of Photochemical and Rate Data for Twenty‐eight Reactions of Interest in Atmospheric Chemistry
Photochemical and rate data have been evaluated for 28 gas phase reactions of interest for the chemistry of the stratosphere. The results are presented on data sheets, one per reaction. For each reaction, the available data are summarized. Where possible there is given a preferred value for the rate constant or, for the photochemical reactions, preferred values for primary quantum yields and optical absorption coefficients.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87745/2/267_1.pd
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