Stabilization Environment for Swing Stabilization and MEDEVAC Hoists

This paper presents data related to helicopter sling load stabilization and MEDEVAC (Medical Evacuation) rescues collected by cadets performing research in the field at the United States Military Academy (West Point, NY) and Sapienza University of Rome (Rome, Italy) since 2018. The aim of this paper is to identify engineering constraints in MEDEVAC rescues. Constraints in two typical scenarios are presented. This information can then be included in simulations and models of swing stabilization and hoist control methods. Information is obtained through a literature review and interviews with U.S. Army helicopter pilots and crew chiefs who perform MEDEVAC rescues

Calibration standars of nuclear microprobes

El Micro-haz de iones Pesados (MiP) del laboratorio Tandar constituye un instrumento de características únicas en el país, pues puede proveer haces de iones pesados de dimensiones micrométricas acelerados hasta decenas de MeV de energía. La búsqueda de tamaños de haz más pequeños ha creado la necesidad de contar con estándares de calibración de elevada calidad de resolución. En el presente trabajo se desarrollaron los primeros prototipos para calibrar la focalización del haz: estructuras metálicas de cobre o niquel en forma de grilla con orificios cuadrados. Se emplearon dos métodos de fabricación. En el primero se utilizaron técnicas de fotolitografía convencional sobre un sustrato de silicio con foto-resina, mientras que en el segundo se utilizó el MiP para micro-mecanizar sustratos de Niobato de Litio (LiNbO3). En ambos casos se finalizó el proceso de fabricación del patrón con electrodeposición de cobre o níquel sobre la matriz desarrollada. Mediante la técnica fotolitográfica se fabricaron grillas de níquel que varían entre 130 y 180 mesh**. Mediante micro-mecanizado con el MiP se fabricaron grillas de cobre de entre 500 y 2000 mesh sobre sustratos de LiNbO3.The Micro-heavy ion beam (MiP) at Tandar’s Lab is a unique instrument in the country, as it can provide heavy ion beams at micrometer-scale accelerated to tens of MeV energy. The quest for smaller beam sizes has created the need for calibration standards of high resolution quality. In this paper we developed the first prototypes to calibrate the beam focusing: metal structures of copper or nickel shaped grid with square holes. We used two methods of manufacture. Were used in the first conventional photolithography techniques on a silicon substrate with photoresin while the second was used for micromachining with MiP substrates of lithium niobate (LiNbO3). In both cases the process for the manufacture was finished with electro-deposition of copper or nickel on the matrix developed. By photolithographic technique nickel grids were manufactured varying between 130 and 180 mesh. By MiP micromachining copper grids were produced between 500 and 2000 mesh on LiNbO3 substrates.Fil: Arena, S.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Faya, T.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Lell, J.. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes. Gerencia de Investigación y Aplicaciones; ArgentinaFil: Vega, N.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Davidson, Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Nesprias, Francisco Jose Gabriel. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes. Gerencia de Investigación y Aplicaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Debray, M.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes. Gerencia de Investigación y Aplicaciones; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentin

Apical invasion of intestinal epithelial cells by salmonella typhimurium requires villin to remodel the brush border actin cytoskeleton

Funding Information: We thank R. Friedman, C. Mulet and T. Pedron for technical help. We thank T. Marlovits for antibodies, H.D. Hardt and J. Galan for Salmonella strains, and D. Zhou and V. Koronakis for plasmids. We acknowledge France-BioImaging infrastructure supported by the French National Research Agency (ANR-10-INSB-04-01, «Investments for the future»). This work was supported by the ERC (P.S. Advanced Grant HOMEOEPITH, number 232798). P.J.S. is an HHMI senior foreign scholar. The authors declare no conflict of interest. Publisher Copyright: © 2015 Elsevier Inc.Salmonella invasion of intestinal epithelial cells requires extensive, though transient, actin modifications at the site of bacterial entry. The actin-modifying protein villin is present in the brush border where it participates in the constitution of microvilli and in epithelial restitution after damage through its actin-severing activity. We investigated a possible role for villin in Salmonella invasion. The absence of villin, which is normally located at the bacterial entry site, leads to a decrease in Salmonella invasion. Villin is necessary for early membrane-associated processes and for optimal ruffle assembly by balancing the steady-state level of actin. The severing activity of villin is important for Salmonella invasion in vivo. The bacterial phosphatase SptP tightly regulates villin phosphorylation, while the actin-binding effector SipA protects F-actin and counterbalances villin-severing activity. Thus, villin plays an important role in establishing the balance between actin polymerization and actin severing to facilitate the initial steps of Salmonella entry.publishersversionpublishe

Apical invasion of intestinal epithelial cells by salmonella typhimurium requires villin to remodel the brush border actin cytoskeleton

Funding Information: We thank R. Friedman, C. Mulet and T. Pedron for technical help. We thank T. Marlovits for antibodies, H.D. Hardt and J. Galan for Salmonella strains, and D. Zhou and V. Koronakis for plasmids. We acknowledge France-BioImaging infrastructure supported by the French National Research Agency (ANR-10-INSB-04-01, «Investments for the future»). This work was supported by the ERC (P.S. Advanced Grant HOMEOEPITH, number 232798). P.J.S. is an HHMI senior foreign scholar. The authors declare no conflict of interest. Publisher Copyright: © 2015 Elsevier Inc.Salmonella invasion of intestinal epithelial cells requires extensive, though transient, actin modifications at the site of bacterial entry. The actin-modifying protein villin is present in the brush border where it participates in the constitution of microvilli and in epithelial restitution after damage through its actin-severing activity. We investigated a possible role for villin in Salmonella invasion. The absence of villin, which is normally located at the bacterial entry site, leads to a decrease in Salmonella invasion. Villin is necessary for early membrane-associated processes and for optimal ruffle assembly by balancing the steady-state level of actin. The severing activity of villin is important for Salmonella invasion in vivo. The bacterial phosphatase SptP tightly regulates villin phosphorylation, while the actin-binding effector SipA protects F-actin and counterbalances villin-severing activity. Thus, villin plays an important role in establishing the balance between actin polymerization and actin severing to facilitate the initial steps of Salmonella entry.publishersversionpublishe

COVID-19 patients require multi-disciplinary rehabilitation approaches to address persisting symptom profiles and restore pre-COVID quality of life

Long-COVID diagnosis is prominent, and our attention must support those experiencing debilitating and long-standing symptoms. To establish patient pathways, we must consider the societal and economic impacts of sustained COVID-19. Accordingly, we sought to determine the pertinent areas impacting quality of life (QoL) following a COVID-19 infection. Three hundred and eighty-one participants completed a web-based survey (83% female, 17% male) consisting of 70 questions across 7 sections (demographics, COVID-19 symptoms; QoL; sleep quality; breathlessness; physical activity and mental health). Mean age, height, body mass and body mass index (BMI) were 42 ± 12 years, 167.6 ± 10.4 cm, 81.2 ± 22.2 kg, and 29.1 ± 8.4 kg.m2, respectively. Participant health was reduced because of COVID-19 symptoms (“Good health” to “Poor health” [P<0.001]). Survey respondents who work reported ongoing issues with performing moderate (83%) and vigorous (79%) work-related activities. COVID-19 patients report reduced capacity to participate in activities associated with daily life, including employment activities. Bespoke COVID-19 support pathways must consider multi-disciplinary approaches that address the holistic needs of patients to restore pre-pandemic quality of life and address experienced health and wellbeing challenges

Deformation effects in the 28^{28}Si+12^{12}C and 28^{28}Si+28^{28}Si reaction Search

The possible occurence of highly deformed configurations is investigated in the $^{40}$Ca and $^{56}$Ni di-nuclear systems as formed in the $^{28}$Si+$^{12}$C,$^{28}$Si reactions by using the properties of emitted light charged particles. Inclusive as well as exclusive data of the heavy fragments and their associated light charged particles have been collected by using the {\sc ICARE} charged particle multidetector array. The data are analysed by Monte Carlo CASCADE statistical-model calculations using a consistent set of parameters with spin-dependent level densities. Significant deformation effects at high spin are observed as well as an unexpected large $^{8}$Be cluster emission of a binary nature.Comment: 3 pages latex, 2 eps figures, paper presented in "wokshop on physics with multidetector array (pmda2000)Calcutta, India (to be published at PRAMANA, journal of Physics, India

Interface-Coupled BiFeO<inf>3</inf>/BiMnO<inf>3</inf> Superlattices with Magnetic Transition Temperature up to 410 K

This research was funded by the Engineering and Physical Sciences Research Council, (EP/P50385X/1), the European Research Council (ERC-2009-AdG 247276 NOVOX). The work at Texas A&M was funded by the U.S. National Science Foundation (DMR-1401266). The work at Los Alamos was supported by the U.S. Department of Energy through the LANL/LDRD program and was performed, in part, at the Center for Integrated Nanotechnologies, a U.S. Department of Energy, Office of Basic Energy Sciences user facility. Use of the National Synchrotron Light Source, Brookhaven National Laboratory, was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-98CH10886.This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1002/admi.20150059