97 research outputs found
Nuclear Mass Dependence of Chaotic Dynamics in Ginocchio Model
The chaotic dynamics in nuclear collective motion is studied in the framework
of a schematic shell model which has only monopole and quadrupole degrees of
freedom. The model is shown to reproduce the experimentally observed global
trend toward less chaotic motion in heavier nuclei. The relation between
current approach and the earlier studies with bosonic models is discussed.Comment: 11 Page REVTeX file, 2 postscript figures, uuencode
Direct reaction measurements with a 132Sn radioactive ion beam
The (d,p) neutron transfer and (d,d) elastic scattering reactions were
measured in inverse kinematics using a radioactive ion beam of 132Sn at 630
MeV. The elastic scattering data were taken in a region where Rutherford
scattering dominated the reaction, and nuclear effects account for less than 8%
of the cross section. The magnitude of the nuclear effects was found to be
independent of the optical potential used, allowing the transfer data to be
normalized in a reliable manner. The neutron-transfer reaction populated a
previously unmeasured state at 1363 keV, which is most likely the
single-particle 3p1/2 state expected above the N=82 shell closure. The data
were analyzed using finite range adiabatic wave calculations and the results
compared with the previous analysis using the distorted wave Born
approximation. Angular distributions for the ground and first excited states
are consistent with the previous tentative spin and parity assignments.
Spectroscopic factors extracted from the differential cross sections are
similar to those found for the one neutron states beyond the benchmark
doubly-magic nucleus 208Pb.Comment: 22 pages, 7 figure
Reactions of a Be-10 beam on proton and deuteron targets
The extraction of detailed nuclear structure information from transfer
reactions requires reliable, well-normalized data as well as optical potentials
and a theoretical framework demonstrated to work well in the relevant mass and
beam energy ranges. It is rare that the theoretical ingredients can be tested
well for exotic nuclei owing to the paucity of data. The halo nucleus Be-11 has
been examined through the 10Be(d,p) reaction in inverse kinematics at
equivalent deuteron energies of 12,15,18, and 21.4 MeV. Elastic scattering of
Be-10 on protons was used to select optical potentials for the analysis of the
transfer data. Additionally, data from the elastic and inelastic scattering of
Be-10 on deuterons was used to fit optical potentials at the four measured
energies. Transfers to the two bound states and the first resonance in Be-11
were analyzed using the Finite Range ADiabatic Wave Approximation (FR-ADWA).
Consistent values of the spectroscopic factor of both the ground and first
excited states were extracted from the four measurements, with average values
of 0.71(5) and 0.62(4) respectively. The calculations for transfer to the first
resonance were found to be sensitive to the size of the energy bin used and
therefore could not be used to extract a spectroscopic factor.Comment: 16 Pages, 10 figure
Universal Predictions for Statistical Nuclear Correlations
We explore the behavior of collective nuclear excitations under a
multi-parameter deformation of the Hamiltonian. The Hamiltonian matrix elements
have the form , with a
parametric correlation of the type . The studies are done in both the regular and chaotic regimes of the
Hamiltonian. Model independent predictions for a wide variety of correlation
functions and distributions which depend on wavefunctions and energies are
found from parametric random matrix theory and are compared to the nuclear
excitations. We find that our universal predictions are observed in the nuclear
states. Being a multi-parameter theory, we consider general paths in parameter
space and find that universality can be effected by the topology of the
parameter space. Specifically, Berry's phase can modify short distance
correlations, breaking certain universal predictions.Comment: Latex file + 12 postscript figure
Induced Parity Nonconserving Interaction and Enhancement of Two-Nucleon Parity Nonconserving Forces
Two-nucleon parity nonconserving (PNC) interaction induced by the
single-particle PNC weak potential and the two-nucleon residual strong
interaction is considered. An approximate analytical formula for this Induced
PNC Interaction (IPNCI) between proton and neutron is derived (), and the
interaction constant is estimated. As a result of coherent contributions from
the nucleons to the PNC potential, IPNCI is an order of magnitude stronger
() than the residual weak two-nucleon interaction and has a
different coordinate and isotopic structure (e.g., the strongest part of IPNCI
does not contribute to the PNC mean field). IPNCI plays an important role in
the formation of PNC effects, e.g., in neutron-nucleus reactions. In that case,
it is a technical way to take into account the contribution of the distant
(small) components of a compound state which dominates the result. The absence
of such enhancement () in the case of T- and P-odd interaction
completes the picture.Comment: Phys. Rev. C, to appear; 17 pages, revtex 3, no figure
Effects of T- and P-odd weak nucleon interaction in nuclei: renormalizations due to residual strong interaction, matrix elements between compound states and their correlations with P-violating matrix elements
Manifestations of P-,T-odd weak interaction between nucleons in nucleus are
considered. Renormalization of this interaction due to residual strong
interaction is studied. Mean squared matrix elements of P-,T-odd weak
interaction between compound states are calculated. Correlators between
P-,T-odd and P-odd, T-even weak interaction matrix elements between compound
states are considered and estimates for these quantities are obtained.Comment: Submitted to Phys. Rev. C; 21 pages, REVTEX 3, no figure
Mutation of HIV-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside KP1461
The deoxycytidine analog KP1212, and its prodrug KP1461, are prototypes of a new class of antiretroviral drugs designed to increase viral mutation rates, with the goal of eventually causing the collapse of the viral population. Here we present an extensive analysis of viral sequences from HIV-1 infected volunteers from the first βmechanism validationβ phase II clinical trial of a mutagenic base analog in which individuals previously treated with antiviral drugs received 1600 mg of KP1461 twice per day for 124 days. Plasma viral loads were not reduced, and overall levels of viral mutation were not increased during this short-term study, however, the mutation spectrum of HIV was altered. A large number (N = 105 per sample) of sequences were analyzed, each derived from individual HIV-1 RNA templates, after 0, 56 and 124 days of therapy from 10 treated and 10 untreated control individuals (>7.1 million base pairs of unique viral templates were sequenced). We found that private mutations, those not found in more than one viral sequence and likely to have occurred in the most recent rounds of replication, increased in treated individuals relative to controls after 56 (p = 0.038) and 124 (p = 0.002) days of drug treatment. The spectrum of mutations observed in the treated group showed an excess of A to G and G to A mutations (p = 0.01), and to a lesser extent T to C and C to T mutations (p = 0.09), as predicted by the mechanism of action of the drug. These results validate the proposed mechanism of action in humans and should spur development of this novel antiretroviral approach.Koronis Pharmaceutical
Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function
Chronic kidney disease (CKD) is an increasing global public health concern, particularly among populations of African ancestry. We performed an interrogation of known renal loci, genome-wide association (GWA), and IBC candidate-gene SNP association analyses in African Americans from the CARe Renal Consortium. In up to 8,110 participants, we performed meta-analyses of GWA and IBC array data for estimated glomerular filtration rate (eGFR), CKD (eGFR <60 mL/min/1.73 m2), urinary albumin-to-creatinine ratio (UACR), and microalbuminuria (UACR >30 mg/g) and interrogated the 250 kb flanking region around 24 SNPs previously identified in European Ancestry renal GWAS analyses. Findings were replicated in up to 4,358 African Americans. To assess function, individually identified genes were knocked down in zebrafish embryos by morpholino antisense oligonucleotides. Expression of kidney-specific genes was assessed by in situ hybridization, and glomerular filtration was evaluated by dextran clearance. Overall, 23 of 24 previously identified SNPs had direction-consistent associations with eGFR in African Americans, 2 of which achieved nominal significance (UMOD, PIP5K1B). Interrogation of the flanking regions uncovered 24 new index SNPs in African Americans, 12 of which were replicated (UMOD, ANXA9, GCKR, TFDP2, DAB2, VEGFA, ATXN2, GATM, SLC22A2, TMEM60, SLC6A13, and BCAS3). In addition, we identified 3 suggestive loci at DOK6 (p-valueβ=β5.3Γ10β7) and FNDC1 (p-valueβ=β3.0Γ10β7) for UACR, and KCNQ1 with eGFR (pβ=β3.6Γ10β6). Morpholino knockdown of kcnq1 in the zebrafish resulted in abnormal kidney development and filtration capacity. We identified several SNPs in association with eGFR in African Ancestry individuals, as well as 3 suggestive loci for UACR and eGFR. Functional genetic studies support a role for kcnq1 in glomerular development in zebrafish
Low-Pathogenic Avian Influenza Viruses in Wild House Mice
Background: Avian influenza viruses are known to productively infect a number of mammal species, several of which are commonly found on or near poultry and gamebird farms. While control of rodent species is often used to limit avian influenza virus transmission within and among outbreak sites, few studies have investigated the potential role of these species in outbreak dynamics.
Methodology/Principal Findings: We trapped and sampled synanthropic mammals on a gamebird farm in Idaho, USA that had recently experienced a low pathogenic avian influenza outbreak. Six of six house mice (Mus musculus) caught on the outbreak farm were presumptively positive for antibodies to type A influenza. Consequently, we experimentally infected groups of naΓ―ve wild-caught house mice with five different low pathogenic avian influenza viruses that included three viruses derived from wild birds and two viruses derived from chickens. Virus replication was efficient in house mice inoculated with viruses derived from wild birds and more moderate for chicken-derived viruses. Mean titers (EID50 equivalents/mL) across all lung samples from seven days of sampling (three mice/day) ranged from 103.89 (H3N6) to 105.06 (H4N6) for the wild bird viruses and 102.08 (H6N2) to 102.85 (H4N8) for the chicken-derived viruses. Interestingly, multiple regression models indicated differential replication between sexes, with significantly (p\u3c0.05) higher concentrations of avian influenza RNA found in females compared with males.
Conclusions/Significance: Avian influenza viruses replicated efficiently in wild-caught house mice without adaptation, indicating mice may be a risk pathway for movement of avian influenza viruses on poultry and gamebird farms. Differential virus replication between males and females warrants further investigation to determine the generality of this result in avian influenza disease dynamics
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