Oscillation dynamics of embolic microspheres in flows with red blood cell suspensions

Dynamic nature of particle motion in blood flow is an important determinant of embolization based cancer therapy. Yet, the manner in which the presence of high volume fraction of red blood cells influences the particle dynamics remains unknown. Here, by investigating the motions of embolic microspheres in pressure-driven flows of red blood cell suspensions through capillaries, we illustrate unique oscillatory trends in particle trajectories, which are not observable in Newtonian fluid flows. Our investigation reveals that such oscillatory behavior essentially manifests when three simultaneous conditions, namely, the Reynolds number beyond a threshold limit, degree of confinement beyond a critical limit, and high hematocrit level, are fulfilled simultaneously. Given that these conditions are extremely relevant to fluid dynamics of blood or polymer flow, the observations reported here bear significant implications on embolization based cancer treatment as well as for complex multiphase fluidics involving particle

Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis.

CD8+ T cells are believed to play an important role in multiple sclerosis (MS), yet their role in MS pathogenesis remains poorly defined. Although myelin proteins are considered potential autoantigenic targets, prior studies of myelin-reactive CD8+ T cells in MS have relied on in vitro stimulation, thereby limiting accurate measurement of their ex vivo precursor frequencies and phenotypes. Peptide:MHC I tetramers were used to identify and validate 5 myelin CD8+ T cell epitopes, including 2 newly described determinants in humans. The validated tetramers were used to measure the ex vivo precursor frequencies and phenotypes of myelin-specific CD8+ T cells in the peripheral blood of untreated MS patients and HLA allele-matched healthy controls. In parallel, CD8+ T cell responses against immunodominant influenza epitopes were also measured. There were no differences in ex vivo frequencies of tetramer-positive myelin-specific CD8+ T cells between MS patients and control subjects. An increased proportion of myelin-specific CD8+ T cells in MS patients exhibited a memory phenotype and expressed CD20 compared to control subjects, while there were no phenotypic differences observed among influenza-specific CD8+ T cells. Longitudinal assessments were also measured in a subset of MS patients subsequently treated with anti-CD20 monoclonal antibody therapy. The proportion of memory and CD20+ CD8+ T cells specific for certain myelin but not influenza epitopes was significantly reduced following anti-CD20 treatment. This study, representing a characterization of unmanipulated myelin-reactive CD8+ T cells in MS, indicates these cells may be attractive targets in MS therapy

Primary versus delayed repair for bile duct injuries sustained during cholecystectomy: results of a survey of the Association Francaise de Chirurgie

BACKGROUND: Bile duct injuries (BDIs) sustained during a cholecystectomy still remain a major surgical problem, and it is still not clear whether the injury should be repaired immediately or a delayed repair is preferred. METHODS: A retrospective national French survey was conducted to compare the results of immediate (at time of cholecystectomy), early (within 45 days after a cholecystectomy) and late (beyond 45 days after a cholecystectomy) surgical repair for BDI sustained during a cholecystectomy. RESULTS: Forty-seven surgical centres provided 640 cases of bile duct injury sustained during a cholecystectomy of which 543 were analysed for the purpose of the present study. The timing of repair was immediate in 194 cases (35.7%), early in 216 cases (39.8%) and late in 133 cases (24.5%). The type of repair was a suture repair in 157 cases (81%), and a bilio-digestive reconstruction in 37 cases (19%) for immediate repair; a suture repair in 119 cases (55.1%) and a bilio-digestive anastomosis in 96 cases (44.9%) for the early repair; and a bilio-digestive reconstruction in 129 cases (97%) and a suture repair in 4 cases (3%) for late repair. A second procedure was required in 110 cases (56.7%) for immediate repair, 80 cases (40.7%) for early repair (P < 0.05) and in 9 cases (6.8%) for late repair (P < 0.001). CONCLUSION: The timing of surgical repair for a bile duct injury sustained during a cholecystectomy influences significantly the rate of a second procedure and a late repair should be preferred option

Structural properties in Sr0.61a0.39Nb2O6 in the temperature range 10 K to 500 K investigated by high-resolution neutron powder diffraction and specific heat measurements

We report high-resolution neutron powder diffraction on Sr0.61Ba0.39Nb2O6, SBN61, in the temperature range 15-500 K. The results indicate that the low-temperature anomalies (T<100K) observed in the dielectric dispersion are due to small changes in the incommensurate modulation of the NbO6-octahedra, as no structural phase transition of the average structure was observed. This interpretation is supported by specific heat measurements, which show no latent heat, but a glass-like behavior at low temperatures. Furthermore we find that the structural changes connected with the ferroelectric phase transition at Tc approx. 350K start already at 200K, explaining the anisotropic thermal expansion in the temperature range 200-300K observed in a recent x-ray diffraction study.Comment: Accepted by PRB (2006

Assessment of JSBACHv4.30 as a land component of ICON-ESM-V1 in comparison to its predecessor JSBACHv3.2 of MPI-ESM1.2

We assess the land surface model JSBACHv4 (Jena Scheme for Biosphere Atmosphere Coupling in Hamburg version 4), which was recently developed at the Max Planck Institute for Meteorology as part of the effort to build the new Icosahedral Nonhydrostatic (ICON) Earth system model (ESM), ICON-ESM. We assess JSBACHv4 in simulations coupled with ICON-A, the atmosphere model of ICON-ESM, hosting JSBACHv4 as land component to provide the surface boundary conditions. The assessment is based on a comparison of simulated albedo, land surface temperature (LST), leaf area index (LAI), terrestrial water storage (TWS), fraction of absorbed photosynthetic active radiation (FAPAR), net primary production (NPP), and water use efficiency (WUE) with corresponding observational data. JSBACHv4 is the successor of JSBACHv3; therefore, another purpose of this study is to document how this step in model development has changed model biases. This is achieved by also assessing, in parallel, the results of coupled land-atmosphere simulations with the preceding model ECHAM6 hosting JSBACHv3. Large albedo biases appear in both models over ice sheets and in central Asia. The temperate to boreal warm bias observed in simulations with JSBACHv3 largely remained in JSBACHv4, despite the very good agreement with observed LST in the global mean. For the assessment of changes in land water storage, a novel procedure is suggested to compare the gravitational data from the Gravity Recovery And Climate Experiment (GRACE) satellites to simulated TWS. It turns out that the agreement of the changes in the seasonal cycle of TWS is sensitive to the representation of precipitation in the atmosphere model. The LAI is generally too high, which is partly caused by too high soil moisture and also by the parameterization of the phenology itself. The pattern of WUE is, for both models, largely as observed. In India, WUE is too high, probably because JSBACH does not incorporate irrigation in our simulations. WUE differences between the two models can be traced back to differences in precipitation patterns in the two coupled land-atmosphere simulations. For both models, most NPP biases can be associated with biases in water stress, LAI, and FAPAR. In particular, the NPP bias of the Eurasian steppes has switched from positive in JSBACHv3 to negative in JSBACHv4. This difference is mainly caused by weaker precipitation and lower FAPAR of ICON-A-JSBACHv4 in July, which is most probably caused by a feedback loop between too little soil moisture, evaporation, and clouds. While the size and patterns of biases in albedo and LST are largely similar between the two model versions, they are less well correlated for precipitation- and vegetation-related variables like FAPAR. Overall, the biases found in the different assessment variables are either already known from the previous implementation in the Max Planck Institute Earth System Model (MPI-ESM) or have changed because of the coupling with the new atmospheric component ICON-A. Accordingly, this study demonstrates the technically successful completion of the re-implementation of JSBACH into ICON-ESM-V1. As discussed, there is a good perspective on mitigating the biases by an improved representation of the processes

On critical behavior of phase transitions in certain antiferromagnets with complicated ordering

Within the four-loop \ve expansion, we study the critical behavior of certain antiferromagnets with complicated ordering. We show that an anisotropic stable fixed point governs the phase transitions with new critical exponents. This is supported by the estimate of critical dimensionality $N_c^C=1.445(20)$ obtained from six loops via the exact relation $N_c^C={1/2} N_c^R$ established for the real and complex hypercubic models.Comment: Published versio