Common visual problems in children with disability

Children with disability are at a substantially higher risk of visual impairment (VI) (10.5% compared with 0.16%) but also of ocular disorders of all types, including refractive errors and strabismus. The aetiology of VI in children with disability reflects that of the general population and includes cerebral VI, optic atrophy, as well as primary visual disorders such as retinal dystrophies and structural eye anomalies. VI and other potentially correctable ocular disorders may not be recognised without careful assessment and are frequently unidentified in children with complex needs. Although assessment may be more challenging than in other children, identifying these potential additional barriers to learning and development may be critical. There is a need to develop clearer guidelines, referral pathways and closer working between all professionals involved in the care of children with disability and visual disorders to improve our focus on the assessment of vision and outcomes for children with disability

Proposal for a Workable Good Faith Exception to the Exclusionary Rule: Prospective Judgments

This Comment addresses the workability of a good faith exception to the exclusionary rule. The author begins by reviewing the development of the exclusionary rule and the good faith exception, and then discusses the arguments against the exception. The author argues that various Supreme Court decisions illustrate the Court\u27s willingness to reevaluate the objectives of the exclusionary rule and portend the adoption of a good faith exception in which evidence will be held admissible when an officer acts under the reasonable, though mistaken, belief that his search or seizure was legal. The author proposes a prospective judgment procedure, which preserves the deterrent efficacy of the exclusionary rule and promotes development of fourth amendment principles

Direct administration of 2-hydroxypropyl-beta-cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements

<p>Cochlear response measurements from two different animals made before (red) and after (blue) treatment with HPβCD (Panel A) and TTX (Panel B) to 80 dB SPL 4 kHz tone bursts. Cochlear response waveform maintained CAP-like morphology after HPβCD treatment, consistent with reduced mechanical drive to neural excitation (Panel B, blue). In contrast, response waveform is EPSP-like following TTX treatment. Unlike TTX, results from HPβCD do not support the hypothesis that the auditory nerve is a site of action for 13 mM HPβCD.</p

Analysis of the root system architecture of Arabidopsis provides a quantitative readout of crosstalk between nutritional signals

As plant roots forage the soil for food and water, they translate a multifactorial input of environmental stimuli into a multifactorial developmental output that manifests itself as root system architecture (RSA). Our current understanding of the underlying regulatory network is limited because root responses have traditionally been studied separately for individual nutrient deficiencies. In this study, we quantified 13 RSA parameters of Arabidopsis thaliana in 32 binary combinations of N, P, K, S, and light. Analysis of variance showed that each RSA parameter was determined by a typical pattern of environmental signals and their interactions. P caused the most important single-nutrient effects, while N-effects were strongly light dependent. Effects of K and S occurred mostly through nutrient interactions in paired or multiple combinations. Several RSA parameters were selected for further analysis through mutant phenotyping, which revealed combinations of transporters, receptors, and kinases acting as signaling modules in K–N interactions. Furthermore, nutrient response profiles of individual RSA features across NPK combinations could be assigned to transcriptionally coregulated clusters of nutrient-responsive genes in the roots and to ionome patterns in the shoots. The obtained data set provides a quantitative basis for understanding how plants integrate multiple nutritional stimuli into complex developmental programs

The evolution of gregariousness in parasitoid wasps

Data are assembled on the clutch-size strategies adopted by extant species of parasitoid wasp. These data are used to reconstruct the history of clutch-size evolution in the group using a series of plausible evolutionary assumptions. Extant families are either entirely solitary, both solitary and gregarious, or else clutch size is unknown. Parsimony analysis suggests that the ancestors of most families were solitary, a result which is robust to different phylogenetic relationships and likely data inadequacies. This implies that solitariness was ubiquitous throughout the initial radiation of the group, and that transitions to gregariousness have subsequently occurred a minimum of 43 times in several, but not all lineages. Current data suggest that species-rich and small-bodied lineages are more likely to have evolved gregariousness, and contain more species with small gregarious brood sizes. I discuss the implications of these data for clutch-size theory

Multirate control strategies for avoiding sample losses. Application to UGV path tracking

When in a digital control strategy there are samples lost due to limitations, diff t multirate (MR) control options can be used for solving the problem: Dual-rate inferential control (IC) and model-based dual-rate control (MBDR). The objective of this contribution is to analyze, compare, and to assess their behavior under different perspectives. Is a dual-rate inferential control better than a model-based dual-rate control? Both options lead to a periodically time-varying discrete-time system and for this reason a lifted modeling is considered. An efficient algorithm is used for computing a MR systems frequency response for these control structures. The robust performance and disturbance effects are studied in detail under sample losses and process uncertainty, and some considerations are reported. A new QFT (quantitative feedback theory) procedure for dual-rate systems analysis is also described. Analysis and simulation examples and experimental results for UGV path tracking are introduced in this work, revealing that MBDR outperforms IC when the model contains important uncertainties.Comment: 41 pages, 24 figure

Heavy Quark Parameters and Vcb from Spectral Moments in Semileptonic B Decays

We extract the heavy quark masses and non-perturbative parameters from the Delphi preliminary measurements of the first three moments of the charged lepton energy and hadronic mass distributions in semileptonic B decays, using a multi-parameter fit. We adopt two formalisms, one of which does not rely on a 1/mc expansion and makes use of running quark masses. The data are consistent and the level of accuracy of the experimental inputs largely determines the present sensitivity. The results allow to improve on the uncertainty in the extraction of Vcb.Comment: 13 pages, 2 figure

Replacement for the 10 page paper? A pilot project using blogs and wikis for a collaborative EBM assignment in a 3rd year internal medical clerkship

Objective Pilot a group assignment using blogs and wikis to develop evidence-based medicine skills in third year medical students on an internal medicine clerkship. Instead of the clerkship’s previous individual ten-page paper assignment, the students were divided into four groups of sixteen. During the clerkship, students are on geographically dispersed rotations. The earlier ten-page paper had required the students to complete a patient history and physical write-up. With the pilot project, each group was assigned a librarian and a physician faculty mentor. Each student recorded on the blog a clinical scenario and question they encountered. They were encouraged to communicate with the librarian to construct a well formed clinical question. Each student group then came to consensus on which question to pursue and collaborated on a wiki including a list of citations to the best available evidence, a critique of the studies, and implications for the patient

Delay-independent dual-rate PID controller for a packetbased Networked Control System

In this paper, a novel delay-independent control structure for a networked control system (NCS) is proposed, where packet-based control strategies with predictor-based and dual-rate control techniques are integrated. The control solution is able to cope with some networked communication problems such as time-varying delays, packet dropouts and packet disorder. In addition, the proposed approach enables to reduce network load, and usage of connected devices, while maintaining a satisfactory control performance. As a delayindependent control solution, no network-induced delay measurement is needed for controller implementation. In addition, the control scheme is applicable to open-loop unstable plants. Control system stability is ensured in terms of linear matrix inequalities (LMIs). Simulation results show the main benefits of the control approach, which are experimentally validated by means of a Cartesian-robot-based test-bed platform.Comment: 39 pages, 9 figure

Borrowed alleles and convergence in serpentine adaptation

ACKNOWLEDGMENTS. We thank members of the L.Y. and K.B. laboratories for helpful discussions. This work was supported through the European Research Council Grant StG CA629F04E (to L.Y.); a Harvard University Milton Fund Award (to K.B.); Ruth L. Kirschstein National Research Service Award 1 F32 GM096699 from the NIH (to L.Y.); National Science Foundation Grant IOS-1146465 (to K.B.); NIH National Institute of General Medical Sciences Grant 2R01GM078536 (to D.E.S.); and Biotechnology and Biological Sciences Research Council Grant BB/L000113/1 (to D.E.S.)Peer reviewedPublisher PD