A review of artificial sebum formulations, their compositions, uses and physicochemical characteristics

Sebum is a complex mixture of skin lipids responsible for lubrication, moisture retention and skin protection from external factors such as bacteria and fungi. The physicochemical properties of natural sebum are not well understood and are not easily accessible. Artificial sebum is widely used for sebum-related research such as dermal bioaccessibility, fingerprint production, dermatology, removal and sebum studies. It was found that the composition of artificial sebum affects the bioaccessibility of metals and drugs as well as the growth of some strains of bacteria. Squalene present in sebum was also found to be responsible for creating yellow stains on fabrics, whereas an increased concentration of fatty acids and triglycerides can lead to higher malodour of fabrics. Moreover, sebum and artificial sebum are poorly characterized with only 20 of 81 formulations characterized by certain techniques such as differential scanning calorimetry, nuclear magnetic resonance and thin-layer chromatography. This article reviews the artificial sebum formulations reported in the open literature between 1965 and 2023. We have discussed the compositions, uses and characterization techniques of artificial sebum used in the previous work and compared their properties to those of human sebum. A total of 81 artificial sebum formulations were found across the literature with 17 new formulations identified. The artificial sebum composition varies greatly between publications and there is no consistent formulation. There is a wide range of chemicals that are used as the main components of artificial sebum. We have highlighted the effect of chemical composition and individual compounds on the overall properties of the artificial sebum reported, and recommend that there is a great potential for creating personalized cosmetics and home care products once the characteristics of sebum are better understood.<br/

Real-Time Reflexion Modelling in architecture reconciliation: A multi case study

Context Reflexion Modelling is considered one of the more successful approaches to architecture reconciliation. Empirical studies strongly suggest that professional developers involved in real-life industrial projects find the information provided by variants of this approach useful and insightful, but the degree to which it resolves architecture conformance issues is still unclear. Objective This paper aims to assess the level of architecture conformance achieved by professional architects using Reflexion Modelling, and to determine how the approach could be extended to improve its suitability for this task. Method An in vivo, multi-case-study protocol was adopted across five software systems, from four different financial services organizations. Think-aloud, video-tape and interview data from professional architects involved in Reflexion Modelling sessions were analysed qualitatively. Results This study showed that (at least) four months after the Reflexion Modelling sessions less than 50% of the architectural violations identified were removed. The majority of participants who did remove violations favoured changes to the architectural model rather than to the code. Participants seemed to work off two specific architectural templates, and interactively explored their architectural model to focus in on the causes of violations, and to assess the ramifications of potential code changes. They expressed a desire for dependency analysis beyond static-source-code analysis and scalable visualizations. Conclusion The findings support several interesting usage-in-practice traits, previously hinted at in the literature. These include (1) the iterative analysis of systems through Reflexion models, as a precursor to possible code change or as a focusing mechanism to identify the location of architecture conformance issues, (2) the extension of the approach with respect to dependency analysis of software systems and architectural modelling templates, (3) improved visualization support and (4) the insight that identification of architectural violations in itself does not lead to their removal in the majority of instances.This work was supported, in part, by Science Foundation Ireland Grants 12/IP/1351 and 10/CE/I1855 to Lero – the Irish Software Engineering Research Centre (www.lero.ie) and by the University of Brighton under the Rising Star Scheme awarded to Nour Ali

Building health literacy in a Polish region: protocol for the POWER project in Lower Silesia

There is a high prevalence of premature mortality and unhealthy lifestyle behaviours in Lower Silesia in Poland (regional capital is the city of Wroclaw). One plausible reason is low health literacy among this population. Health literacy is one of the most important elements of public health and health promotion endeavours. It can be conceptualised as abroad range of cognitive and social skills as well as knowledge needed by an individual to maintain good health, prevent or manage diseases, and effectively engage with healthcare professionals and resources. The Health Promotion Foundation (HPF), in collaboration with regional institutions and organisations, initiated in 2017 a broad initiative to improve health in this region. The overarching aim of the wider programme is to improve the quality of care among primary care patients. The project stream led by HPF aims to improve knowledge and health-related competences in the population of primary care patients in Lower Silesia. It involves (1) needs assessment based on the analysis of data on health status and neds from 50 participating primary care clinics, followed by (2) development of tailored face-to-face workshops that will be delivered by trained public health students, (3) who will be mentored using train-the-trainer approach. It is anticipated that the project will impact on three main areas in the long term. First, it will lead to creation of a package of workshops that could be delivered to other primary care patients. Second, it will create opportunities for students majoring in public health in the region to become directly involved in activities focused on health education and promotion. Three, it is anticipated that the project will lead to improvements in health and wellbeing among the participating patient groups. The present report describes the scope and method of the project

Bioinspired Physico‐Chemical Surface Modifications for the Development of Advanced Retentive Systems

A major aspiration in advanced materials is to create artificial adhesive surfaces for wearable medical devices to meet the demands of the body's challenging settings and dynamics. For instance, dentures replace missing teeth and operate within the oral cavity, where an interplay between forces, muscles, saliva, and roughness of mucosa undermine their ability to grip oral tissues. Consequently, the lack of effective retentive strategies represents a source of dissatisfaction for denture wearers globally. Nature is rich in examples that employ physical and chemical adhesive strategies to optimize interfacial forces in dry and wet environments. Here, keratin‐coated octopus‐like suction cups are presented at the micro‐ and macroscale to improve the retention of rigid poly(methyl methacrylate). Microtopographies are obtained using two‐photon polymerization and maskless lithography, while denture prototypes with macrotopographies are derived via digital light processing 3D printing. Results suggest that microtopographies and keratin‐coated surfaces sustain higher maximum adhesion stress than the non‐topographical and non‐coated surfaces in moist environments, where retention is typically lacking. Proof‐of‐concept dentures demonstrate higher maximum detachment forces than conventional dentures with and without denture adhesive within dry and wet environments. This interdisciplinary research highlights the potential application of a nature‐inspired physico‐chemical approach in the next generation of complete dentures

An automatic architecture reconstruction and refactoring framework

A variety of sources have noted that a substantial proportion of non trivial software systems fail due to unhindered architectural erosion. This design deterioration leads to low maintainability, poor testability and reduced development speed. The erosion of software systems is often caused by inadequate understanding, documentation and maintenance of the desired implementation architecture. If the desired architecture is lost or the deterioration is advanced, the reconstruction of the desired architecture and the realignment of this desired architecture with the physical architecture both require substantial manual analysis and implementation effort. This paper describes the initial development of a framework for automatic software architecture reconstruction and source code migration. This framework offers the potential to reconstruct the conceptual architecture of software systems and to automatically migrate the physical architecture of a software system toward a conceptual architecture model. The approach is implemented within a proof of concept prototype which is able to analyze java system and reconstruct a conceptual architecture for these systems as well as to refactor the system towards a conceptual architecture

Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies

Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or without ionization radiotherapy. In this comprehensive review, we first provide a detailed clinical understanding of rhabdomyosarcoma including its classification and subtypes, diagnosis, and treatment strategies. Later, we focus on chemotherapy strategies for this childhood sarcoma and discuss the impact of three mechanisms that are involved in the chemotherapy response including apoptosis, macro-autophagy, and the unfolded protein response. Finally, we discuss in vivo mouse and zebrafish models and in vitro three-dimensional bioengineering models of rhabdomyosarcoma to screen future therapeutic approaches and promote muscle regeneration.S.G. was supported by the URGP (56977) and CHRIM (OG2023-24-05) operating grant