518 research outputs found
Crime and Public Health: Interdisciplinary Approach to Education
Dr. Karen Miner-Romanoff and Dr. Leslie King state that although crime rates have decreased in the last several years, they remain alarmingly high. Recidivism rates, in the meantime, continue to rise with up to half of all new prison inmates incarcerated for reoffending after their initial release (Matz, et al., 2012). As the costs of a failed criminal justice system becomes unsustainable, scholars search for new evidence-based, innovative and collaborative solutions to lower crime and increased public health and safety. As a result of this collaboration, some criminal justice and public health leaders are seeking to develop new theoretical and methodological linkages in order to effectively address the challenges (Matz, et al., 2012). Akers and Lanier (2009) proposed a theoretical framework called âEpidemiological Criminologyâ as a construct for scholars and practitioners to create the needed interdisciplinary linkages. In response to the necessity for public health and criminal justice to establish interdisciplinary linkages, it is necessary to develop academic curriculum to educate a new general of professionals prepared for this challenge.https://fuse.franklin.edu/forum-2013/1011/thumbnail.jp
Role of carbon dioxide and ion transport in the formation of sub-embryonic fluid by the blastoderm of the Japanese quail
1. The explanted blastoderm of the Japanese quail was used to explore the role of ions and carbon dioxide in determining the rate of sub-embryonic fluid (SEF) production between 54 and 72 h of incubation.
2. Amiloride, an inhibitor of Na+/H+ exchange, at concentrations of 10-3 to 10-6 M substantially decreased the rate of SEF production when added to the albumen culture medium. N-ethylmaleimide, an inhibitor of V type H+ ATPase, also decreased this rate but only to a small extent at the highest dose applied, 10-3 M. Both inhibitors had no effect on SEF production when added to the SEF. 3. The inhibitors of cellular bicarbonate and chloride exchange, 4-acetamido-4-'isothiocyano-2, 2-'disulphonic acid (SITS) and 4,4'diisothiocyanostilbene-2,2-'disulphonic acid (DIDS), had no effect upon SEF production.
4. Ouabain, an inhibitor of Na+/K+ ATPase, decreased SEF production substantially at all concentrations added to the SEF (10-3 to 10-6 M). Three sulphonamide inhibitors of carbonic anhydrase, acetazolamide, ethoxzolamide and benzolamide, decreased SEF production when added to the SEF at concentrations of 10-3 to 10-6 M. Benzolamide was by far the most potent. Neither ouabain nor the sulphonamides altered SEF production when added to the albumen culture medium.
5. Using a cobalt precipitation method, carbonic anhydrase activity was localised to the endodermal cells of the area vasculosa. The carbonic anhydrase activity was primarily associated with the lateral plasma membranes, which together with the potent inhibitory effect of benzolamide, suggests the carbonic anhydrase of these cells is the membrane-associated form, CA IV.
6. The changes in SEF composition produced by inhibitors were consistent with the production of SEF by local osmotic gradients.
7. It is concluded that a Na+/K+ ATPase is located on the basolateral membranes of the endodermal cells of the area vasculosa , and that a sodium ion/hydrogen ion exchanger is located on their apical surfaces. Protons for this exchanger would be provided by the hydration of CO2 catalysed by the membrane-associated carbonic anhydrase. Furthermore, it is proposed that the prime function of the endodermal cells of the area vasculosa is the production of SEF
Cigarette ignition propensity, smoking behavior, and toxicant exposure: A natural experiment in Canada
<p>Abstract</p> <p>Background</p> <p>This study used a 'pre-post' research design to measure the impact of the Canadian reduced ignition propensity law on cigarette toxicity and smoking behavior among Canadian smokers.</p> <p>Method</p> <p>The study was conducted in Ontario, Canada over a ten-month period in 2005-2006, consisting of 4 laboratory visits (baseline N = 61, final N = 42). At Visit 1, questionnaire data and biospecimens were collected. During the following 24 hours, participants smoked 5 cigarettes <it>ad libitum </it>through a topography recording device and collected their cigarette butts. Visit 2 consisted of a questionnaire and smoking one cigarette to measure laboratory topography values. After ten months, these procedures were repeated.</p> <p>Results</p> <p>Generalized estimating equations, with law status (pre and post) as a fixed within-subject factor, were used to determine changes in behavior and biomarker exposure. Overall, there were no significant differences in smoking topography, breath carbon monoxide, and saliva cotinine pre-post law (<it>p</it>>0.1). However, analyses revealed a significant increase in the summed concentrations of hydroxyfluorene metabolites (N = 3),, and 1-hydroxypyrene in urine, with at notable increase in hydroxyphenanthrene metabolites (N = 3) (<it>p</it><sub>ÎŁhydroxyfluorene </sub>= 0.013, 22% increase; <it>p<sub>1-hydroxypyrene </sub></it>= 0.018, 24% increase; <it>p</it><sub>ÎŁhydroxyphenanthrene </sub>= 0.061, 17% increase).</p> <p>Conclusion</p> <p>While the results suggest no change in topography variables, data showed increases in exposure to three PAH biomarkers following reduced ignition propensity implementation in Canada. These findings suggest that human studies should be considered to evaluate policy impacts.</p
Effect of egg turning and incubation time on carbonic anhydrase gene expression in the blastoderm of the Japanese quail (Coturnix c. japonica)
(1) The gene expression of carbonic anhydrase, a key enzyme for the production sub-embryonic fluid (SEF), was assessed in turned and unturned eggs of the Japanese quail. The plasma membrane-associated isoforms CA IV, CAIX, CA XII, CA XIV, and the cytoplasmic isoform CA II, were
investigated in the extra-embryonic tissue of the blastoderm and in embryonic blood.
(2) Eggs were incubated at 37.6C, c. 60% R.H., and turned hourly (90 ) or left unturned. From 48 to 96 hours of incubation mRNA was extracted from blastoderm tissue, reverse-transcribed to cDNA and quantified by real-time qPCR using gene-specific primers. Blood collected at 96h was processed identically.
(3) Blastoderm CAIV gene expression increased with the period of incubation only in turned eggs, with maxima at 84 and 96h of incubation. Only very low levels were found in blood.
(4) Blastoderm CA II gene expression was greatest at 48 and 54h of incubation, subsequently declining to much lower levels and una ected by turning. Blood CA II gene expression was about 25-fold greater than that in the blastoderm.
(5) The expression of CA IX in the blastoderm was the highest of all isoforms, yet unaffected by turning.
CA XII did not amplify and CA XIV was present at unquantifiable low levels.
(6) It is concluded that solely gene expression for CA IV is sensitive to egg turning, and that increased CA IV gene expression could account for the additional SEF mass found at 84-96h of incubation.
in embryos of turned eggs
Boolean delay equations on networks: An application to economic damage propagation
We introduce economic models based on Boolean Delay Equations: this formalism
makes easier to take into account the complexity of the interactions between
firms and is particularly appropriate for studying the propagation of an
initial damage due to a catastrophe. Here we concentrate on simple cases, which
allow to understand the effects of multiple concurrent production paths as well
as the presence of stochasticity in the path time lengths or in the network
structure.
In absence of flexibility, the shortening of production of a single firm in
an isolated network with multiple connections usually ends up by attaining a
finite fraction of the firms or the whole economy, whereas the interactions
with the outside allow a partial recovering of the activity, giving rise to
periodic solutions with waves of damage which propagate across the structure.
The damage propagation speed is strongly dependent upon the topology. The
existence of multiple concurrent production paths does not necessarily imply a
slowing down of the propagation, which can be as fast as the shortest path.Comment: Latex, 52 pages with 22 eps figure
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From Introduction: "In this paper are presented the results obtained to date from the inspections of steel pilings. The investigation will be continued by additional inspections of pilings in other parts of the country in order to cover a winder range of soil environments.
The Current State of Performance Appraisal Research and Practice: Concerns, Directions, and Implications
On the surface, it is not readily apparent how some performance appraisal research issues inform performance appraisal practice. Because performance appraisal is an applied topic, it is useful to periodically consider the current state of performance research and its relation to performance appraisal practice. This review examines the performance appraisal literature published in both academic and practitioner outlets between 1985 and 1990, briefly discusses the current state of performance appraisal practice, highlights the juxtaposition of research and practice, and suggests directions for further research
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