Selection on the Human Bitter Taste Gene, TAS2R16, inEurasian Populations

Bitter taste is one of the most important senses alerting humans to noxious foods. In gatherer communities, sensitivity to bitterness is presumably advantageous because of various noxious plants. TAS2R16 is the gene coding the taste receptor molecules for some of the most common toxins in plants. A previous study of this gene indicated selection has increased the frequency of a derived allele in this gene that arose before the human expansion out of Africa. We have applied a different methodology for detecting selection, the Long Range Haplotype (LRH) analysis, to TAS2R16 in a larger sampling of populations from around the world. The haplotype with the derived alleles at both the functional polymorphism and a polymorphism in the regulatory region of TAS2R16 showed evidence for recent positive selection in most of the Eurasian populations, though the highest selection signal occurs in Mbuti Pygmies, an African hunter-gatherer group. In Eurasia, only populations of Mesopotamia and the southeast coast of China have no signals of selection. The evidence of recent selection found in most Eurasian populations differs from the geographic pattern seen in the earlier study of selection. One can speculate that the difference may result from a gathering lifestyle extending into the most recent 10,000 yrs and the need to recognize newly encountered bitter natural toxins as populations expanded into new environments and the biota changes with the ending of the most recent ice age. Alternatively, the promoter region variant may be a marker for altered function beyond what the derived amino acid allele conferred

Radial growth responses of upland oaks following recurrent restoration treatments in northern Mississippi

Fire exclusion over the past century has substantially altered composition, structure, and fuel dynamics in upland oak-hickory (Quercus-Carya) forests in the Southeastern United States. Numerous restoration efforts have been made to re-establish historical disturbance regimes into these altered forests. However, our understanding of the implications of restorative disturbances on stand dynamics has primarily been limited to shifts in species composition and post-disturbance regeneration. Therefore, we examined annual radial growth responses of dominant upland oaks following a combination of prescribed fires (2004, 2006, 2008, 2010, 2012, and 2014) and thinning (starting in 2004) treatments (thin+burn) in stands which had previously been unburned since the early 1900s. Radial stem growth rates were quantified using tree cores from 22 post oak (Q. stellata) and southern red oak (Q. falcata) in a 2.5-acre thin+burn and control stand at the Strawberry Plains Audubon Center in northern Mississippi. Radial growth rates were not significantly greater following repeated thinning and prescribed burning than prior to treatment initiation for either post oak or southern red oak. For the first 6 years after the initial thin, the annual ring width for southern red oak was identical in the thin+burn (1.9 ± 0.1 mm year-1) and control (2.0 ± 0.2 mm year-1) stands. However, in 2010 radial growth for southern red oak in the thin+burn increased such that the annual ring width for 2010 was 22 percent greater in the thin+burn than in the control stands. In contrast to the positive growth response in southern red oak (2 percent), post oak demonstrated a significantly different (p = 0.014) negative response (-19 percent) in the relative percent change in total radial growth for the 11-year period post-treatment initiation when compared to the 11-year period prior to treatment initiation. Radial growth for both species was negatively impacted by a severe drought in 2007 with southern red oak exhibiting the greatest decrease in radial growth. Results from this study highlight the underlying role of climatic factors and species life history characteristics in evaluating radial growth patterns following forest disturbances

Prosodic phrasing, pitch range, and word order variation in Murrinhpatha

Like many Indigenous Australian languages, Murrinhpatha has flexible word order with no apparent configurational syntax. We analyzed an experimental corpus of Murrinhpatha utterances for associations between different thematic role orders, intonational phrasing patterns and pitch downtrends. We found that initial constituents (Agents or Patients) tend to carry the highest pitch targets (HiF0), followed by patterns of downstep and declination. Sentence-final verbs always have lower Hif0 values than either initial or medial Agents or Patients. Thematic role order does not influence intonational patterns, with the results suggesting that Murrinhpatha has positional prosody, although final nominals can disrupt global pitch downtrends regardless of thematic role

Toxin Induced Parkinsonism and Hospitalization Related Adverse Outcome Mitigation for Parkinson’s Disease: A Comprehensive Review

Patients with Parkinson’s disease admitted to the hospital have unique presentations. This unique subset of patients requires a multidisciplinary approach with a knowledge-based care team that can demonstrate awareness of complications specific to Parkinson’s disease to reduce critical care admissions, morbidity, and mortality. Early recognition of toxic exposures, medication withdrawals, or medication-induced symptoms can reduce morbidity and mortality. This review can assist in the critical assessment of new or exacerbating Parkinson’s disease symptoms

Quantum chaos in a Bose-Hubbard dimer with modulated tunnelling

In the large-$N$, classical limit, the Bose-Hubbard dimer undergoes a transition to chaos when its tunnelling rate is modulated in time. We use exact and approximate numerical simulations to determine the features of the dynamically evolving state that are correlated with the presence of chaos in the classical limit. We propose the statistical distance between initially similar number distributions as a reliable measure to distinguish regular from chaotic behaviour in the quantum dynamics. Besides being experimentally accessible, number distributions can be efficiently reconstructed numerically from binned phase-space trajectories in a truncated Wigner approximation. Although the evolving Wigner function becomes very irregular in the chaotic regions, the truncated Wigner method is nevertheless able to capture accurately the beyond mean-field dynamics.Comment: 10 pages, 10 figure

Saddle-point scrambling without thermalisation

Out-of-time-order correlators (OTOCs) have proven to be a useful tool for studying thermalisation in quantum systems. In particular, the exponential growth of OTOCS, or scrambling, is sometimes taken as an indicator of chaos in quantum systems, despite the fact that saddle points in integrable systems can also drive rapid growth in OTOCs. By analysing the Dicke model and a driven Bose-Hubbard dimer, we demonstrate that the OTOC growth driven by chaos can, nonetheless, be distinguished from that driven by saddle points through the long-term behaviour. Besides quantitative differences in the long-term average, the saddle point gives rise to large oscillations not observed in the chaotic case. The differences are also highlighted by entanglement entropy, which in the chaotic driven dimer matches a Page curve prediction. These results illustrate additional markers that can be used to distinguish chaotic behaviour in quantum systems, beyond the initial exponential growth in OTOCs.Comment: 7 pages, 5 figure

Comparison of three commercial sparse-matrix crystallization screens

Sparse-matrix sampling using commercially available crystallization screen kits has become the most popular way of determining the preliminary crystallization conditions for macromolecules. In this study, the efficiency of three commercial screening kits, Crystal Screen and Crystal Screen 2 (Hampton Research), Wizard Screens I and II (Emerald BioStructures) and Personal Structure Screens 1 and 2 (Molecular Dimensions), has been compared using a set of 19 diverse proteins. 18 proteins yielded crystals using at least one crystallization screen. Surprisingly, Crystal Screens and Personal Structure Screens showed dramatically different results, although most of the crystallization formulations are identical as listed by the manufacturers. Higher molecular weight polyethylene glycols and mixed precipitants were found to be the most effective precipitants in this study