Sleep and respiration: Implications for pulmonary rehabilitation

Despite the growing interest in the role of the inspiratory and accessory muscles of respiration in chronic respiratory disease, few therapists have considered the role sleep may play in the deterioration of a patient's clinical condition. A number of important physiological changes to respiration occur during sleep, which affect chest wall mechanics and gas exchange. The ensuing abnormalities caused by sleep hypoventilation and fragmentation can severely affect daytime function and wellbeing. Nocturnal nasal positive pressure ventilation (NIPPV) is now established as an effective means of preventing such changes in patients with chest wall and lung disease. Therapists involved in pulmonary rehabilitation programs must recognise the potential for nocturnal respiratory events to severely affect daytime function and understand the importance of reversing nocturnal respiratory failure in order to maximise the rehabilitation potential of patients

AOIPS 3 user's guide. Volume 2: Program descriptions

The Atmospheric and Oceanographic Information Processing System (AOIPS) 3 is the version of the AOIPS software as of April 1989. The AOIPS software was developed jointly by the Goddard Space Flight Center and General Sciences Corporation. A detailed description of very AOIPS program is presented. It is intended to serve as a reference for such items as program functionality, program operational instructions, and input/output variable descriptions. Program descriptions are derived from the on-line help information. Each program description is divided into two sections. The functional description section describes the purpose of the program and contains any pertinent operational information. The program description sections lists the program variables as they appear on-line, and describes them in detail

Group A Streptococcal Peptides expressed in HBsAg-S VLPs as a vaccine candidate

Streptococcus pyogenes, or Group A Streptococcus (GAS) is responsible for significant patient morbidity and mortality in the developing world and within the Australian Indigenous population. GAS is responsible for a variety of diseases such as invasive necrotizing fasciitis and toxic shock syndrome, as well as non-invasive diseases, such as pharyngitis, impetigo, scarlet fever and otitis media. However, GAS sequelae such as rheumatic fever and rheumatic heart disease are responsible for the highest morbidity. The 30-valent vaccine candidate currently in trials is inappropriately specialised to serotypes present in areas with low GAS incidence, such as the United States. The difficulty in creation of a suitable vaccine lies in part with the variety of GAS virulence factors. The M protein is a highly abundant, multifunctional immunogenic surface protein which confers resistance to phagocytes and complement mediated protection. As sections of the M protein is highly conserved, it has been the focus of vaccination research. Furthermore, protein fragments J8 and J14 within the M protein have given encouraging results within a mouse model. Virus-like particle (VLP) technology offers a promising alternative to existing vaccination delivery systems. VLPs are able to induce both cell mediated and humoral immune responses. In this study, the use of a chimeric hepatitis B surface antigen VLP expressing M protein epitopes p145, J8 and J14 for use as a dual vaccine against Hepatitis B virus (HBV) and GAS is investigated. Specifically, PCR generated DNA sequences of J8, J14 and p145 from the M protein of GAS have been cloned into the highly immunogenic ‘a’ determinant region of the HBsAg-S VLP and transformed into human embryonic kidney (HEK293T) cells. Expressed recombinant HBsAg-S-GAS-m protein constructs were assayed by ELISA to confirm presentation of GAS epitopes. ELISA results showing high titres were obtained for VLP:p145 but low titres were obtained for VLP:J8 and VLP:J14. Further sequencing of plasmid constructs, protein expression and antigenic screening of proteins is required before the study can progress to proof-of-concept murine challenge models

Roscoe Reid Graham (1890 to 1948): a Canadian pioneer in general surgery.

Roscoe Reid Graham, a Canadian surgeon trained at the University of Toronto, was a true pioneer in the field of general surgery. Although he may be best known for his omental patch repair of perforated duodenal ulcers-often referred to as the Graham patch -he had a number of other significant accomplishments that decorated his surgical career. Dr. Graham is credited with being the first surgeon to successfully enucleate an insulinoma. He ventured to do an essentially brand new operation based solely on his patient\u27s symptoms and physical findings, a courageous move that even some of the most talented surgeons would shy away from. He also spent a large portion of his career dedicated to the study of rectal prolapse, working tirelessly to rid his patients of this awful affliction. He was recognized by a number of different surgical associations for his operative successes and was awarded membership to those both in Canada and the United States. Despite all of these accolades, Dr. Graham remained grounded and always fervent in his dedication to the patient and their presenting symptom(s), reminding us that to do anything more would be meddlesome. In an age when medical professionals are often all too eager to make unnecessary interventions, it is imperative that we look back at our predecessors such as Roscoe Reid Graham, for they will continually redirect us toward our one and only obligation: the patient

Deformation of the Cape Chignecto Pluton, Cobequid Highlands, Nova Scotia: thrusting at the Meguma-Avalon boundary

The Early Carboniferous Cape Chignecto pluton, at the western end of the Cobequid Highlands in the Avalon Terrane of Nova Scotia, consists predominantly of two-feldspar biotite granite. Intrusion of smaller diorite bodies locally melted and hybridized the granite. Diabase and microgranite dykes cut the plutons. Much of the pluton has a flat-lying mylonitic foliation, with a mineral elongation lineation trending between north and west. Quartz is dynamically recrystallized, but feldspars show predominantly brittle deformation. The phiton was probably deformed under greenschist facies conditions, after cooling. C-S fabrics observed in the field, and tails on porphyroclasts seen in thin section, indicate northward overthrusting. The Hadrynian Jeffers Group is thrust over the south edge of the phiton in the Fowler Brook inlier. At its north edge, the pluton is probably thrust over volcanic rocks of die Fountain Lake Group. The deformation of the pluton is constrained by stratigraphic relationships and isotopic dates to a Namurian or possibly early Westphalian age. Deformation within the pluton is correlated with Namurian uplift of the Cobequid and Caledonia Highlands. It records either transpression resulting from the curvature of the Meguma-Avalon boundary or a major component of convergent movement between the Meguma and Avalon terranes. RÉSUMÉ Le pluton de Cape Chignecto, daté du début du Carbonifere et situé à l'extremité occidentale des Monts Cobequid (Lanière d'Avalon, Nouvelle-Écosse), est formé en majeure partie de granite à biotite à deux feldspaths. Le granite subit une fonte et une hybridation locales lore de l’ intrusion de batis dioritiques de plus faibles dimensions. Des dykes de diabase et de microgranite recoupent les plutons. La majeure partie du pluton présente une foliation mylonitique horizontale, avec une linétion d'éirement orientée entre le nord et l’ouesL On note une recristallisation dynamique du quartz mais la déformation des feldspaths est surtout fragile. Le pluton fut probablement déformé sous des conditions appartenant au faciès des schistes verts, et ce après son refroidissement. Des fabriques planaires C-S, observées sur le terrain, et des ombres de pression dissymdtriques, vues en lame mince, indiquent un charriage vers le nord. Le Groupe hadrynien de Jeffers chevauche l'extrémité méridionale du pluton dans la fenetre de Fowler Brook. A son extrémité septentrionale, le pluton chevauche probablement les volcanites du Groupe de Fountain Lake. Les relations stratigraphiqueset des datations radiométriques limitent l'âge de la déformation du pluton au Namurien ou possiblement au début du Westphalien. On corrèle la déformation au sein du pluton avec la surrection namurienne des monts Cobequid et Caledonia. Cette déformation enregistre soil une transpression résultant de la cambrure de la jonction Meguma-Avalon, soil une forte composanle de mouvement convergent entre les lanières de Meguma et d* Avalon. [Traduit par le journal

Core-level photoemission spectroscopy of nitrogen bonding in GaNxAs1–x alloys

The nitrogen bonding configurations in GaNxAs1–x alloys grown by molecular beam epitaxy with 0.07=0.03, the nitrogen is found to exist in a single bonding configuration – the Ga–N bond; no interstitial nitrogen complexes are present. The amount of nitrogen in the alloys is estimated from the XPS using the N 1s photoelectron and Ga LMM Auger lines and is found to be in agreement with the composition determined by x-ray diffraction

Origin of the n-type conductivity of InN: the role of positively charged dislocations

As-grown InN is known to exhibit high unintentional n-type conductivity. Hall measurements from a range of high-quality single-crystalline epitaxially grown InN films reveal a dramatic reduction in the electron density (from low 1019 to low 1017 cm–3) with increasing film thickness (from 50 to 12 000 nm). The combination of background donors from impurities and the extreme electron accumulation at InN surfaces is shown to be insufficient to reproduce the measured film thickness dependence of the free-electron density. When positively charged nitrogen vacancies (VN+) along dislocations are also included, agreement is obtained between the calculated and experimental thickness dependence of the free-electron concentration

Modelling the hepatitis B vaccination programme in prisons

A vaccination programme offering hepatitis B (HBV) vaccine at reception into prison has been introduced into selected prisons in England and Wales. Over the coming years it is anticipated this vaccination programme will be extended. A model has been developed to assess the potential impact of the programme on the vaccination coverage of prisoners, ex-prisoners, and injecting drug users (IDUs). Under a range of coverage scenarios, the model predicts the change over time in the vaccination status of new entrants to prison, current prisoners and IDUs in the community. The model predicts that at baseline in 2012 57% of the IDU population will be vaccinated with up to 72% being vaccinated depending on the vaccination scenario implemented. These results are sensitive to the size of the IDU population in England and Wales and the average time served by an IDU during each prison visit. IDUs that do not receive HBV vaccine in the community are at increased risk from HBV infection. The HBV vaccination programme in prisons is an effective way of vaccinating this hard-to-reach population although vaccination coverage on prison reception must be increased to achieve this