60 research outputs found
Scientific optimization of a ground-based CMB polarization experiment
We investigate the science goals achievable with the upcoming generation of
ground-based Cosmic Microwave Background polarization experiments and calculate
the optimal sky coverage for such an experiment including the effects of
foregrounds. We find that with current technology an E-mode measurement will be
sample-limited, while a B-mode measurement will be detector-noise-limited. We
conclude that a 300 sq deg survey is an optimal compromise for a two-year
experiment to measure both E and B-modes, and that ground-based polarization
experiments can make an important contribution to B-mode surveys. Focusing on
one particular experiment, QUaD, a proposed bolometric polarimeter operating
from the South Pole, we find that a ground-based experiment can make a high
significance measurement of the acoustic peaks in the E-mode spectrum, and will
be able to detect the gravitational lensing signal in the B-mode spectrum. Such
an experiment could also directly detect the gravitational wave component of
the B-mode spectrum if the amplitude of the signal is close to current upper
limits. We also investigate how a ground-based experiment can improve
constraints on the cosmological parameters. We estimate that by combining two
years of QUaD data with the four-year WMAP data, an optimized ground-based
polarization experiment can improve constraints on cosmological parameters by a
factor of two. If the foreground contamination can be reduced, the measurement
of the tensor-to-scalar ratio can be improved by up to a factor of six over
that obtainable from WMAP alone.Comment: 17 pages, 11 figures replaced with version accepted by MNRA
QUaD: A High-Resolution Cosmic Microwave Background Polarimeter
We describe the QUaD experiment, a millimeter-wavelength polarimeter designed
to observe the Cosmic Microwave Background (CMB) from a site at the South Pole.
The experiment comprises a 2.64 m Cassegrain telescope equipped with a
cryogenically cooled receiver containing an array of 62 polarization-sensitive
bolometers. The focal plane contains pixels at two different frequency bands,
100 GHz and 150 GHz, with angular resolutions of 5 arcmin and 3.5 arcmin,
respectively. The high angular resolution allows observation of CMB temperature
and polarization anisotropies over a wide range of scales. The instrument
commenced operation in early 2005 and collected science data during three
successive Austral winter seasons of observation.Comment: 23 pages, author list and text updated to reflect published versio
Genotyping and antifungal susceptibility testing of Cryptococcus neoformans isolates from Cameroonian HIV-positive adult patients
Cryptococcus neoformans is the most common cause of meningitis amongst adult Africans with HIV/AIDS. The widespread use of fluconazole may lead to the emergence of isolates with reduced susceptibility. We studied C.neoformans isolates from HIV-infected patients with cryptococcal meningitis. Genotyping and antifungal testing were performed to assess the genetic diversity, occurrence of mixed infections and in vitro activity of antifungal agents. Isolates were recovered from cerebrospinal fluid prior to systemic antifungal treatment. Six isolates were studied for each sample (a total of 114 isolates from 19 patients). Serotyping was performed via LAC 1 and CAP 64 gene amplification and genotyping was performed using phage M13 core, (GACA)(4) and (GTG)(5) primers and restriction polymorphism analysis of the URA5 gene. Susceptibilities for amphotericin B, flucytosine, fluconazole, voriconazole and posaconazole were tested by the Sensititre YeastOne (R) method. All strains were identified as C.neoformans var. grubii serotype A. We identified nine major genotypes. Up to two genotypes were identified in the same sample. None of the isolates were resistant to the studied drugs. However, 13 of 114 strains exhibited a reduced susceptibility to fluconazole and 13 of 114 strains exhibited a reduced susceptibility to flucytosine. No correlation was found between the genotype and susceptibility. This study confirms the prevalence of C.neoformans serotype A in Cameroon. Two genotypes may be responsible for a single episode of cryptococcosis. The possibility of mixed infection and diminished susceptibility to fluconazole or flucytosine must be considered for the management of cryptococcosis
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