Multi-object spectroscopy of the field surrounding PKS 2126-158: Discovery of a z=0.66 galaxy group

The high-redshift radio-loud quasar PKS 2126-158 is found to have a large number of red galaxies in close apparent proximity. We use the Gemini Multi-Object Spectrograph (GMOS) on Gemini South to obtain optical spectra for a large fraction of these sources. We show that there is a group of galaxies at $z\sim0.66$, coincident with a metal-line absorption system seen in the quasar's optical spectrum. The multiplexing capabilities of GMOS also allow us to measure redshifts of many foreground galaxies in the field surrounding the quasar. The galaxy group has five confirmed members, and a further four fainter galaxies are possibly associated. All confirmed members exhibit early-type galaxy spectra, a rare situation for a Mg II absorbing system. We discuss the relationship of this group to the absorbing gas, and the possibility of gravitational lensing of the quasar due to the intervening galaxies.Comment: Monthly Notices of the Royal Astronomical Society, in press. 10 pages, 8 figure

Microlensing Constraints on Broad Absorption and Emission Line Flows in the Quasar H1413+117

We present new integral field spectroscopy of the gravitationally lensed broad absorption line (BAL) quasar H1413+117, covering the ultraviolet to visible rest-frame spectral range. We observe strong microlensing signatures in lensed image D, and we use this microlensing to simultaneously constrain both the broad emission and broad absorption line gas. By modeling the lens system over the range of probable lensing galaxy redshifts and using on a new argument based on the wavelength-independence of the broad line lensing magnifications, we determine that there is no significant broad line emission from smaller than ~20 light days. We also perform spectral decomposition to derive the intrinsic broad emission line (BEL) and continuum spectrum, subject to BAL absorption. We also reconstruct the intrinsic BAL absorption profile, whose features allow us to constrain outflow kinematics in the context of a disk-wind model. We find a very sharp, blueshifted onset of absorption of 1,500 km/s in both C IV and N V that may correspond to an inner edge of a disk-wind's radial outflow. The lower ionization Si IV and Al III have higher-velocity absorption onsets, consistent with a decreasing ionization parameter with radius in an accelerating outflow. There is evidence of strong absorption in the BEL component which indicates a high covering factor for absorption over two orders of magnitude in outflow radius.Comment: 29 pages, 8 figure

A Description of COVID-19 Lifestyle Restrictions Among a Sample of Rural Appalachian Women

Background: COVID-19 has led to swift federal and state response to control virus transmission, which has resulted in unprecedented lifestyle changes for U.S. citizens including social distancing and isolation. Understanding the impact of COVID-19 lifestyle restrictions and related behavioral risks is important, particularly among individuals who may be more vulnerable (such as rural women with a history of substance use living in Appalachia). Purpose: The overall purpose of this study was to better understand the perceptions of lifestyle changes due to COVID-19 restrictions among this vulnerable group. Methods: The study included a mixed methods survey with a convenience sample of rural women (n=33) recruited through a closed, private Facebook group. Results: Study findings indicated that COVID-19 restrictions related to limited social activities and interactions with family and friends had a significant impact on women. Implications: Findings suggest that social isolation may have a number of unintended consequences for rural women, and implications for rural health practitioners are discussed

A Comparison of Appalachian and Non-Appalachian Kentucky DUI Offenders

Background: Driving under the influence has been an overlooked consequence of the opioid epidemic. Although recent reports have highlighted the increased prevalence of DUI in rural communities and the extensive mental health problems and criminal and drug use histories among rural Appalachian DUI offenders, it is unclear how Appalachian DUI populations compare to DUI offenders in other regions. Purpose: To help fill this void in the literature, the current study uses a statewide sample to examine how Appalachian DUI offenders differ from non-Appalachian DUI offenders in a predominantly rural state. Methods: Assessment records were examined for 11,640 Kentucky DUI offenders who completed an intervention in 2017. Appalachian DUI offenders were compared to non-Appalachian metro and nonmetro DUI offenders. Demographic information, DUI violation details, DSM-5 substance-use disorder criteria, and referral information were compared using ANCOVAs and logistic regression models. Results: More than one fourth of the sample were convicted in an Appalachian county. Compared to non-Appalachian DUI offenders, Appalachian offenders were significantly older and more likely to have a prior DUI conviction, to meet DSM-5 criteria for a drug-use disorder, and to drive while drug-impaired. Referral and intervention compliance also varied across groups. Implications: Results suggest that Appalachian DUI offenders are more drug-involved and have increased risk of recidivism. Findings indicate a need for practitioners to consider the distinct needs of Appalachian DUI offenders during service delivery. Future research should explore alternative intervention methods for preventing continued impaired driving in Appalachia given limited treatment availability in the region

How to Trust Your Diffusion Model: A Convex Optimization Approach to Conformal Risk Control

Score-based generative modeling, informally referred to as diffusion models, continue to grow in popularity across several important domains and tasks. While they provide high-quality and diverse samples from empirical distributions, important questions remain on the reliability and trustworthiness of these sampling procedures for their responsible use in critical scenarios. Conformal prediction is a modern tool to construct finite-sample, distribution-free uncertainty guarantees for any black-box predictor. In this work, we focus on image-to-image regression tasks and we present a generalization of the Risk-Controlling Prediction Sets (RCPS) procedure, that we term $K$-RCPS, which allows to $(i)$ provide entrywise calibrated intervals for future samples of any diffusion model, and $(ii)$ control a certain notion of risk with respect to a ground truth image with minimal mean interval length. Differently from existing conformal risk control procedures, ours relies on a novel convex optimization approach that allows for multidimensional risk control while provably minimizing the mean interval length. We illustrate our approach on two real-world image denoising problems: on natural images of faces as well as on computed tomography (CT) scans of the abdomen, demonstrating state of the art performance

Differential microlensing measurements of quasar broad-line kinematics in Q2237+0305

The detailed workings of the central engines of powerful quasars remain a mystery. This is primarily due to the fact that, at their cosmological distances, the inner regions of these quasars are spatially unresolvable. Reverberation mapping is now beginning to unlock the physics of the Broad Emission Line Region (BELR) in nearby, low-luminosity quasars, however it is still unknown whether this gas is dominated by virial motion, by outflows, or infall. The challenge is greater for more distant, powerful sources due to the very long response time of the BELR to changes in the continuum. We present a new technique for probing the kinematic properties of the BELR and accretion disk of high-z quasars using differential microlensing, and show how substantial information can be gained through a single observation of a strongly-lensed quasar using integral field spectroscopy. We apply this technique to GMOS IFU observations of the multiply-imaged quasar Q2237+0305, and find that the observed microlensing signature in the CIII] broad emission line favours gravitationally-dominated dynamics over an accelerating outflow

Tslp Production by Dendritic Cells Is Modulated by IL-1β and Components of the Endoplasmic Reticulum Stress Response

Thymic stromal lymphopoietin (TSLP) produced by epithelial cells acts on dendritic cells (DCs) to drive differentiation of TH2-cells, and is therefore important in allergic disease pathogenesis. However, DCs themselves make significant amounts of TSLP in response to microbial products, but little is known about the key downstream signals that induce and modulate this TSLP secretion from human DCs. We show that human monocyte derived DC (mDC) secretion of TSLP in response to Candida albicans and β-glucans requires dectin-1, Syk, NF-κB, and p38 MAPK signaling. In addition, TSLP production by mDCs is greatly enhanced by IL-1β, but not TNF-α, in contrast to epithelial cells. Furthermore, TSLP secretion is significantly increased by signals emanating from the endoplasmic reticulum (ER) stress response, specifically the unfolded protein response sensors, inositol-requiring transmembrane kinase/endonuclease 1 and protein kinase R-like ER kinase, which are activated by dectin-1 stimulation. Thus, TSLP production by mDCs requires the integration of signals from dectin-1, the IL-1 receptor, and ER stress signaling pathways. Autocrine TSLP production is likely to play a role in mDC-controlled immune responses at sites removed from epithelial cell production of the cytokine, such as lymphoid tissue