Characterization of the turbulent flame front surface in spark ignition engines during spark ignition operation to identify controlled auto-ignition and abnormal combustion

This is the author's version of a work that was accepted for publication in International Journal of Engine Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published as https://doi.org/10.1177/1468087420933780[EN] The combustion diagnostics and subsequent analysis are standardized tools based on the estimation of the heat release law (HRL). From this estimation, the different combustion parameters can be obtained: combustion phasing and duration, heat release rate, and so on. This analysis might be usually enough to study traditional spark ignition (SI) engines. However, with the new upcoming SI engines, this is probably not the case anymore, since different combustion modes can be operated in the same engine, as for instance a combination of SI and controlled auto-ignition (CAI) combustion modes. When different combustion modes are combined, it seems interesting to study in more depth the HRL, trying to get more data and to study the differences among the diverse combustion modes. Toward this end, a methodology to go deeper in the study of the HRL is proposed in this work, consisting of, mainly quantifying and taking into account the most relevant influencing parameters: the fuel properties (mainly its lower heating value), the in-cylinder oxygen content, the density of the burned and unburned zones, the laminar combustion speed, and the turbulence effect. With the proposed methodology, a standard SI combustion, developed by a flame front, can be characterized at any given operating point. This would allow to predict which the combustion developement would be, at this operating point, assuming it to be developed by a flame front. Subsequently, this SI combustion prediction can be compared to the one obtained experimentally, making it possible to identify and analyze abnormal combustion phenomena, as well as to study the differences between a combustion developed by a flame front (SI) and by auto-ignition (CAI). Derived from this work, an alternative equation to experimentally characterize the laminar combustion velocity has also been proposed, in order to improve its applicability in a wider range of fuel/air ratios and dilution degrees.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: the Spanish Ministry of Science, Innovation and Universities for funding the PhD. studies of Jorge Valero-Marco (contract BES-2016-077610). This work was partly funded by Renault, and by FEDER and the Spanish Government through project TRA2015-67136-R.Macian Martinez, V.; López, JJ.; Martín, J.; Valero-Marco, J. (2021). Characterization of the turbulent flame front surface in spark ignition engines during spark ignition operation to identify controlled auto-ignition and abnormal combustion. International Journal of Engine Research. 22(7):2149-2168. https://doi.org/10.1177/14680874209337802149216822

Cervical artery dissection: An atypical presentation with Ehlers-Danlos-like collagen pathology?

The authors took skin biopsies of the macroscopically normal skin of seven consecutive patients with spontaneous cervical artery dissection (SCAD). Histologically, alterations of the collagen and elastic fiber networks were found in six patients. In five, the histologic, immunohistochemical, and ultrastructural changes were similar to those usually found in Ehlers-Danlos syndrome (EDS). This suggests that SCAD is frequently associated with the dermal alterations seen in EDS

Vital and functional outcomes of the first-ever hemispheric stroke, epidemiological comparative study between Kunming (China) and Limoges (France)

AbstractBackgroundClinical outcomes and socioeconomic consequences after a stroke may differ between regions.MethodsOne cohort was established prospectively in Kunming (China) to compare with a cohort of 156 stroke patients included in Limoges (France). During 1 year, patients hospitalized within 48hours for a first-ever hemispheric stroke were included. Demographic data and neurocardiovascular risk factors were registered. Hemiplegia was evaluated. Functional outcome was assessed using the Barthel Index (BI) after 3 months.ResultsOne hundred and eighteen patients were included in Kunming. Patients of Kunming were younger (61.4±13.4 vs 72.3±14.6 years in Limoges, P<0.0001), more involved in professional activity (36.4% vs 12.8%, P<0.0001). Survival analysis indicated that mortality did not differ between cohorts, but independently predicted by coma at the 2nd day (HR=9.33, 95% CI [4.39, 19.78]) and age>70 years (HR=6.29, 95% CI [2.36, 16.59]). Despite a better baseline BI for patients of Kunming (50.0±34.9 vs 37.4±34.2, P=0.0031), after adjustment for confusing, patients in Limoges had a 2.11 OR 95% CI [1.03, 4.31]) to reach a BI>80 at 3 months.ConclusionsFunctional recovery for patients of Kunming was not as good as expected. The socioeconomic consequences of stroke in Kunming are significant as they involved younger subjects who were still in work

The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity

Ion channels are well placed to transduce environmental cues into signals used by cells to generate a wide range of responses, but little is known about their role in the regulation of RNA metabolism. Here we show that the TRPV4 cation channel binds the DEAD-box RNA helicase DDX3X and regulates its function. TRPV4-mediated Ca2+ influx releases DDX3X from the channel and drives DDX3X nuclear translocation, a process that involves calmodulin (CaM) and the CaM-dependent kinase II. Genetic depletion or pharmacological inhibition of TRPV4 diminishes DDX3X-dependent functions, including nuclear viral export and translation. Furthermore, TRPV4 mediates Ca2+ influx and nuclear accumulation of DDX3X in cells exposed to the Zika virus or the purified viral envelope protein. Consequently, targeting of TRPV4 reduces infectivity of dengue, hepatitis C and Zika viruses. Together, our results highlight the role of TRPV4 in the regulation of DDX3X-dependent control of RNA metabolism and viral infectivity

Methodology for Phase Doppler Anemometry Measurements on a Multi-Hole Diesel Injector

[EN] In this paper, a methodology for Phase Doppler Anemometry (PDPA) measurements on a multi-hole diesel injector is developed. Several key considerations were taken into account in this methodology: The windows for PDPA optical access must be clean, since fuel impregnated in these could preclude the droplets velocity acquisition. Some parts, including a device for spray isolation, were designed and manufactured to fulfill this goal. Taking into account that only one spray is measured, the isolation device captures all except three of the sprays (including the spray of interest). The two plumes accompanying the main spray were thought to conserve the actual air entrainment and thus the spray behavior. The spray of interest was aligned horizontally to ease the way that the PDPA measurements are carried out. The plume was lined up by means of the MIE-Scattering macroscopic optical technique. Images were acquired for several injection events and spray contours were detected and processed with a purpose-built Matlab tool. At each time step a spray axis inclination was estimated using the centroids from instantaneous contours. Also, preliminary droplet velocity measurements were made to check the effectiveness of the alignment and spray isolation strategies. Both geometrical characterization and spray alignment had very low measurement error. Radial velocity profiles show that PDPA measurements with this set-up configuration preserved the spray behavior.This research was performed in the frame of the project "Estudio de la interaccion chorro-pared en condiciones realistas de motor" reference TRA2015-67679-c2-1-R from Ministerio de Economia y Competitividad (Spanish Ministry of Economy). The equipment used in this work has been partially supported by FEDER Project funds "Dotacion de infraestructuras cientifico tectinas para el Centro Integral de Mejora Energetica y Medioambiental de Sistemas de Transporte (CiMeT), (FEDER-ICTS-2012-06)", framed in the operation program of unique scientific and technical infrastructure of the Ministry of Science and Innovation of Spain. Jhoan S. Giraldo was supported by a research grant from Generalitat Valenciana (Programa Santiago Grisolia, GRISOLIA/2013/007).Payri, R.; Gimeno, J.; Marti-Aldaravi, P.; Giraldo-Valderrama, JS. (2017). Methodology for Phase Doppler Anemometry Measurements on a Multi-Hole Diesel Injector. Experimental Techniques. 41(2):95-102. https://doi.org/10.1007/s40799-016-0154-1S95102412Lee J, Kang S, Rho B (2002) Intermittent atomization characteristics of multi-hole and single-hole diesel nozzle. KSME Int J 16(12):1693–1701Lee BH, Song JH, Chang YJ, Jeon CH (2010) Effect of the number of fuel injector holes on characteristics of combustion and emissions in a diesel engine. Int J Automot Technol 11(6):783– 791Lee J, Kaug S, Rho B (2003) Atomization characteristics of intermittent multi-hole diesel spray using time-resolved pdpa data. KSME Int J 17(5):766–775Zhou L-Y, Dong S-F, Cui H-F, Wu X-W, Xue F-Y, Luo F-Q (2016) Measurements and analyses on the transient discharge coefficient of each nozzle hole of multi-hole diesel injector. Sensors Actuators A Phys 244:198–205Payri R, Salvador FJ, Manin J, Viera A (2016) Diesel ignition delay and lift-off length through different methodologies using a multi-hole injector. Appl Energy 162:541–550Payri R, García-Oliver JM, Bardi M, Manin J (2012) Fuel temperature influence on diesel sprays in inert and reacting conditions. Appl Therm Eng 35:185–195Payri F, Payri R, Bardi M, Carreres M (2014) Engine combustion network: Influence of the gas properties on the spray penetration and spreading angle. Exp Thermal Fluid Sci 53:236– 243Payri R, Gimeno J, Bardi M, Plazas AH (2013) Study liquid length penetration results obtained with a direct acting piezo electric injector. Appl Energy 106(0):152–162Soare V (2007) Phase Doppler Measurements in Diesel Dense Sprays: Optimisation of Measurements and Study of the Orifice Geometry Influence over the Spray at Microscopic Level. PhD thesis, Universitat Politècnica de ValenciaAraneo L, Tropea C (2000) Improving phase doppler measurements in a diesel spray. SAE paperCoghe A, Cossali GE (2012) Quantitative optical techniques for dense sprays investigation: A survey. Optics and Lasers in Engineering 50(1):46–56. Advances in Flow VisualizationPayri R, Araneo L, Shakal J, Soare V (2008) Phase doppler measurements: system set-up optimization for characterization of a diesel nozzle. J Mech Sci Technol 22(8):1620–1632Desantes JM, Payri R, Salvador FJ, Soare V (2005) Phase doppler measurements: system set-up optimization for characterization of a diesel nozzle. In: SAE Technical Paper. SAE International, 04Bracco FV, Reitz RD (1979) On the dependence of spray angle and other spray parameters on nozzle design and operating conditions. SAE Technical PaperGavaises M, Andriotis A (2006) Cavitation inside multi-hole injectors for large diesel engines and its effect on the near-nozzle spray structure. In: SAE Technical Paper. SAE International, 04Macian V, Payri R, Garcia A, Bardi M (2012) Experimental evaluation of the best approach for diesel spray images segmentation. Exp Tech 36(6):26–34Payri R, Gimeno J, Viera JP, Plazas AH (2013) Needle lift profile influence on the vapor phase penetration for a prototype diesel direct acting piezoelectric injector. Fuel 113:257– 265Koo Ja-Ye Hung C, Martin JK (1997) Injection pressure effects upon droplet behaviour in transient diesel sprays. SAE PaperLee J, Kang S, Rho B (2003) Time-resolved analysis of turbulent mixing flow characteristics of intermittent multi-hole diesel spray using 2-d pdpa. JSME International Journal Series B Fluids and Thermal Engineering 46 (3):425–433Sinnamon J, Lancaster D, Stiener J (1980) An experimental and analytical study of engine fuel spray trajectories. SAE Technical PaperDesantes JM, Salvador FJ, López JJ, De la Morena J (2011) Study of mass and momentum transfer in diesel sprays based on x-ray mass distribution measurements and on a theoretical derivation. Exp Fluids 50 (2):233–246Hinze (1975) Turbulence. McGraw-Hill, New YorkSchlichting H (1979) Boundary Layer Theory. McGraw-Hill, New YorkDesantes JM, Payri R, Salvador FJ, Gil A (2006) Development and validation of a theoretical model for diesel spray penetration. Fuel 85:910–91

Protective role of chaperone-mediated autophagy against atherosclerosis

Significance Cardiovascular diseases remain the leading cause of death worldwide, with atherosclerosis being the most common source of clinical events. Metabolic changes with aging associate with concurrent increased risk of both type 2 diabetes and cardiovascular disease, with the former further raising the risk of the latter. The activity of a selective type of autophagy, chaperone-mediated autophagy (CMA), decreases with age or upon dietary excesses. Here we study whether reduced CMA activity increases risk of atherosclerosis in mouse models. We have identified that CMA is up-regulated early in response to proatherogenic challenges and demonstrate that reduced systemic CMA aggravates vascular pathology in these conditions. We also provide proof-of-concept support that CMA up-regulation is an effective intervention to reduce atherosclerosis severity and progression

Comparison of different techniques for characterizing the diesel injector internal dimensions

[EN] The geometry of certain parts of diesel injectors is key to the injection, atomization and fuel-air mixing phenomena. Small variations on the geometrical parameters may have a strong influence on the aforementioned processes. Thus, OEMs need to assess their manufacturing tolerances, whereas researchers in the field (both experimentalists and modelers) rely on the accuracy of a certain metrology technique for their studies. In the current paper, an investigation of the capability of different experimental techniques to determine the geometry of a modern diesel fuel injector has been performed. For this purpose, three main elements of the injector have been evaluated: the control volume inlet and outlet orifices, together with the nozzle orifices. While the direct observation of the samples through an optical microscope is only possible for the simplest pieces, both Computed Tomography Scanning and the visualization of silicone molds technique have proven their ability to characterize the most complex internal shapes corresponding to the internal injector elements. Indeed, results indicate that the differences observed among these methodologies for the determination of the control volume inlet orifice diameter and the nozzle orifice dimensions are smaller than the uncertainties related to the experimental techniques, showing that they are both equally accurate. This implies that the choice of a given technique for the particular application of determining the geometry of diesel injectors can be done on the basis of availability, intrusion and costs, rather than on its accuracy.This work was partly sponsored by "Ministerio de Economia y Competitividad", of the Spanish Government, in the frame of the Project "Estudio de la interaccion chorro-pared en condiciones realistas de motor", Reference TRA2015-67679-c2-1-R.Salvador, FJ.; Gimeno, J.; De La Morena, J.; Carreres, M. (2018). Comparison of different techniques for characterizing the diesel injector internal dimensions. Experimental Techniques. 42(5):467-472. https://doi.org/10.1007/s40799-018-0246-1S467472425Mobasheri R, Peng Z, Mostafa S (2012) Analysis the effect of advanced injection strategies on engine performance and pollutant emissions in a heavy duty DI-diesel engine by CFD modeling. Int J Heat Fluid Flow 33(1):59–69Dhar A, Agarwal AK (2015) Experimental investigations of the effect of pilot injection on performance, emissions and combustion characteristics of Karanja biodiesel fuelled CRDI engine. Energy Convers Manag 93:357–366Mohan B, Yang W, Chou SK (2013) Fuel injection strategies for performance improvement and emissions reduction in compression ignition engines—a review. Renew Sust Energ Rev 28(x):664–676Petrovic V, Bracanovic Z, Grozdanic B, Petrovic S, Sazhin S, Knezevic D (2015) The design of a full flow dilution tunnel with a critical flow venturi for the measurement of diesel engine particulate emission. FME Trans 43(2):99–106Ilić Z, Rasuo B, Jovanović M, Janković D (2013) Impact of changing quality of air/fuel mixture during flight of a piston engine aircraft with respect to vibration low frequency spectrum. FME Trans 41(1):25–32Luján JM, Tormos B, Salvador FJ, Galgar K (2009) Comparative analysis of a DI diesel engine fuelled with biodiesel blends during the European MVEG-A cycle: Preliminaru study I. Biomass & Bioenergy 33(6–7):941–947Postrioti L, Mariani F, Battistoni M (2012) Experimental and numerical momentum flux evaluation of high pressure diesel spray. Fuel 98:149–163Payri R, Salvador FJ, Gimeno J, Venegas O (2016) A technique to match the refractive index of different diesel fuels with the refractive index of transparent materials to improve the experimental visualization. Exp Tech 40(1):261–269Duran SP, Porter JM, Parker TE (2015) Ballistic imaging of diesel sprays using a picosecond laser: characterization and demonstration. Appl Opt 54(7):1743Payri R, Salvador FJ, Gimeno J et al (2011) Flow regime effects on non-cavitating injection nozzles over spray behavior. Int J Heat Fluid Flow 32(1):273–284Koukouvinis P, Gavaises M, Li J, Wang L (2016) Large Eddy simulation of diesel injector including cavitation effects and correlation to erosion damage. Fuel 175:26–39Som S, Aggarwal SK (2010) Effects of primary breakup modeling on spray and combustion characteristics of compression ignition engines. Combust Flame 157(6):1179–1193Salvador FJ, De la Morena J, Martínez-López J, Jaramillo D (2017) Assessment of compressibility effects on internal nozzle flow in diesel injectors at very high injection pressures. Energy Convers Manag 132:221–230Salvador FJ, Gimeno J, de la Morena J, Martí-Aldaraví P (2012) Using one-dimensional modelling to analyze the influence of the use of biodiesels on the dynamic behaviour of solenoid-operated injectors in common rail systems: Results of the simulation and discussion. Energy Convers Manag 54(1):122–132Taghavifar H, Khalilarya S, Jafarmadar S, Baghery F (2016) 3-D numerical consideration of nozzle structure on combustion and emission characteristics of DI diesel injector. Appl Math Model 40(19–20):8630–8646Edelbauer W (2017) Numerical simulation of cavitating injector flow and liquid spray break-up by combination of Eulerian–Eulerian and volume-of-fluid methods. Comput Fluids 144:19–33Salvador FJ, Carreres M, Jaramillo D, Martínez-López J (2015) Comparison of microsac and VCO diesel injector nozzles in terms of internal nozzle flow characteristics. Energy Convers Manag 103:284–299Salvador FJ, Martínez-López J, Romero JV, Roselló MD (2013) Study of the influence of the needle eccentricity on the internal flow in diesel injector nozzles by computational fluid dynamics calculations. Int J Comput Math 91, no. June:24–31Payri R, Salvador FJ, Carreres M, De la Morena J (Apr. 2016) Fuel temperature influence on the performance of a last generation common-rail diesel ballistic injector. Part II: 1D model development, validation and analysis. Energy Convers Manag 114:376–391Salvador FJ, Hoyas S, Novella R, Martinez-López J (2011) Numerical simulation and extended validation of two-phase compressible flow in diesel injector nozzles. Proc Inst Mech Eng Part-D-J Automob Eng 225(D4):545–563Satkoski C, Shaver G (2011) Piezoelectric fuel injection: pulse-to-pulse coupling and flow rate estimation. IEEE/ASME Trans Mechatron 16(4):627–642Ferrari A, Mittica A (2016) Response of different injector typologies to dwell time variations and a hydraulic analysis of closely-coupled and continuous rate shaping injection schedules. Appl Energy 169:899–911Payri R, Salvador FJ, Gimeno J, De la Morena J (2011) Analysis of diesel spray atomization by means of a near-nozzle field visualization technique. At Sprays 21(9):753–774Li T, Moon S, Sato K, Yokohata H (Feb. 2017) A comprehensive study on the factors affecting near-nozzle spray dynamics of multi-hole GDI injectors. Fuel 190:292–302Yu W, Yang W, Zhao F (2017) Investigation of internal nozzle flow, spray and combustion characteristics fueled with diesel, gasoline and wide distillation fuel (WDF) based on a piezoelectric injector and a direct injection compression ignition engine. Appl Therm Eng 114:905–920Salvador FJ, Carreres M, Crialesi-Esposito M, Plazas AH (2017) Determination of critical operating and geometrical parameters in diesel injectors through one dimensional modelling, design of experiments and an analysis of variance. Proc Inst Mech Eng Part D J Automob EngMacian V, Bermúdez V, Payri R, Gimeno J (2003) New technique for determination of internal geometry of a diesel nozzle with the use of silicone methodology. Exp Tech 27, no April:39–43Piano A, Millo F, Postrioti L, Biscontini G, Cavicchi A, and Pesce FC, (2016) “Numerical and experimental assessment of a solenoid common-rail injector operation with advanced injection strategies,” SAE Int J Engines 9(1)Mitroglou N, Lorenzi M, Santini M, Gavaises M (2016) Application of X-ray micro-computed tomography on high-speed cavitating diesel fuel flows. Exp Fluids 57(11):1–14Kastengren AL, Tilocco FZ, Powell CF, Manin J, Pickett LM, Payri R, Bazyn T (2012) Engine combustion network (ECN): measurements of nozzle geometry and hydraulic behavior. At Sprays 22(12):1011–1052Otsu N (1979) A threshold selection method from gray-level histograms. IEEE Trans Syst Man Cybern 9(1):62–6