The Effect of Exercise Intensity on Postprandial Blood Lipids in Physically-Inactive Men

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A Census of Star-Forming Galaxies in the z~9-10 Universe based on HST+Spitzer Observations Over 19 CLASH clusters: Three Candidate z~9-10 Galaxies and Improved Constraints on the Star Formation Rate Density at z~9

We utilise a two-color Lyman-Break selection criterion to search for z~9-10 galaxies over the first 19 clusters in the CLASH program. A systematic search yields three z~9-10 candidates. While we have already reported the most robust of these candidates, MACS1149-JD, two additional z~9 candidates are also found and have H_{160}-band magnitudes of ~26.2-26.9. A careful assessment of various sources of contamination suggests <~1 contaminants for our z~9-10 selection. To determine the implications of these search results for the LF and SFR density at z~9, we introduce a new differential approach to deriving these quantities in lensing fields. Our procedure is to derive the evolution by comparing the number of z~9-10 galaxy candidates found in CLASH with the number of galaxies in a slightly lower redshift sample (after correcting for the differences in selection volumes), here taken to be z~8. This procedure takes advantage of the fact that the relative volumes available for the z~8 and z~9-10 selections behind lensing clusters are not greatly dependent on the details of the lensing models. We find that the normalization of the UV LF at z~9 is just 0.28_{-0.20}^{+0.39}\times that at z~8, ~1.4_{-0.8}^{+3.0}x lower than extrapolating z~4-8 LF results. While consistent with the evolution in the UV LF seen at z~4-8, these results marginally favor a more rapid evolution at z>8. Compared to similar evolutionary findings from the HUDF, our result is less insensitive to large-scale structure uncertainties, given our many independent sightlines on the high-redshift universe.Comment: 22 pages, 11 figures, 5 tables, accepted for publication in the Astrophysical Journal, updated to include the much deeper Spitzer/IRAC observations over our three z~9-10 candidate

European Red List of Habitats Part 1. Marine habitats

The European Red List of Habitats provides an overview of the risk of collapse (degree of endangerment) of marine, terrestrial and freshwater habitats in the European Union (EU28) and adjacent regions (EU28+), based on a consistent set of categories and criteria, and detailed data and expert knowledge from involved countries1. A total of 257 benthic marine habitat types were assessed. In total, 19% (EU28) and 18% (EU28+) of the evaluated habitats were assessed as threatened in categories Critically Endangered, Endangered and Vulnerable. An additional 12% were Near Threatened in the EU28 and 11% in the EU28+. These figures are approximately doubled if Data Deficient habitats are excluded. The percentage of threatened habitat types differs across the regional seas. The highest proportion of threatened habitats in the EU28 was found in the Mediterranean Sea (32%), followed by the North-East Atlantic (23%), the Black Sea (13%) and then the Baltic Sea (8%). There was a similar pattern in the EU28+. The most frequently cited pressures and threats were similar across the four regional seas: pollution (eutrophication), biological resource use other than agriculture or forestry (mainly fishing but also aquaculture), natural system modifications (e.g. dredging and sea defence works), urbanisation and climate change. Even for habitats where the assessment outcome was Data Deficient, the Red List assessment process has resulted in the compilation of a substantial body of useful information to support the conservation of marine habitats

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Changes in the levels of circulating proteins are associated with Alzheimer’s disease (AD), whereas their pathogenic roles in AD are unclear. Here, we identified soluble ST2 (sST2), a decoy receptor of interleukin-33–ST2 signaling, as a new disease-causing factor in AD. Increased circulating sST2 level is associated with more severe pathological changes in female individuals with AD. Genome-wide association analysis and CRISPR–Cas9 genome editing identified rs1921622, a genetic variant in an enhancer element of IL1RL1, which downregulates gene and protein levels of sST2. Mendelian randomization analysis using genetic variants, including rs1921622, demonstrated that decreased sST2 levels lower AD risk and related endophenotypes in females carrying the Apolipoprotein E (APOE)-ε4 genotype; the association is stronger in Chinese than in European-descent populations. Human and mouse transcriptome and immunohistochemical studies showed that rs1921622/sST2 regulates amyloid-beta (Aβ) pathology through the modulation of microglial activation and Aβ clearance. These findings demonstrate how sST2 level is modulated by a genetic variation and plays a disease-causing role in females with AD

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer’s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18–94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology

Euclid preparation. Spectroscopy of active galactic nuclei with NISP

The statistical distribution and evolution of key properties (e.g. accretion rate, mass, or spin) of active galactic nuclei (AGN), remain an open debate in astrophysics. The ESA Euclid space mission, launched on July 1st 2023, promises a breakthrough in this field. We create detailed mock catalogues of AGN spectra, from the rest-frame near-infrared down to the ultraviolet, including emission lines, to simulate what Euclid will observe for both obscured (type 2) and unobscured (type 1) AGN. We concentrate on the red grisms of the NISP instrument, which will be used for the wide-field survey, opening a new window for spectroscopic AGN studies in the near-infrared. We quantify the efficiency in the redshift determination as well as in retrieving the emission line flux of the H$\alpha$+[NII] complex as Euclid is mainly focused on this emission line as it is expected to be the brightest one in the probed redshift range. Spectroscopic redshifts are measured for 83% of the simulated AGN in the interval where the H$\alpha$+[NII] is visible (0.89<z<1.83 at a line flux $>2x10^{-16}$ erg s$^{-1}$ cm$^{-2}$, encompassing the peak of AGN activity at $z\simeq 1-1.5$) within the spectral coverage of the red grism. Outside this redshift range, the measurement efficiency decreases significantly. Overall, a spectroscopic redshift is correctly determined for ~90% of type 2 AGN down to an emission line flux of $3x10^{-16}$ erg s$^{-1}$ cm$^{-2}$, and for type 1 AGN down to $8.5x10^{-16}$ erg s$^{-1}$ cm$^{-2}$. Recovered black hole mass values show a small offset with respect to the input values ~10%, but the agreement is good overall. With such a high spectroscopic coverage at z<2, we will be able to measure AGN demography, scaling relations, and clustering from the epoch of the peak of AGN activity down to the present-day Universe for hundreds of thousand AGN with homogeneous spectroscopic information.Comment: 29 pages, 23 figures. Submitted to A&A, revised versio

Euclid preparation: XXXVIII. Spectroscopy of active galactic nuclei with NISP

The statistical distribution and evolution of key properties of active galactic nuclei (AGN), such as their accretion rate, mass, and spin, remains a subject of open debate in astrophysics. The ESA Euclid space mission, launched on July 1 2023, promises a breakthrough in this field. We create detailed mock catalogues of AGN spectra from the rest-frame near-infrared down to the ultraviolet -including emission lines -to simulate what Euclid will observe for both obscured (type 2) and unobscured (type 1) AGN. We concentrate on the red grisms of the NISP instrument, which will be used for the wide-field survey, opening a new window for spectroscopic AGN studies in the near-infrared. We quantify the efficiency in the redshift determination as well as in retrieving the emission line flux of the Hα+[N II] complex, as Euclid is mainly focused on this emission line, given that it is expected to be the brightest one in the probed redshift range. Spectroscopic redshifts are measured for 83% of the simulated AGN in the interval where the Hα is visible (i.e. 0.89 &lt; z &lt; 1.83 at a line flux of &gt; 2 × 10-16 erg s-1 cm-2, encompassing the peak of AGN activity at z ≃ 1 - 1.5) within the spectral coverage of the red grism. Outside this redshift range, the measurement efficiency decreases significantly. Overall, a spectroscopic redshift iscorrectly determined for about 90% of type 2 AGN down to an emission line flux of roughly 3 × 10-16 erg s-1 cm-2, and for type 1 AGN down to 8.5 × 10-16 erg s-1 cm-2. Recovered values for black hole mass show a small offset with respect to the input values by about 10%, but the agreement is good overall. With such a high spectroscopic coverage at z &lt; 2, we will be able to measure AGN demography, scaling relations, and clustering from the epoch of the peak of AGN activity down to the present-day Universe for hundreds of thousands of AGN with homogeneous spectroscopic information