Conditions for safe underground gasification of lignite in Poland

Particular attention was paid to geotechnical problems encountered during lignite mining in Polish deposit conditions. Geotechnical protection of safe lignite utilization by its gasification involves many issues such as presence of underground water, predicted land subsidence and deformation, etc. Great importance is attached to surface facilities and buildings safety and to protection of urban areas.Особлива увага приділялася геотехнічним проблемам, з якими стикаються при видобутку бурового вугілля в Польщі. При геотехнічному захисті безпечного видобутку бурого вугілля за допомогою газифікації виникає багато проблем, таких як: наявність підземних вод, просідання земної поверхні, деформація і т.д. Величезне значення приділяється наземним спорудам, їх безпеці та охороні міських районів.Особое внимание уделялось геотехническим проблемам, с которыми сталкиваются при добыче бурового угля в Польше. При геотехнической защите безопасной добычи бурого угля с помощью газификации возникает много проблем, таких как: наличие подземных вод, проседание земной поверхности, деформация и т.д. Огромное значение уделяется наземным сооружениям, их безопасности и охране городских районов

KDEL receptors assist dengue virus exit from the endoplasmic reticulum

Membrane receptors at the surface of target cells are key host factors for virion entry; however, it is unknown whether trafficking and secretion of progeny virus requires host intracellular receptors. In this study, we demonstrate that dengue virus (DENV) interacts with KDEL receptors (KDELR), which cycle between the ER and Golgi apparatus, for vesicular transport from ER to Golgi. Depletion of KDELR by siRNA reduced egress of both DENV progeny and recombinant subviral particles (RSPs). Coimmunoprecipitation of KDELR with dengue structural protein prM required three positively charged residues at the N terminus, whose mutation disrupted protein interaction and inhibited RSP transport from the ER to the Golgi. Finally, siRNA depletion of class II Arfs, which results in KDELR accumulation in the Golgi, phenocopied results obtained with mutagenized prME and KDELR knockdown. Our results have uncovered a function for KDELR as an internal receptor involved in DENV trafficking.published_or_final_versio

Optimization of Expanded Polypropylene Foam Coring to Improve Bumper Foam Core Energy Absorbing Capability

To design a cost, weight, and energy efficient bumper foam energy absorber, it is important to consider optimizing the shape of coring employed in the design of the system. In this paper, a number of foam coring patterns are studied by both empirical and analytical methods. The size and shape of proposed core designs are studied in detail with consideration given to several different densities of expanded polypropylene (EPP) foam. Using the finite element method of structural analysis, it is possible to have an inside look at the stress distribution during deformation of foam structures. An optimization study using the finite element method is conducted using the energy absorption ratio as an efficiency parameter. Several coring patterns are studied and recommended for bumper foam core design based on high energy absorption efficiency and low tear stress

Electron spin resonance studies of P\u3csub\u3e2\u3c/sub\u3eH\u3csup\u3e+\u3c/sup\u3e\u3csub\u3e6\u3c/sub\u3eand PH\u3csup\u3e+\u3c/sup\u3e\u3csub\u3e3\u3c/sub\u3e radical cations in rare gas matrices at 4 K. Comparison with theoretical calculations

Detailed experimental and theoreticalelectron spin resonance(ESR) studies of the cation radicals, PH+ 3 and P2H+ 6, isolated in neon and argon matrices are reported. These cations were generated by photoionization (17 eV) and x-irradiation (80 keV) methods. The observed nuclear hyperfine interactions (Atensors) showed reasonable agreement with A iso and A dipolar values calculated at the ab initioconfiguration interaction (CI) level. These ESR results for PH+ 3 clearly indicate its nonplanarity; for P2H+ 6, an earlier theoretical prediction of a C 2h distortion from C 3v was confirmed by these new experimental results which reveal two different H atom environments. The neon magnetic parameters for PH+ 3 are g ∥=2.002(1), g ⊥=2.007(1), A ⊥=920(3), and A ∥=1638(15) MHz for 31P and A(H)≤6 MHz. The neon parameters for P2H+ 6 are g ∥=2.001(1), g ⊥=2.003(1), A ⊥=1527(2), and A ∥=1909(4) MHz for 31P and A(2H)=182(2) and A(4H)=±22(2) MHz

Features and Outcomes of Methamphetamine-associated Pulmonary Arterial Hypertension.

RATIONALE: Although amphetamines are recognized as likely agents to cause drug- and toxin-associated pulmonary arterial hypertension (PAH), (meth)amphetamine-associated PAH (Meth-APAH) has not been well described. OBJECTIVES: To prospectively characterize the clinical presentation, histopathology, and outcomes of Meth-APAH compared with those of idiopathic PAH (iPAH). METHODS: We performed a prospective cohort study of patients with Meth-APAH and iPAH presenting to the Stanford University Pulmonary Hypertension Program between 2003 and 2015. Clinical, pulmonary angiography, histopathology, and outcomes data were compared. We used data from the Healthcare Cost and Utilization Project to estimate the epidemiology of PAH in (meth)amphetamine users hospitalized in California. MEASUREMENTS AND MAIN RESULTS: The study sample included 90 patients with Meth-APAH and 97 patients with iPAH. Patients with Meth-APAH were less likely to be female, but similar in age, body mass index, and 6-minute-walk distance to patients with iPAH. Patients with Meth-APAH reported more advanced heart failure symptoms, had significantly higher right atrial pressure (12.7 ± 6.8 vs. 9.8 ± 5.1 mm Hg; P = 0.001), and had lower stroke volume index (22.2 ± 7.1 vs. 25.5 ± 8.7 ml/m CONCLUSIONS: Meth-APAH is a severe and progressive form of PAH with poor outcomes. Future studies should focus on mechanisms of disease and potential therapeutic considerations

Is EU enlargement bad for environmental policy? Confronting gloomy expectations with evidence

EU, Enlargement, Environment, Climate change, Air pollution, GMOs,

Validity of Adolescent Diet Recall 48 Years Later

Few studies have evaluated the validity of adolescent diet recall after many decades. Between 1943 and 1970, yearly diet records were completed by parents of adolescents participating in an ongoing US study. In 2005–2006, study participants who had been 13–18 years of age when the diet records were collected were asked to complete a food frequency questionnaire regarding their adolescent diet. Food frequency questionnaires and diet records were available for 72 participants. The authors calculated Spearman correlation coefficients between food, food group, and nutrient intakes from the diet records and food frequency questionnaire and deattenuated them to account for the effects of within-person variation measured in the diet records on the association. The median deattenuated correlation for foods was 0.30, ranging from −0.53 for a beef, pork, or lamb sandwich to 0.99 for diet soda. The median deattenuated correlation for food groups was 0.31 (range: −0.48 for breads to 0.70 for hot beverages); for nutrient intakes, it was 0.25 (range: −0.08 for iron to 0.82 for vitamin B12). Some dietary factors were reasonably recalled 3–6 decades later. However, this food frequency questionnaire did not validly measure overall adolescent diet when completed by middle-aged and older adults on average 48 years after adolescence