Superconducting quantum interference devices with submicron Nb/HfTi/Nb junctions for investigation of small magnetic particles

We investigated, at temperature $4.2\,\mathrm{K}$, electric transport, flux noise and resulting spin sensitivity of miniaturized Nb direct current superconducting quantum interference devices (SQUIDs) based on submicron Josephson junctions with HfTi barriers. The SQUIDs are either of the magnetometer-type or gradiometric in layout. In the white noise regime, for the best magnetometer we obtain a flux noise $S_{\Phi}^{1/2}=250\,\mathrm{n}\Phi_0/\mathrm{Hz}^{1/2}$, corresponding to a spin sensitivity $S^{1/2}_\mu\,\ge\,29\,\mu_B/\mathrm{Hz}^{1/2}$. For the gradiometer we find $S_{\Phi}^{1/2}=300\,\mathrm{n}\Phi_0/\mathrm{Hz}^{1/2}$ and $S^{1/2}_\mu\,\ge\,44\,\mu_B/\mathrm{Hz}^{1/2}$. The devices can still be optimized with respect to flux noise and coupling between a magnetic particle and the SQUID, leaving room for further improvement towards single spin resolution.Comment: 4 pages, 3 figure

Magnetization reversal of an individual exchange biased permalloy nanotube

We investigate the magnetization reversal mechanism in an individual permalloy (Py) nanotube (NT) using a hybrid magnetometer consisting of a nanometer-scale SQUID (nanoSQUID) and a cantilever torque sensor. The Py NT is affixed to the tip of a Si cantilever and positioned in order to optimally couple its stray flux into a Nb nanoSQUID. We are thus able to measure both the NT's volume magnetization by dynamic cantilever magnetometry and its stray flux using the nanoSQUID. We observe a training effect and temperature dependence in the magnetic hysteresis, suggesting an exchange bias. We find a low blocking temperature $T_B = 18 \pm 2$ K, indicating the presence of a thin antiferromagnetic native oxide, as confirmed by X-ray absorption spectroscopy on similar samples. Furthermore, we measure changes in the shape of the magnetic hysteresis as a function of temperature and increased training. These observations show that the presence of a thin exchange-coupled native oxide modifies the magnetization reversal process at low temperatures. Complementary information obtained via cantilever and nanoSQUID magnetometry allows us to conclude that, in the absence of exchange coupling, this reversal process is nucleated at the NT's ends and propagates along its length as predicted by theory.Comment: 8 pages, 4 figure

Transport and Noise Properties of sub-100-nm Planar Nb Josephson Junctions with Metallic Hf-Ti Barriers for nano-SQUID Applications

We analyze electric transport and noise properties at 4.2 K of self-shunted superconductor-normal metal-superconductor (SNS) sandwich-type Josephson junctions, comprising Nb as the superconductor and Hf-Ti as the normal conducting material, with lateral dimensions down to approximately 80 nm. The junctions are fabricated with an optimized multilayer Nb technology based on nanopatterning by electron-beam lithography and chemical-mechanical polishing. The dependence of transport properties on the junction geometry (lateral size and barrier thickness d(Hf-Ti)) is studied, yielding a characteristic voltage V-c up to approximately 100 mu V for the smallest d(Hf-Ti) = 17 nm. The observed small hysteresis in the current-voltage curves of devices with high V-c and large size can be attributed to self-heating of the junctions and fitted with an extended version of the resistively shunted junction model. Measurements of voltage noise of single junctions are consistent with the model including self-heating effects. The potential of our technology for further miniaturization of nanoscale superconducting quantum interference devices and for the improvement of their performance is discussed

YBa2Cu3O7 and Nb NanoSQUIDs for the Investigation of Magnetization Reversal of Individual Magnetic Nanoparticles

We report on the fabrication, performance and application of sensitive YBa2Cu3O7 (YBCO) and Nb nanoSQUIDs to magnetization reversal measurements of individual magnetic nanoparticles. The YBCO SQUIDs are based on grain boundary Josephson junctions and are patterned in a single layer of epitaxially grown YBCO films by Ga focused ion beam milling. The Nb SQUIDs contain sandwich-type Josephson junctions with normal conducting HfTi barriers; they are fabricated with a multilayer technology that includes patterning by e-beam lithography and a combination of milling techniques and chemical-mechanical polishing. Due to the small inductance of the SQUID loops, ultralow white flux noise at 4.2 K can be achieved, which yields spin sensitivities of down to a few Bohr magnetons per unit bandwidth for a magnetic nanoparticle placed at 10 nm distance to the SQUID loop

High- Q Magnetic Levitation and Control of Superconducting Microspheres at Millikelvin Temperatures

We report the levitation of a superconducting lead-tin sphere with 100 μm diameter (corresponding to a mass of 5.6 μg) in a static magnetic trap formed by two coils in an anti-Helmholtz configuration, with adjustable resonance frequencies up to 240 Hz. The center-of-mass motion of the sphere is monitored magnetically using a dc superconducting quantum interference device as well as optically and exhibits quality factors of up to 2.6 7107. We also demonstrate 3D magnetic feedback control of the motion of the sphere. The setup is housed in a dilution refrigerator operating at 15 mK. By implementing a cryogenic vibration isolation system, we can attenuate environmental vibrations at 200 Hz by approximately 7 orders of magnitude. The combination of low temperature, large mass, and high quality factor provides a promising platform for testing quantum physics in previously unexplored regimes with high mass and long coherence times

Driving a low critical current Josephson junction array with a mode-locked laser

Data for article "Driving a low critical current Josephson junction array with a mode-locked laser"

Environmental arginine controls multinuclear giant cell metabolism and formation

Multinucleated giant cells (MGCs) are implicated in many diseases including schistosomiasis, sarcoidosis and arthritis. MGC generation is energy intensive to enforce membrane fusion and cytoplasmic expansion. Using receptor activator of nuclear factor kappa-Beta ligand (RANKL) induced osteoclastogenesis to model MGC formation, here we report RANKL cellular programming requires extracellular arginine. Systemic arginine restriction improves outcome in multiple murine arthritis models and its removal induces preosteoclast metabolic quiescence, associated with impaired tricarboxylic acid (TCA) cycle function and metabolite induction. Effects of arginine deprivation on osteoclastogenesis are independent of mTORC1 activity or global transcriptional and translational inhibition. Arginine scarcity also dampens generation of IL-4 induced MGCs. Strikingly, in extracellular arginine absence, both cell types display flexibility as their formation can be restored with select arginine precursors. These data establish how environmental amino acids control the metabolic fate of polykaryons and suggest metabolic ways to manipulate MGC-associated pathologies and bone remodelling. Multinucleated giant cells (MGCs) are important in the pathogenesis of various diseases. Here, the authors demonstrate that extracellular presence of the amino acid arginine is required for MGC formation and metabolism, suggesting a translational impact for strategies utilizing systemic arginine depletion in MGC-mediated diseases

Prevalence trends and individual patterns of antiepileptic drug use in pregnancy 2006-2016: A study in the five Nordic countries, United States, and Australia

Purpose To describe recent international trends in antiepileptic drug (AED) use during pregnancy and individual patterns of use including discontinuation and switching.Methods We studied pregnancies from 2006 to 2016 within linked population-based registers for births and dispensed prescription drugs from Denmark, Finland, Iceland, Norway, Sweden, and New South Wales, Australia and claims data for public and private insurance enrollees in the United States. We examined the prevalence of AED use: the proportion of pregnancies with >= 1 prescription filled from 3 months before pregnancy until birth, and individual patterns of use by trimester.Results Prevalence of AED use in almost five million pregnancies was 15.3 per 1000 (n = 75 249) and varied from 6.4 in Sweden to 34.5 per 1000 in the publicly-insured US population. AED use increased in all countries in 2006-2012 ranging from an increase of 22% in Australia to 104% in Sweden, and continued to rise or stabilized in the countries in which more recent data were available. Lamotrigine, clonazepam, and valproate were the most commonly used AEDs in the Nordic countries, United States, and Australia, respectively. Among AED users, 31% only filled a prescription in the 3 months before pregnancy. Most filled a prescription in the first trimester (59%) but few filled prescriptions in every trimester (22%).Conclusions Use of AEDs in pregnancy rose from 2006 to 2016. Trends and patterns of use of valproate and lamotrigine reflected the safety data available during this period. Many women discontinued AEDs during pregnancy while some switched to another AED