A randomized placebo-controlled pilot study of the efficacy and safety of D-cycloserine in people with chronic back pain.

BACKGROUND: Few effective pharmacological treatment options exist for chronic back pain, the leading cause of disability in the US, and all are associated with significant adverse effects. OBJECTIVE: To determine the efficacy and safety of D-cycloserine, a partial agonist to the N-methyl-D-aspartate receptor, in the treatment of chronic low back pain. METHODS: A total of 41 participants with chronic back pain who met all inclusion and exclusion criteria were enrolled in a double-blind, placebo-controlled randomized pilot trial of D-cycloserine. Treatment was administered orally for six weeks at escalating daily doses of 100 mg, 200 mg, and 400 mg, each for two weeks. The primary outcome measure was back pain intensity using the Numeric Rating Scale (0-10). Secondary measures were back pain-related questionnaires: McGill Pain Questionnaire short form, painDETECT, PANAS, and BDI. The pre-specified analysis was a two-way repeated measures analysis of variance. RESULTS: A treatment difference was observed between groups treated with D-cycloserine and placebo at six weeks of 1.05 ± 3.1 units on the Numeric Rating Scale, with an effect size of 0.4 and p = 0.14. This trend of better chronic back pain relief with D-cycloserine was also observed in the secondary measures. No safety issues were seen. CONCLUSION: The difference in mean pain between the D-cycloserine and placebo groups did not reach statistical significance. However, a clinically meaningful effect size in the magnitude of pain relief was observed with a consistent pattern across multiple outcome measures with good safety, supporting further research into the effectiveness of D-cycloserine for chronic back pain

Software Agents for Automated Transaction Negotiations: Implementation and Evaluation

Software agents have the potential to serve as effective surrogates of humans in conducting business transactions in an electronic commerce environment. The reported proceeding research aims to evaluate the performance of software agents in automated transaction negotiations. As part of this research, agents are being built using IBM aglets, and their performance evaluation within various experimental settings is currently underway

Dynamical symmetries and the Ermakov invariant

Ermakov systems possessing Noether point symmetry are identified among the Ermakov systems that derive from a Lagrangian formalism and, the Ermakov invariant is shown to result from an associated symmetry of dynamical character. The Ermakov invariant and the associated Noether invariant, are sufficient to reduce these systems to quadratures

Satellite provided customer promises services, a forecast of potential domestic demand through the year 2000. Volume 4: Sensitivity analysis

The overall purpose was to forecast the potential United States domestic telecommunications demand for satellite provided customer promises voice, data and video services through the year 2000, so that this information on service demand would be available to aid in NASA program planning. To accomplish this overall purpose the following objectives were achieved: (1) development of a forecast of the total domestic telecommunications demand; (2) identification of that portion of the telecommunications demand suitable for transmission by satellite systems; (3) identification of that portion of the satellite market addressable by consumer promises service (CPS) systems; (4) identification of that portion of the satellite market addressable by Ka-band CPS system; and (5) postulation of a Ka-band CPS network on a nationwide and local level. The approach employed included the use of a variety of forecasting models, a parametric cost model, a market distribution model and a network optimization model. Forecasts were developed for: 1980, 1990, and 2000; voice, data and video services; terrestrial and satellite delivery modes; and C, Ku and Ka-bands

Satellite provided fixed communications services: A forecast of potential domestic demand through the year 2000: Volume 2: Main text

Potential satellite-provided fixed communications services, baseline forecasts, net long haul forecasts, cost analysis, net addressable forecasts, capacity requirements, and satellite system market development are considered

Satellite provided fixed communication services: A forecast of potential domestic demand through the year 2000. Volume 1: Executive summary

Telecommunications service demand, net addressable forecast, capacity requirements, and satellite system market development are considered

Satellite provided customer premises services: A forecast of potential domestic demand through the year 2000. Volume 1: Executive summary

Development of a forecast of the total domestic telecommunications demand, identification of that portion of the telecommunications demand suitable for transmission by satellite systems, identification of that portion of the satellite market addressable by CPS systems, identification of that portion of the satellite market addressable by Ka-band CPS system, and postulation of a Ka-band CPS network on a nationwide and local level were achieved. The approach employed included the use of a variety of forecasting models, a parametric cost model, a market distribution model and a network optimization model. Forecasts were developed for: 1980, 1990, 2000; voice, data and video services; terrestrial and satellite delivery modes; and C, Ku and Ka-bands

Satellite fixed communications service: A forecast of potential domestic demand through the year 2000. Volume 3: Appendices

Voice applications, data applications, video applications, impacted baseline forecasts, market distribution model, net long haul forecasts, trunking earth station definition and costs, trunking space segment cost, trunking entrance/exit links, trunking network costs and crossover distances with terrestrial tariffs, net addressable forecasts, capacity requirements, improving spectrum utilization, satellite system market development, and the 30/20 net accessible market are considered

Satellite provided customer premise services: A forecast of potential domestic demand through the year 2000. Volume 3: Appendices

Voice applications, data applications, video applications, impacted baseline forecasts, market distribution, potential CPS (customers premises services) user classes, net long haul forecasts, CPS cost analysis, overall satellite forecast, CPS satellite market, Ka-band CPS satellite forecast, nationwide traffic distribution model, and intra-urban topology are discussed

Kinetics of Heterogeneous Reaction between o-Toluidine Nitrate & Red Fuming Nitric Acid

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