1,051 research outputs found
Indications of repair of radon-induced chromosome damage in human lymphocytes: an adaptive response induced by low doses of X-rays.
Naturally occurring radon is a relatively ubiquitous environmental carcinogen to which large numbers of people can be exposed over their lifetimes. The accumulation of radon in homes, therefore, has led to a large program to determine the effects of the densely ionizing alpha particles that are produced when radon decays. In human lymphocytes, low doses of X-rays can decrease the number of chromatid deletions induced by subsequent high doses of clastogens. This has been attributed to the induction of a repair mechanism by the low-dose exposures. Historically, chromosome aberrations induced by radon have been considered to be relatively irreparable. The present experiments, however, show that if human peripheral blood lymphocytes are irradiated with low doses of X-rays (2 cGy) at 48 hr of culture, before being exposed to radon at 72 hr of culture, the yield of chromatid deletions induced by radon is decreased by a factor of two. Furthermore, the numbers of aberrations per cell do not follow a Poisson distribution but are overdispersed, as might be expected because high-linear energy transfer (high LET) alpha particles have a high relative biological effectiveness compared to low-LET radiations such as X-rays or gamma rays. Pretreatment with a low dose of X-rays decreases the overdispersion and leads to a greater proportion of the cells having no aberrations, or lower numbers of aberrations, than is the case in cells exposed to radon alone.(ABSTRACT TRUNCATED AT 250 WORDS
Knot Theory: from Fox 3-colorings of links to Yang-Baxter homology and Khovanov homology
This paper is an extended account of my "Introductory Plenary talk at Knots
in Hellas 2016" conference We start from the short introduction to Knot Theory
from the historical perspective, starting from Heraclas text (the first century
AD), mentioning R.Llull (1232-1315), A.Kircher (1602-1680), Leibniz idea of
Geometria Situs (1679), and J.B.Listing (student of Gauss) work of 1847. We
spend some space on Ralph H. Fox (1913-1973) elementary introduction to diagram
colorings (1956). In the second section we describe how Fox work was
generalized to distributive colorings (racks and quandles) and eventually in
the work of Jones and Turaev to link invariants via Yang-Baxter operators, here
the importance of statistical mechanics to topology will be mentioned. Finally
we describe recent developments which started with Mikhail Khovanov work on
categorification of the Jones polynomial. By analogy to Khovanov homology we
build homology of distributive structures (including homology of Fox colorings)
and generalize it to homology of Yang-Baxter operators. We speculate, with
supporting evidence, on co-cycle invariants of knots coming from Yang-Baxter
homology. Here the work of Fenn-Rourke-Sanderson (geometric realization of
pre-cubic sets of link diagrams) and Carter-Kamada-Saito (co-cycle invariants
of links) will be discussed and expanded.
Dedicated to Lou Kauffman for his 70th birthday.Comment: 35 pages, 31 figures, for Knots in Hellas II Proceedings, Springer,
part of the series Proceedings in Mathematics & Statistics (PROMS
Atmospheric aerosols at the Pierre Auger Observatory and environmental implications
The Pierre Auger Observatory detects the highest energy cosmic rays.
Calorimetric measurements of extensive air showers induced by cosmic rays are
performed with a fluorescence detector. Thus, one of the main challenges is the
atmospheric monitoring, especially for aerosols in suspension in the
atmosphere. Several methods are described which have been developed to measure
the aerosol optical depth profile and aerosol phase function, using lasers and
other light sources as recorded by the fluorescence detector. The origin of
atmospheric aerosols traveling through the Auger site is also presented,
highlighting the effect of surrounding areas to atmospheric properties. In the
aim to extend the Pierre Auger Observatory to an atmospheric research platform,
a discussion about a collaborative project is presented.Comment: Regular Article, 16 pages, 12 figure
A Multi-Component Measurement of the Cosmic Ray Composition Between 10^{17} eV and 10^{18} eV
The average mass composition of cosmic rays with primary energies between
eV and eV has been studied using a hybrid detector consisting
of the High Resolution Fly's Eye (HiRes) prototype and the MIA muon array.
Measurements have been made of the change in the depth of shower maximum,
, and in the change in the muon density at a fixed core location,
, as a function of energy. The composition has also been
evaluated in terms of the combination of and . The
results show that the composition is changing from a heavy to lighter mix as
the energy increases.Comment: 14 pages including 3 figures in revtex epsf style, submited to PR
Measurement of the Cosmic Ray Energy Spectrum and Composition from 10^{17} to 10^{18.3} eV Using a Hybrid Fluorescence Technique
We study the spectrum and average mass composition of cosmic rays with
primary energies between 10^{17} eV and 10^{18} eV using a hybrid detector
consisting of the High Resolution Fly's Eye (HiRes) prototype and the MIA muon
array. Measurements have been made of the change in the depth of shower maximum
as a function of energy. A complete Monte Carlo simulation of the detector
response and comparisons with shower simulations leads to the conclusion that
the cosmic ray intensity is changing f rom a heavier to a lighter composition
in this energy range. The spectrum is consistent with earlier Fly's Eye
measurements and supports the previously found steepening near 4 \times 10^{17}
eV .Comment: 39 pages, 15 figures, in revtex4 epsf style, submited to AP
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