A high resolution millimetre and submillimetre study of W3

The continuum bolometer receiver on the James Clerk Maxwell telescope has been used to map the dense core of the star formation region W3 with a spatial resolution of 15-20 arcsec. At 350 and 800 μm, the region appears as two principal peaks around the known IR sources IRS4 and IRS5, while at 1100 μm, a further peak is noted which is interpreted as being due to free-free emission around IRS2. Taking into account the free-free contribution to the intensity, the continuum dust emission from the region is found to be consistent with optically thin emission at all of the three wavelengths considered. Values for the dust optical depth, hydrogen column density, mass, and central density have been obtained for each of the main peaks

Feeding Patterns and Attachment Ability of \u3ci\u3eAltica Subplicata\u3c/i\u3e (Coleoptera: Chrysomelidae) on Sand-Dune Willow

To investigate feeding patterns of a specialist herbivore, Altica subplicata, larvae and adults were caged separately on host plants, Salix cordata, and leaf damage was estimated. Young, relatively more pubescent leaves near the tops of the shoots were consumed more than older leaves. Larvae clearly preferred the young, pubescent leaves and avoided the oldest leaves. Adults showed a stronger preference for the first five young leaves, but amount of consumption did not differ among the older leaves. Attachment ability on smooth and pubescent leaves was examined as a possible factor influencing feeding patterns. Scanning electron microscopy of tarsal adhesive structures and leaf surfaces was conducted to investigate how A. subplicata attaches to its host. Adhesive setae on the tarsi of adults may be effective for attachment on the older, smooth leaves and their tarsal claws are likely used to cling to trichomes of pubescent leaves. Larvae have fleshy adhesive pads for attachment. Laboratory experiments on attachment of larvae and adults to smooth and pubescent leaves under various wind conditions showed that wind caused difficulty in attachment and movement, but leaf pubescence did not affect the number of beetles that fell off leaves. However, larvae fell off more quickly when placed on pubescent leaves. Thus, other factors such as nutritional quality and microclimate provided by trichomes may be responsible for the preference for pubescent leaves exhibited by A. subplicata

A submillimetre wavelength spectral line search of the Orion molecular cloud core

A submillimetre wavelength molecular line search of the Orion molecular cloud has been made covering a total of about 5 percent of the frequency range 342.8 - 358.6 GHz. This search, coupled with the authors' previous observations of submillimetre transitions in this cloud, has led to the detection of 22 transitions of 14 molecular species, of which 16 are reported here for the first time. No unidentified lines have been detected in the present search. Mapping observations have been obtained for several of the lines and, in the case of H2CO the authors have been able to compare the present data with that obtained from other telescopes, to estimate the density and abundance in the emitting region

Public policies for the working poor: The earned income tax credit versus minimum wage legislation

This paper documents the declining relationship between low hourly wages and low household income over the last half-century and how this has reduced the share of minimum wage workers who live in poor households. It then compares recent and prospective increases in the earned income tax credit (EITC) and the minimum wage as methods of increasing the labor earnings of poor workers. Data from the Current Population Survey (CPS) are used to simulate the effects of both programs. Increases in the EITC between 1989 and 1992 delivered a much larger proportion of a given dollar of benefits to the poor than did increases in the minimum wage from $3.35 to$4.25. Scheduled increases in the EITC through 1996 will also do far more for the working poor than raising the minimum wage.

Millimetre and submillimetre molecular line observations of the reflection nebula NGC 2023

Observations in the CO J = 2 - 1, CO J = 3 - 2 and HCO+ J = 4 - 3 transitions of the molecular cloud associated with NGC 2023 are presented. The observations reveal the complex structure of the gas in the surrounding cloud, and show the presence of several hot-spots which may represent separate bodies of gas. A search has been made for the source of excitation of two nearby groups of Herbig-Haro objects recently discovered by Malin et al. (1987). No such objects can be clearly identified from the data. CO J = 3 - 2 spectra taken at positions lying on the CO J = 1 - 0 shell observed by Gatley et al. (1987) show marked enhancements in peak line strength relative to coincident CO J = 2 - 1 data. By contrast, no such enhancements are observed away from the shell. Observations of the submillimeter wavelength HCO+ J = 4 - 3 transition show that the line strength is greatest in the vicinity of the shell structure. Simple large velocity gradient modeling of the excitation conditions of the shell material suggests that the gas may be hot (Tkin ~ 140 K), dense, and optically thin

Seasonal Variability of Saturn's Tropospheric Temperatures, Winds and Para-H2_2 from Cassini Far-IR Spectroscopy

Far-IR 16-1000 $\mu$m spectra of Saturn's hydrogen-helium continuum measured by Cassini's Composite Infrared Spectrometer (CIRS) are inverted to construct a near-continuous record of upper tropospheric (70-700 mbar) temperatures and para-H$_2$ fraction as a function of latitude, pressure and time for a third of a Saturnian year (2004-2014, from northern winter to northern spring). The thermal field reveals evidence of reversing summertime asymmetries superimposed onto the belt/zone structure. The temperature structure that is almost symmetric about the equator by 2014, with seasonal lag times that increase with depth and are qualitatively consistent with radiative climate models. Localised heating of the tropospheric hazes (100-250 mbar) create a distinct perturbation to the temperature profile that shifts in magnitude and location, declining in the autumn hemisphere and growing in the spring. Changes in the para-H$_2$ ($f_p$) distribution are subtle, with a 0.02-0.03 rise over the spring hemisphere (200-500 mbar) perturbed by (i) low-$f_p$ air advected by both the springtime storm of 2010 and equatorial upwelling; and (ii) subsidence of high-$f_p$ air at northern high latitudes, responsible for a developing north-south asymmetry in $f_p$. Conversely, the shifting asymmetry in the para-H$_2$ disequilibrium primarily reflects the changing temperature structure (and the equilibrium distribution of $f_p$), rather than actual changes in $f_p$ induced by chemical conversion or transport. CIRS results interpolated to the same point in the seasonal cycle as re-analysed Voyager-1 observations show qualitative consistency, with the exception of the tropical tropopause near the equatorial zones and belts, where downward propagation of a cool temperature anomaly associated with Saturn's stratospheric oscillation could potentially perturb tropopause temperatures, para-H$_2$ and winds. [ABRIDGED]Comment: Preprint accepted for publication in Icarus, 29 pages, 18 figure

High-frequency oscillatory ventilation in pediatric acute hypoxemic respiratory failure: disease-specific morbidity survival analysis.

BackgroundMultiple ventilatory strategies for acute hypoxemic respiratory failure (AHRF) in children have been advocated, including high-frequency oscillatory ventilation (HFOV). Despite the frequent deployment of HFOV, randomized controlled trials remain elusive and currently there are no pediatric trials looking at its use. Our longitudinal study analyzed the predictive clinical outcome of HFOV in pediatric AHRF given disease-specific morbidity.MethodsA retrospective 8-year review on pediatric intensive care unit admissions with AHRF ventilated by HFOV was performed. Primary outcomes included survival, morbidity, length of stay (LOS), and factors associated with survival or mortality.ResultsA total of 102 patients underwent HFOV with a 66 % overall survival rate. Survivors had a greater LOS than nonsurvivors (p = 0.001). Mortality odds ratio (OR) for patients without bronchiolitis was 8.19 (CI = 1.02, 65.43), and without pneumonia it was 3.07 (CI = 1.12, 8.39). A lower oxygenation index (OI) after HFOV commencement and at subsequent time points analyzed predicted survival. After 24 h, mortality was associated with an OI > 35 [OR = 31.11 (CI = 3.25, 297.98)]. Sepsis-related mortality was associated with a higher baseline FiO(2) (0.88 vs. 0.65), higher OI (42 vs. 22), and augmented metabolic acidosis (pH of 7.25 vs. 7.32) evaluated 4 h on HFOV (p < 0.05).ConclusionHigh-frequency oscillatory ventilation may be safely utilized. It has a 66 % overall survival rate in pediatric AHRF of various etiologies. Patients with morbidity limited to the respiratory system and optimized oxygenation indices are most likely to survive on HFOV

Lactobacillus delbrueckii ssp. bulgaricus B-30892 can inhibit cytotoxic effects and adhesion of pathogenic Clostridium difficile to Caco-2 cells

<p>Abstract</p> <p>Background</p> <p>Probiotic microorganisms are receiving increasing interest for use in the prevention, treatment, or dietary management of certain diseases, including antibiotic-associated diarrhea (AAD). <it>Clostridium difficile </it>is the most common cause of AAD and the resulting <it>C. difficile </it>– mediated infection (CDI), is potentially deadly. <it>C. difficile </it>associated diarrhea (CDAD) is manifested by severe inflammation and colitis, mostly due to the release of two exotoxins by <it>C. difficile </it>causing destruction of epithelial cells in the intestine. The aim of this study was to determine the effect of probiotic bacteria <it>Lactobacillus delbrueckii </it>ssp. <it>bulgaricus </it>B-30892 (LDB B-30892) on <it>C. difficile</it>-mediated cytotoxicity using Caco-2 cells as a model.</p> <p>Methods</p> <p>Experiments were carried out to test if the cytotoxicity induced by <it>C. difficile-</it>conditioned-medium on Caco-2 cells can be altered by cell-free supernatant (CFS) from LDB B-30892 in different dilutions (1:2 to 1:2048). In a similar experimental setup, comparative evaluations of other probiotic strains were made by contrasting the results from these strains with the results from LDB B-30892, specifically the ability to affect <it>C. difficile </it>induced cytotoxicity on Caco-2 monolayers. Adhesion assays followed by quantitative analysis by Giemsa staining were conducted to test if the CFSs from LDB B-30892 and other probiotic test strains have the capability to alter the adhesion of <it>C. difficile </it>to the Caco-2 monolayer. Experiments were also performed to evaluate if LDB B-30892 or its released components have any bactericidal effect on <it>C. difficile</it>.</p> <p>Results and discussion</p> <p>Co-culturing of LDB B-30892 with <it>C. difficile </it>inhibited the <it>C. difficile-</it>mediated cytotoxicity on Caco-2 cells. When CFS from LDB B-30892-<it>C. difficile </it>co-culture was administered (up to a dilution of 1:16) on Caco-2 monolayer, there were no signs of cytotoxicity. When CFS from separately grown LDB B-30892 was mixed with the cell-free toxin preparation (CFT) of separately cultured <it>C. difficile</it>, the LDB B-30892 CFS was inhibitory to <it>C. difficile </it>CFT-mediated cytotoxicity at a ratio of 1:8 (LDB B-30892 CFS:<it>C. difficile </it>CFT). We failed to find any similar inhibition of <it>C. difficile-</it>mediated cytotoxicity when other probiotic organisms were tested in parallel to LDB B-30892. Our data of cytotoxicity experiments suggest that LDB B-30892 releases one or more bioactive component(s) into the CFS, which neutralizes the cytotoxicity induced by <it>C. difficile</it>, probably by inactivating its toxin(s). Our data also indicate that CFS from LDB B-30892 reduced the adhesion of <it>C. difficile </it>by 81%, which is significantly (<it>P </it><0.01) higher than all other probiotic organisms tested in this study.</p> <p>Conclusion</p> <p>This study reveals the very first findings that <it>Lactobacillus delbrueckii </it>ssp. <it>bulgaricus </it>B-30892 (LDB B-30892) can eliminate <it>C. difficile</it>-mediated cytotoxicity, using Caco-2 cells as a model. The study also demonstrates that LDB B-30892 can reduce the colonization of <it>C. difficile </it>cells in colorectal cells. More study is warranted to elucidate the specific mechanism of action of such reduction of cytotoxicity and colonization.</p

CO J = 4 - 3 observations of molecular clouds

A survey of the CO J= 4-3 transition has been made towards a sample of seven galactic molecular clouds. These data have been combined with spectra for the lower CO transitions to examine how they vary in line shape with different transition. Such variations are examined using LVG modelling techniques to obtain estimates of the physical state of the emitting gas. The authors discuss the implications and importance that observations of these submillimetre wavelength transitions have in refining knowledge of the gas in molecular clouds