12,124 research outputs found
Chord Label Personalization through Deep Learning of Integrated Harmonic Interval-based Representations
The increasing accuracy of automatic chord estimation systems, the
availability of vast amounts of heterogeneous reference annotations, and
insights from annotator subjectivity research make chord label personalization
increasingly important. Nevertheless, automatic chord estimation systems are
historically exclusively trained and evaluated on a single reference
annotation. We introduce a first approach to automatic chord label
personalization by modeling subjectivity through deep learning of a harmonic
interval-based chord label representation. After integrating these
representations from multiple annotators, we can accurately personalize chord
labels for individual annotators from a single model and the annotators' chord
label vocabulary. Furthermore, we show that chord personalization using
multiple reference annotations outperforms using a single reference annotation.Comment: Proceedings of the First International Conference on Deep Learning
and Music, Anchorage, US, May, 2017 (arXiv:1706.08675v1 [cs.NE]
Depolarisation cooling of an atomic cloud
We propose a cooling scheme based on depolarisation of a polarised cloud of
trapped atoms. Similar to adiabatic demagnetisation, we suggest to use the
coupling between the internal spin reservoir of the cloud and the external
kinetic reservoir via dipolar relaxation to reduce the temperature of the
cloud. By optical pumping one can cool the spin reservoir and force the cooling
process. In case of a trapped gas of dipolar chromium atoms, we show that this
cooling technique can be performed continuously and used to approach the
critical phase space density for BECComment: 8 pages, 5 figure
Interplay of size and Landau quantizations in the de Haas-van Alphen oscillations of metallic nanowires
We examine the interplay between size quantization and Landau quantization in
the De Haas-Van Alphen oscillations of clean, metallic nanowires in a
longitudinal magnetic field for `hard' boundary conditions, i.e. those of an
infinite round well, as opposed to the `soft' parabolically confined boundary
conditions previously treated in Alexandrov and Kabanov (Phys. Rev. Lett. {\bf
95}, 076601 (2005) (AK)). We find that there exist {\em two} fundamental
frequencies as opposed to the one found in bulk systems and the three
frequencies found by AK with soft boundary counditions. In addition, we find
that the additional `magic resonances' of AK may be also observed in the
infinite well case, though they are now damped. We also compare the numerically
generated energy spectrum of the infinite well potential with that of our
analytic approximation, and compare calculations of the oscillatory portions of
the thermodynamic quantities for both models.Comment: Title changed, paper streamlined on suggestion of referrees, typos
corrected, numerical error in figs 2 and 3 corrected and final result
simplified -- two not three frequencies (as in the previous version) are
observed. Abstract altered accordingly. Submitted to Physical Review
A new twist to an old story: HE 0450-2958, and the ULIRG(optically bright QSO) transition hypothesis
We report on interferometric imaging of the CO J=1--0 and J=3--2 line
emission from the controversial QSO/galaxy pair HE 0450--2958. {\it The
detected CO J=1--0 line emission is found associated with the disturbed
companion galaxy not the luminous QSO,} and implies , which is \ga 30% of the dynamical mass in
its CO-luminous region. Fueled by this large gas reservoir this galaxy is the
site of an intense starburst with , placing
it firmly on the upper gas-rich/star-forming end of Ultra Luminous Infrared
Galaxies (ULIRGs, ). This makes HE 0450--2958 the
first case of extreme starburst and powerful QSO activity, intimately linked
(triggered by a strong interaction) but not coincident. The lack of CO emission
towards the QSO itself renews the controversy regarding its host galaxy by
making a gas-rich spiral (the typical host of Narrow Line Seyfert~1 AGNs) less
likely. Finally, given that HE 0450--2958 and similar IR-warm QSOs are
considered typical ULIRG(optically bright QSO) transition candidates, our
results raise the possibility that some may simply be {\it gas-rich/gas-poor
(e.g. spiral/elliptical) galaxy interactions} which ``activate'' an optically
bright unobscured QSO in the gas-poor galaxy, and a starburst in the gas-rich
one. We argue that such interactions may have gone largely unnoticed even in
the local Universe because the combination of tools necessary to disentagle the
progenitors (high resolution and S/N optical {\it and} CO imaging) became
available only recently.Comment: 25 pages, 5 figures, accepted for publication by The Astrophysical
Journa
Chiral density waves in quark matter within the Nambu--Jona-Lasinio model in an external magnetic field
A possibility of formation of static dual scalar and pseudoscalar density
wave condensates in dense quark matter is considered for the
Nambu--Jona-Lasinio model in an external magnetic field. Within a mean-field
approximation, the effective potential of the theory is obtained and its minima
are numerically studied; a phase diagram of the system is constructed. It is
shown that the presence of a magnetic field favors the formation of spatially
inhomogeneous condensate configurations at low temperatures and arbitrary
non-zero values of the chemical potential.Comment: 13 pages, 4 figure
A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds
Complement factor C5a is one of the most powerful pro-inflammatory agents involved in recruitment of leukocytes, activation of phagocytes and other inflammatory responses. C5a triggers inflammatory responses by binding to its G-protein-coupled C5a-receptor (C5aR). Excessive or erroneous activation of the C5aR has been implicated in numerous inflammatory diseases. The C5aR is therefore a key target in the development of specific anti-inflammatory compounds. A very potent natural inhibitor of the C5aR is the 121-residue chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS). Although CHIPS effectively blocks C5aR activation by binding tightly to its extra-cellular N terminus, it is not suitable as a potential anti-inflammatory drug due to its immunogenic properties. As a first step in the development of an improved CHIPS mimic, we designed and synthesized a substantially shorter 50-residue adapted peptide, designated CHOPS. This peptide included all residues important for receptor binding as based on the recent structure of CHIPS in complex with the C5aR N terminus. Using isothermal titration calorimetry we demonstrate that CHOPS has micromolar affinity for a model peptide comprising residues 7–28 of the C5aR N terminus including two O-sulfated tyrosine residues at positions 11 and 14. CD and NMR spectroscopy showed that CHOPS is unstructured free in solution. Upon addition of the doubly sulfated model peptide, however, the NMR and CD spectra reveal the formation of structural elements in CHOPS reminiscent of native CHIPS
The diagnostic accuracy of CT and MRI for the detection of lymph node metastases in gallbladder cancer:A systematic review and meta-analysis
BACKGROUND: Lymph node metastases (LNM) are an ominous prognostic factor in gallbladder cancer (GBC) and, when present, should preclude surgery. However, uncertainty remains regarding the optimal imaging modality for pre-operative detection of LNM and international guidelines vary in their recommendations. The purpose of this study was to systematically review the diagnostic accuracy of computed tomography (CT) versus magnetic resonance imaging (MRI) in the detection of LNM of GBC. METHODS: A literature search of studies published until November 2017 concerning the diagnostic accuracy of CT or MRI regarding the detection of LNM in GBC was performed. Data extraction and risk of bias assessment was performed independently by two reviewers. The sensitivity of CT and MRI in the detection of LNM was reviewed. Additionally, estimated summary sensitivity, specificity and diagnostic accuracy of MRI were calculated in a patient based meta-analysis. RESULTS: Nine studies including 292 patients were included for narrative synthesis and 5 studies including 158 patients were selected for meta-analysis. Sensitivity of CT ranged from 0.25 to 0.93. Estimated summary diagnostic accuracy parameters of MRI were as follows: sensitivity 0.75 (95% CI 0.6 - 0.85), specificity 0.83 (95% CI 0.74 - 0.90), LR + 4.52 (95% CI 2.55-6.48) and LR- 0.3 (95% CI 0.15 - 0.45). Small (<10 mm) LNM were most frequently undetected on pre-operative imaging. Due to a lack of data, no subgroup analysis comparing the diagnostic accuracy of CT versus MRI could be performed. CONCLUSION: The value of current imaging strategies for the pre-operative assessment of nodal status in GBC remains unclear, especially regarding the detection of small LNM. Additional research is warranted in order to establish uniformity in international guidelines, improve pre-operative nodal staging and to prevent futile surgery
Doppler Ultrasound of Vascular Complications After Pediatric Liver Transplantation:Incidence, Time of Detection, and Positive Predictive Value
Purpose Doppler ultrasound (DUS) is widely used to detect vascular complications after pediatric liver transplantation (LT). This study aimed to assess the moment of first detection of vascular complications with DUS, and to determine the positive predictive value (PPV) of DUS. Materials and Methods Patients aged 0–18 years who underwent LT between 2015 and 2019 were retrospectively included. 92 LTs in 83 patients were included (median age: 3.9 years, interquartile range: 0.7–10.5). Patients underwent perioperative (intra-operative and immediately postoperative) and daily DUS surveillance during the first postoperative week, and at 1, 3, and 12 months. Vascular complications were categorized for the hepatic artery, portal vein, and hepatic veins. DUS findings were compared to surgical or radiological findings during the 1-year follow-up. Results 52 vascular complications were diagnosed by DUS in 35/92 LTs (38%). 15 out of 52 (28.8%) were diagnosed perioperatively, 29/52 (55.8%) were diagnosed on postoperative days 1–7, and 8/52 (15.4%) after day 7. The PPV for all vascular complications diagnosed with DUS was 92.3%. During the 1-year follow-up, 18/19 (94.7%) hepatic artery complications, 19/26 (73.1%) portal vein complications, and 7/7 (100%) hepatic vein complications were diagnosed perioperatively or during the first week. Conclusion The majority of vascular complications during the first year after pediatric LT were diagnosed by DUS perioperatively or during the first week, with a high PPV. Our findings provide important information regarding when to expect different types of vascular complications on DUS, which might improve DUS post-LT surveillance protocols
Diagnostic performance of preoperative CT in differentiating between benign and malignant origin of suspicious gallbladder lesions
Purpose: To determine diagnostic performance of preoperative CT in differentiating between benign and malignant suspicious gallbladder lesions and to develop a preoperative risk score. Method: All patients referred between January 2007 and September 2018 for suspicion of gallbladder cancer (GBC) or incidentally found GBC were retrospectively analyzed. Patients were excluded when preoperative CT or histopathologic examination was lacking. Two radiologists, blinded to histopathology results, independently reviewed CT images to differentiate benign disease from GBC. Multivariable analysis and internal validation were used to develop a risk score for GBC. Model discrimination, calibration, and diagnostic performance were assessed. Results: In total, 118 patients with 39 malignant (33 %) and 79 benign (67 %) lesions were included. Sensitivity of CT for diagnosing GBC was 90 % (95 % confidence interval [CI]: 76?97). Specificity rates were 61 % (95 % CI: 49?72) and 59 % (95 % CI: 48?70). Three predictors of GBC (irregular lesion aspect, absence of fat stranding, and locoregional lymphadenopathy) were included in the risk score ranging from -1 to 4. Adequate performance was found (AUC: 0.79, calibration slope: 0.89). In patients allocated >0 points, the model showed higher performance in excluding GBC than the radiologists (sensitivity 92 % [95 % CI: 79?98]). Moreover, when allocated >3 points, the risk score was superior in diagnosing GBC (specificity 99 % [95 % CI: 93?100]). Conclusions: Sensitivity rates of CT for differentiation between benign and malignant gallbladder lesions are high, however specificity rates are relatively low. The proposed risk score may facilitate differentiation between benign and malignant suspicious gallbladder lesions
Post-treatment three-dimensional voxel-based dosimetry after Yttrium-90 resin microsphere radioembolization in HCC
BACKGROUND: Post-therapy [(90)Y] PET/CT-based dosimetry is currently recommended to validate treatment planning as [(99m)Tc] MAA SPECT/CT is often a poor predictor of subsequent actual [(90)Y] absorbed dose. Treatment planning software became available allowing 3D voxel dosimetry offering tumour-absorbed dose distributions and dose-volume histograms (DVH). We aim to assess dose–response effects in post-therapy [(90)Y] PET/CT dosimetry in SIRT-treated HCC patients for predicting overall and progression-free survival (OS and PFS) and four-month follow-up tumour response (mRECIST). Tumour-absorbed dose and mean percentage of the tumour volume (V) receiving ≥ 100, 150, 200, or 250 Gy and mean minimum absorbed dose (D) delivered to 30%, 50%, 70%, and 90% of tumour volume were calculated from DVH’s. Depending on the mean tumour -absorbed dose, treated lesions were assigned to a < 120 Gy or ≥ 120 Gy group. RESULTS: Thirty patients received 36 SIRT treatments, totalling 43 lesions. Median tumour-absorbed dose was significantly different between the ≥ 120 Gy (n = 28, 207 Gy, IQR 154–311 Gy) and < 120 Gy group (n = 15, 62 Gy, IQR 49–97 Gy, p <0 .01). Disease control (DC) was found more frequently in the ≥ 120 Gy group (79%) compared to < 120 Gy (53%). Mean tumour-absorbed dose optimal cut-off predicting DC was 131 Gy. Tumour control probability was 54% (95% CI 52–54%) for a mean tumour-absorbed dose of 120 Gy and 90% (95% CI 87–92%) for 284 Gy. Only D30 was significantly different between DC and progressive disease (p = 0.04). For the ≥ 120 Gy group, median OS and PFS were longer (median OS 33 months, [range 8–33 months] and median PFS 23 months [range 4–33 months]) than the < 120 Gy group (median OS 17 months, [range 5–33 months] and median PFS 13 months [range 1–33 months]) (p < 0.01 and p = 0.03, respectively). CONCLUSIONS: Higher 3D voxel-based tumour-absorbed dose in patients with HCC is associated with four-month DC and longer OS and PFS. DVHs in [(90)Y] SIRT could play a role in evaluative dosimetry
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