Mid-crustal shear zone development under retrograde conditions: pressure–temperature–fluid constraints from the Kuckaus Mylonite Zone, Namibia

The Kuckaus Mylonite Zone (KMZ) forms part of the larger Marshall Rocks–Pofadder shear zone system, a 550 km-long, crustal-scale strike-slip shear zone system that is localized in high-grade granitoid gneisses and migmatites of the Namaqua Metamorphic Complex. Shearing along the KMZ occurred ca. 40 Ma after peak granulite-facies metamorphism during a discrete tectonic event and affected the granulites that had remained at depth since peak metamorphism. Isolated lenses of metamafic rocks within the shear zone allow the P–T–fluid conditions under which shearing occurred to be quantified. These lenses consist of an unsheared core that preserves relict granulite-facies textures and is mantled by a schistose collar and mylonitic envelope that formed during shearing. All three metamafic textural varieties contain the same amphibolite-facies mineral assemblage, from which calculated pseudosections constrain the P–T conditions of deformation at 2.7–4.2 kbar and 450–480 °C, indicating that deformation occurred at mid-crustal depths through predominantly viscous flow. Calculated T–MH2O diagrams show that the mineral assemblages were fluid saturated and that lithologies within the KMZ must have been rehydrated from an external source and retrogressed during shearing. Given that the KMZ is localized in strongly dehydrated granulites, the fluid must have been derived from an external source, with fluid flow allowed by local dilation and increased permeability within the shear zone. The absence of pervasive hydrothermal fractures or precipitates indicates that, even though the KMZ was fluid bearing, the fluid/rock ratio and fluid pressure remained low. In addition, the fluid could not have contributed to shear zone initiation, as an existing zone of enhanced permeability is required for fluid infiltration. We propose that, following initiation, fluid infiltration caused a positive feedback that allowed weakening and continued strain localization. Therefore, the main contribution of the fluid was to produce retrograde mineral phases and facilitate grain-size reduction. Features such as tectonic tremor, which are observed on active faults under similar conditions as described here, may not require high fluid pressure, but could be explained by reaction weakening under hydrostatic fluid pressure conditions

Mid-crustal shear zone development under retrograde conditions: pressure–temperature–fluid constraints from the Kuckaus Mylonite Zone, Namibia

The Kuckaus Mylonite Zone (KMZ) forms part of the larger Marshall Rocks–Pofadder shear zone system, a 550 km-long, crustal-scale strike-slip shear zone system that is localized in high-grade granitoid gneisses and migmatites of the Namaqua Metamorphic Complex. Shearing along the KMZ occurred ca. 40 Ma after peak granulite-facies metamorphism during a discrete tectonic event and affected the granulites that had remained at depth since peak metamorphism. Isolated lenses of metamafic rocks within the shear zone allow the P–T–fluid conditions under which shearing occurred to be quantified. These lenses consist of an unsheared core that preserves relict granulite-facies textures and is mantled by a schistose collar and mylonitic envelope that formed during shearing. All three metamafic textural varieties contain the same amphibolite-facies mineral assemblage, from which calculated pseudosections constrain the P–T conditions of deformation at 2.7–4.2 kbar and 450–480 °C, indicating that deformation occurred at mid-crustal depths through predominantly viscous flow. Calculated T–MH2O diagrams show that the mineral assemblages were fluid saturated and that lithologies within the KMZ must have been rehydrated from an external source and retrogressed during shearing. Given that the KMZ is localized in strongly dehydrated granulites, the fluid must have been derived from an external source, with fluid flow allowed by local dilation and increased permeability within the shear zone. The absence of pervasive hydrothermal fractures or precipitates indicates that, even though the KMZ was fluid bearing, the fluid/rock ratio and fluid pressure remained low. In addition, the fluid could not have contributed to shear zone initiation, as an existing zone of enhanced permeability is required for fluid infiltration. We propose that, following initiation, fluid infiltration caused a positive feedback that allowed weakening and continued strain localization. Therefore, the main contribution of the fluid was to produce retrograde mineral phases and facilitate grain-size reduction. Features such as tectonic tremor, which are observed on active faults under similar conditions as described here, may not require high fluid pressure, but could be explained by reaction weakening under hydrostatic fluid pressure conditions

Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk

Objectives: Our aim was to study the effect of combination therapy with aspirin and dipyridamole (A+D) over aspirin alone (ASA) in secondary prevention after transient ischemic attack or minor stroke of presumed arterial origin and to perform subgroup analyses to identify patients that might benefit most from secondary prevention with A+D. Data sources: The previously published meta-analysis of individual patient data was updated with data from ESPRIT (N=2,739); trials without data on the comparison of A+D versus ASA were excluded. Review methods: A meta-analysis was performed using Cox regression, including several subgroup analyses and following baseline risk stratification. Results: A total of 7,612 patients (5 trials) were included in the analyses, 3,800 allocated to A+D and 3,812 to ASA alone. The trial-adjusted hazard ratio for the composite event of vascular death, non-fatal myocardial infarction and non-fatal stroke was 0.82 (95% confidence interval 0.72-0.92). Hazard ratios did not differ in subgroup analyses based on age, sex, qualifying event, hypertension, diabetes, previous stroke, ischemic heart disease, aspirin dose, type of vessel disease and dipyridamole formulation, nor across baseline risk strata as assessed with two different risk scores. A+D were also more effective than ASA alone in preventing recurrent stroke, HR 0.78 (95% CI 0.68 – 0.90). Conclusion: The combination of aspirin and dipyridamole is more effective than aspirin alone in patients with TIA or ischemic stroke of presumed arterial origin in the secondary prevention of stroke and other vascular events. This superiority was found in all subgroups and was independent of baseline risk. ---------------------------7dc3521430776 Content-Disposition: form-data; name="c14_creators_1_name_family" Halke

Electroweak higher-order effects and theoretical uncertainties in deep-inelastic neutrino scattering

A previous calculation of electroweak O(alpha) corrections to deep-inelastic neutrino scattering, as e.g. measured by NuTeV and NOMAD, is supplemented by higher-order effects. In detail, we take into account universal two-loop effects from \Delta\alpha and \Delta\rho as well as higher-order final-state photon radiation off muons in the structure function approach. Moreover, we make use of the recently released O(alpha)-improved parton distributions MRST2004QED and identify the relevant QED factorization scheme, which is DIS like. As a technical byproduct, we describe slicing and subtraction techniques for an efficient calculation of a new type of real corrections that are induced by the generated photon distribution. A numerical discussion of the higher-order effects suggests that the remaining theoretical uncertainty from unknown electroweak corrections is dominated by non-universal two-loop effects and is of the order 0.0003 when translated into a shift in sin^2\theta_W=1-MW^2/MZ^2. The O(alpha) corrections implicitly included in the parton distributions lead to a shift of about 0.0004.Comment: 25 pages, latex, 8 postscript figure

Sources and effects of fluids in continental retrograde shear zones: Insights from the Kuckaus Mylonite Zone, Namibia

Midcrustal rocks in retrograde metamorphic settings are typically H2O-undersaturated and fluid-absent and have low permeability. Exhumed continental retrograde faults, nonetheless, show evidence for the operation of fluid-mediated weakening mechanisms during deformation at midcrustal conditions. To explore the origin and effects of fluids in retrograde faults, we study the Kuckaus Mylonite Zone (KMZ), an exhumed crustal-scale, strike-slip shear zone in the southern Namibian Namaqua Metamorphic Complex. The KMZ deformed quartzofeldspathic migmatised gneisses at midcrustal retrograde conditions (450-480°C, 270-420 MPa) in the Mesoproterozoic, 40 Ma after granulite facies peak metamorphism at 825°C and 550 MPa. The mylonites contain fully hydrated retrograde mineral assemblages, predominantly adjacent to anastomosing high-strain zones, providing evidence of local H2O saturation and fluid presence during deformation. Whole rock and quartz vein δ18O values suggest that at least some of the fluids were meteoric in origin. The rocks across the shear zone retain the effect of different protoliths, implying little effect of fluid-rock interaction on whole rock major element chemistry. Together with a general scarcity of quartz veins, this suggests that fluid/rock ratios remained low in the KMZ. However, even small amounts of H2O allowed reaction weakening and diffusion-precipitation, followed by growth and alignment of phyllosilicates. In the ultramylonites, a fine grain size in the presence of fluids allowed for grain size sensitive creep. We conclude that the influx of even small volumes of fluids into retrograde shear zones can induce drastic weakening by facilitating grain size sensitive creep and retrograde reactions. In retrograde settings, these reactions consume fluids, and therefore elevated fluid pressures will only be possible after considerable weakening has already occurred. Our findings imply that the range of seismic styles recently documented at active retrograde transform faults may not require high fluid pressures but could also arise from other local weakening mechanisms

Computation of saddle type slow manifolds using iterative methods

This paper presents an alternative approach for the computation of trajectory segments on slow manifolds of saddle type. This approach is based on iterative methods rather than collocation-type methods. Compared to collocation methods, that require mesh refinements to ensure uniform convergence with respect to $\epsilon$, appropriate estimates are directly attainable using the method of this paper. The method is applied to several examples including: A model for a pair of neurons coupled by reciprocal inhibition with two slow and two fast variables and to the computation of homoclinic connections in the FitzHugh-Nagumo system.Comment: To appear in SIAM Journal of Applied Dynamical System

Oral anticoagulant use in cardiovascular disorders: a perspective on present and potential indications for rivaroxaban.

BACKGROUND: Four nonvitamin K antagonist oral anticoagulants (NOACs) have been approved for use in various cardiovascular indications. The direct thrombin inhibitor dabigatran and the direct factor Xa inhibitors apixaban, edoxaban, and rivaroxaban are now increasingly used in clinical practice. For some of these agents, available data from real-world studies support the efficacy and safety data in phase III clinical trials. OBJECTIVES: This review aims to summarize the current status of trials and observational studies of oral anticoagulant use over the spectrum of cardiovascular disorders (excluding venous thrombosis), provide a reference source beyond stroke prevention for atrial fibrillation (AF) and examine the potential for novel applications in the cardiovascular field. METHODS: We searched the recent literature for data on completed and upcoming trials of oral anticoagulants with a particular focus on rivaroxaban. RESULTS: Recent data in specific patient subgroups, such as patients with AF undergoing catheter ablation or cardioversion, have led to an extended approval for rivaroxaban, whereas the other NOACs have ongoing or recently completed trials in this setting. However, there are unmet medical needs for several arterial thromboembolic-related conditions, including patients with: AF and acute coronary syndrome, AF and coronary artery disease undergoing elective percutaneous coronary intervention, coronary artery disease and peripheral artery disease, implanted cardiac devices, and embolic stroke of unknown source. CONCLUSION: NOACs may provide alternative treatment options in areas of unmet need, and numerous studies are underway to assess their benefit-risk profiles in these settings

A new model of a tidally disrupted star

A new semi-analytical model of a star evolving in a tidal field is proposed. The model is a generalization of the so-called 'affine' stellar model. In our model the star is composed of elliptical shells with different parameters and different orientations, depending on time and on the radial Lagrangian coordinate of the shell. The evolution equations of this model are derived from the virial relations under certain assumptions, and the integrals of motion are identified. It is shown that the evolution equations can be deduced from a variational principle. The evolution equations are solved numerically and compared quantitatively with the results of 3D numerical computations of the tidal interaction of a star with a supermassive black hole. The comparison shows very good agreement between the main ``integral'' characteristics describing the tidal interaction event in our model and in the 3D computations. Our model is effectively a one-dimensional Lagrangian model from the point of view of numerical computations, and therefore it can be evolved numerically $10^{2}-10^{3}$ times faster than the 3D approach allows. This makes our model well suited for intensive calculations covering the whole parameter space of the problem.Comment: This version is accepted for publication in ApJ. Stylistic and grammatical changes, new Appendix adde

The promotion of local wellbeing: A primer for policymakers

There is growing interest among policymakers in the promotion of wellbeing as an objective of public policy. In particular, local authorities have been given powers to undertake action to promote wellbeing in their area. Recent advances in the academic literature on wellbeing are giving rise to an increasingly detailed picture of the factors that determine people’s subjective wellbeing (how they think and feel about their lives). However, the concept of subjective wellbeing is poorly understood within local government and much of the evidence base is extremely recent. I therefore review the literature on the definition, measurement, and determinants of wellbeing, and discuss some of its implications for local public policy

Top-transmon: hybrid superconducting qubit for parity-protected quantum computation

Qubits constructed from uncoupled Majorana fermions are protected from decoherence, but to perform a quantum computation this topological protection needs to be broken. Parity-protected quantum computation breaks the protection in a minimally invasive way, by coupling directly to the fermion parity of the system --- irrespective of any quasiparticle excitations. Here we propose to use a superconducting charge qubit in a transmission line resonator (a socalled transmon) to perform parity-protected rotations and read-out of a topological (top) qubit. The advantage over an earlier proposal using a flux qubit is that the coupling can be switched on and off with exponential accuracy, promising a reduced sensitivity to charge noise.Comment: 7 pages, 5 figure