437 research outputs found
Biofilm inhibition of Inula viscosa (L.) Aiton and Globularia alypum L. extracts against Candida infectious pathogens and In vivo action on galleria mellonella model
The increasing importance of fungal infections has fueled the search for new beneficial alternatives substance from plant extracts. The current study investigates the antifungal and antibiofilm activity of Inula viscosa (L.) Aiton and Globularia alypum (L.) leaves extracts against Candida both in vitro and in vivo. The inhibition of planktonic and sessile Candida albicans and Candida glabrata growth using both leaf extracts are evaluated. Moreover; an in vivo infection model using Galleria mellonella larvae; infected and treated with the extracts are performed. All extracts show fungicidal activity; with a minimum fungicidal concentration (MFC) ranging from 128 to 512 mu g mL(-1) against the two selected strains of Candida. In particular, the best results are obtained with methanolic extract ofI. viscosa and G. alypum with an MFC value of 128 mu g mL(-1). The extracts are capable to prevent 90% of biofilm development at minor concentrations ranging from 100.71 +/- 2.49 mu g mL(-1) to 380.4 +/- 0.92 mu g mL(-1). In vivo, tests on Galleria mellonella larvae show that the extracts increase the survival of the larvae infected with Candida. The attained results reveal that I. viscosa and G. alypum extracts may be considered as new antifungal agents and biofilm inhibiting agents for the pharmaceutical and agro-food field
Prostaglandin D2 enhances interleukin -1beta- induced cyclooxygenase-2 expression in osteoarthritic cartilage
LSD1-mediated demethylation of histone h3 lysine 9 contributes to interleukin 1-induced microsomal prostaglandin e synthase-1 expression in human osteoarthritic chondrocytes
Special biconformal changes of K\"ahler surface metrics
The term "special biconformal change" refers, basically, to the situation
where a given nontrivial real-holomorphic vector field on a complex manifold is
a gradient relative to two K\"ahler metrics, and, simultaneously, an
eigenvector of one of the metrics treated, with the aid of the other, as an
endomorphism of the tangent bundle. A special biconformal change is called
nontrivial if the two metrics are not each other's constant multiples. For
instance, according to a 1995 result of LeBrun, a nontrivial special
biconformal change exists for the conformally-Einstein K\"ahler metric on the
two-point blow-up of the complex projective plane, recently discovered by Chen,
LeBrun and Weber; the real-holomorphic vector field involved is the gradient of
its scalar curvature. The present paper establishes the existence of nontrivial
special biconformal changes for some canonical metrics on Del Pezzo surfaces,
viz. K\"ahler-Einstein metrics (when a nontrivial holomorphic vector field
exists), non-Einstein K\"ahler-Ricci solitons, and K\"ahler metrics admitting
nonconstant Killing potentials with geodesic gradients.Comment: 16 page
Relationship between spine osteoarthritis, bone mineral density and bone turn over markers in post menopausal women
Search based software engineering: Trends, techniques and applications
© ACM, 2012. This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution. The definitive version is available from the link below.In the past five years there has been a dramatic increase in work on Search-Based Software Engineering (SBSE), an approach to Software Engineering (SE) in which Search-Based Optimization (SBO) algorithms are used to address problems in SE. SBSE has been applied to problems throughout the SE lifecycle, from requirements and project planning to maintenance and reengineering. The approach is attractive because it offers a suite of adaptive automated and semiautomated solutions in situations typified by large complex problem spaces with multiple competing and conflicting objectives.
This article provides a review and classification of literature on SBSE. The work identifies research trends and relationships between the techniques applied and the applications to which they have been applied and highlights gaps in the literature and avenues for further research.EPSRC and E
Accelerated expansion from structure formation
We discuss the physics of backreaction-driven accelerated expansion. Using
the exact equations for the behaviour of averages in dust universes, we explain
how large-scale smoothness does not imply that the effect of inhomogeneity and
anisotropy on the expansion rate is small. We demonstrate with an analytical
toy model how gravitational collapse can lead to acceleration. We find that the
conjecture of the accelerated expansion being due to structure formation is in
agreement with the general observational picture of structures in the universe,
and more quantitative work is needed to make a detailed comparison.Comment: 44 pages, 1 figure. Expanded treatment of topics from the Gravity
Research Foundation contest essay astro-ph/0605632. v2: Added references,
clarified wordings. v3: Published version. Minor changes and corrections,
added a referenc
- …