Mathematical Modelling of Compressive Strength of Recycled Ceramic Tile Aggregate Concrete Using Modified Regression Theory

At present, the large quantity of wastes generated by the ceramic industry is not reused in any significant quantity. Research has shown the feasibility of incorporating these wastes into concrete production. This will benefit both the ceramic and concrete industries. However, not much research data is available on the use of ceramic wastes as fine aggregate material compared to their use as coarse aggregate material. Moreover, there are presently no models for predicting the properties of ceramic waste aggregate concretes. In this study, a modified regression theory based on Taylor’s series was adopted to formulate mathematical model for predicting compressive strength of concrete into which Recycled Ceramic Tile (RCT) is incorporated as fine aggregate.  Preliminary tests on RCT indicate that it is a suitable fine aggregate material for concrete production. It has also been established that addition of RCT improves compressive strength of concrete and reduces concrete’s workability. The formulated model is a function of the mix proportions of its constituents and its predicted responses are in good agreement with experimentally observed data. The model has been tested using student’s t-test and analysis of variance and has been confirmed to be adequate and hence is validated

Prevalence of Cardiovascular Risk Factors in the Middle-Aged and Elderly Population of a Nigerian Rural Community

Cardiovascular diseases (CVDs) causes of worldwide preventable morbidity and mortality. CVDs are a leading cause of mortality and morbidity in developing countries, and rates are expected to rise over the next few decades. The prevalence of CVD risk factors is dramatically increasing in low-and middle-income African countries, particularly in urban areas. We carried out a cross-sectional population-based survey in Imezi-Owa, a rural community in South East Nigeria to estimate the prevalence of major cardiovascular risk factors in both men and women aged 40–70 years. A total of 858 individuals made up of 247 (28.8%) males and 611 (71.2%) females were recruited. The mean age of the subjects was 59.8 ± 9.9 years. The prevalence of the different cardiovascular risk factors among the 858 subjects was as follows: hypertension 398 (46.4%) subjects, generalized obesity as determined by BMI 257 (30%) subjects, abdominal obesity 266 (31%) subjects, dysglycaemia 38 (4.4%) subjects and hypercholesterolaemia 32 (3.7%) subjects. Prevalence of hypertension and dysglycaemia was higher in men while the others were higher in women. Only hypertension (P = .117) and hypercholesterolaemia (P = .183) did not reveal any significant association with gender. Prevalence of CVD risk factors was highest in subjects aged 65 to 70 years

International Best Practice: Understanding the Core Difference between Medical Laboratory Science and Clinical Laboratory Medicine in Nigeria

Introduction: International best practice (IBP) in the healthcare sector is an approach that is put in place globally, acceptable  standards to ensure patients’ safety while providing quality healthcare to the community. It achieves such standards by defining the job roles of various professionals in the healthcare sector. In the Nigerian healthcare sector, despite the clear definition of the job roles of the medical laboratory scientist and clinical laboratory physicians (pathologist) by the various Acts of Law of the Federal Republic of Nigeria that established these two professions, there seems to be a misapprehension of the differences between these two  professions. This study aimed to evaluate the knowledge of the health workers as it concerns the IBP on the scope of practice of medical laboratory science (MLS) and clinical laboratory medicine in Nigeria. Materials and Methods: Across-sectional, observational design was used for this prospective study involving 427 health workers from the six geopolitical zones in Nigerian and Abuja, using a proportionate sampling technique. It was facility‑based research usinga validated semi-structured self-administered questionnaire. Results: Over 50% of the participants believed that MLS was the same as clinical laboratory medicine. Two hundred and ten  participants (49.2%) did not know that analyses of samples in a clinical laboratory was the job responsibility of a laboratory physician. Conclusion: There was knowledge gap in the practices of both the MLS and the clinical laboratory medicine by health workers. Therefore, there is a need to create awareness through interprofessional education, workshops, and seminars to ensure understanding of job roles as this may promote harmony between these two professions in the health sector. Keywords: Clinical laboratory medicine, international best practice, medical laboratory scienc

Pattern of Blood Pressure Indices among the Residents of a Rural Community in South East Nigeria

Cardiovascular diseases (CVDs) are the main causes of death in industrialized countries, and are significant causes of morbidity and mortality in sub-Saharan Africa. Hypertension is the most common cardiovascular disease in Nigerians, and the risk of CVD associated with hypertension is independent of other risk factors. Despite the high level of awareness of its presence in the developed countries, the level of control is still poor. CVDs tend to be commoner in urban settlements, and it has been hypothesized that rural sub-Saharan Africa is at an early stage of epidemiological transition from communicable to non-communicable diseases (NCD) because of the gradual adoption of unhealthy lifestyles. This study aimed at describing the pattern of blood pressure indices among the hypertensive residents of a rural community in South East Nigeria. A total of 858 individuals comprising 247 males and 611 females took part in the study. 46.4% of the subjects had hypertension. Hypertension was commoner in the males (50.2% vs. 44.8%) (χ2(1) = 1.484; P = 0.223). The males were significantly older and heavier than the females while the females had higher mean values of BMI and WC. The prevalence of hypertension is becoming alarmingly high in the rural communities of sub-Saharan Africa

Heavy metals pollution potentials in the National Iron Ore Mining Company, Itakpe

Heavy metals pollution potential in National Iron Ore Mining Company, Itakpe was investigated. Two mining sites located at the east mining pits such as M3O, which is 370 m above sea level and M2O, which is 350 m above sea level were studied.  Sequential extraction techniques was utilised to examine the distribution effect of the heavy metals pollution potential on the environment. Twelve representative (six-soil, two-sediment, two-plant and two-water) samples were collected, pre-treated and prepared for this study. The atomic absorption spectrometer was used to analyse the concentration of the metals after the sequential and single-stage extractions were determined. Results showed that Chromium, Arsenic, Cadmium and Copper are more bioavailable in the study area than Lead and Iron. This findings indicate that human, animals and plants are exposed to toxic elements (metals and metalloids)

Spheroidal graphite iron production of furnace roof hangers

The wire rod mill of the Ajaokuta Steel Company Limited produces coils, wire rods and re-bars of different sizes. Without the furnace hangers, it will be difficult for the mill to continue to operate. This paper describes the production of furnace roof hangers that are required for re-heating furnace using the spheroidal graphite iron (SGI), highlighting the sand-casting process, charge calculation, and the chemical compositions. The facilities within the foundry shop of the steel company are used to produce furnace roof hangers. The available materials used for the casting of the hangers are the pig iron, scrap ends, foundry returns and magnesium. The process of production was performed through the reheating furnace for the heating of 120 m x 120 m x 120 m billets. One ton induction furnace of low frequency was used as the melting vessel. Also, 6 kg of magnesium was introduced in the ladle before the liquid metal was teemed into it. A Spectro analytical instrument was used to determine the chemical compositions of the materials before and after the casting processes. The analysis of the chemical compositions of produced sample of SGI are presented and discussed

Safety of the surgeon: ‘Double-gloving’ during surgical procedures

Background. In the face of increasing HIV/AIDS prevalence in subSaharan Africa, we evaluate the effectiveness of ‘double-gloving’ during surgery as a means of protecting the surgeon operating on patients with a known or unknown HIV status.Methods. A prospective study was conducted to determine the rate of glove puncture and intraoperative injury in categories of patients with known positive, known negative or unknown HIV status.Results. The surgeon and the first assistant double-gloved in all the 1 050 procedures performed between 2009 and 2013, and a total of 8 400 surgical gloves were used. Sixty-nine patients (6.6%) were HIV-positive, 29 patients (2.8%) were HIV-negative, and the HIV status was unknown for the remaining 952 patients (90.7%). The overall glove puncture rate in the study was 14.5%. The glove puncture rate was 0%, 31% and 15% for HIV-positive, HIV-negative and HIV status unknown, respectively, and this difference was statistically significant. The mean operating time in the group with glove punctures was 148 min (95% confidence interval (CI) 135 - 161), while mean operating time in the group without glove puncture was 88 min (95% CI 84 - 92). Conclusion. Double-gloving offers protection against intraoperative injury. Knowing the HIV status of the patient offers additional protection to the operating surgeon. While we recommend routine double-gloving for surgeons working in HIV-prevalent patient populations, we also advocate for the routine screening for HIV in all surgical patients

Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model

Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disease that results in joint destruction and subsequent loss of function. To better understand its pathogenesis and to facilitate the search for novel RA therapeutics, we profiled the rat model of collagen-induced arthritis (CIA) to discover and characterize blood biomarkers for RA. Peripheral blood mononuclear cells (PBMCs) were purified using a Ficoll gradient at various time points after type II collagen immunization for RNA preparation. Total RNA was processed for a microarray analysis using Affymetrix GeneChip technology. Statistical comparison analyses identified differentially expressed genes that distinguished CIA from control rats. Clustering analyses indicated that gene expression patterns correlated with laboratory indices of disease progression. A set of 28 probe sets showed significant differences in expression between blood from arthritic rats and that from controls at the earliest time after induction, and the difference persisted for the entire time course. Gene Ontology comparison of the present study with previous published murine microarray studies showed conserved Biological Processes during disease induction between the local joint and PBMC responses. Genes known to be involved in autoimmune response and arthritis, such as those encoding Galectin-3, Versican, and Socs3, were identified and validated by quantitative TaqMan RT-PCR analysis using independent blood samples. Finally, immunoblot analysis confirmed that Galectin-3 was secreted over time in plasma as well as in supernatant of cultured tissue synoviocytes of the arthritic rats, which is consistent with disease progression. Our data indicate that gene expression in PBMCs from the CIA model can be utilized to identify candidate blood biomarkers for RA

Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

Respiratory mucosal immunity induced by vaccination is vital for protection from coronavirus infection in animal models. In humans, the capacity of peripheral vaccination to generate sustained immunity in the lung mucosa, and how this is influenced by prior SARS-CoV-2 infection, is unknown. Here we show using bronchoalveolar lavage samples that donors with history of both infection and vaccination have more airway mucosal SARS-CoV-2 antibodies and memory B cells than those only vaccinated. Infection also induces populations of airway spike-specific memory CD4+ and CD8+ T cells that are not expanded by vaccination alone. Airway mucosal T cells induced by infection have a distinct hierarchy of antigen specificity compared to the periphery. Spike-specific T cells persist in the lung mucosa for 7 months after the last immunising event. Thus, peripheral vaccination alone does not appear to induce durable lung mucosal immunity against SARS-CoV-2, supporting an argument for the need for vaccines targeting the airways

Breast Cancer Phenotypes in Africa: A Scoping Review and Meta-Analysis

PURPOSE Africans have been associated with more aggressive forms of breast cancer (BC).However, there is a lack of data regarding the incidence and distribution of different subtypes on the basis of phenotypic classification. This scoping review and meta-analysis was undertaken to determine the distribution pattern of BC phenotypes (luminal, human epidermal growth factor receptor 2 [HER2]1, and triple-negative breast cancer [TNBC]) across the African region. METHODS Four online databases (PubMed, Scopus, ProQuest, and EBSCOhost) were accessed to identify studies published between 2000 and 2022 reporting the representation of receptor status (estrogen receptor, progesterone receptor, and HER2) in African patients with BC. Furthermore, the meta-analysis was carried out using a random-effects model and pooled using the inverse variance method and logit transformation. 95% CI and I2 statistics were calculated using the Clopper-Pearson method to estimate between-study heterogeneity. RESULTS A total of 2,734 records were retrieved, of which 2,133 were retained for further screening. After the screening, 63 studies were finally selected for the scoping review and meta-analysis. The pooled frequency of luminal, HER2-positive (HER21), and TNBC was estimated at 56.30%, 12.61%, and 28.10%, respectively.Northern Africa had the highest frequency of the luminal subtype, while West Africa showed higher frequencies of HER21 and TNBC subtypes. The review also had a representation of only 24 countries in Africa. CONCLUSION Our results highlight the disparity in the representation of molecular subtypes among the people in different regions of Africa. There is a need to incorporate routine molecular subtyping into the management of African patients with BC