Diagnostic and therapeutic considerations in idiopathic hypereosinophilia with warm autoimmune hemolytic anemia.

Hypereosinophilic syndrome (HES) encompasses numerous diverse conditions resulting in peripheral hypereosinophilia that cannot be explained by hypersensitivity, infection, or atopy and that is not associated with known systemic diseases with specific organ involvement. HES is often attributed to neoplastic or reactive causes, such as chronic eosinophilic leukemia, although a majority of cases remains unexplained and are considered idiopathic. Here, we review the current diagnosis and management of HES and present a unique case of profound hypereosinophilia associated with warm autoimmune hemolytic anemia requiring intensive management. This case clearly illustrates the limitations of current knowledge with respect to hypereosinophilia syndrome as well as the challenges associated with its classification and management

Early-type galaxies in the SDSS. II. Correlations between observables

A magnitude limited sample of nearly 9000 early-type galaxies, in the redshift range 0.01 < z < 0.3, was selected from the Sloan Digital Sky Survey using morphological and spectral criteria. The sample was used to study how early-type galaxy observables, including luminosity L, effective radius R_o, surface brightness I_o, color, and velocity dispersion sigma, are correlated with one another. Measurement biases are understood with mock catalogs which reproduce all of the observed scaling relations and their dependences on fitting technique. At any given redshift, the intrinsic distribution of luminosities, sizes and velocity dispersions in our sample are all approximately Gaussian. A maximum likelihood analysis shows that sigma ~ L^{0.25\pm 0.012}, R_o ~ L^{0.63\pm 0.025}, and R_o ~ I^{-0.75\pm 0.02} in the r* band. In addition, the mass-to-light ratio within the effective radius scales as M_o/L ~ L^{0.14\pm 0.02} or M_o/L ~ M_o^{0.22\pm 0.05}, and galaxies with larger effective masses have smaller effective densities: Delta_o ~ M_o^{-0.52\pm 0.03}. These relations are approximately the same in the g*, i* and z* bands. Relative to the population at the median redshift in the sample, galaxies at lower and higher redshifts have evolved only little, with more evolution in the bluer bands. The luminosity function is consistent with weak passive luminosity evolution and a formation time of about 9 Gyrs ago.Comment: 29 pages, 11 figures. Accepted by AJ (scheduled for April 2003). This paper is part II of a revised version of astro-ph/011034

Ectopic production of human placental lactogen by human breast tumors

Serum samples from 72 patients with established carcinoma of the breast were investigated for ectopic presence of hPL. Further, the relationship of ectopically-secreted hPL and hCG-&#946; in breast cancer was investigated. Ten of 72 patients examined had detectable hPL and 12 had detectable hCG-&#946;, at 1-2 ng/ml serum sensitivity of the assay. The presence of hPL in serum of breast cancer patients was found to be independent of that of hCG-&#946;. Sera of 13 patients with cystic mastitis, five with fibroadenoma, two with acute inflamation of breast, 20 normal women (non-pregnant) and 20 normal men did not show any detectable serum hPL or hCG-&#946; at the above mentioned sensitivity of the assay. Since these hormones were not detectable in normal men, normal non-pregnant women, and in patients having other pathological conditions of breast, the possible use of them as markers in cancer is expected

Redshift space 21 cm power spectra from reionization

We construct a simple but self-consistent analytic ionization model for rapid exploration of 21cm power spectrum observables in redshift space. It is fully described by the average ionization fraction $x_e(z)$ and HII patch size $R(z)$ and has the flexibility to accommodate various reionization scenarios. The model associates ionization regions with dark matter halos of the number density required to recover $x_e$ and treats redshift space distortions self-consistently with the virial velocity of such halos. Based on this model, we study the line-of-sight structures in the brightness fluctuations since they are the most immune to foreground contamination. We explore the degeneracy between the HII patch size and nonlinear redshift space distortion in the one dimensional power spectrum. We also discuss the limitations experimental frequency and angular resolutions place on their distinguishability. Angular resolution dilutes even the radial signal and will be a serious limitation for resolving small bubbles before the end of reionization. Nonlinear redshift space distortions suggest that a resolution of order 1 -- 10\arcsec and a frequency resolution of 10kHz will ultimately be desirable to extract the full information in the radial field at $z\sim 10$. First generation instruments such as LOFAR and MWA can potentially measure radial HII patches of a few comoving Mpc and larger at the end of reionization and are unlikely to be affected by nonlinear redshift space distortions.Comment: 13 pages, 10 figures. Revised version. Includes minor changes. Adds appendix on accomodating a distribution of radii for the HII regions. Accepted for publication in Ap

A people-oriented paradigm for smart cities

Most works in the literature agree on considering the Internet of Things (IoT) as the base technology to collect information related to smart cities. This information is usually offered as open data for its analysis, and to elaborate statistics or provide services which improve the management of the city, making it more efficient and more comfortable to live in. However, it is not possible to actually improve the quality of life of smart cities’ inhabitants if there is no direct information about them and their experiences. To address this problem, we propose using a social and mobile computation model, called the Internet of People (IoP) which empowers smartphones to recollect information about their users, analyze it to obtain knowledge about their habits, and provide this knowledge as a service creating a collaborative information network. Combining IoT and IoP, we allow the smart city to dynamically adapt its services to the needs of its citizens, promoting their welfare as the main objective of the city.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Isolating Geometry in Weak Lensing Measurements

Given a foreground galaxy-density field or shear field, its cross-correlation with the shear field from a background population of source galaxies scales with the source redshift in a way that is specific to lensing. Such a source-scaling can be exploited to effectively measure geometrical distances as a function of redshift and thereby constrain dark energy properties, free of any assumptions about the galaxy-mass/mass power spectrum (its shape, amplitude or growth). Such a geometrical method can yield a ~ 0.03 - 0.07 f_{sky}^{-1/2} measurement on the dark energy abundance and equation of state, for a photometric redshift accuracy of dz ~ 0.01 - 0.05 and a survey with median redshift of ~ 1. While these constraints are weaker than conventional weak lensing methods, they provide an important consistency check because the geometrical method carries less theoretical baggage: there is no need to assume any structure formation model (e.g. CDM). The geometrical method is at the most conservative end of a whole spectrum of methods which obtain smaller errorbars by making more restrictive assumptions -- we discuss some examples. Our geometrical approach differs from previous investigations along similar lines in three respects. First, the source-scaling we propose to use is less demanding on the photometric redshift accuracy. Second, the scaling works for both galaxy-shear and shear-shear correlations. Third, we find that previous studies underestimate the statistical errors associated with similar geometrical methods, the origin of which is discussed.Comment: 13 pages, 4 figures, submitted to Ap

A Spitzer Unbiased Ultradeep Spectroscopic Survey

We carried out an unbiased, spectroscopic survey using the low-resolution module of the infrared spectrograph (IRS) on board Spitzer targeting two 2.6 square arcminute regions in the GOODS-North field. IRS was used in spectral mapping mode with 5 hours of effective integration time per pixel. One region was covered between 14 and 21 microns and the other between 20 and 35 microns. We extracted spectra for 45 sources. About 84% of the sources have reported detections by GOODS at 24 microns, with a median F_nu(24um) ~ 100 uJy. All but one source are detected in all four IRAC bands, 3.6 to 8 microns. We use a new cross-correlation technique to measure redshifts and estimate IRS spectral types; this was successful for ~60% of the spectra. Fourteen sources show significant PAH emission, four mostly SiO absorption, eight present mixed spectral signatures (low PAH and/or SiO) and two show a single line in emission. For the remaining 17, no spectral features were detected. Redshifts range from z ~ 0.2 to z ~ 2.2, with a median of 1. IR Luminosities are roughly estimated from 24 microns flux densities, and have median values of 2.2 x 10^{11} L_{\odot} and 7.5 x 10^{11} L_{\odot} at z ~ 1 and z ~ 2 respectively. This sample has fewer AGN than previous faint samples observed with IRS, which we attribute to the fainter luminosities reached here.Comment: Published in Ap

Spatially Resolved Spitzer-IRS Spectral Maps of the Superwind in M82

We have mapped the superwind/halo region of the nearby starburst galaxy M82 in the mid-infrared with $Spitzer-IRS$. The spectral regions covered include the H$_2 S(1)-S(3)$, [NeII], [NeIII] emission lines and PAH features. We estimate the total warm H$_2$ mass and the kinetic energy of the outflowing warm molecular gas to be between $M_{warm}\sim5-17\times10^6$ M$_{\odot}$ and $E_{K}\sim6-20\times10^{53}$ erg. Using the ratios of the 6.2, 7.7 and 11.3 micron PAH features in the IRS spectra, we are able to estimate the average size and ionization state of the small grains in the superwind. There are large variations in the PAH flux ratios throughout the outflow. The 11.3/7.7 and the 6.2/7.7 PAH ratios both vary by more than a factor of five across the wind region. The Northern part of the wind has a significant population of PAH's with smaller 6.2/7.7 ratios than either the starburst disk or the Southern wind, indicating that on average, PAH emitters are larger and more ionized. The warm molecular gas to PAH flux ratios (H$_2/PAH$) are enhanced in the outflow by factors of 10-100 as compared to the starburst disk. This enhancement in the H$_2/PAH$ ratio does not seem to follow the ionization of the atomic gas (as measured with the [NeIII]/[NeII] line flux ratio) in the outflow. This suggests that much of the warm H$_2$ in the outflow is excited by shocks. The observed H$_2$ line intensities can be reproduced with low velocity shocks ($v < 40$ km s$^{-1}$) driven into moderately dense molecular gas ($10^2 <n_H < 10^4$ cm$^{-3}$) entrained in the outflow.Comment: 19 pages and 12 figures; accepted in MNRA