Chiral QCD sum rules for open charm mesons

QCD sum rules for chiral partners in the open-charm meson sector are presented at nonzero baryon net density or temperature. We focus on the differences between pseudo-scalar and scalar as well as vector and axial-vector D mesons and derive the corresponding Weinberg type sum rules. This allows for the identification of such QCD condensates which drive the non-degeneracy of chiral partners in lowest order of the strong coupling alpha_s and which therefore may serve as "order parameters" for chiral restoration (or elements thereof).Comment: 24 pages, 4 figure

surface interpolation and 3d relatability

Although the role of surface-level processes has been demonstrated, visual interpolation models often emphasize contour relationships. We report two experiments on geometric constraints governing 3D interpolation between surface patches without visible edges. Observers were asked to classify pairs of planar patches specified by random dot disparities and visible through circular apertures (aligned or misaligned) in a frontoparallel occluder. On each trial, surfaces appeared in parallel or converging planes with vertical (in Experiment 1) or horizontal (in Experiment 2) tilt and variable amounts of slant. We expected the classification task to be facilitated when patches were perceived as connected. We found enhanced sensitivity and speed for 3D relatable vs. nonrelatable patches. Here 3D relatability does not involve oriented edges but rather inducing patches' orientations computed from stereoscopic information. Performance was markedly affected by slant anisotropy: both sensitivity and speed were worse for patches with horizontal tilt. We found nearly identical advantages of 3D relatability on performance, suggesting an isotropic unit formation process. Results are interpreted as evidence that inducing slant constrains surface interpolation in the absence of explicit edge information: 3D contour and surface interpolation processes share common geometric constraints as formalized by 3D relatability

Introduction of Macromolecules into Bovine Adrenal Medullary Chromaffin Cells and Rat Pheochromocytoma Cells (PC12) by Permeabilization with Streptolysin O: Inhibitory Effect of Tetanus Toxin on Catecholamine Secretion

Conditions are described for controlled plasma membrane permeabilization of rat pheochromocytoma cells (PC12) and cultured bovine adrenal chromaffin cells by Streptolysin O (SLO). The transmembrane pores created by SLO invoke rapid efflux of intracellular 86Rb+ and ATP, and also permit passive diffusion of proteins, including immunoglobulins, into the cells. SLO-permeabilized PC12 cells release [3H]dopamine in response to micromolar concentrations of free Ca2+. Permeabilized adrenal chromaffin cells present a similar exocytotic response to Ca2+ in the presence of Mg2+/ ATP. Permeabilized PC12 cells accumulate antibodies against synaptophysin and calmodulin, but neither antibody reduces the Ca2+-dependent secretory response. Reduced tetanus toxin, although ineffective when applied to intact chromaffin cells, inhibits Ca2+-induced exocytosis by both types of permeabilized cells studied. Omission of dithiothreitol, toxin inactivation by boiling, or preincubation with neutralizing antibodies abolishes the inhibitory effect. The data indicate that plasma membrane permeabilization by Streptolysin O is a useful tool to probe and define cellular components that are involved in the final steps of exocytosis

Assessing a Hydrodynamic Description for Instabilities in Highly Dissipative, Freely Cooling Granular Gases

An intriguing phenomenon displayed by granular flows and predicted by kinetic-theory-based models is the instability known as particle "clustering," which refers to the tendency of dissipative grains to form transient, loose regions of relatively high concentration. In this work, we assess a modified-Sonine approximation recently proposed [Garz\'o et al., Physica A 376, 94 (2007)] for a granular gas via an examination of system stability. In particular, we determine the critical length scale associated with the onset of two types of instabilities -vortices and clusters- via stability analyses of the Navier-Stokes-order hydrodynamic equations by using the expressions of the transport coefficients obtained from both the standard and the modified-Sonine approximations. We examine the impact of both Sonine approximations over a range of solids fraction \phi <0.2 for small restitution coefficients e=0.25--0.4, where the standard and modified theories exhibit discrepancies. The theoretical predictions for the critical length scales are compared to molecular dynamics (MD) simulations, of which a small percentage were not considered due to inelastic collapse. Results show excellent quantitative agreement between MD and the modified-Sonine theory, while the standard theory loses accuracy for this highly dissipative parameter space. The modified theory also remedies a (highdissipation) qualitative mismatch between the standard theory and MD for the instability that forms more readily. Furthermore, the evolution of cluster size is briefly examined via MD, indicating that domain-size clusters may remain stable or halve in size, depending on system parameters.Comment: 4 figures; to be published in Phys. Rev.

In situ radiographic investigation of de lithiation mechanisms in a tin electrode lithium ion battery.

The lithiation and delithiation mechanisms of multiple Sn particles in a customized flat radiography cell were investigated by in amp; 8197;situ synchrotron radiography. For the first time, four de lithiation phenomena in a Sn electrode battery system are highlighted 1 amp; 8197;the de lithiation behavior varies between different Sn particles, 2 amp; 8197;the time required to lithiate individual Sn particles is markedly different from the time needed to discharge the complete battery, 3 amp; 8197;electrochemical deactivation of originally electrochemically active particles is reported, and 4 amp; 8197;a change of electrochemical behavior of individual particles during cycling is found and explained by dynamic changes of de lithiation pathways amongst particles within the electrode. These unexpected findings fundamentaly expand the understanding of the underlying de lithiation mechanisms inside commercial lithium ion batteries LIBs and would open new design principles for high performance next generation LIB

Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells

Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation. By contrast, transmitter release from neurons occurs at specialized intercellular junctions, the synapses. Nevertheless, the mechanisms by which signal molecules are synthesized, stored, and eventually secreted by neurons and endocrine cells are very similar. Neurons and endocrine cells have in common two different types of secretory organelles, indicating the presence of two distinct secretory pathways. The synaptic vesicles of neurons contain excitatory or inhibitory neurotransmitters, whereas the secretory granules (also referred to as dense core vesicles, because of their electron dense content) are filled with neuropeptides and amines. In endocrine cells, peptide hormones and amines predominate in secretory granules. The function and content of vesicles, which share antigens with synaptic vesicles, are unknown for most endocrine cells. However, in B cells of the pancreatic islet, these vesicles contain GABA, which may be involved in intrainsular signaling.' Exocytosis of both synaptic vesicles and secretory granules is controlled by cytoplasmic calcium. However, the precise mechanisms of the subsequent steps, such as docking of vesicles and fusion of their membranes with the plasma membrane, are still incompletely understood. This contribution summarizes recent observations that elucidate components in neurons and endocrine cells involved in exocytosis. Emphasis is put on the intracellular aspects of the release of secretory granules that recently have been analyzed in detail

Analysis of the doubly heavy baryons in the nuclear matter with the QCD sum rules

In this article, we study the doubly heavy baryon states $\Xi_{cc}$, $\Omega_{cc}$, $\Xi_{bb}$ and $\Omega_{bb}$ in the nuclear matter using the QCD sum rules, and derive three coupled QCD sum rules for the masses, vector self-energies and pole residues. The predictions for the mass-shifts in the nuclear matter $\Delta M_{\Xi_{cc}}=-1.11\,\rm{GeV}$, $\Delta M_{\Omega_{cc}}=-0.33\,\rm{GeV}$, $\Delta M_{\Xi_{bb}}=-3.37\,\rm{GeV}$ and $\Delta M_{\Omega_{bb}}=-1.05\,\rm{GeV}$ can be confronted with the experimental data in the future.Comment: 10 pages, 4 figure

Oxaliplatin-DNA adduct formation in white blood cells of cancer patients

In this study, we investigated the kinetics of oxaliplatin-DNA adduct formation in white blood cells of cancer patients in relation to efficacy as well as oxaliplatin-associated neurotoxicity. Thirty-seven patients with various solid tumours received 130 mg m−2 oxaliplatin as a 2-h infusion. Oxaliplatin-DNA adduct levels were measured in the first cycle using adsorptive stripping voltammetry. Platinum concentrations were measured in ultrafiltrate and plasma using a validated flameless atomic absorption spectrometry method. DNA adduct levels showed a characteristic time course, but were not correlated to platinum pharmacokinetics and varied considerably among individuals. In patients showing tumour response, adduct levels after 24 and 48 h were significantly higher than in nonresponders. Oxaliplatin-induced neurotoxicity was more pronounced but was not significantly different in patients with high adduct levels. The potential of oxaliplatin-DNA adduct measurements as pharmacodynamic end point should be further investigated in future trials

Morphological evolution of electrochemically plated stripped lithium microstructures by synchrotron X ray phase contrast tomography

Due to its low redox potential and high theoretical specific capacity, Li metal has drawn worldwide research attention because of its potential use in next generation battery technologies such as Li S and Li O2. Unfortunately, uncontrollable growth of Li microstructures LmSs, e.g., dendrites, fibers during electrochemical Li stripping plating has prevented their practical commercialization. Despite various strategies proposed to mitigate LmS nucleation and or block its growth, a fundamental understanding of the underlying evolution mechanisms remains elusive. Herein, synchrotron in line phase contrast X ray tomography was employed to investigate the morphological evolution of electrochemically deposited dissolved LmSs nondestructively. We present a 3D characterization of electrochemically stripped Li electrodes with regard to electrochemically plated LmSs. We clarify fundamentally the origin of the porous lithium interface growing into Li electrodes. Moreover, cleavage of the separator caused by growing LmS was experimentally observed and visualized in 3D. Our systematic investigation provides fundamental insights into LmS evolution and enables us to understand the evolution mechanisms in Li electrodes more profoundl

The Presampler for the Forward and Rear Calorimeter in the ZEUS Detector

The ZEUS detector at HERA has been supplemented with a presampler detector in front of the forward and rear calorimeters. It consists of a segmented scintillator array read out with wavelength-shifting fibers. We discuss its desi gn, construction and performance. Test beam data obtained with a prototype presampler and the ZEUS prototype calorimeter demonstrate the main function of this detector, i.e. the correction for the energy lost by an electron interacting in inactive material in front of the calorimeter.Comment: 20 pages including 16 figure