secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila

Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The hormones act through G-protein-coupled receptors to activate second messenger systems that in turn control the permeability of secretory epithelia to ions like chloride. In insects, the chloride channel mediating the effects of diuretic hormones was unknown. Surprisingly, we find a pentameric, cys-loop chloride channel, a type of channel normally associated with neurotransmission, mediating hormone-induced transepithelial chloride conductance. This discovery is important because: 1) it describes an unexpected role for pentameric receptors in the membrane permeability of secretory epithelial cells, and 2) it suggests that neurotransmitter-gated ion channels may have evolved from channels involved in secretion

CO and CI maps of the starburst galaxy M82

The first map of an external galaxy in the 3P₁ - 3P0 fine-structure line of atomic carbon (CI) is presented towards the nucleus of the starbuster M82, and compared with the distinction of the CO J = 4 - 3 molecular emission. The CI traces features that are seen in lower transition CO maps, and shows that CI and the CO are well mixed and have similar spatial distributions. There are small differences between the CO J = 4 - 3 line and lower transition CO data towards the NE part of the molecular ring, where the emission is less prominent. The abundance ratio [CI]/[CO] across M82 is very high, with an average value ~ 0.5 across most of the nucleus, a factor at least 5 times that which is typical of dense molecular cloud cores seen in our own Galaxy. This means that on average, CI is overabundant towards M82. This result can be explained using models which provide enhancements to the CI abundance above normal Interstellar Medium values, a result of a greater cosmic ray flux in M82, or where there is substantial mixing of the gas

Electroweak Bremsstrahlung in Dark Matter Annihilation

A conservative upper bound on the total dark matter (DM) annihilation rate can be obtained by constraining the appearance rate of the annihilation products which are hardest to detect. The production of neutrinos, via the process $\chi \chi \to \bar\nu \nu$, has thus been used to set a strong general bound on the dark matter annihilation rate. However, Standard Model radiative corrections to this process will inevitably produce photons which may be easier to detect. We present an explicit calculation of the branching ratios for the electroweak bremsstrahlung processes $\chi \chi \to \bar\nu \nu Z$ and $\chi \chi \to \bar\nu e W$. These modes inevitably lead to electromagnetic showers and further constraints on the DM annihilation cross-section. In addition to annihilation, our calculations are also applicable to the case of dark matter decay.Comment: 7 pages, 4 figures. New appendix with an extensive discussion of Majorana fermions and helicity suppression

Searching for Dark Matter at the LHC with a Mono-Z

We investigate a mono-Z process as a potential dark matter search strategy at the LHC. In this channel a single Z boson recoils against missing transverse momentum, attributed to dark matter particles, $\chi$, which escape the detector. This search strategy is related, and complementary to, monojet and monophoton searches. For illustrative purposes we consider the process $q\bar{q} -> \chi\chi Z$ in a toy dark matter model, where the Z boson is emitted from either the initial state quarks, or from the internal propagator. Among the signatures of this process will be a pair of muons with high pT that reconstruct to the invariant mass of the Z, and large amounts of missing transverse energy. Being a purely electroweak signal, QCD and other Standard Model backgrounds are relatively easily removed with modest selection cuts. We compare the signal to Standard Model backgrounds and demonstrate that, even for conservative cuts, there exist regions of parameter space where the signal may be clearly visible above background in future LHC data, allowing either new discovery potential or the possibility of supplementing information about the dark sector beyond that available from other observable channels.Comment: 11 pages, 13 figure

Evidence for a non-genomic action of testosterone in skeletal muscle which may improve athletic performance: Implications for the female athlete

This review will focus on the proposed second mode of testosterone action (now termed non-genomic) that appears to occur independently of the traditional transcriptional mechanism in mammalian skeletal muscle cells which may enhance skeletal muscle contractile properties. This mechanism of testosterone action differs from the traditional pathway, originating at the cell membrane, having a rapid onset of action, requiring second messengers to execute its effects and is insensitive to inhibitors of traditional androgen receptor action, transcription and protein synthesis. Importantly, unlike the traditional action of testosterone in skeletal muscle, this non-genomic pathway is shown to have a direct acute effect on calcium-dependent components important for the contractile process. The changes within the contractile apparatus may enhance the ability of the muscle to produce explosive power during athletic performance. Rapid increases in Inositol triphosphate mass and calcium release from the sarcoplasmic reticulum have been reported in rodent skeletal muscle cells, and a rapid androgen (dihydrotestosterone)- induced increase in peak force production has been recorded in intact rodent skeletal muscle fibre bundles while showing increases in the activity of the Ras/MAP/ERK mediated pathway. Because the non-genomic action of testosterone is enhanced during increases in exposure to testosterone and is acute in its action, implications for athletic performance are likely greater in females than males due to natural fluctuations in circulating testosterone levels during the female menstrual cycle, reproductive pathology, and changes induced by hormonal contraceptive methods. Research should be undertaken in humans to confirm a pathway for non-genomic testosterone action in human skeletal muscle. Specifically, relationships between testosterone fluctuations and physiological changes within skeletal muscle cells and whole muscle exercise performance need to be examined

Water depletion in the disk atmosphere of Herbig AeBe stars

We present high resolution (R = 100,000) L-band spectroscopy of 11 Herbig AeBe stars with circumstellar disks. The observations were obtained with the VLT/CRIRES to detect hot water and hydroxyl radical emission lines previously detected in disks around T Tauri stars. OH emission lines are detected towards 4 disks. The OH P4.5 (1+,1-) doublet is spectrally resolved as well as the velocity profile of each component of the doublet. Its characteristic double-peak profile demonstrates that the gas is in Keplerian rotation and points to an emitting region extending out to ~ 15-30 AU. The OH, emission correlates with disk geometry as it is mostly detected towards flaring disks. None of the Herbig stars analyzed here show evidence of hot water vapor at a sensitivity similar to that of the OH lines. The non-detection of hot water vapor emission indicates that the atmosphere of disks around Herbig AeBe stars are depleted of water molecules. Assuming LTE and optically thin emission we derive a lower limit to the OH/H2O column density ratio > 1 - 25 in contrast to T Tauri disks for which the column density ratio is 0.3 -- 0.4.Comment: Accepted for publication in Ap

Dark Matter Annihilation Signatures from Electroweak Bremsstrahlung

We examine observational signatures of dark matter annihilation in the Milky Way arising from electroweak bremsstrahlung contributions to the annihilation cross section. It has been known for some time that photon bremsstrahlung may significantly boost DM annihilation yields. Recently, we have shown that electroweak bremsstrahlung of W and Z gauge bosons can be the dominant annihilation channel in some popular models with helicity-suppressed 2 --> 2 annihilation. W/Z-bremsstrahlung is particularly interesting because the gauge bosons produced via annihilation subsequently decay to produce large correlated fluxes of electrons, positrons, neutrinos, hadrons (including antiprotons) and gamma rays, which are all of importance in indirect dark matter searches. Here we calculate the spectra of stable annihilation products produced via gamma/W/Z-bremsstrahlung. After modifying the fluxes to account for the propagation through the Galaxy, we set upper bounds on the annihilation cross section via a comparison with observational data. We show that stringent cosmic ray antiproton limits preclude a sizable dark matter contribution to observed cosmic ray positron fluxes in the class of models for which the bremsstrahlung processes dominate.Comment: 11 pages, 6 figures. Updated to match PRD versio

Gravitational Stirring in Planetary Debris Disks

We describe gravitational stirring models of planetary debris disks using a new multi-annulus planetesimal evolution code. The current code includes gravitational stirring and dynamical friction; future studies will include coagulation, fragmentation, Poynting-Robertson drag, and other physical processes. We use the results of our calculations to investigate the physical conditions required for small bodies in a planetesimal disk to reach the shattering velocity and begin a collisional cascade. Our results demonstrate that disks composed primarily of bodies with a single size will not undergo a collisional cascade which produces small dust grains at 30-150 AU on timescales of 1 Gyr or smaller. Disks with a size distribution of bodies reach conditions necessary for a collisional cascade in 10 Myr to 1 Gyr if the disk is at least as massive as a minimum mass solar nebula and if the disk contains objects with radii of 500 km or larger. The estimated 500 Myr survival time for these disks is close to the median age of roughly 400 Myr derived for nearby stars with dusty disks.Comment: 23 pages of text + 16 Figures; to appear in the Astronomical Journal, January 200

Collisional Cascades in Planetesimal Disks I. Stellar Flybys

We use a new multiannulus planetesimal accretion code to investigate the evolution of a planetesimal disk following a moderately close encounter with a passing star. The calculations include fragmentation, gas and Poynting-Robertson drag, and velocity evolution from dynamical friction and viscous stirring. We assume that the stellar encounter increases planetesimal velocities to the shattering velocity, initiating a collisional cascade in the disk. During the early stages of our calculations, erosive collisions damp particle velocities and produce substantial amounts of dust. For a wide range of initial conditions and input parameters, the time evolution of the dust luminosity follows a simple relation, L_d/L_{\star} = L_0 / [alpha + (t/t_d)^{beta}]. The maximum dust luminosity L_0 and the damping time t_d depend on the disk mass, with L_0 proportional to M_d and t_d proportional to M_d^{-1}. For disks with dust masses of 1% to 100% of the `minimum mass solar nebula' (1--100 earth masses at 30--150 AU), our calculations yield t_d approx 1--10 Myr, alpha approx 1--2, beta = 1, and dust luminosities similar to the range observed in known `debris disk' systems, L_0 approx 10^{-3} to 10^{-5}. Less massive disks produce smaller dust luminosities and damp on longer timescales. Because encounters with field stars are rare, these results imply that moderately close stellar flybys cannot explain collisional cascades in debris disk systems with stellar ages of 100 Myr or longer.Comment: 33 pages of text, 12 figures, and an animation. The paper will appear in the March 2002 issue of the Astronmomical Journal. The animation and a copy of the paper with full resolution figures are at S. Kenyon's planet formation website: http://cfa-www.harvard.edu/~kenyon/p

The Indian family on UK reality television: Convivial culture in salient contexts

This is the author's accepted manuscript. The final published article is available from the link below, copyright 2012 @ the author.This article demonstrates how The Family (2009), a fly-on-the wall UK reality series about a British Indian family, facilitates both current public service broadcasting requirements and mass audience appeal. From a critical cultural studies perspective, the author examines the journalistic and viewer responses to the series where authenticity, universality, and comedy emerge as major themes. Textual analysis of the racialized screen representations also helps locate the series within the contexts of contested multiculturalism, genre developments in reality television and public service broadcasting. Paul Gilroy’s concept of convivial culture is used as a frame in understanding how meanings of the series are produced within a South Asian popular representational space. The author suggests that the social comedy taxonomy is a prerequisite for the making of this particular observational documentary. Further, the popular (comedic) mode of conviviality on which the series depends is both expedient and necessary within the various sociopolitical contexts outlined