The Scattered Disk as the source of the Jupiter Family comets

The short period Jupiter family comets (JFCs) are thought to originate in the Kuiper Belt; specifically, a dynamical subclass of the Kuiper Belt known as the `scattered disk' is argued to be the dominant source of JFCs. However, the best estimates from observational surveys indicate that this source may fall short by more than two orders of magnitude the estimates obtained from theoretical models of the dynamical evolution of Kuiper belt objects into JFCs. We re-examine the scattered disk as a source of the JFCs and make a rigorous estimate of the discrepancy. We find that the uncertainties in the dynamical models combined with a change in the size distribution function of the scattered disk at faint magnitudes (small sizes) beyond the current observational limit offer a possible but problematic resolution to the discrepancy. We discuss several other possibilities: that the present population of JFCs is a large fluctuation above their long term average, that larger scattered disk objects tidally break-up into multiple fragments during close planetary encounters as their orbits evolve from the trans-Neptune zone to near Jupiter, or that there are alternative source populations that contribute significantly to the JFCs. Well-characterized observational investigations of the Centaurs, objects that are transitioning between the trans-Neptune Kuiper belt region and the inner solar system, can test the predictions of the non-steady state and the tidal break-up hypotheses. The classical and resonant classes of the Kuiper belt are worth re-consideration as significant additional or alternate sources of the JFCs.Comment: 33 pages, 6 figures. Revised Content. To be published in The Astrophysical Journa

Search for L5 Earth Trojans with DECam

Most of the major planets in the Solar system support populations of co-orbiting bodies, known as Trojans, at their L4 and L5 Lagrange points. In contrast, Earth has only one known co-orbiting companion. This paper presents the results from a search for Earth Trojans (ETs) using the DECam instrument on the Blanco Telescope at CTIO. This search found no additional Trojans in spite of greater coverage compared to previous surveys of the L5 point. Therefore, the main result of this work is to place the most stringent constraints to date on the population of ETs. These constraints depend on assumptions regarding the underlying population properties, especially the slope of the magnitude distribution (which in turn depends on the size and albedo distributions of the objects). For standard assumptions, we calculate upper limits to a 90 per cent confidence limit on the L5 population of N_(ET) < 1 for magnitude H < 15.5, N_(ET) = 60–85 for H < 19.7, and N_(ET) = 97 for H = 20.4. This latter magnitude limit corresponds to Trojans ∼300 m in size for albedo 0.15. At H = 19.7, these upper limits are consistent with previous L4 ET constraints and significantly improve L5 constraints

Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics

AbstractCalcium homeostasis is central to all cellular functions and has been studied for decades. Calcium acts as a critical second messenger for both extracellular and intracellular signaling and is fundamental in cell life and death decisions (Berridge et al., 2000) [1]. The calcium gradient in the cell is coupled with an inherent ability of the divalent cation to reversibly bind multiple target biological molecules to generate an extremely versatile signaling system [2]. Calcium signals are used by the cell to control diverse processes such as development, neurotransmitter release, muscle contraction, metabolism, autophagy and cell death. “Cellular calcium overload” is detrimental to cellular health, resulting in massive activation of proteases and phospholipases leading to cell death (Pinton et al., 2008) [3]. Historically, cell death associated with calcium ion perturbations has been primarily recognized as necrosis. Recent evidence clearly associates changes in calcium ion concentrations with more sophisticated forms of cellular demise, including apoptosis (Kruman et al., 1998; Tombal et al., 1999; Lynch et al., 2000; Orrenius et al., 2003) [4–7]. Although the endoplasmic reticulum (ER) serves as the primary calcium store in the metazoan cell, dynamic calcium release to the cytosol, mitochondria, nuclei and other organelles orchestrate diverse coordinated responses. Most evidence supports that calcium transport from the ER to mitochondria plays a significant role in regulating cellular bioenergetics, production of reactive oxygen species, induction of autophagy and apoptosis. Recently, molecular identities that mediate calcium traffic between the ER and mitochondria have been discovered (Mallilankaraman et al., 2012a; Mallilankaraman et al., 2012b; Sancak et al., 2013)[8–10]. The next questions are how they are regulated for exquisite tight control of ER–mitochondrial calcium dynamics. This review attempts to summarize recent advances in the role of calcium in regulation of ER and mitochondrial function. This article is part of a Special Issue entitled: Calcium signaling in health and disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau

A Study on Various Meteoroid Disintegration Mechanisms as Observed from the Resolute Bay Incoherent Scatter Radar (RISR)

There has been much interest in the meteor physics community recently regarding the form that meteoroid mass flux arrives in the upper atmosphere. Of particular interest are the relative roles of simple ablation, differential ablation, and fragmentation in the meteoroid mass flux observed by the Incoherent Scatter Radars (ISR). We present here the first-ever statistical study showing the relative contribution of the above-mentioned three mechanisms. These are also one of the first meteor results from the newly-operational Resolute Bay ISR. These initial results emphasize that meteoroid disintegration into the upper atmosphere is a complex process in which all the three above-mentioned mechanisms play an important role though fragmentation seems to be the dominant mechanism. These results prove vital in studying how meteoroid mass is deposited in the upper atmosphere which has important implications to the aeronomy of the region and will also contribute in improving current meteoroid disintegration/ablation models

A fast, accurate, and easy to implement Kapur-Rokhlin quadrature scheme for singular integrals in axisymmetric geometries

Many applications in magnetic confinement fusion require the efficient calculation of surface integrals with singular integrands. The singularity subtraction approaches typically used to handle such singularities are complicated to implement and low order accurate. In contrast, we demonstrate that the Kapur-Rokhlin quadrature scheme is well-suited for the logarithmically singular integrals encountered for toroidally axisymmetric confinement system, is easy to implement, and is high order accurate. As an illustration, we show how to apply this quadrature scheme for the efficient and accurate calculation of the normal component of the magnetic field due to the plasma on the plasma boundary, via the virtual casing principle.Comment: 19 pages, 2 figure

Extrasolar planetary dynamics with a generalized planar Laplace-Lagrange secular theory

The dynamical evolution of nearly half of the known extrasolar planets in multiple-planet systems may be dominated by secular perturbations. The commonly high eccentricities of the planetary orbits calls into question the utility of the traditional Laplace-Lagrange (LL) secular theory in analyses of the motion. We analytically generalize this theory to fourth-order in the eccentricities, compare the result with the second-order theory and octupole-level theory, and apply these theories to the likely secularly-dominated HD 12661, HD 168443, HD 38529 and Ups And multi-planet systems. The fourth-order scheme yields a multiply-branched criterion for maintaining apsidal libration, and implies that the apsidal rate of a small body is a function of its initial eccentricity, dependencies which are absent from the traditional theory. Numerical results indicate that the primary difference the second and fourth-order theories reveal is an alteration in secular periodicities, and to a smaller extent amplitudes of the planetary eccentricity variation. Comparison with numerical integrations indicates that the improvement afforded by the fourth-order theory over the second-order theory sometimes dwarfs the improvement needed to reproduce the actual dynamical evolution. We conclude that LL secular theory, to any order, generally represents a poor barometer for predicting secular dynamics in extrasolar planetary systems, but does embody a useful tool for extracting an accurate long-term dynamical description of systems with small bodies and/or near-circular orbits.Comment: 14 pages, 12 figures, 1 table, accepted for publication in Ap

Prevalence and pattern of self-medication in elderly individuals

Background: Self-medication that is taking medicines without prescription by the doctor is highly prevalence in the community. Elderly population is more likely to self-medicate due to multiple morbidities. This study was undertaken to evaluate the prevalence and pattern of use of self-medication among elderly individuals.Methods: Study was carried out at tertiary care hospital. The questionnaire which was used in our earlier studies regarding self-medication was utilized. After obtaining consent, the elderly individuals (≥60 years) reporting for health check-up were requested to fill up the questionnaire themselves or were asked to respond to questions verbally in the case of illiterate. Questionnaire mainly contained demographic and clinical data and self-medication details - frequency, symptoms/disease for self-medication, drugs, reasons for self-medication, sources of information, awareness regarding the risk of self-medication.Results: Out of 200 elderly included in the study, 177(88.5%) reported self-medication in 6-month recall period. About 60% were male and mean age - 69.64±6.21 (60-85) years. About 21% reported frequent self-medication. Abdominal pain (16%) and headache (14%) were the most common symptoms, and diabetes (7%) was the most common disease for self-medication. Allopathic medicines (55%) mainly paracetamol (13.5%) were most frequently used followed by home remedies (23%) and ayurvedic (17%). Previous experience with the drug (50%) followed by advertisements (23.2%) were common source of information. Most common reasons for self-medication were convenience (69.5%) and cost (56%). None of respondents were aware of risks of self-medicationConclusion: Self-medication is highly prevalent in elderly people who are unaware of risks involved

Determinants of Sugar-Sweetened Beverage Consumption among Indian Adults: Findings from the National Family Health Survey-4

BACKGROUND: Sugar-sweetened beverages (SSBs) are associated with obesity, and various other noncommunicable diseases (NCDs). The aim of the study was to study the patterns of consumption of SSBs and association of SSB consumption with various socioeconomic factors and fried food consumption. METHODOLOGY: We used data of the 4th round of National Family Health Survey. We used multiple logistic regression to estimate the extent of the relationship between consumption of aerated drinks and various predictors. Furthermore, generalized structural equation modeling (GSEM) was used to derive a path diagram that showed a significant linkage between aerated drinks and observed variables. RESULTS: Our study showed a clear association between consumption of aerated drinks with socioeconomic variables age, sex, marital status, and wealth index. The consumption of aerated drinks was also significantly associated with watching television and eating fried foods. CONCLUSION: Aerated drinks are a popular source of added sugar in the Indian diet. Limiting such factors can prove to be beneficial in reducing their consumption and further help in reducing the burden of NCDs

Comparison of linkage analysis methods for genome-wide scanning of extended pedigrees, with application to the TG/HDL-C ratio in the Framingham Heart Study

BACKGROUND: High triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) jointly increase coronary disease risk. We performed linkage analysis for TG/HDL-C ratio in the Framingham Heart Study data as a quantitative trait, using methods implemented in LINKAGE, GENEHUNTER (GH), MCLINK, and SOLAR. Results were compared to each other and to those from a previous evaluation using SOLAR for TG/HDL-C ratio on this sample. We also investigated linked pedigrees in each region using by-pedigree analysis. RESULTS: Fourteen regions with at least suggestive linkage evidence were identified, including some that may increase and some that may decrease coronary risk. Ten of the 14 regions were identified by more than one analysis, and several of these regions were not previously detected. The best regions identified for each method were on chromosomes 2 (LOD = 2.29, MCLINK), 5 (LOD = 2.65, GH), 7 (LOD = 2.67, SOLAR), and 22 (LOD = 3.37, LINKAGE). By-pedigree multi-point LOD values in MCLINK showed linked pedigrees for all five regions, ranging from 3 linked pedigrees (chromosome 5) to 14 linked pedigrees (chromosome 7), and suggested localizations of between 9 cM and 27 cM in size. CONCLUSION: Reasonable concordance was found across analysis methods. No single method identified all regions, either by full sample LOD or with by-pedigree analysis. Concordance across methods appeared better at the pedigree level, with many regions showing by-pedigree support in MCLINK when no evidence was observed in the full sample. Thus, investigating by-pedigree linkage evidence may provide a useful tool for evaluating linkage regions