Five-loop additive renormalization in the phi^4 theory and amplitude functions of the minimally renormalized specific heat in three dimensions

We present an analytic five-loop calculation for the additive renormalization constant A(u,epsilon) and the associated renormalization-group function B(u) of the specific heat of the O(n) symmetric phi^4 theory within the minimal subtraction scheme. We show that this calculation does not require new five-loop integrations but can be performed on the basis of the previous five-loop calculation of the four-point vertex function combined with an appropriate identification of symmetry factors of vacuum diagrams. We also determine the amplitude functions of the specific heat in three dimensions for n=1,2,3 above T_c and for n=1 below T_c up to five-loop order. Accurate results are obtained from Borel resummations of B(u) for n=1,2,3 and of the amplitude functions for n=1. Previous conjectures regarding the smallness of the resummed higher-order contributions are confirmed. Borel resummed universal amplitude ratios A^+/A^- and a_c^+/a_c^- are calculated for n=1.Comment: 30 pages REVTeX, 3 PostScript figures, submitted to Phys. Rev.

Scaling of thermal conductivity of helium confined in pores

We have studied the thermal conductivity of confined superfluids on a bar-like geometry. We use the planar magnet lattice model on a lattice $H\times H\times L$ with $L \gg H$. We have applied open boundary conditions on the bar sides (the confined directions of length $H$) and periodic along the long direction. We have adopted a hybrid Monte Carlo algorithm to efficiently deal with the critical slowing down and in order to solve the dynamical equations of motion we use a discretization technique which introduces errors only $O((\delta t)^6)$ in the time step $\delta t$. Our results demonstrate the validity of scaling using known values of the critical exponents and we obtained the scaling function of the thermal resistivity. We find that our results for the thermal resistivity scaling function are in very good agreement with the available experimental results for pores using the tempComment: 5 two-column pages, 3 figures, Revtex

Critical Behavior of O(n)-symmetric Systems With Reversible Mode-coupling Terms: Stability Against Detailed-balance Violation

We investigate nonequilibrium critical properties of $O(n)$-symmetric models with reversible mode-coupling terms. Specifically, a variant of the model of Sasv\'ari, Schwabl, and Sz\'epfalusy is studied, where violation of detailed balance is incorporated by allowing the order parameter and the dynamically coupled conserved quantities to be governed by heat baths of different temperatures $T_S$ and $T_M$, respectively. Dynamic perturbation theory and the field-theoretic renormalization group are applied to one-loop order, and yield two new fixed points in addition to the equilibrium ones. The first one corresponds to $\Theta = T_S / T_M = \infty$ and leads to model A critical behavior for the order parameter and to anomalous noise correlations for the generalized angular momenta; the second one is at $\Theta = 0$ and is characterized by mean-field behavior of the conserved quantities, by a dynamic exponent $z = d / 2$ equal to that of the equilibrium SSS model, and by modified static critical exponents. However, both these new fixed points are unstable, and upon approaching the critical point detailed balance is restored, and the equilibrium static and dynamic critical properties are recovered.Comment: 18 pages, RevTeX, 1 figure included as eps-file; submitted to Phys. Rev.

Time course metabolome of Roux-en-Y gastric bypass confirms correlation between leptin, body weight and the microbiome

Roux-en-Y gastric bypass (RYGB) is an effective way to lose weight and reverse type 2 dia- betes. We profiled the metabolome of 18 obese patients (nine euglycemic and nine diabet- ics) that underwent RYGB surgery and seven lean subjects. Plasma samples from the obese patients were collected before the surgery and one week and three months after the surgery. We analyzed the metabolome in association to five hormones (Adiponectin, Insulin, Ghrelin, Leptin, and Resistin), four peptide hormones (GIP, Glucagon, GLP1, and PYY), and two cytokines (IL-6 and TNF). PCA showed samples cluster by surgery time and many microbially driven metabolites (indoles in particular) correlated with the three months after the surgery. Network analysis of metabolites revealed a connection between carbohydrate (mannosamine and glucosamine) and glyoxylate and confirms glyoxylate association to dia- betes. Only leptin and IL-6 had a significant association with the measured metabolites. Lep- tin decreased immediately after RYGB (before significant weight loss), whereas IL-6 showed no consistent response to RYGB. Moreover, leptin associated with tryptophan in support of the possible role of leptin in the regulation of serotonin synthesis pathways in the gut. These results suggest a potential link between gastric leptin and microbial-derived metabolites in the context of obesity and diabetes

Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming

Small nucleolar and small Cajal body RNAs (snoRNAs and scaRNAs) of the H/ACA box and C/D box type are generated by exonucleolytic shortening of longer precursors. Removal of the last few nucleotides at the 3' end is known to be a distinct step. We report that, in human cells, knock-down of the poly(A) specific ribonuclease (PARN), previously implicated only in mRNA metabolism, causes the accumulation of oligoadenylated processing intermediates of H/ACA box but not C/D box RNAs. In agreement with a role of PARN in snoRNA and scaRNA processing, the enzyme is concentrated in nucleoli and Cajal bodies. Oligo(A) tails are attached to a short stub of intron sequence remaining beyond the mature 3' end of the snoRNAs. The noncanonical poly(A) polymerase PAPD5 is responsible for addition of the oligo(A) tails. We suggest that deadenylation is coupled to clean 3' end trimming, which might serve to enhance snoRNA stability