Shattered Time: Can a Dissipative Time Crystal Survive Many-Body Correlations?

We investigate the emergence of a time crystal in a driven-dissipative many-body spin array. In this system the interplay between incoherent spin pumping and collective emission stabilizes a synchronized non-equilibrium steady state which in the thermodynamic limit features a self-generated time-periodic pattern imposed by collective elastic interactions. In contrast to prior realizations where the time symmetry is already broken by an external drive, here it is only spontaneously broken by the elastic exchange interactions and manifest in the two-time correlation spectrum. Employing a combination of exact numerical calculations and a second-order cumulant expansion, we investigate the impact of many-body correlations on the time crystal formation and establish a connection between the regime where it is stable and a slow growth rate of the mutual information, signalling that the time crystal studied here is an emergent semi-classical out-of-equilibrium state of matter. We also confirm the rigidity of the time crystal to single-particle dephasing. Finally, we discuss an experimental implementation using long-lived dipoles in an optical cavity.Comment: v1: Initial commit; v2: Added references, fixed a couple typos, and made some small, stylistic changes; v3: Update to reflect publication. Includes additional references and some minor addition

The Annexin A2/S100A10 System in Health and Disease: Emerging Paradigms

Since its discovery as a src kinase substrate more than three decades ago, appreciation for the physiologic functions of annexin A2 and its associated proteins has increased dramatically. With its binding partner S100A10 (p11), A2 forms a cell surface complex that regulates generation of the primary fibrinolytic protease, plasmin, and is dynamically regulated in settings of hemostasis and thrombosis. In addition, the complex is transcriptionally upregulated in hypoxia and promotes pathologic neoangiogenesis in the tissues such as the retina. Dysregulation of both A2 and p11 has been reported in examples of rodent and human cancer. Intracellularly, A2 plays a critical role in endosomal repair in postarthroplastic osteolysis, and intracellular p11 regulates serotonin receptor activity in psychiatric mood disorders. In human studies, the A2 system contributes to the coagulopathy of acute promyelocytic leukemia, and is a target of high-titer autoantibodies in patients with antiphospholipid syndrome, cerebral thrombosis, and possibly preeclampsia. Polymorphisms in the human ANXA2 gene have been associated with stroke and avascular osteonecrosis of bone, two severe complications of sickle cell disease. Together, these new findings suggest that manipulation of the annexin A2/S100A10 system may offer promising new avenues for treatment of a spectrum of human disorders

Molecular definition of group 1 innate lymphoid cells in the mouse uterus

Determining the function of uterine lymphocytes is challenging because of the rapidly changing nature of the organ in response to sex hormones and, during pregnancy, to the invading fetal trophoblast cells. Here we provide the first genome-wide transcriptome atlas of mouse uterine group 1 innate lymphoid cells (g1 ILCs) at mid-gestation. The composition of g1 ILCs fluctuates throughout reproductive life, with Eomes-veCD49a+ ILC1s dominating before puberty and specifically expanding in second pregnancies, when the expression of CXCR6, a marker of memory cells, is upregulated. Tissue-resident Eomes+CD49a+ NK cells (trNK), which resemble human uterine NK cells, are most abundant during early pregnancy, and showcase gene signatures of responsiveness to TGF-β, connections with trophoblast, epithelial, endothelial and smooth muscle cells, leucocytes, as well as extracellular matrix. Unexpectedly, trNK cells express genes involved in anaerobic glycolysis, lipid metabolism, iron transport, protein ubiquitination, and recognition of microbial molecular patterns. Conventional NK cells expand late in gestation and may engage in crosstalk with trNK cells involving IL-18 and IFN-γ. These results identify trNK cells as the cellular hub of uterine g1 ILCs at mid-gestation and mark CXCR6+ ILC1s as potential memory cells of pregnancy.This work was funded by a Wellcome Trust Investigator Award 200841/Z/16/Z, the Centre for Trophoblast Research (CTR), and the Cambridge NIHR BRC Cell Phenotyping Hub to FC, the Associazione Italiana Ricerca per la Ricerca sul Cancro (AIRC) - Special Project 5x1000 no. 9962, AIRC IG 2017 Id.19920 and AIRC 2014 Id. 15283 to LM, and Ministero della Salute RF-2013, GR-2013-02356568 to PV. IF was funded by a CTR PhD fellowship

Taiwan and Changing Global Order: Perspectives from the 2012 Young Leaders Delegation

This special issue of the Asia Colloquia Papers examines some of the diverse issues that confront Taiwan in the context of changing global and Asia-Pacific regional order. The papers, written by senior students who participated in a May 2012 study trip to Taiwan, look at such topics as the role of education in indigenous peoples’ self-determination in Taiwan and Canada; evolving China-Taiwan relations and their multiple implications; changing migration patterns in Taiwan in the context of contemporary globalization; and new developments in Taiwan’s role as an aid donor in Africa. The students presented their papers to Taiwan audiences during a study tour as part of the Young Leaders Delegation programme sponsored by the Ministry of Foreign Affairs of Taiwan, the Republic of China. The Young Leaders Delegation programme aims to introduce senior university students from abroad to contemporary Taiwan and its complex challenges

Nickel-Catalyzed C(sp³)–H Arylation of Diarylmethane Derivatives with Aryl Fluorides

A novel nickel-catalyzed C­(sp³)–H arylation with nonactivated aryl fluorides is reported. The use of 1,3-bis­(2,4,6-trimethylphenyl)­imidazol-2-ylidene (IMes) as a ligand was found to be critical to the success of the reaction. This new method enables the synthesis of a wide range of triarylmethane derivatives