Intractable hypoglycemia in pregnancy

Insulinomas are rare tumours developed from pancreatic beta cells; 27 cases of insulinoma associated with pregnancy have been reported till date, mostly diagnosed before the 16th week. Triad of insulinoma; hypoglycemic symptoms, plasma glucose < 3.0 mmol/L, symptomatic relief with glucose administration. 28-year-old primi presented to us at 29 weeks with high BP and neuroglycopenic symptoms. Repeated episodes of loss of consciousness with hypoglycemia since 14 weeks. On evaluation diagnosed to have insulinoma and managed conservatively with dietary modifications, and medical treatment. She failed to respond and pregnancy was terminated due to high BP, hypoglycemia and Doppler changes. Delivered a stillborn girl at 31 weeks. Underwent laparotomy post-delivery for enucleation of the lesion. Quick normalization of sugar levels and overall recovery remarkable. Patient is on regular follow up. Insulinoma is a rare cause of severe repeated episodes of hypoglycemia early in pregnancy

Effect of monoclonal and Assorted Seedling Rootstocks on Long Term Growth and Yield of Hevea Clones

Seven Hevea brasiliensis clones were evaluated on two types of rootstocks, assorted seedling rootstocks (AR) and monoclonal rootstock (MR) over 19 years. Influence of rootstock on scion growth and rubber yield was assessed based on juvenile height, circumference of the main trunk (cm), number of branches, branching height and cumulative dry rubber yield (g per tree per tapping, conventionally abbreviated gt–1 t–1). Highest cumulative yield (g per tree per tapping) over the 12 years for which the trees were tapped was obtained from clone RRII 105 (MR: 1076 g per tree per tapping and AR: 497 g per tree per tapping), followed by RRII 203 (MR: 661; AR: 538), RRII 208 (MR: 477; AR: 486), RRII 118 (MR: 497; AR: 452). Gl 1 yielded the least, 219 g per tree per tapping (MR) and 378 g per tree per tapping (AR); GT1 produced 335 g per tree per tapping (MR) and 375 g per tree per tapping (AR). RRII 118 had the greatest circumference at age 19 (91.4 cm on MR) 88.8 on AR, followed by RRII 105 (MR: 87.4 cm AR: 89.2 cm) and GT 1 (MR: 88.5 cm; AR: 84.4cm). Effect of scion clone was significant (p\u3c0.01) only for trunk circumference at opening, but not for cumulative rubber yield at age 11 (4 years after opening) or cumulative rubber yield at age 19 (12 years after opening). Most importantly, rootstock and clone x rootstock interaction did not significantly affect rubber yield or tree circumference at any evaluation time. There was no evidence to suggest that growth and yield of clones was influenced significantly by rootstock typ

Biochemical characterisation of a PL24 ulvan lyase from seaweed-associated Vibrio sp. FNV38

Ulvan is a green macroalgal cell wall polysaccharide that has tremendous potential for valorisation due to its unique composition of sulphated rhamnose, glucuronic acid, iduronic acid and xylose. Several potential applications such as production of biofuels, bioplastics and other value-added products necessitate the breakdown of the polysaccharide to oligomers or monomers. Research on ulvan saccharifying enzymes has been continually increasing over the last decade, with the increasing focus on valorisation of seaweed biomass for a biobased economy. Lyases are the first of several enzymes that are involved in saccharifying the polysaccharide and several ulvan lyases have been structurally and biochemically characterised to enable their effective use in the valorisation processes. This study investigates the whole genome of Vibrio sp. FNV38, an ulvan metabolising organism and biochemical characteristics of a PL24 ulvan lyase that it possesses. The genome of Vibrio sp. FNV38 has a diverse CAZy profile with several genes involved in the metabolism of ulvan, cellulose, agar, and alginate. The enzyme exhibits optimal activity at pH 8.5 in 100 mM Tris–HCl buffer and 30 °C. However, its thermal stability is poor with significant loss of activity after 2 h of incubation at temperatures above 25 °C. Breakdown product analysis reveals that the enzyme depolymerised the polysaccharide predominantly to disaccharides and tetrasaccharides.</p

Sharing best practices through online communities of practice: a case study

<p>Abstract</p> <p>Introduction</p> <p>The USAID-funded Capacity Project established the Global Alliance for Pre-Service Education (GAPS) to provide an online forum to discuss issues related to teaching and acquiring competence in family planning, with a focus on developing countries' health related training institutions. The success of the Global Alliance for Nursing and Midwifery's ongoing web-based community of practice (CoP) provided a strong example of the successful use of this medium to reach many participants in a range of settings.</p> <p>Case description</p> <p>GAPS functioned as a moderated set of forums that were analyzed by a small group of experts in family planning and pre-service education from three organizations. The cost of the program included the effort provided by the moderators and the time to administer responses and conduct the analysis.</p> <p>Discussion and evaluation</p> <p>Family planning is still considered a minor topic in health related training institutions. Rather than focusing solely on family planning competencies, GAPS members suggested a focus on several professional competencies (e.g. communication, leadership, cultural sensitivity, teamwork and problem solving) that would enhance the resulting health care graduate's ability to operate in a complex health environment. Resources to support competency-based education in the academic setting must be sufficient and appropriately distributed. Where clinical competencies are incorporated into pre-service education, responsible faculty and preceptors must be clinically proficient. The interdisciplinary GAPS memberships allowed for a comparison and contrast of competencies, opportunities, promising practices, documents, lessons learned and key teaching strategies.</p> <p>Conclusions</p> <p>Online CoPs are a useful interface for connecting developing country experiences. From CoPs, we may uncover challenges and opportunities that are faced in the absorption of key public health competencies required for decreasing maternal mortality and morbidity. Use of the World Health Organization (WHO) Implementing Best Practices Knowledge Gateway, which requires only a low bandwidth connection, gave educators an opportunity to engage in the discussion even in the most Internet access-restricted places (e.g. Ethiopia). In order to sustain an online CoP, funds must come from an international organization (e.g. WHO regional office) or university that can program the costs long-term. Eventually, the long-term effectiveness and sustainability of GAPS rests on its transfer to the members themselves.</p

The Psy-Security-Curriculum ensemble: British Values curriculum policy in English schools

Framed as being in response to terrorist attacks and concerns about religious bias in some English schools, ‘British Values’ (BV) curriculum policy forms part of the British Government’s Counter-Terrorism and Security Act, 2015. This includes a Duty on teachers in England to actively promote British Values to deter students from radicalisation. This paper, first, traces the history of Britishness in the curriculum to reveal a prevalence of nationalistic, colonial values. Next, an ensemble of recent policies and speeches focusing on British Values is analysed, using a psycho-political approach informed by anti-colonial scholarship. Finally, we interrogate two key critiques of the British Values curriculum discourse: the universality of British Values globally, and concerns over the securitisation of education. Findings indicate that the constitution of white British supremacist subjectivities operate through curriculum as a defence mechanism against perceived threats to white privilege, by normalising a racialised state-controlled social order. The focus is on ‘British’ values, but the analytic framework and findings have wider global significance

Racialized Architectural Space: A Critical Understanding of its Production, Perception and Evaluation

Academic inquiry into the concept of space as racialized can be traced back to at least as far as the turn of the twentieth century with sociologist W. E. B. Dubois’ promulgation of the “color-line” theory. More recently, numerous postmodern scholars from a variety of fields have elucidated the various ways in which physical space (i.e., the built environment), as a social product, embodies racialized ideologies exhibited and reproduced by segregation, economics and other social practices. The dialogue on race and space has primarily been limited to the urban scales of city, neighborhood, community and street. Socio-spatial research that centers around race rarely addresses this phenomenon at the scale of architecture – the individual building or a particular development. Such a failure to critically examine the role of the architectural product in the creation and reproduction of socio-spatial and socio-racial inequality yields the field of architectural practice exempt and blameless in its tangible contribution to the psychosocial and geospatial marginalization of communities of color, as in, for example, the case of gentrification. This paper attempts to illustrate the fact that architecture, like all of the built physical environment, is not ahistorical, apolitical – and certainly not race neutral – but, as a social product, is also understood clearly within these contexts, and its psychological and social impacts and outcomes must be examined with a racially critical lens, particularly in heterogeneous urban communities

Impact of a birth training programme on knowledge and anxiety among expectant couples in a selected hospital, Bangalore

Introduction: Pregnancy and childbirth are major event which happens in the life of a woman. Fear and anxiety are very common in couples.Feelings of protectiveness towards the partner and child also can be anxiety producing for the expectant father. Each task depicts the inherent change in both structure and function of the male's family role which is influenced by society and the family unit. A birth training programme was conducted among expectant couples and assessed their knowledge and anxiety level in a selected hospital Bangalore. Methods and materials: By purposive sampling technique 20 couples were selected and allotted into experimental and control group. Knowledge and anxiety of mothers and their husbands were assessed. Findings revealed that there was a significant difference in knowledge between experimental and control group (p &lt;0.001) mothers and husbands. There was a significant difference in anxiety level between experimental and control group (p&lt;0.001) mothers and husbands. Conclusion: The study reveals that a training programme to be conducted for a couple in order to help them to manage and face the pregnancy period and labour process without anxiety and fear

Structural, Optical, and Compactness Characteristics of Nanocrystalline CaNb2O6 Synthesized through an Autoigniting Combustion Method

Nanoparticles of calcium metaniobate compound are prepared by an autoigniting combustion technique and its structural, optical, and dielectric properties are investigated. The X-ray diffraction, Fourier-transform Raman, and infrared studies reveal that calcium metaniobate possesses phase pure orthorhombic columbite structure with space group of Pbcn. The average particle size of the as-prepared nanoparticles obtained from both the Scherrer formula and transmission electron microscopy is ~37 nm. The optical band gap calculated from Tauc's Plot is 3.25 eV. Photoluminescence studies reveal that Calcium metaniobate can be used as an idealphotoluminarmaterial. The powders are pelletised and sintered at an optimized temperature of 1350∘C in a short duration of two hours, yielding a high density. The morphology of the sintered pellet is further examined using scanning electron microscopy. The dielectric constant and loss factor values measured at 5 MHz for a well-sintered Calcium metaniobate pellet are found to be 27.6 and 5.3×10−4 respectively, at room temperature