Efficacy of intranasal olopatidine hydrochloride as an add on therapy in mild to moderate allergic rhinitis

Background: Treatment with intranasal olopatidine hydrochloride spray is proposed for patients with chronic perennial and seasonal rhinitis. Hence we compared the efficacy of intranasal mometasone furoate as an add-on therapy with existing standard treatment in a randomized, open label comparative study.Methods: A prospective, randomized, single blinded, comparative study in patients with chronic perennial and seasonal rhinitis. Patients were divided into two groups to receive intranasal olopatidine therapy and intranasal saline plus existing standard treatment with levocetrizine and vitamin C orally. Improvement in symptoms like nasal obstruction, nasal discharge, sneezing, nasal itching, itching of eyes, watering of eyes were assessed by a questionnaire at 2, 4, 6 and 8 weeks and  by a reduction of  eosinophil count in blood and nasal smear examination  at baseline and 8 weeks.Results: At the end of  8 weeks the percentage reduction of nasal obstruction in  olopatidine hydrochloride  and saline were  93.1%  and  36.07% respectively, rhinorrhoea was 90.34% and 36.42%, nasal itching  was 85.76% and 41.37%  sneezing symptoms were 89.6%  and 37.86%, itching in the eyes was 94.6% and 44.05% and watering in the eyes were 87.1% in group A and 38.07% in group B. At the end of 8 weeks, there was reduction in absolute eosinophil count and it attributed to 57.5% in olopatidine hydrochloride and 11.9% in saline group and reduction in nasal smear count scoring was 60.7% and 18.2% respectively.Conclusions: Intranasal olopatidine hydrochloride is highly effective, in the treatment of allergic rhinitis

OPAC 2.0: towards the next generation of online library catalogues

While the 4th Law of S.R. Ranganathan’s Five Laws of Library Science (1931) says that: “Save the time of the reader”, it is a big question to ask whether the current Library catalogues precisely do this for its library patrons. There is a common understanding that the evolution of OPAC should be in line with the evolution of technology and its services. They have to be designed in such a way that the users should be able to find what they are looking for in a timely manner only then they will be more satisfied, and more likely to feel like their needs have been met. While it is mandatory that the OPACs should not be a complex matrix for the users, it is important that it should encompass the current trends and features of advancements. There is no doubt that Librarians are the Architects to design best next generation OPACs by amalgamating Web 2.0 tools and the social networking aspects to the traditional catalogues which offer interacting options to the patrons. This paper looks at the current trend in formulating the next generation of Online Library catalogues with glimpses of isolated experiments and improvements in the library catalogues coupled with various open source software packages for OPAC 2.0 and the benefits to the users therewith

Antibacterial and wound healing activities of melastoma malabathricum linn.

Melastoma malabathricum Linn. (Melastomataceae), locally known as senduduk putih, is a wellknown plant in Malaysian traditional medicine. On the basis of its traditional use and literature reference,this plant was selected for evaluation of its wound healing and antibacterial activities. Methanol extract of M. malabathricum was examined for its wound healing activity in the form of an ointment in two types of wound model in rats: (i) the excision wound model and (ii) the incision wound model. The methanol extract ointment produced a significant response in both of the wound types tested. The results were also comparable with the standard drug, nitrofurazone, in terms of wound contracting ability, wound closure time, tensile strength and regeneration of tissues at the wound site. Regarding antibacterial activity, M. malabathricum extract inhibited the different clinical wound isolates of S. aureus and P. aeruginosa with MIC ranging from 3.0 mg/ml for 3 of the 4 clinical strains of S. aureus to 8.0 mg/ml for all the 3 clinical strains of P. aeruginosa tested.Keywords: Melastoma malabathricum; Antibacterial; Methanol extract; Wound healing

A study to assess the effectiveness of structured teaching programme on knowledge regarding cardio pulmonary resuscitation among degree students in a selected college, Komarapalayam

An evaluative study to assess the effectiveness of structured teaching programme on knowledge regarding Cardio Pulmonary Resuscitation among degree students in selected colleges, Komarapalayam was conducted by as a partial fulfillment of the requirements for the degree of Master of Science in nursing at Anbu college of nursing, Komarapalayam affiliated to the Tamil Nadu Dr.M.G.R. Medical University, Chennai. OBJECTIVES : 1. To assess the knowledge level regarding cardio pulmonary resuscitation among degree students in selected colleges. 2. To find out the relationship between pretest and posttest knowledge score regarding CPR among degree students. 3. To find out the association between knowledge regarding cardio pulmonary resuscitation among degree students with selected socio demographic variables. HYPOTHESES : On the basis of the objectives the following hypotheses have been formulated : H1: There will be a significant difference between pretest and post test knowledge score regarding cardio pulmonary resuscitation. H2: There will be a significant association between the knowledge with selected demographic variables of the degree students (such as age, sex, religion, previous information regarding cardio pulmonary resuscitation). METHOD OF STUDY ; Conceptual framework for the study was based on the open system theory of J.W.Kenny’s. Research design used for this study was quasi experimental one group pre test and post test design. The study was conducted in Anbu Arts and Science College, Komarapalayam.. The population for this study was degree students. Purposive sampling technique was used to select the sample. Data collection tool consisted of demographic variables, questionnaire regarding Anatomy and Physiology of Heart, Cardiac arrest and CPR to assess the level of knowledge among degree students. The content validity of the tool was done by 5 experts in different fields. Reliability was obtained by Karal Pearson’s method, the score was r=0.9 which was highly reliable. Pilot study was conducted in Anbu arts and Science College (other department) to find out the feasibility of conducting the study. The collected data was tabulated, analyzed and interpreted by using descriptive and inferential statistical methods. FINDINGS : Major findings of the study were regarding the effectiveness of STP on the level of Knowledge. The obtained‘t’ value is 20.66 .Hence the null hypothesis was rejected. There was significant association was found between knowledge scores of degree students regarding Cardiopulmonary Resuscitation with their demographic variables such as Source of information (P0.05). The stated hypothesis was accepted. Based on the findings, the implication and recommendations were drawn

Acute toxicity study and antipyretic effect of the brown alga tTurbinaria conoides (J. agardh) kuetz.

The active principles of brown alga, Turbinaria conoides (J.Agardh) Kuetz. (Sargassaceae) was extracted with n-hexane, cyclohexane, methanol and ethanol-water (1:1) and investigated for acute toxicity and antipyretic activity. Phytochemical analysis of the extracts revealed the presence of steroids, flavonoids and reducing sugars. Acute toxicity study was performed in Wistar rats after administration of extracts orally. No mortality was observed up to the dose of 5g/kg for methanol and ethanol-water (1:1) extracts whereas n-hexane and cyclohexane extracts were found to be toxic at the dose levels of 1g/kg and 2 g/kg respectively. In biochemical analysis, n-hexane, cyclohexane and ethanol-water (1:1) extracts caused a significant (

ANTIMICROBIAL EVALUATION OF ETHANOLIC EXTRACT OF SELECTED SEED SHELLS

Objective: The study was undertaken to evaluate the antimicrobial activity of ethanolic extract of polyherbal seed shells. Methods: The seed of Momordica charantia, Manikara zapota, Emblica officinalis, Syzygium cumini, collected from the local market, Mathikere, Bangalore, India. Ethanolic extract was prepared from the dried seed powders using solvent 80% ethanol. Initially, antimicrobial activity of the extract was performed by agar well diffusion method against two bacterial strains (Escherichia coli, and Staphylococcus aureus) and two fungal pathogens (Aspergillus niger and Candida albicans). Results: The antimicrobial study results revealed that the test extract was strongly inhibited the growth of bacteria, whereas it was not inhibited the growth of fungal organisms used in this study. Conclusion: The results suggest that ethanolic extract of seeds possess antimicrobial properties which can be used for the treatment of infectious diseases

Functional outcome of platelet rich plasma on lateral epicondylitis of elbow

Background: The study was conducted with the aim to explore the efficacy of platelet rich plasma in sixty patients who presented to us with lateral epicondylitis of elbow where conservative management has failed.Methods: Between 2013 and 2015, 60 patients (M: F- 20: 40) with lateral epicondylitis of elbow were included. All patients presented to us with lateral epicondylitis of elbow where conservative management has failed. All patients are treated with platelet rich plasma injection. Serial follow-up were done at 1, 6 and 12 month.Results: All sixty patients had significant improvement before and after platelet rich plasma injection. The mean VAS score and the Mayo score suggests significant improvement in pain and elbow function following platelet rich plasma treatment. Conclusions: Platelet rich plasma improves pain and elbow function in patients suffering from lateral epicondylitis where conservative management has failed. Platelet rich plasma treatment may decrease the overall time for healing, and thereby decreasing the overall need for surgical intervention

PATTERN OF DRUG PRESCRIBING IN OSTEOARTHRITIS PATIENTS ATTENDING ORTHOPAEDIC OUTPATIENT DEPARTMENT OF A TERTIARY CARE HOSPITAL

Arthritis is a disease with acute or chronic inflammation of joint, often accompanied by pain, swelling and stiffness and resulting from infection or injury. Pain is the most common symptom and is accompanied by deformity or disability. There are many types of arthritis, of these osteoarthritis (OA) is a chronic,degenerative disorder of multiple aetiology, characterized by loss of articular cartilage and periarticular bone remodelling. OA causes joint pain, typically worse with weight bearing and activity, and joint stiffness even at rest. There is no permanent cure, and gradual, although slow progression is most common. Keywords: Osteoarthritis (OA), Tertiary care hospital.Â

ANTIULCER ACTIVITY OF CANAVALIA VIROSA (ROXB) W&A LEAVES IN ANIMAL MODEL

ABSTRACT Canavalia Virosa (Roxb) W&A Leaves has been widely used in Siddha system of medicine for various diseases. The powder of Kozhi Avarai Ilai Chooranam showed a significant inhibitory effect was screened at 200 mg/kg, for the in vivo antiulcer activity on chemical induced ulcer in rats. Ranitidine (60mg/kg) used as reference standard. Single dose (200 mg/kg) treatment with the siddha drug Kozhi Avarai Ilai Chooranam produced 30% antiulcer effect. The trial drug showed a significant antiulcer activity (P<0.01) and were comparable with that of standard thus validating the traditional claim of the plant