Increased Alpha-Band Power during the Retention of Shapes and Shape-Location Associations in Visual Short-Term Memory

Studies exploring the role of neural oscillations in cognition have revealed sustained increases in alpha-band (~8–14 Hz) power during the delay period of delayed-recognition short-term memory tasks. These increases have been proposed to reflect the inhibition, for example, of cortical areas representing task-irrelevant information, or of potentially interfering representations from previous trials. Another possibility, however, is that elevated delay-period alpha-band power (DPABP) reflects the selection and maintenance of information, rather than, or in addition to, the inhibition of task-irrelevant information. In the present study, we explored these possibilities using a delayed-recognition paradigm in which the presence and task relevance of shape information was systematically manipulated across trial blocks and electroencephalographic was used to measure alpha-band power. In the first trial block, participants remembered locations marked by identical black circles. The second block featured the same instructions, but locations were marked by unique shapes. The third block featured the same stimulus presentation as the second, but with pretrial instructions indicating, on a trial-by-trial basis, whether memory for shape or location was required, the other dimension being irrelevant. In the final block, participants remembered the unique pairing of shape and location for each stimulus. Results revealed minimal DPABP in each of the location-memory conditions, whether locations were marked with identical circles or with unique task-irrelevant shapes. In contrast, alpha-band power increases were observed in both the shape-memory condition, in which location was task irrelevant, and in the critical final condition, in which both shape and location were task relevant. These results provide support for the proposal that alpha-band oscillations reflect the retention of shape information and/or shape–location associations in short-term memory

Constraining warm dark matter with cosmic shear power spectra

We investigate potential constraints from cosmic shear on the dark matter particle mass, assuming all dark matter is made up of light thermal relic particles. Given the theoretical uncertainties involved in making cosmological predictions in such warm dark matter scenarios we use analytical fits to linear warm dark matter power spectra and compare (i) the halo model using a mass function evaluated from these linear power spectra and (ii) an analytical fit to the non-linear evolution of the linear power spectra. We optimistically ignore the competing effect of baryons for this work. We find approach (ii) to be conservative compared to approach (i). We evaluate cosmological constraints using these methods, marginalising over four other cosmological parameters. Using the more conservative method we find that a Euclid-like weak lensing survey together with constraints from the Planck cosmic microwave background mission primary anisotropies could achieve a lower limit on the particle mass of 2.5 keV.Comment: 26 pages, 9 figures, minor changes to match the version accepted for publication in JCA

Flowing with Time: a New Approach to Nonlinear Cosmological Perturbations

Nonlinear effects are crucial in order to compute the cosmological matter power spectrum to the accuracy required by future generation surveys. Here, a new approach is presented, in which the power spectrum, the bispectrum and higher order correlations, are obtained -- at any redshift and for any momentum scale -- by integrating a system of differential equations. The method is similar to the familiar BBGKY hierarchy. Truncating at the level of the trispectrum, the solution of the equations corresponds to the summation of an infinite class of perturbative corrections. Compared to other resummation frameworks, the scheme discussed here is particularly suited to cosmologies other than LambdaCDM, such as those based on modifications of gravity and those containing massive neutrinos. As a first application, we compute the Baryonic Acoustic Oscillation feature of the power spectrum, and compare the results with perturbation theory, the halo model, and N-body simulations. The density-velocity and velocity-velocity power spectra are also computed, showing that they are much less contaminated by nonlinearities than the density-density one. The approach can be seen as a particular formulation of the renormalization group, in which time is the flow parameter.Comment: 20 pages, 7 figures. Matches version published on JCA

Microlensing of Quasars By Stars In Their Damped Lyman alpha Absorbers

The damped Lyman alpha absorbers (DLAs) in quasar spectra are believed to be the progenitors of present-day disk galaxies. We examine the probability for microlensing of background quasars by stars in their DLAs. Microlensing by an individual star should magnify the continuum but not the broad emission lines of the quasars. Consequently, the equivalent width distribution of microlensed quasars would be distorted. We model a representative spiral galaxy as a closed system composed of a bulge, a disk, and a halo, and evolve the mass fraction of stars in the disk based on the observed metallicity of DLAs at high redshifts. The microlensing signatures are stronger if the halo of the galaxy is made of Massive Compact Halo Objects (MACHOs). In this case, the distortion imprinted by microlensing on the equivalent width distribution of quasar emission lines can be detected with high significance in a sample of about 10 DLAs with HI column densities N>10^21 cm^-2 and absorption redshifts z_abs<1. About a tenth of all quasars with DLAs (N>10^20 cm^-2) might show excess variability on timescales shorter than five years. A search for these signals would complement microlensing searches in local galaxies and calibrate the MACHO mass fraction in galactic halos at high redshifts.Comment: 25 pages, 8 figures, final version accepted for publication in Ap

Gravitational Analogues, Geometric Effects and Gravitomagnetic Charge

This essay discusses some geometric effects associated with gravitomagnetic fields and gravitomagnetic charge as well as the gravity theory of the latter. Gravitomagnetic charge is the duality of gravitoelectric charge (mass) and is therefore also termed the dual mass which represents the topological property of gravitation. The field equation of gravitomagnetic matter is suggested and a static spherically symmetric solution of this equation is offered. A possible explanation of the anomalous acceleration acting on Pioneer spacecrafts are briefly proposed.Comment: 9 pages,0 figures, Late

Imagining Sounds and Images : Decoding the Contribution of Unimodal and Transmodal Brain Regions to Semantic Retrieval in the Absence of Meaningful Input

In the absence of sensory information, we can generate meaningful images and sounds from representations in memory. However, it remains unclear which neural systems underpin this process and whether tasks requiring the top-down generation of different kinds of features recruit similar or different neural networks. We asked people to internally generate the visual and auditory features of objects, either in isolation (car, dog) or in specific and complex meaning-based contexts (car/dog race). Using an fMRI decoding approach, in conjunction with functional connectivity analysis, we examined the role of auditory/visual cortex and transmodal brain regions. Conceptual retrieval in the absence of external input recruited sensory and transmodal cortex. The response in transmodal regions-including anterior middle temporal gyrus-was of equal magnitude for visual and auditory features yet nevertheless captured modality information in the pattern of response across voxels. In contrast, sensory regions showed greater activation for modality-relevant features in imagination (even when external inputs did not differ). These data are consistent with the view that transmodal regions support internally generated experiences and that they play a role in integrating perceptual features encoded in memory

Topology of non-linear structure in the 2dF Galaxy Redshift Survey

We study the evolution of non-linear structure as a function of scale in samples from the 2dF Galaxy Redshift Survey, constituting over 221 000 galaxies at a median redshift of z=0.11. The two flux-limited galaxy samples, located near the southern galactic pole and the galactic equator, are smoothed with Gaussian filters of width ranging from 5 to 8 Mpc/h to produce a continuous galaxy density field. The topological genus statistic is used to measure the relative abundance of overdense clusters to void regions at each scale; these results are compared to the predictions of analytic theory, in the form of the genus statistic for i) the linear regime case of a Gaussian random field; and ii) a first-order perturbative expansion of the weakly non-linear evolved field. The measurements demonstrate a statistically significant detection of an asymmetry in the genus statistic between regions corresponding to low- and high-density volumes of the universe. We attribute the asymmetry to the non-linear effects of gravitational evolution and biased galaxy formation, and demonstrate that these effects evolve as a function of scale. We find that neither analytic prescription satisfactorily reproduces the measurements, though the weakly non-linear theory yields substantially better results in some cases, and we discuss the potential explanations for this result.Comment: 13 pages, matching proof to be published in MNRAS; new version adds reference and corrects figure

Propylene glycol inactivates respiratory viruses and prevents airborne transmission

Viruses are vulnerable as they transmit between hosts, and we aimed to exploit this critical window. We found that the ubiquitous, safe, inexpensive and biodegradable small molecule propylene glycol (PG) has robust virucidal activity. Propylene glycol rapidly inactivates a broad range of viruses including influenza A, SARS-CoV-2 and rotavirus and reduces disease burden in mice when administered intranasally at concentrations commonly found in nasal sprays. Most critically, vaporised PG efficiently abolishes influenza A virus and SARS-CoV-2 infectivity within airborne droplets, potently preventing infection at levels well below those tolerated by mammals. We present PG vapour as a first-in-class non-toxic airborne virucide that can prevent transmission of existing and emergent viral pathogens, with clear and immediate implications for public health

The effects of short-term, progressive exercise training on disease activity in smouldering multiple myeloma and monoclonal gammopathy of undetermined significance:a single-arm pilot study

Background: High levels of physical activity are associated with reduced risk of the blood cancer multiple myeloma (MM). MM is preceded by the asymptomatic stages of monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM) which are clinically managed by watchful waiting. A case study (N = 1) of a former elite athlete aged 44 years previously indicated that a multi-modal exercise programme reversed SMM disease activity. To build from this prior case study, the present pilot study firstly examined if short-term exercise training was feasible and safe for a group of MGUS and SMM patients, and secondly investigated the effects on MGUS/SMM disease activity. Methods: In this single-arm pilot study, N = 20 participants diagnosed with MGUS or SMM were allocated to receive a 16-week progressive exercise programme. Primary outcome measures were feasibility and safety. Secondary outcomes were pre- to post-exercise training changes to blood biomarkers of MGUS and SMM disease activity– monoclonal (M)-protein and free light chains (FLC)– plus cardiorespiratory and functional fitness, body composition, quality of life, blood immunophenotype, and blood biomarkers of inflammation. Results: Fifteen (3 MGUS and 12 SMM) participants completed the exercise programme. Adherence was 91 ± 11%. Compliance was 75 ± 25% overall, with a notable decline in compliance at intensities &gt; 70% V̇O2PEAK. There were no serious adverse events. There were no changes to M-protein (0.0 ± 1.0 g/L, P =.903), involved FLC (+ 1.8 ± 16.8 mg/L, P =.839), or FLC difference (+ 0.2 ± 15.6 mg/L, P =.946) from pre- to post-exercise training. There were pre- to post-exercise training improvements to diastolic blood pressure (− 3 ± 5 mmHg, P =.033), sit-to-stand test performance (+ 5 ± 5 repetitions, P =.002), and energy/fatigue scores (+ 10 ± 15%, P =.026). Other secondary outcomes were unchanged. Conclusions: A 16-week progressive exercise programme was feasible and safe, but did not reverse MGUS/SMM disease activity, contrasting a prior case study showing that five years of exercise training reversed SMM in a 44-year-old former athlete. Longer exercise interventions should be explored in a group of MGUS/SMM patients, with measurements of disease biomarkers, along with rates of disease progression (i.e., MGUS/SMM to MM). Registration: https://www.isrctn.com/ISRCTN65527208 (14/05/2018)