995 research outputs found
Oscillations of neutral B mesons systems
The oscillation phenomenon in the neutral B mesons systems is now well
established.
The motivations and principles of the measurements are given; then the most
recent results from the LEP experiments, the CDF collaboration at Fermilab and
the SLD collaboration at SLAC are reviewed.
The present world average of the \bd meson oscillation frequency is \dmd =
0.471 \pm 0.016 \ps and the lower limit on the \bs oscillation frequency is
\dms > 12.4 \ps at 95% CL.Comment: 9 page
Constraints on anomalous quartic gauge boson couplings from photon pair events from 189 GeV to 209 GeV
The analysis of acoplanar photon pair events with missing energy and transverse momentum measured in the ALEPH detector at centre-of-mass energies between 189 and 209 GeV, leads to constraints on anomalous quartic gauge couplings in the reaction . From 1-parameter fits, and using only the cross-section variation in the low missing mass region, the following 95 % CL constraints are obtained on the anomalous parameters and : ,
Cisternal Organization of the Endoplasmic Reticulum during Mitosis
The endoplasmic reticulum (ER) of animal cells is a single, dynamic, and continuous membrane network of interconnected cisternae and tubules spread out throughout the cytosol in direct contact with the nuclear envelope. During mitosis, the nuclear envelope undergoes a major rearrangement, as it rapidly partitions its membrane-bound contents into the ER. It is therefore of great interest to determine whether any major transformation in the architecture of the ER also occurs during cell division. We present structural evidence, from rapid, live-cell, three-dimensional imaging with confirmation from high-resolution electron microscopy tomography of samples preserved by high-pressure freezing and freeze substitution, unambiguously showing that from prometaphase to telophase of mammalian cells, most of the ER is organized as extended cisternae, with a very small fraction remaining organized as tubules. In contrast, during interphase, the ER displays the familiar reticular network of convolved cisternae linked to tubules
Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies
Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the “insulin paradox”). Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber system (GFS), a simple escape response neuronal circuit, by increasing targeting of the gap junctional protein innexin shaking-B to gap junctions (GJs). Endosomal recycling of GJs was also stimulated in cultured human cells when IIS was reduced. Furthermore, increasing the activity of the recycling small guanosine triphosphatases (GTPases) Rab4 or Rab11 was sufficient to maintain GJs upon elevated IIS in cultured human cells and in flies, and to rescue age-related loss of GJs and of GFS function. Lowered IIS thus elevates endosomal recycling of GJs in neurons and other cell types, pointing to a cellular mechanism for therapeutic intervention into aging-related neuronal disorders
Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies
Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the “insulin paradox”). Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber system (GFS), a simple escape response neuronal circuit, by increasing targeting of the gap junctional protein innexin shaking-B to gap junctions (GJs). Endosomal recycling of GJs was also stimulated in cultured human cells when IIS was reduced. Furthermore, increasing the activity of the recycling small guanosine triphosphatases (GTPases) Rab4 or Rab11 was sufficient to maintain GJs upon elevated IIS in cultured human cells and in flies, and to rescue age-related loss of GJs and of GFS function. Lowered IIS thus elevates endosomal recycling of GJs in neurons and other cell types, pointing to a cellular mechanism for therapeutic intervention into aging-related neuronal disorders
Measurement of Inverse Pion Photoproduction at Energies Spanning the N(1440) Resonance
Differential cross sections for the process pi^- p -> gamma n have been
measured at Brookhaven National Laboratory's Alternating Gradient Synchrotron
with the Crystal Ball multiphoton spectrometer. Measurements were made at 18
pion momenta from 238 to 748 MeV/c, corresponding to E_gamma for the inverse
reaction from 285 to 769 MeV. The data have been used to evaluate the gamma n
multipoles in the vicinity of the N(1440) resonance. We compare our data and
multipoles to previous determinations. A new three-parameter SAID fit yields 36
+/- 7 (GeV)^-1/2 X 10^-3 for the A^n_1/2 amplitude of the P_11.Comment: 14 pages, 8 figures, submitted to PR
Impact of insulin signaling and proteasomal activity on physiological 2 output of a neuronal circuit in aging D. melanogaster
The insulin family of growth factors plays an important role in development and function of the nervous system. Reduced insulin and insulin-growth-factor signaling (IIS), however, can improve symptoms of neurodegenerative diseases in laboratory model organisms and protect against age-associated decline in neuronal function. Recently, we showed that chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber escape response circuit. Here, we expand our initial findings by demonstrating that reduced functional output in the giant fiber system of aging flies can be prevented by increasing proteasomal activity within the circuit. Manipulations of IIS in neurons can also affect longevity, underscoring the relevance of the nervous system for aging
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