ProactiveCrowd: modeling proactive steering behaviours for agent-based crowd simulation

How to realistically model an agent's steering behavior is a critical issue in agent-based crowd simulation. In this work, we investigate some proactive steering strategies for agents to minimize potential collisions. To this end, a behavior-based modeling framework is first introduced to model the process of how humans select and execute a proactive steering strategies in crowded situations and execute the corresponding behavior accordingly. We then propose behavior models for two inter-related proactive steering behaviors, namely gap seeking and following. These behaviors can be frequently observed in real-life scenarios, and they can easily affect overall crowd dynamics. We validate our work by evaluating the simulation results of our model with the real-world data and comparing the performance of our model with that of another state-of-the-art crowd model. The results show that the performance of our model is better or at least comparable to the compared model in terms of the realism at both individual and crowd level

Automated Analysis of a Nematode Population-based Chemosensory Preference Assay

The nematode, Caenorhabditis elegans' compact nervous system of only 302 neurons underlies a diverse repertoire of behaviors. To facilitate the dissection of the neural circuits underlying these behaviors, the development of robust and reproducible behavioral assays is necessary. Previous C. elegans behavioral studies have used variations of a "drop test", a "chemotaxis assay", and a "retention assay" to investigate the response of C. elegans to soluble compounds. The method described in this article seeks to combine the complementary strengths of the three aforementioned assays. Briefly, a small circle in the middle of each assay plate is divided into four quadrants with the control and experimental solutions alternately placed. After the addition of the worms, the assay plates are loaded into a behavior chamber where microscope cameras record the worms' encounters with the treated regions. Automated video analysis is then performed and a preference index (PI) value for each video is generated. The video acquisition and automated analysis features of this method minimizes the experimenter's involvement and any associated errors. Furthermore, minute amounts of the experimental compound are used per assay and the behavior chamber's multi-camera setup increases experimental throughput. This method is particularly useful for conducting behavioral screens of genetic mutants and novel chemical compounds. However, this method is not appropriate for studying stimulus gradient navigation due to the close proximity of the control and experimental solution regions. It should also not be used when only a small population of worms is available. While suitable for assaying responses only to soluble compounds in its current form, this method can be easily modified to accommodate multimodal sensory interaction and optogenetic studies. This method can also be adapted to assay the chemosensory responses of other nematode species

Analysis of RTN signals in Resistive-Switching RAM device and its correlation with device operations

Filament rupture/restoration induced by movement of defects, e.g. oxygen ions/vacancies, is considered as the switching mechanism in HfO2 RRAM. However, details of filament alteration during switching are still speculative, due to the limitations of existing experiment-based probing techniques, impeding its understanding. In this work, for the first time, an RTN-based defect tracking technique is developed for RRAM devices, which can monitor the movements of defects and statistically provide their spatial and energy profiles. The critical filament region is experimentally identified and its alteration is observed and correlated with switching operations under various operation conditions. This provides a useful tool for further development of RRAM technology

The SHER-HIAF Ring Lattice Design

Super Heavy Experimental Ring (SHER) is one of the rings of the next accelerator complex High Intensity Heavy Ion Accelerator Facility (HIAF) at IMP[4]. Here, present ideas of the lattice design for the operation of the large acceptance ring are presented. The SHER ring has to be optimized for e-cooling and the lattice is designed for different modes. First of all, it is designed in the so called isochronous mode as time-of-flight mass spectrometer for short-lived secondary nuclei. Secondly, SHER can also be used to be a storage ring for collecting and cooling the secondary rare isotope beams from the transport line. In order to fulfil it's purpose, the ion optics can be set to different ion optical modes

Magnetic field calculation for a 13 MeV PET cyclotron

A design study of the main magnet for a 13 MeV cyclotron has been carried out in a joint collaboration between the Korea Cancer Center Hospital (KCCH) and POSTECH. A maximum energy of 13 MeV has been chosen to produce radioisotopes such as /sup 18/F. There are four magnet sectors, each with radial-ridged shape. Maximum magnetic fields are 1.85 T and 0.48 T at hill and valley centers, respectively. The total size of the cyclotron is less than 2 m in diameter. The program TOSCA has been utilized for the field calculation and optimization. In this paper, we describe design parameters of the 13 MeV PET cyclotron, with emphasis on the magnetic field shape and the beam optics calculation. (3 refs)

The activation energy for GaAs/AlGaAs interdiffusion

Copyright 1997 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. This article appeared in Journal of Applied Physics 82, 4842 (1997) and may be found at

A new analytical method for stability analysis of rock blocks with basal erosion in sub-horizontal strata by considering the eccentricity effect

The basal cavity of a rock block formed due to differential weathering is an important predisposing factor for rockfall in hard–soft interbedded rocks, which induces an eccentricity situation at the base of the rock block. Rock block falling due to the non-uniform distribution with the failure modes of toppling or sliding is defined as biased rockfall in this study. Taking into account the non-uniform stress distribution due to the eccentricity effect, a new analytical method is proposed for three-dimensional stability analysis of biased rockfall. The development of non-uniform stress distribution stress calculated by this analytical method was verified by numerical simulation. The biased rockfall progresses from partial damage of the soft underlying layer, caused by non-uniform distributed stress, to toppling and sliding of overhanging hard rock block due to overall unbalanced force. Therefore, a set of factors of safety (Fos's) against partial damage (compressive and tensile damage of the soft underlying layer) and overall failure (toppling and sliding of the hard rock block) are used to determine the rockfall susceptibility level. The analytical method is applied and validated using biased rockfalls on the northeastern edge of the Sichuan Basin in southwest China, where a significant number of rockfalls consisting of overhanging thick sandstone and underlying mudstone occur. The evolution process of biased rockfalls is divided into four stages, initial state, basal cavity formation, partially unstable and failure. The proposed method is validated by calculating Fos's of the typical unstable rock blocks in the study area. As the cavity continues to grow, the continuous retreat of mudstone causes stress redistribution between the hard and soft rock layers. This results in damage to the underlying soft rock layer due to the development of the non-uniform distribution, ultimately leading to the failure of the hard rock block. The critical retreat ratio is determined to be 0.33, which is used to classify the low and moderate rockfall susceptibility in the eastern Sichuan Basin. The proposed analytical method provides insights into the evolution of biased rockfall and a means for early identification and susceptibility assessment of rockfall.</p

Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats

Adult spinal motoneurons can regenerate their axons into a peripheral nerve (PN) graft following root avulsion injury if the graft is implanted immediately after the lesion is induced. The present study was designed to determine how avulsed motoneurons respond to a PN graft if implantation takes place a few days to a few weeks later. Survival, regeneration, and gene expression changes of injured motoneurons after delayed PN graft implantation were studied. The survival rates of spinal motoneurons were 78%, 65%, 57%, or 53% if a PN graft was implanted immediately, 1, 2, or 3 weeks after root avulsion, respectively. Interestingly, most of the surviving motoneurons were able to regenerate their axons into the graft regardless of the delay. All regenerating motoneurons expressed p75, but not nNOS, while all motoneurons that failed to regenerate expressed nNOS, but not p75. p75 and nNOS may, therefore, be used as markers for success or failure to regenerate axons. In the group with immediate graft implantation, 85% of the surviving motoneurons extended axons into the PN graft, while in the groups in which implantation was delayed 1, 2, or 3 weeks, 84%, 82%, and 83% of the surviving motoneurons, respectively, were found to have regenerated into the grafts. These findings indicate that avulsed spinal motoneurons retain the ability to regenerate for at least 3 weeks, and perhaps for as long as they survive. Therefore, the delayed implantation of a PN graft after root avulsion may provide a continued conducive environment to support regeneration.published_or_final_versio

Functional protease-activated receptors in the dorsal motor nucleus of the vagus

Protease-activated receptors (PARs), a family member of G-protein coupled receptors, are present and functionally active in a wide variety of cells. The object of this study was to demonstrate the presence and function of PAR-1 and PAR-2 in the dorsal motor nucleus of the vagus (DMV).DMNV neurons were isolated from neonatal rat brainstems using micro-dissection and enzymatic digestion. Neurons were cultured in Neurobasal medium A containing 2% B27 supplement. Intracellular calcium concentration ([Ca 2 +  ] i ) was measured using fura-2 based microspectrometry. Expression of PARs was detected by RT-PCR and immunofluorescent staining.Thrombin and PAR-1 agonist peptide activate PAR-1 with a maximum change in [Ca 2 +  ] i expressed as δF/F0 of 229 ± 14% and 137 ± 7%, respectively. Trypsin and PAR-2 agonist peptide activate PAR-2 with a maximum δF/F0 change of 258 ± 12% and 242 ± 10%, respectively. Inhibition of phospholipase C (PLC) by U73312 (1 μm) decreased the maximal change in δF/F0 induced by PAR-1 activation from 140 ± 17% to 21 ± 3%, while the PAR-2-mediated maximal change in δF/F0 decreased from 185 ± 21% to 19 ± 6%. Blockade of IP3 receptor with 2APB inhibited the maximal change in δF/F0 due to PAR-1 and PAR-2 activation by 72 ± 13% and 71 ± 20% respectively. PAR-1 immnuoreactivity was present in DMV neurons. Increase in transcripts for PAR-1 and PAR-2 were detected in DMV tissues derived from IBD rats relative to control animals. Our results indicate that PAR-1 and PAR-2 are present in the DMV neurons, and their activation leads to increases in intracellular calcium via signal transduction mechanism that involves activation of PLC and the production of IP3.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79371/1/j.1365-2982.2009.01391.x.pd