A Computational Investigation of Cardiac Caveolae as a Source of Persistent Sodium Current

Recent studies of cholesterol-rich membrane microdomains, called caveolae, reveal that caveolae are reservoirs of “recruitable” sodium ion channels. Caveolar channels constitute a substantial and previously unrecognized source of sodium current in cardiac cells. In this paper we model for the first time caveolar sodium currents and their contributions to cardiac action potential morphology. We show that the β-agonist-induced opening of caveolae may have substantial impacts on peak overshoot, maximum upstroke velocity, and ultimately conduction velocity. Additionally, we show that prolonged action potentials and the formation of potentially arrhythmogenic afterdepolarizations, can arise if caveolae open intermittently throughout the action potential. Our simulations suggest that caveolar sodium current may constitute a route, which is independent of channelopathies, to delayed repolarization and the arrhythmias associated with such delays

Multivariate assessments of activity-related skeletal changes: Interpreting Bell Beaker specialized male archery and social organization in Central Europe

Objectives The Bell Beaker period witnessed the rise of individual inhumations with “wealthy” burial contexts containing archery-related grave goods, leading archaeologists to label the individuals in these tombs as “archers.” This study looks to (1) compare the skeletons from male “archer” burials with those from male “non-archer” burials—those not having archery-related grave goods—in order to assess a possible link between burial context and physical activity, and (2) apply a biomechanics profile to evaluate whether the individuals associated with these “archer” burials practiced specialized archer activity. Materials and Methods The corpus (males only) included 46 “archers” and 40 “non-archers” from Bell Beaker individual inhumations. Osteological data included measurements, scores of entheseal changes, and a diagnosis of certain pathologies. Data analyses involved visual observations, hypothesis tests, dimension reduction, and MANOVA, with approaches aimed at exploring the treatment of data missingness. Results Measurement data revealed no differences between the two groups. Evaluations of entheseal changes found that “non-archers” had consistently more instances of bone surface modifications than “archers.” Individual assessments of specialized archer occupation identified 11 possible specialized archers. Discussion These findings indicate a possible labor differentiation represented through the presence of a probably prestigious “archer” burial context. This suggests a link between grave good presence and labor, but not between a Bell Beaker archery occupation and an “archer” burial context. Data analyses support the application of biomechanics to osteological analyses in order to assess specialized activity on the skeleton

Scarf osteotomy versus metatarsophalangeal arthrodesis in forefoot first ray disorders: Comparison of functional outcomes

SummaryIntroductionScarf osteotomies of the first metatarsal and metatarsophalangeal arthrodesis are the two most frequent surgical forefoot reconstructive procedures.HypothesisWe compared functional results of isolated arthrodesis of the first metatarsophalangeal joint with an isolated Scarf osteotomy of the first metatarsal.Materials and methodsThis was a retrospective, observational, continuous study of patients operated between 1993 and 2008. After patients who had undergone a procedure on the lateral rays, extremely elderly patients, lost to follow-up patients and those with incomplete questionnaires had been excluded, there remained two comparable groups of 25 patients. Mean age was 60 in the arthrodesis group [41–70] and 59.8 in the Scarf group [47–71]. The Scarf group included 25 hallux valgus (100%) compared to 16 hallux valgus (64%) and nine hallux rigidus (36%) in the arthrodesis group. Complications were recorded. Evaluation of functional results was based on the most recent functional or quality of life scores (AOFAS, FFI, FAAM, SF 36) and a questionnaire on physical and athletic ability.ResultsThere was no significant difference in the rate of complications between the two groups. There was no difference in pain according to the AOFAS score with 35.6/40 (±6.5) in the Scarf group and 34.5 (±5.9) in the arthrodesis group. Global satisfaction was also similar between the Scarf and arthrodesis groups: 91.4% and 90% of very satisfied or satisfied patients, respectively. The FFI score was higher in the Scarf group than in the arthrodesis group: 8.6 (±20.1) and 19.8 (±17.7) respectively. Functional results were better in the Scarf group than in the arthrodesis group with a FAAM Daily Activity score of 80.2 (±12.1) compared to 68 (±7.2), a FAAM Sports Activity score of 29.7 (±6.7) compared to 25.2 (±7.6) and a FAAM Global Function score of 94% (±10.8) compared to 87% (±15.7), respectively. The Global SF36 score was higher in the Scarf group than in the arthrodesis group: 70.9% (±14.1) and 62.3% (±20.6) respectively, which was due to a higher Mental Health score in the Scarf group: 68.7% (±14.2) and 60.4% (±19.3) respectively. In the area of sports activities the Scarf group practiced more hiking than the arthrodesis group (74% versus 42% respectively). There was no difference for other activities.Discussion and conclusionThis study provides detailed information on the level of physical and sports activities that are practiced following these procedures, so that the patient can be better informed.Level of evidenceLevel III. Comparative retrospective

Stability of Horava-Lifshitz Black Holes in the Context of AdS/CFT

The anti--de Sitter/conformal field theory (AdS/CFT) correspondence is a powerful tool that promises to provide new insights toward a full understanding of field theories under extreme conditions, including but not limited to quark-gluon plasma, Fermi liquid and superconductor. In many such applications, one typically models the field theory with asymptotically AdS black holes. These black holes are subjected to stringy effects that might render them unstable. Ho\v{r}ava-Lifshitz gravity, in which space and time undergo different transformations, has attracted attentions due to its power-counting renormalizability. In terms of AdS/CFT correspondence, Ho\v{r}ava-Lifshitz black holes might be useful to model holographic superconductors with Lifshitz scaling symmetry. It is thus interesting to study the stringy stability of Ho\v{r}ava-Lifshitz black holes in the context of AdS/CFT. We find that uncharged topological black holes in $\lambda=1$ Ho\v{r}ava-Lifshitz theory are nonperturbatively stable, unlike their counterparts in Einstein gravity, with the possible exceptions of negatively curved black holes with detailed balance parameter $\epsilon$ close to unity. Sufficiently charged flat black holes for $\epsilon$ close to unity, and sufficiently charged positively curved black holes with $\epsilon$ close to zero, are also unstable. The implication to the Ho\v{r}ava-Lifshitz holographic superconductor is discussed.Comment: 15 pages, 6 figures. Updated version accepted by Phys. Rev. D, with corrections to various misprints. References update

A teleparallel model for the neutrino

The main result of the paper is a new representation for the Weyl Lagrangian (massless Dirac Lagrangian). As the dynamical variable we use the coframe, i.e. an orthonormal tetrad of covector fields. We write down a simple Lagrangian - wedge product of axial torsion with a lightlike element of the coframe - and show that variation of the resulting action with respect to the coframe produces the Weyl equation. The advantage of our approach is that it does not require the use of spinors, Pauli matrices or covariant differentiation. The only geometric concepts we use are those of a metric, differential form, wedge product and exterior derivative. Our result assigns a variational meaning to the tetrad representation of the Weyl equation suggested by J.B.Griffiths and R.A.Newing.Comment: 4 pages, REVTe

Complete Calabi-Yau metrics from Kahler metrics in D=4

In the present work the local form of certain Calabi-Yau metrics possessing a local Hamiltonian Killing vector is described in terms of a single non linear equation. The main assumptions are that the complex $(3,0)$-form is of the form $e^{ik}\widetilde{\Psi}$, where $\widetilde{\Psi}$ is preserved by the Killing vector, and that the space of the orbits of the Killing vector is, for fixed value of the momentum map coordinate, a complex 4-manifold, in such a way that the complex structure of the 4-manifold is part of the complex structure of the complex 3-fold. The link with the solution generating techniques of [26]-[28] is made explicit and in particular an example with holonomy exactly SU(3) is found by use of the linearization of [26], which was found in the context of D6 branes wrapping a holomorphic 1-fold in a hyperkahler manifold. But the main improvement of the present method, unlike the ones presented in [26]-[28], does not rely in an initial hyperkahler structure. Additionally the complications when dealing with non linear operators over the curved hyperkahler space are avoided by use of this method.Comment: Version accepted for publication in Phys.Rev.

Semi-classical stability of AdS NUT instantons

The semi-classical stability of several AdS NUT instantons is studied. Throughout, the notion of stability is that of stability at the one-loop level of Euclidean Quantum Gravity. Instabilities manifest themselves as negative eigenmodes of a modified Lichnerowicz Laplacian acting on the transverse traceless perturbations. An instability is found for one branch of the AdS-Taub-Bolt family of metrics and it is argued that the other branch is stable. It is also argued that the AdS-Taub-NUT family of metrics are stable. A component of the continuous spectrum of the modified Lichnerowicz operator on all three families of metrics is found.Comment: 18 pages, 3 figures; references adde

Remarks on evolution of space-times in 3+1 and 4+1 dimensions

A large class of vacuum space-times is constructed in dimension 4+1 from hyperboloidal initial data sets which are not small perturbations of empty space data. These space-times are future geodesically complete, smooth up to their future null infinity, and extend as vacuum space-times through their Cauchy horizon. Dimensional reduction gives non-vacuum space-times with the same properties in 3+1 dimensions.Comment: 10pp, exposition improved; final versio

Near-Constant Mean Curvature Solutions of the Einstein Constraint Equations with Non-Negative Yamabe Metrics

We show that sets of conformal data on closed manifolds with the metric in the positive or zero Yamabe class, and with the gradient of the mean curvature function sufficiently small, are mapped to solutions of the Einstein constraint equations. This result extends previous work which required the conformal metric to be in the negative Yamabe class, and required the mean curvature function to be nonzero.Comment: 15 page