129 research outputs found
M1 Resonances in Unstable Magic Nuclei
Within a microscopic approach which takes into account RPA configurations,
the single-particle continuum and more complex
configurations isoscalar and isovector M1 excitations for the unstable nuclei
Ni and Sn are calculated. For comparison, the
experimentally known M1 excitations in Ca and Pb have also been
calculated. In the latter nuclei good agreement in the centroid energy, the
total transition strength and the resonance width is obtained. With the same
parameters we predict the magnetic excitations for the unstable nuclei. The
strength is sufficiently concentrated to be measurable in radioactive beam
experiments. New features are found for the very neutron rich nucleus Ni
and the neutron deficient nucleus Sn.Comment: 17 pages (LATEX), 12 figures (available from the authors),
KFA-IKP(TH)-1993-0
A liquid Xenon Positron Emission Tomograph for small animal imaging : first experimental results of a prototype cell
A detector using liquid Xenon (LXe) in the scintillation mode is studied for
Positron Emission Tomography (PET) of small animals. Its specific design aims
at taking full advantage of the Liquid Xenon scintillation properties. This
paper reports on energy, time and spatial resolution capabilities of the first
LXe prototype module equipped with a Position Sensitive Photo- Multiplier tube
(PSPMT) operating in the VUV range (178 nm) and at 165 K. The experimental
results show that such a LXe PET configuration might be a promising solution
insensitive to any parallax effect.Comment: 34 pages, 18 pages, to appear in NIM
Anosov representations: Domains of discontinuity and applications
The notion of Anosov representations has been introduced by Labourie in his
study of the Hitchin component for SL(n,R). Subsequently, Anosov
representations have been studied mainly for surface groups, in particular in
the context of higher Teichmueller spaces, and for lattices in SO(1,n). In this
article we extend the notion of Anosov representations to representations of
arbitrary word hyperbolic groups and start the systematic study of their
geometric properties. In particular, given an Anosov representation of
into G we explicitly construct open subsets of compact G-spaces, on which
acts properly discontinuously and with compact quotient.
As a consequence we show that higher Teichmueller spaces parametrize locally
homogeneous geometric structures on compact manifolds. We also obtain
applications regarding (non-standard) compact Clifford-Klein forms and
compactifications of locally symmetric spaces of infinite volume.Comment: 63 pages, accepted for publication in Inventiones Mathematica
Metabolism of no-carrier-added 2-[18F]fluoro-L-tyrosine in rats
Background: Several fluorine-18 labelled fluoroamino acids have been evaluated as tracers for the quantitative assessment of cerebral protein synthesis in vivo by positron emission tomography (PET). Among these, 2-[18F]fluoro-L-tyrosine (2-[18F]Tyr) has been studied in mice at a low specific activity. Its incorporation into proteins is fast and metabolism via other pathways is limited. The present in vivo study was carried out in normal awake rats using no-carrier-added 2-[18F]Tyr. Under normal physiological conditions, we have studied the incorporation into proteins and the metabolism of the tracer in different brain areas.
Methods: No-carrier-added 2-[18F]Tyr was administered to awake rats equipped with chronic
arterial and venous catheters. The time course of the plasma activity was studied by arterial blood sampling. The biodistribution of the activity in the main organs was studied at the end of the
experiment. The distribution of radioactive species in plasma and brain regions was studied by
acidic precipitation of the proteins and HPLC analysis of the supernatant.
Results: The absolute uptake of radioactivity in brain regions was homogenous. In awake rats, nocarrier-added 2-[18F]Tyr exhibits a fast and almost quantitative incorporation into the proteins
fractions of cerebellum and cortex. In striatum, this incorporation into proteins and the unchanged
fraction of the tracer detected by HPLC could be lower than in other brain regions.
Conclusion: This study confirms the potential of 2-[18F]fluoro-L-tyrosine as a tracer for the
assessment of the rate of protein synthesis by positron emission tomography. The observed
metabolism suggests a need for a correction for the appearance of metabolites, at least in plasma
Comparative methods for PET image segmentation in pharyngolaryngeal squamous cell carcinoma
Several methods have been proposed for the segmentation of ¹⁸F-FDG uptake in PET. In this study, we assessed the performance of four categories of ¹⁸F-FDG PET image segmentation techniques in pharyngolaryngeal squamous cell carcinoma using clinical studies where the surgical specimen served as the benchmark
68Ga-Chloride PET Reveals Human Pancreatic Adenocarcinoma Xenografts in Rats—Comparison with FDG
Switching on the Lights for Gene Therapy
Strategies for non-invasive and quantitative imaging of gene expression in vivo have been developed over the past decade. Non-invasive assessment of the dynamics of gene regulation is of interest for the detection of endogenous disease-specific biological alterations (e.g., signal transduction) and for monitoring the induction and regulation of therapeutic genes (e.g., gene therapy). To demonstrate that non-invasive imaging of regulated expression of any type of gene after in vivo transduction by versatile vectors is feasible, we generated regulatable herpes simplex virus type 1 (HSV-1) amplicon vectors carrying hormone (mifepristone) or antibiotic (tetracycline) regulated promoters driving the proportional co-expression of two marker genes. Regulated gene expression was monitored by fluorescence microscopy in culture and by positron emission tomography (PET) or bioluminescence (BLI) in vivo. The induction levels evaluated in glioma models varied depending on the dose of inductor. With fluorescence microscopy and BLI being the tools for assessing gene expression in culture and animal models, and with PET being the technology for possible application in humans, the generated vectors may serve to non-invasively monitor the dynamics of any gene of interest which is proportionally co-expressed with the respective imaging marker gene in research applications aiming towards translation into clinical application
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Limits of geometries
A geometric transition is a continuous path of geometric structures that changes type, meaning that the model geometry, i.e., the homogeneous space on which the structures are modeled, abruptly changes. In order to rigorously study transitions, one must define a notion of geometric limit at the level of homogeneous spaces, describing the basic process by which one homogeneous geometry may transform into another. We develop a general framework to describe transitions in the context that both geometries involved are represented as sub-geometries of a larger ambient geometry. Specializing to the setting of real projective geometry, we classify the geometric limits of any sub-geometry whose structure group is a symmetric subgroup of the projective general linear group. As an application, we classify all limits of three-dimensional hyperbolic geometry inside of projective geometry, finding Euclidean, Nil, and Sol geometry among the limits. We prove, however, that the other Thurston geometries, in particular ℍ2 × ℝ and SL2ℝ, do not embed in any limit of hyperbolic geometry in this sense
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