96 research outputs found
Effects of a modified muscle sparing posterior technique in hip hemiarthroplasty for displaced intracapsular fractures on postoperative function compared to a standard lateral approach (HemiSPAIRE): protocol for a randomised controlled trial
This is the final version. Available on open access from BMJ publishing via the DOI in this recordIntroduction Currently National Institute for Health and Care Excellence clinical guidelines in the UK suggest that surgeons performing partial hip replacements (hemiarthroplasty) should consider using the lateral approach. Alternatively, a newer, modified posterior approach using a muscle sparing technique named âSave Piriformis and Internus, Repairing Externusâ (SPAIRE) can be used leaving the major muscles intact. This randomised controlled trial (RCT) aims to compare the SPAIRE approach to the standard lateral approach, to determine if it allows patients to mobilise better and experience improved function after surgery.
Methods and analysis HemiSPAIRE is a two-arm, assessor-blinded, definitive pragmatic RCT with nested pilot and qualitative studies. Two hundred and twenty-eight participants with displaced intracapsular fractures requiring hip hemiarthroplasty will be individually randomised 1:1 to either the SPAIRE, or control (standard lateral approach) surgical procedure. Outcomes will be assessed at postoperative day 3 (POD3) and 120 (POD120). The primary outcome measure will be level of function and mobility using the Oxford Hip Score at POD120. Secondary outcomes include: De Morton Mobility Index (DEMMI), Cumulated Ambulatory Score and Numeric Pain Rating Scale (NPRS) at POD3; DEMMI, NPRS and EQ-5D-5L at POD120, complications, acute and total length of hospital stay, and mortality. Primary analysis will be on an intention-to-treat basis. Participant experiences of the impact of surgery and recovery period will be examined via up to 20 semi-structured telephone interviews.
Ethics and dissemination The protocol has been approved by Yorkshire and the HumberâBradford Leeds Research Ethics Committee. Recruitment commenced in November 2019. Findings will be disseminated via research articles in peer-reviewed journals, presentations at conferences, public involvement events, patient groups and media releases. A summary of the trial findings will be shared with participants at the end of the study.
Trial registration number NCT04095611.National Institute for Health Research (NIHR
Public health campaigns and obesity - a critique
<p>Abstract</p> <p>Background</p> <p>Controlling obesity has become one of the highest priorities for public health practitioners in developed countries. In the absence of safe, effective and widely accessible high-risk approaches (e.g. drugs and surgery) attention has focussed on community-based approaches and social marketing campaigns as the most appropriate form of intervention. However there is limited evidence in support of substantial effectiveness of such interventions.</p> <p>Discussion</p> <p>To date there is little evidence that community-based interventions and social marketing campaigns specifically targeting obesity provide substantial or lasting benefit. Concerns have been raised about potential negative effects created by a focus of these interventions on body shape and size, and of the associated media targeting of obesity.</p> <p>Summary</p> <p>A more appropriate strategy would be to enact high-level policy and legislative changes to alter the obesogenic environments in which we live by providing incentives for healthy eating and increased levels of physical activity. Research is also needed to improve treatments available for individuals already obese.</p
Studies on some fish parasites of public health importance in the southern area of Saudi Arabia
Unravelling polar lipids dynamics during embryonic development of two sympatric brachyuran crabs (Carcinus maenas and Necora puber) using lipidomics
Embryogenesis is an important stage of marine invertebrates with bi-phasic life cycles, as it
conditions their larval and adult life. Throughout embryogenesis, phospholipids (PL) play a key role
as an energy source, as well as constituents of biological membranes. However, the dynamics of
PL during embryogenesis in marine invertebrates is still poorly studied. The present work used a
lipidomic approach to determine how polar lipid profiles shift during embryogenesis in two sympatric
estuarine crabs, Carcinus maenas and Necora puber. The combination of thin layer chromatography,
liquid chromatography â mass spectrometry and gas chromatography â mass spectrometry allowed
us to achieve an unprecedented resolution on PL classes and molecular species present on newly
extruded embryos (stage 1) and those near hatching (stage 3). Embryogenesis proved to be a
dynamic process, with four PL classes being recorded in stage 1 embryos (68 molecular species in
total) and seven PL classes at stage 3 embryos (98 molecular species in total). The low interspecific
difference recorded in the lipidomic profiles of stage 1 embryos appears to indicate the existence of
similar maternal investment. The same pattern was recorded for stage 3 embryos revealing a similar
catabolism of embryonic resources during incubation for both crab species
Chronic effects of nitrogenous compounds on survival and growth of juvenile pink shrimp
TOWARDS AN ACCOUNTABLE AND QUALITY PUBLIC ADMINISTRATION IN HONG KONG: REDRESSING ADMINISTRATIVE GRIEVANCES THROUGH THE OMBUDSMAN
Privacy interests in biobanking : a preliminary view on a European perspective
Rapid technological advances, the establishment of large-scale biobanks, and the exchange of data across international boundaries raise a variety of questions for regulators struggling with the problem of how to govern such stores of information and the processes connected with them. Engaging with the pressing issues of privacy, consent, access to data, and benefit sharing, "Principles and Practice in Biobank Governance" draws together the latest empirical research from the UK, Europe, America, Australia and Asia to focus on these challenges. Current models of governance are critiqued, principles and policies are debated, and new models and theoretical frameworks are presented through this intellectually stimulating, informative volume. This truly international volume offers new insights from a range of disciplinary perspectives and will be essential reading for policy makers and scholars across a range of social sciences, including sociology, bioethics, law and social policy
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