Novel Chalcone-Based Fluorescent Human Histamine H3 Receptor Ligands as Pharmacological Tools

Novel fluorescent chalcone-based ligands at human histamine H3 receptors (hH3R) have been designed, synthesized, and characterized. Compounds described are non-imidazole analogs of ciproxifan with a tetralone motif. Tetralones as chemical precursors and related fluorescent chalcones exhibit affinities at hH3R in the same concentration range like the reference antagonist ciproxifan (hH3R pKi value of 7.2). Fluorescence characterization of our novel ligands shows emission maxima about 570 nm for yellow fluorescent chalcones and ≥600 nm for the red fluorescent derivatives. Interferences to cellular autofluorescence could be excluded. All synthesized chalcone compounds could be used to visualize hH3R proteins in stably transfected HEK-293 cells using confocal laser scanning fluorescence microscopy. These novel fluorescent ligands possess high potential to be used as pharmacological tools for hH3R visualization in different tissues

The Effect of Surfaces on the Tunneling Density of States of an Anisotropically Paired Superconductor

We present calculations of the tunneling density of states in an anisotropically paired superconductor for two different sample geometries: a semi-infinite system with a single specular wall, and a slab of finite thickness and infinite lateral extent. In both cases we are interested in the effects of surface pair breaking on the tunneling spectrum. We take the stable bulk phase to be of $d_{x^2-y^2}$ symmetry. Our calculations are performed within two different band structure environments: an isotropic cylindrical Fermi surface with a bulk order parameter of the form $\Delta\sim k_x^2-k_y^2$, and a nontrivial tight-binding Fermi surface with the order parameter structure coming from an anti-ferromagnetic spin-fluctuation model. In each case we find additional structures in the energy spectrum coming from the surface layer. These structures are sensitive to the orientation of the surface with respect to the crystal lattice, and have their origins in the detailed form of the momentum and spatial dependence of the order parameter. By means of tunneling spectroscopy, one can obtain information on both the anisotropy of the energy gap, |\Delta(\p)|, as well as on the phase of the order parameter, \Delta(\p) = |\Delta(\p)|e^{i\varphi(\p)}.Comment: 14 pages of revtex text with 11 compressed and encoded figures. To appear in J. Low Temp. Phys., December, 199

The wave-vector power spectrum of the local tunnelling density of states: ripples in a d-wave sea

A weak scattering potential imposed on a $CuO_2$ layer of a cuprate superconductor modulates the local density of states $N(x,\omega)$. In recently reported experimental studies scanning-tunneling maps of $N(x,\omega)$ have been Fourier transformed to obtain a wave-vector power spectrum. Here, for the case of a weak scattering potential, we discuss the structure of this power spectrum and its relationship to the quasi-particle spectrum and the structure factor of the scattering potential. Examples of quasi-particle interferences in normal metals and $s$- and d-wave superconductors are discussed.Comment: 22 pages, 21 figures; enlarged discussion of the d-wave response, to be published in Physical Review

Figure drawing

Call number: LD2668 .T4 1956 T6

Andreev Reflection In Ferromagnet-Superconductor Junctions

The transport properties of a ferromagnet-superconductor (FS) junction are studied in a scattering formulation. Andreev reflection at the FS interface is strongly affected by the exchange interaction in the ferromagnet. The conductance G_FS of a ballistic point contact between F and S can be both larger or smaller than the value G_FN with the superconductor in the normal state, depending on the ratio of the exchange and Fermi energies. If the ferromagnet contains a tunnel barrier (I), the conductance G_FIFS exhibits resonances which do not vanish in linear response -- in contrast to the Tomasch oscillations for non-ferromagnetic materials.Comment: 8 pages, RevTeX v3.0, including 3 encapsulated postscript figures; [2017: figures included in text

Fatal affairs - conjugational transfer of a dinoflagellate-killing plasmid between marine Rhodobacterales

The roseobacter group of marine bacteria is characterized by a mosaic distribution of ecologically important phenotypes. These are often encoded on mobile extrachromosomal replicons. So far, conjugation had only been experimentally proven between the two model organisms Phaeobacter inhibens and Dinoroseobacter shibae. Here, we show that two large natural RepABC-type plasmids from D. shibae can be transferred into representatives of all known major Rhodobacterales lineages. Complete genome sequencing of the newly established Phaeobacter inhibens transconjugants confirmed their genomic integrity. The conjugated plasmids were stably maintained as single copy number replicons in the genuine as well as the new host. Co-cultivation of Phaeobacter inhibens and the transconjugants with the dinoflagellate Prorocentrum minimum demonstrated that Phaeobacter inhibens is a probiotic strain that improves the yield and stability of the dinoflagellate culture. The transconjugant carrying the 191 kb plasmid, but not the 126 kb sister plasmid, killed the dinoflagellate in co-culture

New Measurement of the Cosmic-Ray Positron Fraction from 5 to 15 GeV

We present a new measurement of the cosmic-ray positron fraction at energies between 5 and 15 GeV with the balloon-borne HEAT-pbar instrument in the spring of 2000. The data presented here are compatible with our previous measurements, obtained with a different instrument. The combined data from the three HEAT flights indicate a small positron flux of non-standard origin above 5 GeV. We compare the new measurement with earlier data obtained with the HEAT-e+- instrument, during the opposite epoch of the solar cycle, and conclude that our measurements do not support predictions of charge sign dependent solar modulation of the positron abundance at 5 GeV.Comment: accepted for publication in PR

Are There Any Significant Differences in Terms of Age and Sex in Pedestrian and Cyclist Accidents?

This study has analyzed sex-specific differences in pedestrian and cyclist accidents involving passenger cars. The most frequently injured body regions, types of injuries, which show sex-specific differences and the general accident parameters of females and males were compared. Accident data from three different European countries (Austria, Netherlands, Sweden) were analyzed. The current analysis shows that for both, females and males, pedestrian and cyclist injuries are sustained mainly to the body regions head, thorax, upper extremities and lower extremities. The results show that the odds for sustaining skeletal injuries to the lower extremities (incl. pelvis) in females are significantly higher. It was observed in all datasets, that the odds of females being involved in a rural accident or an accident at night are lower than for males. Elderly pedestrian and cyclist (≥60YO) tend to sustain more severe injuries (AIS2+ and AIS3+) than younger pedestrian and cyclists

Test of Antiproton Apparatus

This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440

Inter-Edge interaction in the Quantum Hall Effect

We consider effects of the interaction between electrons drifting along the opposite sides of a narrow sample under the conditions of the quantum Hall effect. A spatial variation of this interaction leads to backward scattering of collective excitations propagating along the edges. Experiments on propagation of the edge modes in samples with constrictions may give information about the strength of the inter-edge electron interaction in the quantum Hall regime.Comment: 12 Pages, Latex, Accepted for publication in PRL