Time to AIDS from 1992 to 1999 in HIV-1-Infected Subjects with Known Date of Infection.

To estimate the change in AIDS incubation time during three periods characterized by different availability of antiretroviral treatments, data from the French Hospital Database on HIV of 4702 HIV-1-positive subjects with a documented date of infection were analyzed. Times from seroconversion to AIDS were compared in three periods: period 1 from January 1992 to June 1995 (monotherapy); period 2 from July 1995 to June 1996 (dual therapy); and period 3 from July 1996 to June 1999 (triple therapy). Nonparametric survival analyses were performed to account for staggered entries in the database and during each period. From periods 1 to 3, antiretroviral treatments were initiated earlier after infection, more subjects were treated, and the nature of regimens changed (25.6% of subjects were treated with monotherapy in period 1, 34.6% were treated with dual therapy in period 2, and 53.4% were treated with triple therapy in period 3). Compared with period 1, the relative hazard (RH) of AIDS was 0.31 in period 3 (95% confidence interval [CI]: 0.24-0.39). When comparing period 3 with period 2, the RH of AIDS was 0.36 (CI: 0.29-0.45). Assuming a log normal distribution, the median time to AIDS was estimated as 8.0 years in period 1 (CI: 6.0-10.6), 9.8 years in period 2 (CI: 8.5, 11.2), and 20.0 years in period 3 (CI: 17.1-23.3). This lengthening in time to AIDS from 1992 to 1999 was particularly marked in the period after the introduction of triple therapy, including protease inhibitors

The diagnostic accuracy and cost-effectiveness of magnetic resonance spectroscopy and enhanced magnetic resonance imaging techniques in aiding the localisation of prostate abnormalities for biopsy : a systematic review and economic evaluation

Peer reviewedPublisher PD

Some Aspects of Rotational and Magnetic Energies for a Hierarchy of Celestial Objects

Celestial objects, from earth like planets to clusters of galaxies, possess angular momentum and magnetic fields. Here we compare the rotational and magnetic energies of a whole range of these celestial objects together with their gravitational self energies and find a number of interesting relationships. The celestial objects, due to their magnetic fields, also posses magnetic moments. The ratio of magnetic moments of these objects with the nuclear magnetic moments also exhibits interesting trends. We also compare their gyromagnetic ratio which appears to fall in a very narrow range for the entire hierarchy of objects. Here we try to understand the physical aspects implied by these observations and the origin of these properties in such a wide range of celestial objects, spanning some twenty orders in mass, magnetic field and other parameters.Comment: 12 pages, 37 equation

On the Relativistic Description of the Nucleus

We discuss a relativistic theory of the atomic nuclei in the framework of the hamiltonian formalism and of the mesonic model of the nucleus. Attention is paid to the translational invariance of the theory. Our approach is centered on the concept of spectral amplitude, a function in the Dirac spinor space. We derive a Lorentz covariant equation for the latter, which requires as an input the baryon self-energy. For this we either postulate the most general Lorentz-Poincar\'e invariant expression or perform a calculation via a Bethe-Salpeter equation starting from a nucleon-nucleus interaction. We discuss the features of the nuclear spectrum obtained in the first instance. Finally the general constraints the self-energy should satisfy because of analyticity and Poincar\'e covariance are discussed

Using health surveillance systems data to assess the impact of AIDS and antiretroviral treatment on adult morbidity and mortality in Botswana

Introduction: Botswana's AIDS response included free antiretroviral treatment (ART) since 2002, achieving 80% coverage of persons with CD450% and >30% through 2011, while continuing to increase in older women. Conclusions: Adult mortality in Botswana fell markedly as ART coverage increased. HIV prevalence declines may reflect ART-associated reductions in sexual transmission. Triangulation of surveillance system data offers a reasonable approach to evaluate impact of HIV/AIDS interventions, complementing cohort approaches that monitor individual-level health outcomes

Effects of Short Range Correlations on Ca Isotopes

The effect of Short Range Correlations (SRC) on Ca isotopes is studied using a simple phenomenological model. Theoretical expressions for the charge (proton) form factors, densities and moments of Ca nuclei are derived. The role of SRC in reproducing the empirical data for the charge density differences is examined. Their influence on the depletion of the nuclear Fermi surface is studied and the fractional occupation probabilities of the shell model orbits of Ca nuclei are calculated. The variation of SRC as function of the mass number is also discussed.Comment: 11 pages (RevTex), 6 Postscript figures available upon request at [email protected] Physical Review C in prin

Evaluation of Clinical and Immunological Markers for predicting Virological Failure in a HIV/AIDS treatment cohort in Busia, Kenya

In resource-limited settings where viral load (VL) monitoring is scarce or unavailable, clinicians must use immunological and clinical criteria to define HIV virological treatment failure. This study examined the performance of World Health Organization (WHO) clinical and immunological failure criteria in predicting virological failure in HIV patients receiving antiretroviral therapy (ART)

The Particle-Vibration Coupling Form Factor

peer reviewe

Role of the Nuclear and Electromagnetic Interactions in the Coherent Dissociation of the Relativistic 7^7Li Nucleus into the 3^3H + 4^4He Channel

The differential cross section in the transverse momentum $Q$ and a total cross section of $(31\pm4)$ mb for the coherent dissociation of a 3-A-GeV/$c$ $^7$Li nucleus through the $^3$H$+^4$He channel have been measured on emulsion nuclei. The observed $Q$ dependence of the cross section is explained by the predominant supposition of the nuclear diffraction patterns on light (C, N, O) and heavy (Br, Ag) emulsion nuclei. The contributions to the cross section from nuclear diffraction ($Q\le400$ MeV/$c$) and Coulomb $(Q\le50$ MeV/$c$) dissociations are calculated to be 40.7 and 4 mb, respectively.Comment: ISSN 0021-3640, Pleiades Publishing, Ltd., 200