Sport, Muslim Identities and Cultures in the UK, an Emerging Policy Issue: Case Studies of Leicester and Birmingham

This is an Accepted Manuscript of an article published by Taylor & Francis Group in European Sport Management Quarterly on 04/09/2010, available online: http://dx.doi.org/10.1080/16184742.2010.502743An understanding of diversity and its implications for policy is critical to those charged with delivering sporting services in culturally plural societies. This paper reports a research project which aimed to examine how, on the one hand, Muslims in two specific local contexts in the UK (Leicester in the East Midlands; Birmingham in the West Midlands) make sense of the relationship between their religious (Islamic) identities and sporting interests and, on the other, how local policy makers perceived and responded to the sporting needs of these Muslim communities. According to the 2001 census, Leicester and Birmingham represent, respectively, one of the most ethnically diverse areas in Britain and the domicile for one-third of the Muslim population in Britain. Interviews were undertaken with representatives of Muslim organizations, governmental and quasi-governmental sporting organizations, in both cities. Critical Discourse Analysis of interviewees’ responses reveal pluralistic views on a range of issues such as: the ‘‘(un)suitability’’ of the environment/space provided for, or accessed by, Muslims to practise sport; funding; gender equity; equity and social inclusion agenda versus cultural and religious diversities; and a resistance (on the part of policy makers) to target provision at faith groups

Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies

Background: Identification of single nucleotide polymorphisms (SNPs) associated with gene expression levels, known as expression quantitative trait loci (eQTLs), may improve understanding of the functional role of phenotype-associated SNPs in genome-wide association studies (GWAS). The small sample sizes of some previous eQTL studies have limited their statistical power. We conducted an eQTL investigation of microarray-based gene and exon expression levels in whole blood in a cohort of 5257 individuals, exceeding the single cohort size of previous studies by more than a factor of 2. Results: We detected over 19,000 independent lead cis-eQTLs and over 6000 independent lead trans-eQTLs, targeting over 10,000 gene targets (eGenes), with a false discovery rate (FDR) < 5%. Of previously published significant GWAS SNPs, 48% are identified to be significant eQTLs in our study. Some trans-eQTLs point toward novel mechanistic explanations for the association of the SNP with the GWAS-related phenotype. We also identify 59 distinct blocks or clusters of trans-eQTLs, each targeting the expression of sets of six to 229 distinct trans-eGenes. Ten of these sets of target genes are significantly enriched for microRNA targets (FDR < 5%). Many of these clusters are associated in GWAS with multiple phenotypes. Conclusions: These findings provide insights into the molecular regulatory patterns involved in human physiology and pathophysiology. We illustrate the value of our eQTL database in the context of a recent GWAS meta-analysis of coronary artery disease and provide a list of targeted eGenes for 21 of 58 GWAS loci. Electronic supplementary material The online version of this article (doi:10.1186/s13059-016-1142-6) contains supplementary material, which is available to authorized users

The Genotype-Tissue Expression (GTEx) project

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues