46 research outputs found
Clinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry
- Author
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Get PDFBackground: Clinical complexity is increasingly prevalent among patients with atrial fibrillation (AF). The ‘Atrial fibrillation Better Care’ (ABC) pathway approach has been proposed to streamline a more holistic and integrated approach to AF care; however, there are limited data on its usefulness among clinically complex patients. We aim to determine the impact of ABC pathway in a contemporary cohort of clinically complex AF patients. Methods: From the ESC-EHRA EORP-AF General Long-Term Registry, we analysed clinically complex AF patients, defined as the presence of frailty, multimorbidity and/or polypharmacy. A K-medoids cluster analysis was performed to identify different groups of clinical complexity. The impact of an ABC-adherent approach on major outcomes was analysed through Cox-regression analyses and delay of event (DoE) analyses. Results: Among 9966 AF patients included, 8289 (83.1%) were clinically complex. Adherence to the ABC pathway in the clinically complex group reduced the risk of all-cause death (adjusted HR [aHR]: 0.72, 95%CI 0.58–0.91), major adverse cardiovascular events (MACEs; aHR: 0.68, 95%CI 0.52–0.87) and composite outcome (aHR: 0.70, 95%CI: 0.58–0.85). Adherence to the ABC pathway was associated with a significant reduction in the risk of death (aHR: 0.74, 95%CI 0.56–0.98) and composite outcome (aHR: 0.76, 95%CI 0.60–0.96) also in the high-complexity cluster; similar trends were observed for MACEs. In DoE analyses, an ABC-adherent approach resulted in significant gains in event-free survival for all the outcomes investigated in clinically complex patients. Based on absolute risk reduction at 1 year of follow-up, the number needed to treat for ABC pathway adherence was 24 for all-cause death, 31 for MACEs and 20 for the composite outcome. Conclusions: An ABC-adherent approach reduces the risk of major outcomes in clinically complex AF patients. Ensuring adherence to the ABC pathway is essential to improve clinical outcomes among clinically complex AF patients
Impact of renal impairment on atrial fibrillation: ESC-EHRA EORP-AF Long-Term General Registry
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Get PDFBackground: Atrial fibrillation (AF) and renal impairment share a bidirectional relationship with important pathophysiological interactions. We evaluated the impact of renal impairment in a contemporary cohort of patients with AF. Methods: We utilised the ESC-EHRA EORP-AF Long-Term General Registry. Outcomes were analysed according to renal function by CKD-EPI equation. The primary endpoint was a composite of thromboembolism, major bleeding, acute coronary syndrome and all-cause death. Secondary endpoints were each of these separately including ischaemic stroke, haemorrhagic event, intracranial haemorrhage, cardiovascular death and hospital admission. Results: A total of 9306 patients were included. The distribution of patients with no, mild, moderate and severe renal impairment at baseline were 16.9%, 49.3%, 30% and 3.8%, respectively. AF patients with impaired renal function were older, more likely to be females, had worse cardiac imaging parameters and multiple comorbidities. Among patients with an indication for anticoagulation, prescription of these agents was reduced in those with severe renal impairment, p <.001. Over 24 months, impaired renal function was associated with significantly greater incidence of the primary composite outcome and all secondary outcomes. Multivariable Cox regression analysis demonstrated an inverse relationship between eGFR and the primary outcome (HR 1.07 [95% CI, 1.01–1.14] per 10 ml/min/1.73 m2 decrease), that was most notable in patients with eGFR <30 ml/min/1.73 m2 (HR 2.21 [95% CI, 1.23–3.99] compared to eGFR ≥90 ml/min/1.73 m2). Conclusion: A significant proportion of patients with AF suffer from concomitant renal impairment which impacts their overall management. Furthermore, renal impairment is an independent predictor of major adverse events including thromboembolism, major bleeding, acute coronary syndrome and all-cause death in patients with AF
Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry
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- ?zin B.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Get PDFBackground: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P <.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
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- Woodford C
- Woods J
- Wotorson L
- Wright L
- Wu G
- Wu R
- Wu S
- Wu W
- Wu X
- Wu Zhe
- Wynne S
- Wölfl C
- Xia J
- Xiao L
- Xiao R
- Xie M
- Xie R
- Xing C
- Xing W
- Xiong J
- Xu B
- Xu DAN YI
- Xu J
- Xu T
- Yan H
- Yan Xiaoting
- Yandamuri S
- Yang HEE JUNG
- Yang HEE JUNG
- Yang M
- Yang P
- Yang Q
- Yang T
- Yang X
- Yang Y
- Yang Z
- Yao H
- Yao X
- Yao Y
- Yao Z
- Yashinski C
- Ye G
- Yedinak S
- Yeh N
- Yeung M
- Young A
- Young C
- Young L
- Yu B
- Yu H
- Yu Q
- Yuan Y
- Yunes R
- Zadra R
- Zagnoni S
- Zambelli M
- Zbik S
- Zebrack J
- Zelenka J
- Zelik J
- Zeuthen E
- Zhai M
- Zhang A
- Zhang B
- Zhang C
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang R
- Zhang S
- Zhang Ting
- Zhang Wen
- Zhang X
- Zhang Y
- Zhao C
- Zhao JIAYI STELLA
- Zhao L
- Zhao P
- Zhao R
- Zhao Y
- Zheng Y
- Zheng Z
- Zhi Y
- Zhong H
- Zhong R
- Zhou C
- Zhou Juan
- Zhou Xingyu
- Zhou Yingyuan
- Zhu Wangqin
- Zhu X
- Zhu Y
- Ziefle S
- Zilz N
- Zineldine A
- Zlatewa R
- Zoghbi J
- Zong C
- Zong D
- Zong X
- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Get PDFBACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial
- Author
- Abram Simon
- Acharya Ashutosh
- Adcode Megan
- Agrawal Pranshu
- Al Mouazzen Louay
- Aland Utuman
- Allison Joanna
- Allsop Lynne
- Amero Justine
- Anand Sanjay
- Anand Sanjeev
- Andrews Barry
- Ann Sewell Terri
- Anthony Deborah
- Appleby Sarah
- Areirobulos Miltiades
- Armstrong Jo
- Aslam-Pervez Nayef
- Bagg Christina
- Baig Abdul
- Baker Simon
- Banks Daniel
- Bannister Emily
- Barcelona Massimo
- Barker Karen
- Batting Martha
- Beard David J
- Beesley Kate
- Bell Amanda
- Bell Judith
- Bhaskaran Arun
- Bond Amy
- Bottomley Nicholas
- Boulton Rebecca
- Bourke Henry
- Bray Rachel
- Brear Tracy
- Briggs Shannon
- Brown Chloe
- Brown Emma
- Brown Harry
- Brown Mark
- Brown Michael
- Brown Sarah
- Buckley Sarah
- Bullock Susan
- Burden Debbie
- Cable Sarah
- Campbell Helen
- Campbell Marion
- Campbell Terence
- Carr Andrew
- Cartwright James
- Carvelli Paula
- Chegwin Katie
- Chikate Albert
- Chissell Hugh
- Christie Carla
- Clark Damian
- Clifton Rupert
- Connor Lynda
- Cook Jonathan A
- Cook Rebecca
- Cornell Thomas
- Cottingham Megan
- Coulthard James
- Coupe Ben
- Coutts Abbie
- Cowen Laura
- Craig Emma
- Cronin Julie
- Croucher Andrea
- Da Rocha Joana
- Damen Alexander
- Daniel Diane
- Darian Thelma
- Davies Andrew
- Davies Caroline
- Davies Jackie
- Davies Llinos
- Davies Loretta
- Davies Timothy
- Davis Jack
- de Feyter Pascal
- Deakin Marc
- Dean Suzy
- Dearnley Kim
- Denis Elizabeth
- Deo Sunny
- Desai Vikram
- Devooght-Johnson Nicki
- Diaz Stephanie
- Dickinson Gareth
- Diment Sarah
- Ditchfield Lisa
- Dixey Ross
- Dodd Christopher
- Dodd Matt
- Dodds Alexander
- Draycott Stephen
- Duncan Jo
- Dunne Debra
- Easow Rashmi
- Emsley Richard
- Esler Colin
- Essop-Adam Amirah
- Evans Anne
- Fenlon Emma
- Ferrari Gill
- Ferrell Emma
- Finnigan Tom
- Fletcher Eve
- Fletcher Heidi
- Foster Eliza
- Foster Louise
- Foxton Julie
- Francis Katharine
- Frasquet-Garcia Antonio
- Freeman-Hicks Amanda
- Gainard Glyn
- Gilbert Rob
- Giles Hazel
- Gill Mandy
- Gokturk Abdulkerim
- Graham-Woollard Dave
- Gray Glaxy
- Greshon Akiko
- Haddad Fares
- Haines Christina
- Hall Andrew
- Hall Chrissie
- Hamilton Elizabeth
- Harnett Paul
- Hatton Catriona
- Hawkes-Blackburn Catherine
- Haywood Laura
- Hazlerigg Alexandra
- Heeley Cheryl
- Hendy Craig
- Hillout Paula
- Hirst Charlotte
- Holland Tim
- Honeywell Cassie
- Hopkins Susan
- Houchen-Wolloff Linzy
- Howarth Faye
- Howell Tessa
- Howells Nick
- Hudak Alison
- Hynes Samantha
- Iqbaz Hafiz
- Jackson Tracy
- Jackson William
- Jayabev Chethan
- Jayachandran Jayadeep
- Jeeves Katie
- Jeffrey Helen
- Jina Irfan
- Johnson Hilary
- Jones Andrew
- Jones Luke
- Joshi Yogesh
- Kadunyi Joyce
- Kapur Richard
- Kelly Andrew
- Kent Benjamin
- Kerrison Sharon
- Kessly Sandra
- Kincaid Robin
- King Victoria
- Kiszely Alastair
- Knight Rachel
- Krishnan Harry
- Kulkarni Kunal
- Kulkarni Sushrut
- Lamb Sarah E
- Lang Gail
- Lankester Benedict
- Latham Sandra
- Lazizi Mohamed
- Leal Jose
- Lewis Alison
- Li Jiyang
- Lovegrove Wayne
- Lyons Joanne
- Lythe Vanessa
- MacDonald-Taylor Karen
- Maher Niall
- Manara Jon
- Marie Suddens Charlie
- Markham Lucy
- Massey Daniel
- Mayahi Reza
- McCafferty Laura
- McDonnell Stephen
- McGowan Angela
- McGowan Kerri
- McKay Niamh
- McKenna David
- Mclintock Heather
- McLoughlin Emma
- McNestry Paul
- Mendoza Sheena
- Metcalfe Andy
- Middleton Simon
- Mirza Burhan
- Modi Nishil
- Mohammed Aslam
- Mohammed Haadiya
- Monk Paul
- Montaser Rugaia
- Morgado Areia Carlos
- Morgan Tania
- Morris Susan
- Mostafa Ahmed
- Murdoch Rosie
- Murphy Carl
- Murray James
- Nash Dominic
- Navadgi Basalingappa
- Negrut Corina
- Newman James
- Nichols Jessica
- Nicholson Anne
- Nisbett Toby
- O'Callaghan Jamie
- O'Grady John
- O'Leary Sean
- O'Mahony Brendan
- O'Sullivan Susan
- Ollerenshaw Joanna
- Paez Arsenio
- Pai Vishai
- Panes Alice
- Parker Nicola
- Parkinson Valerie
- Parsons Georgie
- Partridge Susan
- Patel Rahul
- Paton Bruce
- Peacocke Alice
- Peat George
- Pecheva Mira
- Pepper Ali
- Phillips Michael
- Pinkney Thomas
- Plank Karan
- Porteous Andrew
- Powell Tim
- Price Andrew
- Putnis Sven
- Quinn Leanne
- Reichert Ines
- Rewbury Jane
- Richardson Fern
- Riches Joanne
- Riddlestone Peter
- Roberton Andrew
- Robinson James
- Rogerson Lawrie
- Ross Denise
- Rumonovic Rowan
- Rupasinghe Shav
- Rushbrook Jeremy
- Sales Rafael
- Sands Johnson David
- Santamaria Marta
- Satish Venkat
- Scott-Dempster Clare
- Selvaratnam Veenesh
- Shah Feisal
- Sharma Pankaj
- Shean Katharine
- Shelton Sarah
- Shirkey Beverly A
- Sivarajan Sinduja
- Slack Katie
- Smith Graham
- Smith James
- Smith Jon
- Smith Lara
- Smith Nick
- Snipe Carol
- Snow Martyn
- Spalding Tim
- Stables Gareth
- Stevens Jarrad
- Stockport Jane
- Stoddard James
- Stokes Jamie
- Summers Jessica
- Sutcliffe Sarah
- Sutton Paul
- Sweed Tamar
- Sykes Adam
- Symons Sean
- Tardivel Alison
- Taylor Clare
- Templeton-Ward Oliver
- Teuke Joanna
- Thelwall Claire
- Theodorides Anthony
- Thomas Caradog
- Thompson Peter
- Thonse Raghuram
- Thornhill Anna
- Travers Jenny
- Triggs David
- Turner Philip
- Vachtsevanos Leonidas
- Van De Snepscheut-Jones Katja
- Varachia Husein
- Venables Ian
- Vertue Mark
- Vetharajan Niraj
- Vichos Iason
- Vint Helen
- Virdee Harshinder
- Whitbread Lucy
- Whitcher Alison
- Whitehead Victoria
- Wilcock Danielle
- Wilcock David
- Wilcocks Katharine
- Wilkinson Helen
- Williams James
- Williams Marie
- Williams Mark
- Wilson Ben
- Wilson Chris
- Wilson Eva
- Wood Dianne
- Wood Richard
- Wood Simon
- Worstenholme Lindsey
- Wright Daniel
- Wright David
- Wroath Belinda
- Young Lucy
- Zebracki Esther
- Publication venue
- Elsevier
- Publication date
- 20/08/2022
- Field of study
Get PDFBackgroundAnterior cruciate ligament (ACL) rupture is a common debilitating injury that can cause instability of the knee. We aimed to investigate the best management strategy between reconstructive surgery and non-surgical treatment for patients with a non-acute ACL injury and persistent symptoms of instability.MethodsWe did a pragmatic, multicentre, superiority, randomised controlled trial in 29 secondary care National Health Service orthopaedic units in the UK. Patients with symptomatic knee problems (instability) consistent with an ACL injury were eligible. We excluded patients with meniscal pathology with characteristics that indicate immediate surgery. Patients were randomly assigned (1:1) by computer to either surgery (reconstruction) or rehabilitation (physiotherapy but with subsequent reconstruction permitted if instability persisted after treatment), stratified by site and baseline Knee Injury and Osteoarthritis Outcome Score—4 domain version (KOOS4). This management design represented normal practice. The primary outcome was KOOS4 at 18 months after randomisation. The principal analyses were intention-to-treat based, with KOOS4 results analysed using linear regression. This trial is registered with ISRCTN, ISRCTN10110685, and ClinicalTrials.gov, NCT02980367.FindingsBetween Feb 1, 2017, and April 12, 2020, we recruited 316 patients. 156 (49%) participants were randomly assigned to the surgical reconstruction group and 160 (51%) to the rehabilitation group. Mean KOOS4 at 18 months was 73·0 (SD 18·3) in the surgical group and 64·6 (21·6) in the rehabilitation group. The adjusted mean difference was 7·9 (95% CI 2·5–13·2; p=0·0053) in favour of surgical management. 65 (41%) of 160 patients allocated to rehabilitation underwent subsequent surgery according to protocol within 18 months. 43 (28%) of 156 patients allocated to surgery did not receive their allocated treatment. We found no differences between groups in the proportion of intervention-related complications.InterpretationSurgical reconstruction as a management strategy for patients with non-acute ACL injury with persistent symptoms of instability was clinically superior and more cost-effective in comparison with rehabilitation management
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
- Ang Daniel
- Ann Taehee
- Annan Lynda
- Ansari Jawaher
- Ansari Jawaher
- Anscombe Eleanor
- Anyamene Nicola
- Appleby Bonny
- Appleby Rowan
- Archer Denise
- Archer Denise
- Archer Simon
- Archer Simon
- Arnott Seonaid
- Arsanious Nasr
- Ashcroft Jan
- Ashworth Sue
- Ashworth Sue
- Askew Sarah
- Aslam Natasha
- Atkinson Jane
- Atkinson Lorraine
- Attlee Julie
- Auladin Raidah
- Austin (nee Glover) Gemma
- Austin Mandy
- Avery Alison
- Avis Joanne
- Aya Viviana
- Azirar Hanna
- Bachand Francois
- Bahary JeanPaul
- Bahl Amit
- Bahl Amit
- Bailey Laura
- Bailey Linda
- Baines Kizzy
- Baird Noelle
- Bak Dagmara
- Bakawala Rehana
- Baker Erin
- Baker Ivanna
- Bakija Zeljka
- Bakker Piet
- Balderson Jane
- Ball Julie
- Balogun Shaki
- Bamford Linda
- Banda Laillah-Crystal
- Barber Dave
- Baria Karin
- Barkati Maroie
- Barkati Maroie
- Barke Nyssa
- Barlow David
- Barnbrooke Sarah
- Barnes Alison
- Barnes Nicky
- Barnett Christian
- Barnett Debra
- Barron Chris
- Barron Claire
- Barter Elisa
- Barwell Lorraine
- Bashir Bashir
- Bashir Faheem
- Basu Devy
- Bateman Samantha
- Bates Emma
- Batish Cheryl
- Batz Margaret
- Bauman Glenn
- Baumber Shelley
- Baxter Matt
- Bayley Andrew J
- Beamish Neal
- Beaney Katherine
- Beaney Ronald
- Beard Karen
- Beard Karen
- Beaton Heather
- Beaton Kirsty
- Beattie Louise
- Beauchemin MarieClaude
- Beaumont Erica
- Beausoleil Rachelle
- Beazer Sarah
- Bech-Nielsen Nanette
- Bech-Nielsen Nanette
- Bedoya Luis Diaz de
- Beech Darren
- Beer Nigel
- Beesley Kate
- Beesley Katherine
- Beesley Sharon
- Beety Jane
- Bekulart Sylwia
- Belcher Rebecca
- Bell Karen
- Bellenger Katharine
- Benjaminson Patricia
- Bennett Molly
- Bennett Sarah
- Bennion Carole
- Benson Richard
- Benson Richard
- Benth Silvine
- Benton Louise
- Benton Richard
- Bentzen Lise
- Beresford Mark
- Beresford Mark
- Beresford Mark
- Bergen Leah
- Berghout Koralee
- Berlin Alejandro
- Bermingham Nicola
- Betts Chris
- Bhana Rajanee
- Bhatnagar Adityanarayan
- Bhatnagar Gagan
- Bici Julia
- Bier Bianca
- Binks Colin
- Binns Louise
- Birch Richard
- Bird Stephanie
- Birtle Alison
- Bishop Emma
- Bissa Caterina
- Bissett Donald
- Bisson MarieEve
- Blackwood Geoffrey
- Blaney Hilary
- Blight Kathy
- Blood Paul A
- Bloomfield David
- Bloomfield David
- Bloomfield Mark
- Blundell Martyn
- Blythe Tracy
- Boam Samantha
- Boardman John
- Bohra Vikram
- Bois (nee Harris) Elizabeth
- Bolger Annette
- Bolton Olivia
- Bolton Olivia
- Bond Brittany
- Bone Linzi
- Bonner Scott
- Bonner-Shand Shelagh
- Bonsu Nicole
- Boon Ian
- Borgaonkar Sudhir
- Borre Michael
- Borynec Carol
- Bott Trevor
- Bottomley David
- Bottomley David
- Bottomley David M
- Bottomley Ian
- Bouchard Myriam
- Bourke Amie
- Bourque JeanMarc
- Boutflower Jane
- Bowen Jo
- Bowen Jo
- Bowen Katie
- Bower Lorna
- Bower Lorna C
- Bowers Dawn
- Bowers Richard
- Bowes-Cavanagh Jeanette
- Bowling Lorna
- Bowman Sue
- Bowmer Amanda
- Bownie-Mukumbu Godfrey
- Brady Joanne
- Brady Joanne
- Brain Carol
- Branagan Jenny
- Brander Mike
- Branson (née Dineen) Amy
- Brasso Klaus
- Brasso Klaus
- Braun Michael W
- Brawley Chris
- Brawley Chris
- Breakspear Sally
- Breckin Edmund
- Breen Vivienne
- Brennan Maria
- Brewster Simon
- Briand Wayne
- Briggs Maxine
- Bristow Robert
- Brittain Paul
- Broadley Eve
- Brock Sue
- Brock Sue
- Brogan (nee Roddie) Stephanie
- Brookes Claire
- Brookman Catherine
- Broom Jane
- Broomfield Barbara
- Brough Richard
- Brough Richard
- Brough WA
- Brown Emmanuel
- Brown Grace
- Brown Joanne
- Brown Maggie
- Brown Rebecca
- Brown Richard B
- Brown Richard B
- Brown Sandra
- Brown Simon
- Brown Stephen CW
- Brown Teddy
- Brownless Caroline
- BrucePayne Kim
- Brulinski Patryk
- Brulinski Patryk
- Brundage Michael
- Bryan Rachel
- Bryant Hanna
- Brydon-Hill Ruth
- Bucci Catherine
- Buchan Jonathan
- Buckley Jon
- Buckley Julie
- Bujold Rachel
- Bunn Sarah
- Burbridge Susan
- Burgoyne Jamie-Rae
- Burlace Barbara
- Burlace Barbara
- Burns Rebecca
- Burrage Su
- Bursey Kara
- Butler-Barnes Jenny
- Butt Zainab
- Butterfield Anne
- Butterworth Caryl
- Buus Simon
- Byrne Mary Marg
- Caballes Mark
- Cadiz Lovely
- Callam Sara
- Calvert Clare
- Camara Mary Jane
- Camburn Sister Tracey
- Camilleri Philip
- Camilleri Philip
- Camilleri Philip
- Camilleri Philip
- Campbell Allister
- Campbell Audrey
- Campbell Hilary
- Campbell Yvonne
- Campos Monica
- Canavan Joycelin
- Cannon Philip
- Capaldi Lisa
- Capaldi Lisa
- Capaldi Lisa
- Carbonaro Adriana
- Carefoot Layton
- Carini Serrafina
- Carkner Amy
- Carlino Giulia
- Carlson Cindy
- Carmel Michel
- Carpenter Janice
- Carpenter Janice
- Carpio Viviana
- Carr Philippa
- Carroll Weronika
- Carruthers Ross
- Carter Adam
- Carter Vanda
- Cartwright Debbie
- Carvery Lane
- Casanova Nathalie
- Casanova Nathalie
- Casey Linda
- Casey Sue
- Catt Natalie
- Catton Charles
- Catton Charles N
- Caumont Tom
- Cavanagh Kerrie
- Chadwick David
- Chadwick Eliot
- Chahal Rohit
- Chahine Jacqueline
- Chakraborti Prabir
- Challipalli Amarnath
- Challipalli Amarnath
- Chamberlain Shelley
- Chambers Carla
- Chan Andrew
- Chan Andrew
- Chan Heidi
- Chan Hin Fan
- Chan Olivia
- Chandrashekara Madhura
- Charnley Natalie
- Chatelain AnneMarie
- Chatfield Jenny
- Chauhan Zainab
- Chedham Alison
- Chennattukungu Indukala
- Cherepak Kathy
- Chetiyawardana Samantha
- Chetiyawardana Samantha
- Chettle Judith
- Cheung Arthur
- Cheung Patrick CF
- Chikkamuniyappa Bindu
- Chikkamuniyappa Bindu
- Chikopela Loveness
- Chilcott Helen
- Chipman Penny
- Chivers Rachael
- Chornopyski Tracy
- Choudhury Ananya
- Choudhury Ananya
- Chowdhury Amitava D
- Christensen Anne Juel
- Christensen Tine
- Christmas Sallyanne
- Chrystal Melanie
- Chu William
- Chui Amadeus
- Chung Christina
- Chung Hans T
- Chung Hans T
- Chung Peter
- Chung Peter W M
- Churn Mark
- Churn Mark
- Clancy Joanna
- Clapp Felicity
- Clark Alison
- Clark Diane
- Clark Helen
- Clark Katy
- Clark Su
- Clarke Elizabeth
- Clarke Jude
- Clarke Maria
- Clarke Noel
- Clarke Noel W
- Clarke Peter
- Clarke Rachael
- Clarke Samantha
- Cleary Kristy
- Clements Colette
- Clements Mia AnnaMaria
- Clitheroe Pat
- Cobos-Arrivabene Marta
- Cocks Tracie
- Coe Marc
- Coffin Teresa
- Cogley Lyn
- Cole Aiden
- Cole David J
- Cole David J
- Collard Susan
- Colligan Steve
- Collins Gerald
- Collins Gerald
- Collins Lucy
- Commisso Angela
- Conibear John
- Connolly nee McKenna Sarah
- Connor Marie
- Conroy Ruth
- Conroy Ruth
- Conroy Ruth
- Conway Lisa-Jane
- Conway Rachel
- Cook Adrian
- Cook Adrian D
- Cook Audrey
- Cook Audrey
- Cook Wendy
- Cooke Jill
- Cooke Juniebel
- Cooke Peter
- Coomber Kristy
- Coombs Sarah
- Cooper Adele
- Cooper Sophie
- Coppins Helen
- Corbett Thomas B
- Corcoran Sam
- Corderoy Helen
- Cordwell Amanda
- Corkery Danylle
- Corless Rebecca
- Cormack Margaret
- Cornaby Andrew
- Corner Victoria
- Cornthwaite Stephanie
- Corwin Charlotte
- Cossette Danielle
- Cote Genevieve
- Cotterill Lauren
- Cotts Shannon
- Coubrough Claudia
- Couch Ellie
- Coughlan Tricia
- Cousins Jane
- Cousins Rebecca
- Coutts Tim
- Coventry Thomas
- Cowan Chloe
- Cowan Chloe
- Cowan Richard
- Cowan Richard
- Cowley Sue
- Cox Adam
- Cox Christine
- Coyle Catherine
- Coyle Catherine
- Crawford Melanie
- Crawford Sister Denise
- Creelman Brianna
- Crellin Perric
- Crellin Perric
- Crook Juanita
- Cross Vanessa
- Cross William R
- Crossley Lin
- Crowe (nee Hughes) Dawn
- Crowley Claire
- Crundwell M
- Cserbane Anita
- Cuffe Donna
- Cumming Kirsty
- Cunningham Amy
- Curtis Samantha
- Curtis Sandra
- Cusan Leonello
- Custins Laura
- Cyriac Abby
- Dabbs Marianne
- Dahar Nazeer
- Dahmane Rafika
- Dallas Nicola
- Dalton-Short Ross
- Dalton-Short Ross
- Daly Deirdre
- Danaswamy Patricia
- Danaswamy Patricia
- Daniel Amelia
- Danielson Brita
- Danjoux Cyril
- Darby Helen
- Darch Flora
- Daruwala Pallon
- Das Prantik
- Davda Reena
- Davey Alison
- Davey Elizabeth
- Davidson Cathy
- Davies Emily
- Davies Flor
- Davies Heather
- Davies Joe
- Davies Joseph
- Davies Julie-Ann
- Davies Kirstin
- Davies Llinos
- Davies Stacey
- Davies Sue
- Davies Tracey
- Davison Alison
- Davison Sue
- Dawe David
- Dawson Elizabeth
- Dawson Louise
- Dawson-Athey Linda
- Dayes Ian S
- De Silva-Minor Shiroma
- Dean Lynsey
- Dearnaley David
- Deenihan Emma
- Degendorfer Sarah
- Dekaj Fatjon
- Dell Gillian
- Dellar Conor
- Delouya Guila
- Dent Kathleen
- Desai Parth
- Desai Parth
- Desrosiers Isabelle
- Dewar Lorna
- Dharmaprasad Soney
- Dhinakaran Kathirvelu
- Di Maria Fabio
- Dias Heather
- Dickinson Peter
- Dickson Jeanette
- Dill Kendra
- DiLullo Elenor
- DiMarco Christine
- Din Omar
- Ding Ian
- Dion Helene
- Ditchfield Julie
- Dixit Sanjay
- Dixit Sanjay
- Dlodlo Jessica
- Dobson Tracey
- Dodds David
- Dodge Sister Jan
- Doherty A
- Donaghey Sally
- Donaldson David
- Donnison Michelle
- Douch Emma
- Doughty Victoria
- Dover Serena
- Downs Nichola
- Doyle Kerrie
- Drachenberg Darrel E
- Drakeley Susan
- Drew Ellen
- Drew Mary (Ellen)
- Driscoll Celine
- DSouza David
- Dubey Arbind
- Dubey Arbind
- Duckett Tracey
- Duclos Marie
- Duffy Annie
- Dufour Nathalie
- Dugas Stevie
- Duley Emma
- DuMontier Joelle
- Duncan (nee Keatley) Claire
- Duncan Graeme
- Duncan Ian
- Dunn Sharon
- Dunne Emma
- Durkan Garret
- Durrant Lisa
- Dymond Harvey
- E Choan
- Eady Robin
- Eapen Libni
- Ebacher Annie
- Eccleson Helen
- Edwards Abigail
- Edwards Albert
- Edwards Jackie
- Edwards Steve
- Edwards Steve
- Egan Lisa
- Eichenberger Lois
- El-Modir Ahmed
- El-Saghir Mohammed
- Eleftheriadis Symeon
- ElKerdawy Hala
- Ellard Rose
- Elliott Mark
- Elliott Tony
- Elliott Tony
- ElSokhn Nidale
- Elwell Christine
- Elwell Christine
- Elwell Sue
- Embleton Andrew
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- Escueta Vivette
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- Etheridge Charlotte
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- Evans Marion
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- Evans Richard
- Eze Nancy
- Fair Kim
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- Falconer Alison
- Falconer Alison
- Fallah Fereshteh
- Fallaize Adrian
- Faria Sergio Luiz
- Farnworth Christine
- Farrar Michelle
- Farrell Helen
- Fawcitt Sara
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- Fearnley Mark
- Featherstone Wendy
- Fellows Kathryn
- Fennelly Ruth
- Ferguson Catherine
- Ferguson Catherine
- Fernandez Claire
- Ferreira Miguel
- Fiddes Kathleen
- Fielding Bethany
- Fielding Bethany
- Fildes Diane
- Finnegan Niall
- Firth Alexandra
- Firth Alexandra
- Firth Alexandra
- Firth Elizabeth
- Fish Matt
- Fish Nathan
- Flaherty Jan
- Flaherty Jan
- Flanagan Laura
- Flavin Aileen
- Fletcher Joanne
- Fletcher Julie
- Fletcher Mandy
- Flynn-Batham Marian
- Fode Kirsten
- Folkes Linda
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- Foo Maxine
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- Ford Amy
- Ford Chris
- Ford Daniel
- Ford Daniel
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- Ford Vicky
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- Ford Victoria
- Forkes Janet
- Forkes Janet
- Forkes Janet
- Forman Susan
- Forrest Diane
- Forrest Diane
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- Fosker Chris
- Fossey Gavin
- Foster Emma
- Foster William
- Fourt Monica
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- Frankland Helen
- Franklin Alex
- Frattaroli Paul
- Frazzi Alexandra
- Frew John
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- Galloway Lucy
- Galway Denise
- Gamble Tina
- Gamble Tina
- Gamez Raquel
- Ganabady Malavika
- Gao Annie
- Garcia Leni Santiago
- Gardiner Fiona
- Garner Victoria
- Garrett Gina
- Garrido-Perez Sandra
- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
- George Siny
- GeorgeChayka Danielle
- Geraghty Kerry
- Ghoul Mokhtar
- Gibbins Andrew
- Gibbins Jackie
- Gibbins Kate
- Gibbs Stephanie
- Gibson Sian
- Giddings Emma
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- Gilbert Duncan
- Gilbert Jeanette
- Gilby Lisa
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- Gill Lisa
- Gill Shafiq
- Gillatt David
- Gillatt David
- Gillesen Annelies
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- Gilmartin Claire
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- Ginnelly Helen
- Ginnelly Helen
- Giovannini Julia
- Gipson Anna
- Girolametto Carla
- Gladwell Louise
- Gladwish Adam
- Glaholm John
- Glaholm John
- Gleave Martin E
- Glen Hilary
- Glen Tracy
- Glick Daniel
- Goel Roshni
- Goh Chee
- Goh Chee L
- Golden Sophie
- Goldenberg S Larry
- Goldstein Cindy
- Goldsworthy Simon
- Gollapothu Srilakshmi
- Gomez JoseLuis
- Gomez-Marcos Raquel
- Gonzalez Celia
- Gooch Carol
- Goodhind Frances
- Goodsell Josie
- Goodsell Josie
- Goodwin Emma
- Gopaul Darindra
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- Goss Vanessa
- Gough Jessica
- Gould Aaron
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- Goulding James
- Goyena Ruby
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- Graham Jeffrey
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- Gramlich Colin
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- Gratton Albert
- Grau Isabel
- Gray Emma
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- Green James
- Green Sara
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- Green Sue
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- Greenland Jonathan
- Gregg Jane
- Gregorcic Emily
- Gregory Debbie
- Grieve Sylvia
- Griffen Ailsa
- Griffin Hannah
- Griffiths Dorothy
- Griffiths Leyshon
- Griffiths Theresa
- Griffiths Theresa
- Gruschy Lisa
- Guarino Robyn
- Gudelis Susan O
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Gujral Sandeep
- Gumapac Nicole
- Gunn Melanie
- Gupta Kamalnayan
- Gupta Nishi
- Gurzanski Christina
- Guy Peter
- Gwilt Julie
- Gwilt Julie
- Gwilt Julie
- Haddad Alain
- Hagan Chris
- Hague Dominic
- Haidar Imran
- Haidar Imran
- Haigh Steve
- Haldeos Anne
- Hale Jennifer
- Hall Jane
- Hall Julia
- Hall Julia
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- Hamid Abdel
- Hamill Maureen
- Hamilton Beatrice
- Hamilton Joanna
- Hamilton Ronald
- Hammonds John Christopher
- Hanna Emma
- Hannaford Zeta
- Happle Liz
- Hardie Maryon
- Harding Claudia
- Harding Joshua
- Hardman John
- Hardstaff Lisa
- Hare Jennifer A
- Hargreaves Carolyn
- Hargreaves Jeanette
- Hargreaves Jeanette
- Harinarayanan Sathish
- Harinarayanan Sathish
- Harland Keith
- Harney Jackie
- Harnwell Juliette
- Harpell Rhonda
- Harris (n. Marchant) Emily
- Harris Catherine
- Harris Sarah
- Harris-Burland Angie
- Harrison Alison
- Harrow Sister Kath
- Hart Amber
- Hart Andrew
- Harter Leah
- Hartley Jasmine
- Hartman Carrie
- Hartt Nancy
- Hartwell Lyn
- Harvey Julie
- Harvey Sally
- Harving Niels
- Haskell Annelise
- Hassall Alison
- Hassan Nebah
- Hassan Nebah
- Hathout Lara
- Hatimy Umi
- Haydock Helen
- Haydock Helen
- Hayes Jill A
- Hayward Lesley
- Healey Gail
- Healey-Mariano Jennifer
- Healey-Mariano Jennifer
- Heasley Karen
- Heath Catherine
- Heath Catherine M
- Heckford Louise
- Hedges Andy
- Heeley Janine
- Hefferon Billy
- Hegarty Gemma
- Hejlesen Finn
- Helou Joelle
- Hendel Debra
- Henry Ann
- Henry Ann
- Henry Ann
- Henry Ann
- Henry Joanne
- Henry Joanne
- Henson (nee Savidge) Verity
- Henson Helen
- Herasimtschuk Anna
- Herbert Chris
- Herbert Gaynor
- Heron Jane
- Hetherington Stacey
- Hicks Kimberly
- Higgins Linda
- Hijab Adham
- Hill Elaine
- Hill Judy
- Hill Pipa
- Hill Pippa
- Hillman Paul
- Hillman Paul
- Hilman Serena
- Hilman Serena
- Hindle Margaret
- Hines John
- Hoare Kathryn
- Hocking Christopher
- Hodder June
- Hodge Simon
- Hodges Samantha
- Hodgkinson Sheila
- Hodson Hayley
- Hodson Hayley
- Hogan Holly
- Hogan Vesna
- Hogbin Emma
- Hogbin Emma
- Holbrook Andy
- Holbrook Becky
- Holden Simon
- Holdsworth Amanda
- Hollenhorst Helmut
- Holliday Samantha
- Hollingdale Abigail
- Hollis Keri
- Hollister Robert
- Holloway Caroline
- Holmes Evelyn
- Holwerda Eleanor
- Homer David
- Hood Marion
- Hooper Simon
- Hooton Georgia
- Hore Brendan
- Horne Rhian
- Hornzee Gillian
- Hornzee Gillian
- Horton Sarah
- Horwich Alan
- Hoskin Peter
- Hoskins Ashley
- Hoskins Chloe
- Hotine Jodie
- Hough Adele
- Hough Chris
- Houghton Fionnuala
- Houle Stefanie
- House Gail
- Howard Joanna
- Howard Lucy
- Howard Lucy
- Howitt Pamela
- Hsien John
- Hubley Lynn
- Huddart Robert
- Huddart Robert
- Hudson Zoe
- Hughes Claire
- Hughes Faye
- Hughes Hayley
- Hughes Joanne
- Hughes Kathryn
- Hughes Owen
- Hughes Robert
- Hughes Simon
- Hughes-Davies Luke
- Hugill Angela
- Hugill Angela
- Humber Caroline
- Humpreys Louise
- Hunt Allison
- Hunter Catherine
- Hunter William
- Hunting Liz
- Hutchinson Camille
- Hyde Katherine
- Hyde Katherine
- Hyde Katherine
- Hynds Sharon
- Ibrahim Azman
- Ingham Jo
- Ingle Charlotte
- Inman Hayley
- Innes Helen
- Iordanidi Elina
- Iqbal Fawaad
- Irwin P
- Isaew Andrea
- Iskender Amanda
- Islam Zaheer
- Issa Rami
- Ivie Stephanie
- Jackman Dee
- Jackson Cathy
- Jackson Kim
- Jackson Sister Ann
- Jain Suneil
- Jakeman Christine
- James Naomi
- James Nicholas
- James Nicholas D
- Jamieson Ceri
- Jampana Raj
- Janke Susan
- Jannapureddy Revanth
- Jarvis Claire
- Jastrzebska Patrycja
- Javle P
- Jayachandran Resmi
- Jayachandran Resmi
- Jeffcutt Nicole
- Jeffrey David
- Jelski Joseph
- Jenkins Peter
- Jenkins Suzanne
- Jenner Abigail
- Jennings Marian
- Jepson Debbie
- Jevons Cody
- Jewers Karen
- Jewers Karen
- Jeyasanger Ganesan
- Joe Howard
- John Babbin
- Johns Louise
- Johnson Arlissa
- Johnson Craig
- Johnson Joanne
- Johnson Lyndsey
- Johnson Nigel
- Johnson-Rollings Ashley
- Johnston Laurel
- Johnston Ruth
- Johnstone Dawn
- Johnstone Maria
- Joncas MarieClaude
- Jones (Birch) Janine
- Jones Andrea
- Jones Ania
- Jones Carys
- Jones Cathryn
- Jones Clare
- Jones Dawn
- Jones Gareth
- Jones Ifan
- Jones Jules
- Jones Julia
- Jones Kathryn
- Jones Katie
- Jones Lesley
- Jones Lewis
- Jones Richard
- Jones Rob
- Jones Stephanie
- Jones Stephanie
- Jones-Skipper Kay
- Jonnada Sai
- Jope Carmel
- Jose Sanal
- Joseph Joji
- Joseph Paul K
- Joshi Manisha
- Joshi Manisha
- Joslin Vicky
- Jovic Gordana
- Kaa Bach Birgit
- Kader Nicole
- Kalejaiye Odunayo
- Kaliski Alexandre
- Kalyvas Maria
- Kamran Asim
- Kanaga-Sundaram Subramanian
- Kancherla Kiran
- Kanji Femina
- Kanyi Karen
- Kapur Guarav
- Karim Omer
- Karp Stephen
- Karsera Louise
- Karunakaran Subashini
- Karvat Anand
- Kaushal Malan
- Kavanagh Roisin
- Kavanagh Roisin
- Kay Anne Marie
- Kazingizi Memory
- Keane Patrick
- Kearney S
- Kedge Liz
- Kehoe Laura
- Keith Sarah
- Keith Sarah
- Kelkar Anand
- Kellaway Joanne
- Kelly Alison
- Kelly Kay
- Kemp Gail
- Kempel Mette Moe
- Kendal Wayne S
- Keng-Koh Pek
- Keng-Koh Pek
- Keni Manjusha
- Kennedy Julie
- Kenny Shannon
- Kent Christopher
- Kent Emma
- Kenyon Lucille
- Kershaw Elizabeth
- Key Claire
- Keyes Mira
- Khaksar Sara
- Khan Omar
- Khan Yakhub
- Khaouam Nader
- Khong Rachel
- Khoo Vincent
- Khoo Vincent
- Khoury Ghassan
- Kiff Janet
- Kift Shannon
- Kilmartin John
- Kilroy Stephen
- Kilroy Stephen
- Kiltie Anne
- Kiltie Anne
- Kim David
- Kim TuongVan
- Kim-Sing Charmaine
- KimSing Charmaine
- King Amy
- King Jennifer
- King Jennifer
- King Lisa
- Kinrade Yvonne
- KirbyBello Denise
- Kirk Christine
- Kirk Sister Sarah
- Kirkbride Peter
- Kirkbride Peter
- Kirkby Amy
- Kirkby Sarah
- Kirkpatrick Suriya
- Kisanga Mary
- Kitkowski Caitlin
- Klapp Kathi
- Klotz Laurence
- Klovgaard Karina
- Knackstedt Jochen
- Knapp Jeanette
- Knight (n. Sherburn) Victoria
- Knott Helen
- Knox WF
- Kockelbergh Roger
- Kodavatiganti Ravi
- Koehler Ingrid
- Kokholm Kathrine Friser
- Koll Wayne
- Kong Vickie
- Kotze Michelle
- Koul Rashmi
- Koulouris Zoe
- Koupparis Anthony
- Kowalczyk-Williams Wioletta
- Kowalewska Paulina
- Kronstal Flo
- Krysta Beata
- Kuenzig Greg
- Kujawa Magda
- Kuk Joda
- Kullane Sagal
- Kumar Daniel
- Kumar Muthar
- Kumar Shiyam
- Kumar Vikaash
- Kurian-Downer Sunita
- Kurup Rahul
- Kuzyk Valerie
- Kwan Winkle
- Kyffin Phillippa
- Kynaston Howard
- Kynaston Howard
- Lacey Cathy
- Lachance Nicole
- Lactao Ranee
- Ladouceur Cynthia
- Laing Robert
- Lajoie MarieAndree
- Lake Sister Judith
- Lalani Nafisha
- Laliberte Benoit
- Lam Jacqueline
- Lambert Carole
- Lambert Katy
- Lamoureux Alexandra
- Lang Monika
- Langridge Nicole
- Laniado M
- Lao Bernadeth
- Larkins Rachel
- Larocque Stephanie
- Larouche Julie
- Larson Beverly
- Lassen Yasmin
- Last Debbie
- Lau Maurice
- Laubscher Angelique
- Laughlin Anne
- Laursen Vibeke
- Lavender Helene
- Laverick Rosaleen
- Lavertu Sophie
- Lawless Claire
- Lawless Theresa
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- Lawrence Steph
- Lawrey Sarah
- Lawson Daeria
- Lazarte Jannika
- Leach Deborah
- Lebrun Benoit
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- Lee Bernard
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- Leitao Madalena
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- Lenton Daniel
- Leone Priscilla
- Leone Priscilla
- Leong Nelson
- Leung Michael
- Lew Tanya
- Lewington Val
- Lewis Amanda
- Lewis Christina
- Lewis Joanne
- Lewis Sion
- Ley Samantha
- Li Audrey
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- Liau Joy
- Light Teresa
- Lim Jan
- Lim Jun
- Lindberg Henriette
- Lines Yvonne
- Lipsham Margaret
- Liptrott Sarah
- Lister Debbie
- Litchfield Jayne
- Little Erin
- Little Jessica
- Littler John
- Littler Stephen
- Liu Stanley
- Livsey Jacqueline
- Livsey Jacqueline
- Lloyd-Jones Hugh
- Loblaw Douglas Andrew
- Lock Michael I
- Locke Angela
- Lockwood Carol
- Logue John
- Logue John
- Logue John
- Logue John
- Lokes Rachel
- Lokes Rachel
- Lomas Alia
- Lomas Claire
- Lomax Laurie
- London Clare
- Long Carol
- Long Heather
- Loughlin Kate
- Loughrey Carmel
- Love Clare
- Love Sally
- Lowe Amelia
- Lowi Suzy
- Lucakova Slavka
- Lukka Himu
- Lunau Anne Sofie
- Lydon Anna
- Lydon Anne Marie
- Lynch Rory
- Lyons Ciara
- Mabelin Louies
- Macavoy Tina
- Macdonald Alison
- MacDonald Angela
- MacDonald Graham
- Macefield Rhiannon
- MacGregor Barbara
- Macgregor Carol
- MacIsaac Kathy
- MacIsaac Patricia
- Mackay Rachel
- Macleod Nicholas
- MacMillan Antonia
- MacMullin Lisa
- MacRae Robert M
- Macrory Joanne
- MacVicar Jennifer
- MacVicar Karen
- Madeleine Jude
- Madhava Kudingila
- Madine John
- Magwaro Sophia
- Magwaro Sophia
- Magwaro Sophia
- Mahmood Rana
- Mahmood Rana
- Mahmood Sana
- Mahmud Aamer
- Mahoney Catriona
- Mahoney Sue
- Maitland Katrina
- Maize Christine
- Majumdar Arpita
- Makepeace Barbara
- Malde Rohit
- Malek Leila
- Malik Zafar
- Mallett Debbie
- Malone Shawn
- Malone Shawn C
- Manetta Caroline
- Manganaro Aileen
- Mangar Stephen
- Maniatis Christos
- Manley Rachel
- Mannan Aliyah
- Manning Courtney
- Manning Kimberley
- Mansell Gemma
- Mansfield Carolyn
- Mantle Mark
- Manyangadze Sarah
- Marange Josephine
- Mardell Stephen
- Marek Kathleen
- Mariappan Param
- Marineau Line
- Mark Ian
- Markus Sarah
- Marley Hazel
- Marquis Tania
- Marriott Sue
- Marshall John
- Marshall Lynn
- MarshGray Kimberley
- Marston Kerrie
- Martin AndreGuy
- Martin Jackie
- Martin Joseph
- Martin Karen
- Martindale John
- Martindale John
- Martindale John
- Martinez Maria
- Martinou Maria
- Martins Sarah
- Marty Janet
- Mashegede Beverley
- Mason Jessica
- Mason Malcolm
- Masson Susan
- Masson Susan
- Masters Benjamin
- Masters Lindsey
- Matkins Ellen
- Matthews Laura
- Mattocks Lehentha
- Mayer Heather
- Mayne Barbara
- Mazhar Danish
- McAleese Jonathan
- McAlister Judy
- McAllister Jo
- McAuliffe Sarah
- McBain Hazel
- McBride Julia
- McCabe Alastair
- McCadden Angela
- McCarth Fiona
- McCartin Fiona
- McCaul Damian
- McClelland Marie
- McClements Jane
- McClurey Sister Patricia
- McCormack Anne
- McCormick Marian
- McCracken Jillian
- McCrisken Lauren
- McCrudden Sylvia
- McCully Ruby
- McCurrie Marilyn
- McFarlane Jonathan
- McFarlane Victoria
- McGarry Karen
- McGinley Shannon
- McGlynn Brian
- McGrath John
- McGrath Katherine
- McIndoe Sue
- McInerney Paul
- McInerney Sue
- McInerney Veronica
- Mcintosh Gregor
- McKee Dianne
- McKenna Karen
- McKenzie Michael
- McKernan Margaret
- McKinna Fiona
- McKinna Fiona
- McLain-Smith Susan
- McLaren Duncan
- McLarty Esther
- Mcleod Nick
- McMeekin Faith
- McMenemin Rhona
- McNally Morag
- McNish Jennifer
- McNulty Dawn
- McPhail Neil
- McWilliam Donna
- McWilliam Marie
- Meadows Lorna
- Medisetti Aruna
- Meidhal Petersen Peter
- Melcher Lucinda
- Melcher Lucinda
- Menard Cynthia
- Menard Cynthia
- Mendoza Edeliza
- Merante Pat
- Mercer Lily
- Mercier Barbara
- Merrick Richard
- Metcalf Karen
- Meyer Ralph
- Michael Elena
- Michaelidou Andriana
- Michels Jorg
- Middleton Sharon
- Mikropoulos Christos
- Mikropoulos Christos
- Millage Helen
- Miller Nikki
- Mills Jamie
- Mills Laurie
- Mills-Baldock Tina
- Milner Jessica
- Milosevic Michael
- Mirmooji Ramesh
- Mirza Arafat
- Mislang Albert
- Mistry Heena
- Mistry Leena
- Mitchell Darren
- Mitchell Donna
- Mitchell Lesley
- Mithal Natasha
- Mitra Anita
- Moelker Yvonne
- Moffatt Emily
- Mohamed Fatima
- Mohan Rita
- Mohseeni Arizoo
- Moir Rachel
- Mojidra Chintan
- Mole Lisa
- Moller Christensen Trine
- Molony-Oates Barbara
- Money-Kyrle Julian
- Montebello Joseph
- Montour Julie
- Moody Emma
- Mooney Matthew
- Moore Eleanor
- Moore Eleanor
- Moore Sally
- Moore Sister Helen
- Morales Maria
- Morales-Azofra Fabiola
- Morgan Rachel
- Morgan Scott
- Morris Stephen
- Morris Stephen L
- Morris William James
- Morrison Andrew
- Morrison Jennifer
- Morrison MaryBeth
- Morrow Hugh
- Morton Gerard
- Morton Gerard
- Morton Susan
- Moss Sarah
- Mthethwa Thobekile
- Mui Jimmy
- Mukkath Sandra
- Mumin Anissa
- Mundy Carina
- Munson Lyndsey
- Murad Fatima
- Muraj Zaynab
- Murano Abby
- Murphy Ann
- Murphy Brenda
- Murphy Cara
- Murphy Claire
- Murphy Karen
- Murphy Louise
- Murray Jane
- Murray Stacey
- Murtha Albert
- Musunuru Hima Bindu
- Muthu Kumar Dakshinamoorthy
- Myatt Alison
- Myles Sophie
- Myrehaug Sten
- Nabid Abdenour
- Nabid Abdenour
- Nagar Yoodhvir
- Naim Farhan
- Nakashima Lynne
- Nallathambi Chandran
- Nam Robert K
- Narahari Krishna
- Naraine Nicky
- Nash Dominic
- Nash Maxine
- Nashed Maged
- Natale Salvatore
- Nathan Kannon
- Nathan Kannon
- Nawrozzadeh Mohammed
- Naylor Deirdre
- Naylor Lynne
- Nazari Roonak
- Neal Amy
- Neave Farhad
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- Nelder Matthew
- Nemirov Stephanie
- Neshiri Innocent
- Neville Sean
- Newbery Carol
- Newby Jackie
- Newman Hugh
- Newton Rachel
- Ngumo Alice
- Ngumo Alice
- Nguyen David H A
- Nguyen Julie
- Ngwenya Su
- Nichol Rhonda
- Nicholas Karen
- Nicholls Alison
- Nicholson Alastair
- Nicholson Alastair
- Nieforth Joan
- Nielsen Linda
- Nikapota Ashok
- Nikapota Ashok
- Nixon Jude
- Nobes Jenny
- Nobes Jenny
- Noble Mark
- Noel Lorilee
- Noor Dipa
- Norman Alia
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- Nutman Chris
- Nybom Kirstine
- Nørmark Iversen Helle
- O'Beney Rachael
- O'Brien Neale
- O'Callaghan Jane
- O'Connor Kate
- O'Donnell Helen
- O'Dwyer Sister Jackie
- O'Flynn Kieran
- O'Neil Rebecca
- O'Neill Eilish
- O'Neill John
- O'Sullivan Joe
- OBrien Anna
- ODea Jamie
- Okubanjo Maryanne
- Okubanjo Maryanne
- Olabanji Matthew
- Oladimeji Janet
- Olaniyi-Oduntan Darlletta
- Olaoni Thompson
- Olha Carolynna
- Oliver Joanne
- Oliverio Carmela
- Ong Aldrich D
- Ong Aldrich Dixon
- Oni Titilayo
- Onoge Ekugbe
- Oommen Nikhil
- Oommen Nikhil
- Oosterom Katrien
- Opitz Debbie
- Orford Sara
- Orrell Lucy
- Ostler Peter
- Ostrowski Joe
- Othman Aqilah
- Ouelette Ashley
- Overend Aldyn
- Owen Lisa
- Owen Roger
- Owen Susan
- Owen Tim
- Owens Rob
- Oxley Jon
- Pach Jackie
- Padilla-Harris Cheryl
- Page Nancy
- Pai Howard H
- Paisey Sangeeta
- Palmer Debbie
- Palmer Sarah
- Pamphlett Ian
- Pan Siew Siew
- Panades Miguel
- Panades Miguel
- Panakis Niki
- Panakis Niki
- Panakis Niki
- Panesar Pritpal
- Papakostidi Aristoula
- Parajes Cerila
- Parikh Omi
- Parikh Omi
- Parikh Omi
- Parikh Shefali
- Parker Chris
- Parker Chris C
- Parker Shelley
- Parkinson Katrina
- Parkinson Sharron
- Parliament Matthew B
- Parmar Mahesh K B
- Parmar Max
- Parr Stephen
- Partington Lillian
- Partridge Kerena
- Parulekar Wendy
- Parulekar Wendy R
- Paschalis Alec
- Pascoe Caitlin
- Pascoe Sarah
- Pashley Sarah
- Patel Anup
- Patel Chandni
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- Patel Malti Behn
- Patel Priyanka
- Patel Samir
- Pathmanathan Byiravey
- Patil Nikhilesh
- Patrick Julie
- Patterson Helen
- Patterson Paul
- Pattu Pugazhenthi
- Paul Nancy
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- Pawl Marilyn
- Payne Ann
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- Payne Heather
- Peacock Michael
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- Pearcey Robert
- Pearse Kevin
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- Pearson Sandra
- Peck Suzannah
- Pedley Ian
- Peedell Clive
- Pegler Ruth
- Pegler Suzannah
- Pendrill Amy
- Penhaligon Corrine
- Pentecost Catherine
- Peres Sarin
- Periasamy Manivannan
- Perkins Lauren
- Perry Emily
- Perry Gad A
- Perry Heather
- Perry Jess
- Perry Matthew
- Perry Matthew
- Persad Raj
- Persad Rajendra A
- Pervez Nadeem
- Peterkin Zhane
- Peters John
- Petersen Peter M
- Peterson Jane
- Petroff Avi
- Petrovska Aleksandra
- Petsa Maria
- Pezaro Carmel
- Phan Mau-Don
- Phillips Ann
- Philp Timothy
- Phipps Charlotte
- Pickering Holly
- Pickles Thomas A
- Pigott Katherine
- Pilkington Pauline
- Pillai Sijy
- Pineda Sandra
- Pinnell Erin
- Piper Jane
- Piper Lindsay
- Pippard Lucy
- Plataniotis George
- Platt Danielle
- Plowman Kristian
- Pochini Craig
- Pocock Abigail
- Poder Lone Lund
- Pokhrel Sujata
- Pollard Kay
- Poole Abbie
- Pope Suzanne
- Porter Tim
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- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- Elsevier
- Publication date
- 07/06/2024
- Field of study
Get PDFBackground
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
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- Allen Susan
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- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
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- Amoaten Thomas
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- Anderson Chris
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- Carpenter Janice
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- Carroll Weronika
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- Carter Adam
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- Casanova Nathalie
- Casey Linda
- Casey Sue
- Catt Natalie
- Catton Charles
- Catton Charles N.
- Caumont Tom
- Cavanagh Kerrie
- Chadwick David
- Chadwick Eliot
- Chahal Rohit
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- Chakraborti Prabir
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- Challipalli Amarnath
- Chamberlain Shelley
- Chambers Carla
- Chan Andrew
- Chan Andrew
- Chan Heidi
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- Chan Olivia
- Chandrashekara Madhura
- Charnley Natalie
- Chatelain AnneMarie
- Chatfield Jenny
- Chauhan Zainab
- Chedham Alison
- Chennattukungu Indukala
- Cherepak Kathy
- Chetiyawardana Samantha
- Chetiyawardana Samantha
- Chettle Judith
- Cheung Arthur
- Cheung Patrick CF
- Chikkamuniyappa Bindu
- Chikkamuniyappa Bindu
- Chikopela Loveness
- Chilcott Helen
- Chipman Penny
- Chivers Rachael
- Chornopyski Tracy
- Choudhury Ananya
- Choudhury Ananya
- Choudhury Ananya
- Chowdhury Amitava D
- Christensen Anne Juel
- Christensen Tine
- Christmas Sallyanne
- Chrystal Melanie
- Chu William
- Chui Amadeus
- Chung Christina
- Chung Hans T
- Chung Peter
- Chung Peter W.M.
- Churn Mark
- Churn Mark
- Clancy Joanna
- Clapp Felicity
- Clark Alison
- Clark Diane
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- Clarke Elizabeth
- Clarke Jude
- Clarke Maria
- Clarke Noel
- Clarke Noel W.
- Clarke Peter
- Clarke Rachael
- Clarke Samantha
- Cleary Kristy
- Clements Colette
- Clements Mia AnnaMaria
- Clitheroe Pat
- Cobos-Arrivabene Marta
- Cocks Tracie
- Coe Marc
- Coffin Teresa
- Cogley Lyn
- Cogley Lyn
- Cole Aiden
- Cole David J
- Cole David J
- Collard Susan
- Colligan Steve
- Collins Gerald
- Collins Gerald
- Collins Lucy
- Commisso Angela
- Conibear John
- Connolly nee McKenna Sarah
- Connor Marie
- Conroy Ruth
- Conroy Ruth
- Conway Lisa-Jane
- Conway Rachel
- Cook Adrian
- Cook Adrian D.
- Cook Audrey
- Cook Audrey
- Cook Wendy
- Cooke Jill
- Cooke Juniebel
- Cooke Peter
- Coomber Kristy
- Coombs Sarah
- Cooper Adele
- Cooper Sophie
- Coppins Helen
- Corbett Thomas B
- Corcoran Sam
- Corderoy Helen
- Cordwell Amanda
- Corkery Danylle
- Corless Rebecca
- Cormack Margaret
- Cornaby Andrew
- Corner Victoria
- Cornthwaite Stephanie
- Corwin Charlotte
- Cossette Danielle
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- Cotts Shannon
- Coubrough Claudia
- Couch Ellie
- Coughlan Tricia
- Cousins Jane
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- Coutts Tim
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- Cowan Chloe
- Cowan Chloe
- Cowan Richard
- Cowan Richard
- Cowley Sue
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- Cox Christine
- Coyle Catherine
- Coyle Catherine
- Crawford Melanie
- Crawford Sister Denise
- Creelman Brianna
- Crellin Perric
- Crellin Perric
- Crook Juanita
- Cross Vanessa
- Cross William R.
- Crossley Lin
- Crowe (nee Hughes) Dawn
- Crowley Claire
- Crundwell M
- Cserbane Anita
- Cuffe Donna
- Cumming Kirsty
- Cunningham Amy
- Curtis Samantha
- Curtis Sandra
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- Custins Laura
- Cyriac Abby
- Dabbs Marianne
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- Dallas Nicola
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- Dalton-Short Ross
- Daly Deirdre
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- Danaswamy Patricia
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- Davison Alison
- Davison Sue
- Dawe David
- Dawson Elizabeth
- Dawson Louise
- Dawson-Athey Linda
- Dayes Ian S
- De Silva-Minor Shiroma
- Dean Lynsey
- Dearnaley David
- Deenihan Emma
- Degendorfer Sarah
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- Dodds David
- Dodge Sister Jan
- Doherty A
- Donaghey Sally
- Donaldson David
- Donnison Michelle
- Douch Emma
- Doughty Victoria
- Dover Serena
- Downs Nichola
- Doyle Kerrie
- Drachenberg Darrel E
- Drakeley Susan
- Drew Ellen
- Drew Mary (Ellen)
- Driscoll Celine
- DSouza David
- Dubey Arbind
- Dubey Arbind
- Duckett Tracey
- Duclos Marie
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- DuMontier Joelle
- Duncan (nee Keatley) Claire
- Duncan Graeme
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- Dymond Harvey
- E Choan
- Eady Robin
- Eapen Libni
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- Edwards Abigail
- Edwards Albert
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- Edwards Steve
- Edwards Steve
- Egan Lisa
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- Ellard Rose
- Elliott Mark
- Elliott Tony
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- ElSokhn Nidale
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- Elwell Christine
- Elwell Sue
- Embleton Andrew
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- Fallaize Adrian
- Faria Sergio Luiz
- Farnworth Christine
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- Fearnley Mark
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- Ferguson Catherine
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- Ferreira Miguel
- Fiddes Kathleen
- Fielding Bethany
- Fielding Bethany
- Fildes Diane
- Finnegan Niall
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- Firth Alexandra
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- Firth Elizabeth
- Fish Matt
- Fish Nathan
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- Flaherty Jan
- Flanagan Laura
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- Fode Kirsten
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- Foo Maxine
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- Forcat Silvia
- Forcat Silvia
- Ford Amanda
- Ford Amy
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- Ford Daniel
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- Forkes Janet
- Forkes Janet
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- Forman Susan
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- Gao Annie
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- Gardiner Fiona
- Garner Victoria
- Garrett Gina
- Garrido-Perez Sandra
- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
- George Siny
- GeorgeChayka Danielle
- Geraghty Kerry
- Ghoul Mokhtar
- Gibbins Andrew
- Gibbins Jackie
- Gibbins Kate
- Gibbs Stephanie
- Gibson Sian
- Giddings Emma
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- Gilbert Duncan
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- Gilby Lisa
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- Gillatt David
- Gillesen Annelies
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- Gilmartin Claire
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- Ginnelly Helen
- Ginnelly Helen
- Giovannini Julia
- Gipson Anna
- Girolametto Carla
- Gladwell Louise
- Gladwish Adam
- Glaholm John
- Glaholm John
- Gleave Martin E
- Glen Hilary
- Glen Tracy
- Glick Daniel
- Goel Roshni
- Goh Chee
- Goh Chee L.
- Golden Sophie
- Goldenberg S Larry
- Goldstein Cindy
- Goldstein Cindy
- Goldsworthy Simon
- Gollapothu Srilakshmi
- Gomez JoseLuis
- Gomez-Marcos Raquel
- Gonzalez Celia
- Gooch Carol
- Goodhind Frances
- Goodsell Josie
- Goodsell Josie
- Goodwin Emma
- Gopaul Darindra
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- Goulden Kay
- Goulding James
- Goyena Ruby
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- Gregg Jane
- Gregorcic Emily
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- Griffen Ailsa
- Griffin Hannah
- Griffiths Dorothy
- Griffiths Leyshon
- Griffiths Theresa
- Griffiths Theresa
- Gruschy Lisa
- Guarino Robyn
- Gudelis Susan O
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Gujral Sandeep
- Gumapac Nicole
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- Gurzanski Christina
- Guy Peter
- Gwilt Julie
- Gwilt Julie
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- Haidar Imran
- Haidar Imran
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- Hammonds John Christopher
- Hanna Emma
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- Happle Liz
- Hardie Maryon
- Harding Claudia
- Harding Joshua
- Hardman John
- Hardstaff Lisa
- Hare Jennifer A
- Hargreaves Carolyn
- Hargreaves Jeanette
- Hargreaves Jeanette
- Harinarayanan Sathish
- Harinarayanan Sathish
- Harland Keith
- Harney Jackie
- Harnwell Juliette
- Harpell Rhonda
- Harris (n. Marchant) Emily
- Harris Catherine
- Harris Sarah
- Harris-Burland Angie
- Harrison Alison
- Harrow Sister Kath
- Hart Amber
- Hart Andrew
- Harter Leah
- Hartley Jasmine
- Hartman Carrie
- Hartt Nancy
- Hartwell Lyn
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- Haskell Annelise
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- Hassan Nebah
- Hathout Lara
- Hatimy Umi
- Haydock Helen
- Haydock Helen
- Hayes Jill A
- Hayward Lesley
- Healey Gail
- Healey-Mariano Jennifer
- Healey-Mariano Jennifer
- Heasley Karen
- Heath Catherine
- Heckford Louise
- Hedges Andy
- Heeley Janine
- Hefferon Billy
- Hegarty Gemma
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- Helou Joelle
- Hendel Debra
- Henry Ann
- Henry Ann
- Henry Ann
- Henry Ann
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- Henry Joanne
- Henson (nee Savidge) Verity
- Henson Helen
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- Herbert Chris
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- Hicks Kimberly
- Higgins Linda
- Hijab Adham
- Hill Elaine
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- Hillman Paul
- Hillman Paul
- Hilman Serena
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- Hindle Margaret
- Hines John
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- Hocking Christopher
- Hodder June
- Hodge Simon
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- Hodgkinson Sheila
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- Hodson Hayley
- Hogan Holly
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- Hogbin Emma
- Holbrook Andy
- Holbrook Becky
- Holden Simon
- Holdsworth Amanda
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- Hollis Keri
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- Hornzee Gillian
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- Horwich Alan
- Hoskin Peter
- Hoskin Peter
- Hoskins Ashley
- Hoskins Chloe
- Hotine Jodie
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- Hubley Lynn
- Huddart Robert
- Huddart Robert
- Hudson Zoe
- Hughes Claire
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- Hughes Joanne
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- Hughes Owen
- Hughes Robert
- Hughes Simon
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- Hugill Angela
- Hugill Angela
- Humber Caroline
- Humpreys Louise
- Hunt Allison
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- Hunter William
- Hunting Liz
- Hutchinson Camille
- Hyde Katherine
- Hyde Katherine
- Hyde Katherine
- Hynds Sharon
- Ibrahim Azman
- Ingham Jo
- Ingle Charlotte
- Inman Hayley
- Innes Helen
- Iordanidi Elina
- Iqbal Fawaad
- Irwin P
- Isaew Andrea
- Iskender Amanda
- Islam Zaheer
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- Jackman Dee
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- Jackson Kim
- Jackson Sister Ann
- Jain Suneil
- Jakeman Christine
- James Naomi
- James Nicholas
- Jamieson Ceri
- Jampana Raj
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- Jarvis Claire
- Jastrzebska Patrycja
- Javle P
- Jayachandran Resmi
- Jayachandran Resmi
- Jeffcutt Nicole
- Jeffrey David
- Jelski Joseph
- Jenkins Peter
- Jenkins Suzanne
- Jenner Abigail
- Jennings Marian
- Jepson Debbie
- Jevons Cody
- Jewers Karen
- Jewers Karen
- Jeyasanger Ganesan
- Joe Howard
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- Johnson Arlissa
- Johnson Craig
- Johnson Joanne
- Johnson Lyndsey
- Johnson Nigel
- Johnson-Rollings Ashley
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- Johnston Ruth
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- Johnstone Maria
- Joncas MarieClaude
- Jones (Birch) Janine
- Jones Andrea
- Jones Ania
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- Jones Gareth
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- Jones Katie
- Jones Lesley
- Jones Lewis
- Jones Richard
- Jones Rob
- Jones Stephanie
- Jones Stephanie
- Jones-Skipper Kay
- Jonnada Sai
- Jope Carmel
- Jose Sanal
- Joseph Joji
- Joseph Paul K
- Joshi Manisha
- Joshi Manisha
- Joslin Vicky
- Jovic Gordana
- Kaa Bach Birgit
- Kader Nicole
- Kalejaiye Odunayo
- Kaliski Alexandre
- Kalyvas Maria
- Kamran Asim
- Kanaga-Sundaram Subramanian
- Kancherla Kiran
- Kanji Femina
- Kanyi Karen
- Kapur Guarav
- Karim Omer
- Karp Stephen
- Karsera Louise
- Karunakaran Subashini
- Karvat Anand
- Kaushal Malan
- Kavanagh Roisin
- Kavanagh Roisin
- Kay Anne Marie
- Kazingizi Memory
- Keane Patrick
- Kearney S
- Kedge Liz
- Kehoe Laura
- Keith Sarah
- Keith Sarah
- Kelkar Anand
- Kellaway Joanne
- Kelly Alison
- Kelly Kay
- Kemp Gail
- Kempel Mette Moe
- Kendal Wayne S
- Keng-Koh Pek
- Keng-Koh Pek
- Keni Manjusha
- Kennedy Julie
- Kenny Shannon
- Kent Christopher
- Kent Emma
- Kenyon Lucille
- Kershaw Elizabeth
- Key Claire
- Keyes Mira
- Khaksar Sara
- Khan Omar
- Khan Yakhub
- Khaouam Nader
- Khong Rachel
- Khoo Vincent
- Khoo Vincent
- Khoo Vincent
- Khoury Ghassan
- Kiff Janet
- Kift Shannon
- Kilmartin John
- Kilroy Stephen
- Kilroy Stephen
- Kiltie Anne
- Kiltie Anne
- Kim David
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- KimSing Charmaine
- King Amy
- King Jennifer
- King Jennifer
- King Lisa
- Kinrade Yvonne
- KirbyBello Denise
- Kirk Christine
- Kirk Sister Sarah
- Kirkbride Peter
- Kirkbride Peter
- Kirkby Amy
- Kirkby Sarah
- Kirkpatrick Suriya
- Kisanga Mary
- Kitkowski Caitlin
- Klapp Kathi
- Klotz Laurence
- Klovgaard Karina
- Knackstedt Jochen
- Knapp Jeanette
- Knight (n. Sherburn) Victoria
- Knott Helen
- Knox WF
- Kockelbergh Roger
- Koehler Ingrid
- Kokholm Kathrine Friser
- Koll Wayne
- Kong Vickie
- Kotze Michelle
- Koul Rashmi
- Koulouris Zoe
- Koupparis Anthony
- Kowalczyk-Williams Wioletta
- Kowalewska Paulina
- Kronstal Flo
- Krysta Beata
- Kuenzig Greg
- Kujawa Magda
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- Kumar Daniel
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- Kurup Rahul
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- Kynaston Howard
- Kynaston Howard
- Lacey Cathy
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- Lactao Ranee
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- Laing Robert
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- Lake Sister Judith
- Lalani Nafisha
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- Lam Jacqueline
- Lambert Carole
- Lambert Katy
- Lamoureux Alexandra
- Lang Monika
- Langridge Nicole
- Laniado M
- Lao Bernadeth
- Larkins Rachel
- Larocque Stephanie
- Larouche Julie
- Larson Beverly
- Lassen Yasmin
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- Lau Maurice
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- Lavender Helene
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- Lawless Claire
- Lawless Theresa
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- Lawrence Steph
- Lawrey Sarah
- Lawson Daeria
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- Leach Deborah
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- Leung Michael
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- Lewington Val
- Lewis Amanda
- Lewis Christina
- Lewis Joanne
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- Lipsham Margaret
- Liptrott Sarah
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- Little Jessica
- Littler John
- Littler Stephen
- Liu Stanley
- Livsey Jacqueline
- Livsey Jacqueline
- Lloyd-Jones Hugh
- Loblaw Douglas Andrew
- Lock Michael I
- Locke Angela
- Lockwood Carol
- Logue John
- Logue John
- Logue John
- Logue John
- Lokes Rachel
- Lokes Rachel
- Lomas Alia
- Lomas Claire
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- Loughlin Kate
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- Love Sally
- Lowe Amelia
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- Lukka Himu
- Lunau Anne Sofie
- Lydon Anna
- Lydon Anne Marie
- Lynch Rory
- Lyons Ciara
- Mabelin Louies
- Macavoy Tina
- Macdonald Alison
- MacDonald Angela
- MacDonald Graham
- Macefield Rhiannon
- MacGregor Barbara
- Macgregor Carol
- MacIsaac Kathy
- MacIsaac Patricia
- Mackay Rachel
- Macleod Nicholas
- MacMillan Antonia
- MacMullin Lisa
- MacRae Robert M
- Macrory Joanne
- MacVicar Jennifer
- MacVicar Karen
- Madeleine Jude
- Madhava Kudingila
- Madine John
- Magwaro Sophia
- Magwaro Sophia
- Magwaro Sophia
- Mahmood Rana
- Mahmood Rana
- Mahmood Sana
- Mahmud Aamer
- Mahoney Catriona
- Mahoney Sue
- Maitland Katrina
- Maize Christine
- Majumdar Arpita
- Makepeace Barbara
- Malde Rohit
- Malek Leila
- Malik Zafar
- Mallett Debbie
- Malone Shawn
- Malone Shawn C.
- Manetta Caroline
- Manganaro Aileen
- Mangar Stephen
- Maniatis Christos
- Manley Rachel
- Mannan Aliyah
- Manning Courtney
- Manning Kimberley
- Mansell Gemma
- Mansfield Carolyn
- Mantle Mark
- Manyangadze Sarah
- Marange Josephine
- Mardell Stephen
- Marek Kathleen
- Mariappan Param
- Marineau Line
- Mark Ian
- Markus Sarah
- Marley Hazel
- Marquis Tania
- Marriott Sue
- Marshall John
- Marshall Lynn
- MarshGray Kimberley
- Marston Kerrie
- Martin AndreGuy
- Martin Jackie
- Martin Joseph
- Martin Karen
- Martindale John
- Martindale John
- Martindale John
- Martinez Maria
- Martinou Maria
- Martins Sarah
- Marty Janet
- Mashegede Beverley
- Mason Jessica
- Mason Malcolm
- Masson Susan
- Masson Susan
- Masters Benjamin
- Masters Lindsey
- Masters Lindsey
- Matkins Ellen
- Matthews Laura
- Mattocks Lehentha
- Mayer Heather
- Mayne Barbara
- Mazhar Danish
- McAleese Jonathan
- McAlister Judy
- McAllister Jo
- McAuliffe Sarah
- McBain Hazel
- McBride Julia
- McCabe Alastair
- McCadden Angela
- McCarth Fiona
- McCartin Fiona
- McCaul Damian
- McClelland Marie
- McClements Jane
- McClurey Sister Patricia
- McCormack Anne
- McCormick Marian
- McCracken Jillian
- McCrisken Lauren
- McCrudden Sylvia
- McCully Ruby
- McCurrie Marilyn
- McFarlane Jonathan
- McFarlane Victoria
- McGarry Karen
- McGinley Shannon
- McGlynn Brian
- McGrath John
- McGrath Katherine
- McIndoe Sue
- McInerney Paul
- McInerney Sue
- McInerney Veronica
- Mcintosh Gregor
- McKee Dianne
- McKenna Karen
- McKenzie Michael
- McKernan Margaret
- McKinna Fiona
- McKinna Fiona
- McLain-Smith Susan
- McLaren Duncan
- McLarty Esther
- Mcleod Nick
- McMeekin Faith
- McMenemin Rhona
- McNally Morag
- McNish Jennifer
- McNulty Dawn
- McPhail Neil
- McWilliam Donna
- McWilliam Marie
- Meadows Lorna
- Medisetti Aruna
- Meidhal Petersen Peter
- Melcher Lucinda
- Melcher Lucinda
- Menard Cynthia
- Menard Cynthia
- Mendoza Edeliza
- Merante Pat
- Mercer Lily
- Mercier Barbara
- Merrick Richard
- Metcalf Karen
- Meyer Ralph
- Michael Elena
- Michaelidou Andriana
- Michels Jorg
- Middleton Sharon
- Mikropoulos Christos
- Mikropoulos Christos
- Millage Helen
- Miller Nikki
- Mills Jamie
- Mills Laurie
- Mills-Baldock Tina
- Milner Jessica
- Milosevic Michael
- Mirmooji Ramesh
- Mirza Arafat
- Mislang Albert
- Mistry Heena
- Mistry Leena
- Mitchell Darren
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- Mitchell Lesley
- Mithal Natasha
- Mitra Anita
- Moelker Yvonne
- Moffatt Emily
- Mohamed Fatima
- Mohan Rita
- Mohseeni Arizoo
- Moir Rachel
- Mojidra Chintan
- Mole Lisa
- Moller Christensen Trine
- Molony-Oates Barbara
- Money-Kyrle Julian
- Montebello Joseph
- Montour Julie
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- Rodrigues George B
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- Thomson Alastair H
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- Ward Colin
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- Waring Lynsey
- Waring Lynsey
- Wassall Rebecca
- Watkinson Catrin
- Watson Melanie R
- Watson Michaella
- Watson-Jones Phillip
- Watts Angela
- Watts Erica
- Weaver Andrew
- Weaver Emma
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- Woloshyn Rose
- Wong Jason W T
- Wood Allison
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- Woodward Elizabeth
- Woolf David
- Woolf David
- Workman Bridget
- Worlding Jane
- Worlding Jane
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- Worthington Hannah
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- Wright Seonaid
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- Wronski Sue
- Wu Helen
- Wu Min
- Wyatt Clare
- Wylie James
- Wylie James
- Wylie James
- Wylie James P.
- Wynn Hazel
- Wynn Hazel
- Yanchuk Janet
- Yarrow Sue
- Yassa Michael
- yates Victoria
- Yee Don
- Yeo Tanya
- Yoon Frederick
- Youd Sister Jill
- Young Anita
- Young Bobbie
- Young Douglas
- Young Sally
- Youngs Nora
- Yu Jason
- Yunace Lorrie
- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zarkar Anjali M.
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2024
- Field of study
Get PDFBackground
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Developing skills in strategic transformation
- Author
- Publication venue
- 'Emerald'
- Publication date
- Field of study
No full textStockport Exercise on Prescription Evaluation report
- Author
- Publication venue
- Publication date
- 01/01/1993
- Field of study
No full textSIGLEAvailable from British Library Document Supply Centre-DSC:98/10053 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
