Evolution equations for the perturbations of slowly rotating relativistic stars

We present a new derivation of the equations governing the oscillations of slowly rotating relativistic stars. Previous investigations have been mostly carried out in the Regge-Wheeler gauge. However, in this gauge the process of linearizing the Einstein field equations leads to perturbation equations which as such cannot be used to perform numerical time evolutions. It is only through the tedious process of combining and rearranging the perturbation variables in a clever way that the system can be cast into a set of hyperbolic first order equations, which is then well suited for the numerical integration. The equations remain quite lengthy, and we therefore rederive the perturbation equations in a different gauge, which has been first proposed by Battiston et al. (1970). Using the ADM formalism, one is immediately lead to a first order hyperbolic evolution system, which is remarkably simple and can be numerically integrated without many further manipulations. Moreover, the symmetry between the polar and the axial equations becomes directly apparent.Comment: 13 pages, no figures, MSRAS typesetting, cleaning of the inadvertently disfigured equation

Gravitational Waves from Rotating Proto-Neutron Stars

We study the effects of rotation on the quasi normal modes (QNMs) of a newly born proto neutron star (PNS) at different evolutionary stages, until it becomes a cold neutron star (NS). We use the Cowling approximation, neglecting spacetime perturbations, and consider different models of evolving PNS. The frequencies of the modes of a PNS are considerably lower than those of a cold NS, and are further lowered by rotation; consequently, if QNMs were excited in a sufficiently energetic process, they would radiate waves that could be more easily detectable by resonant-mass and interferometric detectors than those emitted by a cold NS. We find that for high rotation rates, some of the g-modes become unstable via the CFS instability; however, this instability is likely to be suppressed by competing mechanisms before emitting a significant amount of gravitational waves.Comment: 5 pages, proceedings of the 5th Edoardo Amaldi Conference On Gravitational Wave

Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naive to primed cell transition

The differentiation of mouse embryonic stem (ES) cells is controlled by the interaction of multiple signaling pathways, typically mediated by post-translational protein modifications. The addition of O-linked N-acetylglucosamine (O-GlcNAc) to serine and threonine residues of nuclear and cytoplasmic proteins is one such modification (O-GlcNAcylation), whose function in ES cells is only now beginning to be elucidated. Here we demonstrate that the specific inhibition of O-GlcNAc hydrolase (Oga) causes increased levels of protein O-GlcNAcylation and impairs differentiation of mouse ES cells both in serum-free monolayer and in embryoid bodies (EBs). Use of reporter cell lines demonstrates that Oga inhibition leads to a reduction in the number of Sox1-expressing neural progenitors generated following induction of neural differentiation, as well as maintained expression of the ES cell marker Oct4 (Pou5f1). In EBs expression of mesodermal and endodermal markers is also delayed. However, the transition of naïve cells to primed pluripotency indicated by Rex1 (Zfp42), Nanog, Esrrb and Dppa3 downregulation and Fgf5 upregulation remains unchanged. Finally, we demonstrate that increased O-GlcNAcylation results in upregulation of genes normally epigenetically silenced in ES cells, supporting the emerging role for this protein modification in the regulation of histone modifications and DNA methylation. Stem Cells 2014

Theory and reform in the European Union

This substantially updated and revised edition offers a comprehensive overview of the challenges confronting the political system as well as the international politics of the European Union. It draws from a rich spectrum of regional integration theories to determine what the Union actually is and how it is developing. The book examines constitutional politics of the European Union, from the Single European Act to the Treaty of Nice and beyond. The ongoing debate on the future of Europe links together questions of democracy and legitimacy, competences and rights, and the prospects for European polity-building. The aim is to contribute to a better understanding of the emerging European polity and the questions that further treaty reform generate for the future of the regional system. The authors also assess the evolving European security architecture, the limits and possibilities of a genuine European foreign, security and defence policy, and the role of the European Union in the post-Cold War international system. Common themes involve debates about stability and instability, continuity and change, multipolarity and leadership, co-operation and discord, power capabilities and patterns of behaviour. The book traces the defining features of the 'new order' in Europe and incorporates an analysis of the post-September 11 context. This major new edition will be of particular interest to academics, policy-makers and students with an interest in the politics and governance of contemporary Europe, as well as to those pursuing a career in international affairs

Evolution equations for slowly rotating stars

We present a hyperbolic formulation of the evolution equations describing non-radial perturbations of slowly rotating relativistic stars in the Regge--Wheeler gauge. We demonstrate the stability preperties of the new evolution set of equations and compute the polar w-modes for slowly rotating stars.Comment: 27 pages, 2 figure

An intellectual disability syndrome with single nucleotide variants in <i>O-GlcNAc Transferase</i>

Contains fulltext : 220584.pdf (Publisher’s version ) (Open Access)Intellectual disability (ID) is a neurodevelopmental condition that affects ~1% of the world population. In total 5-10% of ID cases are due to variants in genes located on the X chromosome. Recently, variants in OGT have been shown to co-segregate with X-linked intellectual disability (XLID) in multiple families. OGT encodes O-GlcNAc transferase (OGT), an essential enzyme that catalyses O-linked glycosylation with β-N-acetylglucosamine (O-GlcNAc) on serine/threonine residues of thousands of nuclear and cytosolic proteins. In this review, we compile the work from the last few years that clearly delineates a new syndromic form of ID, which we propose to classify as a novel Congenital Disorder of Glycosylation (OGT-CDG). We discuss potential hypotheses for the underpinning molecular mechanism(s) that provide impetus for future research studies geared towards informed interventions

Model-based design of AM components to enable decentralized digital manufacturing systems

Additive manufacturing (AM) is a versatile technology that could add flexibility in manufacturing processes, whether implemented alone or along other technologies. This technology enables on-demand production and decentralized production networks, as production facilities can be located around the world to manufacture products closer to the final consumer (decentralized manufacturing). However, the wide adoption of additive manufacturing technologies is hindered by the lack of experience on its implementation, the lack of repeatability among different manufacturers and a lack of integrated production systems. The later, hinders the traceability and quality assurance of printed components and limits the understanding and data generation of the AM processes and parameters. In this article, a design strategy is proposed to integrate the different phases of the development process into a model-based design platform for decentralized manufacturing. This platform is aimed at facilitating data traceability and product repeatability among different AM machines. The strategy is illustrated with a case study where a car steering knuckle is manufactured in three different facilities in Sweden and Italy

Hydro-without-Hydro Framework for Simulations of Black Hole-Neutron Star Binaries

We introduce a computational framework which avoids solving explicitly hydrodynamic equations and is suitable to study the pre-merger evolution of black hole-neutron star binary systems. The essence of the method consists of constructing a neutron star model with a black hole companion and freezing the internal degrees of freedom of the neutron star during the course of the evolution of the space-time geometry. We present the main ingredients of the framework, from the formulation of the problem to the appropriate computational techniques to study these binary systems. In addition, we present numerical results of the construction of initial data sets and evolutions that demonstrate the feasibility of this approach.Comment: 16 pages, 7 figures. To appear in the Classical and Quantum Gravity special issue on Numerical Relativit

Sprint mechanical characteristics of sub-elite and recreational sprinters

The aim of this study was to explore the sprint mechanical and kinematic characteristics of sub-elite and recreational male sprinters during the acceleration phase of a linear sprint running section. Eighteen sprinters (nine sub-elite, nine recreational) performed two all-out 30-m sprints. Three high speed panning cameras were used to record the entire sprint distance continuously. The sprint velocity-time data of each camera were determined by temporal analysis of the video recording. These values were used to determine the variables of the horizontal F-v profile (theoretical maximal values of horizontal force [F0], velocity [v0], power [Pmax], the maximal ratio of horizontal to resultant force [RFmax], the decline in the ratio of horizontal force production as the running speed increases [DRF]) and key kinematic characteristics. Significant differences were observed between the groups for v0 (0.79 ± 0.24 m∙s-1, p = 0.005), Pmax (3 ± 1.17 W∙kg-1, p = 0.020) and RFmax (3.1 ± 1.2 %, p = 0.021). No statistical differences were found for F0 (0.55 ± 0.46 N∙kg-1, p = 0.25) and DRF (0.2 ± 0.5 %∙s∙m, p = 0.67). The mean running velocity and mean step rate were higher, whereas mean ground contact time was shorter in sub-elite sprinters. There were no differences in mean step length and mean flight time. The subelite sprinters in our study demonstrated the capacity to generate higher amounts of horizontal forces at higher running speeds, apply horizontal force to the ground more efficiently and achieve higher step rates during sprint acceleration than recreational sprinters